thioridazine has been researched along with Amyotrophic Lateral Sclerosis in 2 studies
Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
thioridazine : A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cragnaz, L | 1 |
| Spinelli, G | 1 |
| De Conti, L | 1 |
| Bureau, EA | 1 |
| Brownlees, J | 1 |
| Feiguin, F | 1 |
| Romano, V | 1 |
| Skoko, N | 1 |
| Klima, R | 1 |
| Kettleborough, CA | 1 |
| Baralle, FE | 1 |
| Baralle, M | 1 |
| Seredenina, T | 1 |
| Nayernia, Z | 1 |
| Sorce, S | 1 |
| Maghzal, GJ | 1 |
| Filippova, A | 1 |
| Ling, SC | 1 |
| Basset, O | 1 |
| Plastre, O | 1 |
| Daali, Y | 1 |
| Rushing, EJ | 1 |
| Giordana, MT | 1 |
| Cleveland, DW | 1 |
| Aguzzi, A | 1 |
| Stocker, R | 1 |
| Krause, KH | 1 |
| Jaquet, V | 1 |
2 other studies available for thioridazine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Thioridazine reverts the phenotype in cellular and Drosophila models of amyotrophic lateral sclerosis by enhancing TDP-43 aggregate clearance.
Topics: Amyotrophic Lateral Sclerosis; Animals; Autophagy; Cell Line; Disease Models, Animal; DNA-Binding Pr | 2021 |
Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Female; Gene Expression | 2016 |