thiopyran and Lung-Neoplasms

thiopyran has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for thiopyran and Lung-Neoplasms

Article	Year
A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-κB mediated apoptosis-to-pyroptosis switch. Apoptosis : an international journal on programmed cell death, 2019, Volume: 24, Issue:1-2 Pyroptosis is a novel manner of cell death that can be mediated by chemotherapy drugs. The awareness of pyroptosis is significantly increasing in the fields of anti-tumor research and chemotherapy drugs. Invoking the occurrence of pyroptosis is an attractive prospect for the treatment of lung cancer. Here, the compound L61H10 was obtained as a thiopyran derivative to compare its activity with curcumin. It was indicated that L61H10 exhibited good anti-tumor activity both in vitro and in vivo via the switch of apoptosis-to-pyroptosis, which was associated with the NF-κB signaling pathway. In addition, L61H10 had no obvious side effects both in vitro and in vivo. In brief, L61H10 is shown to be a potential anti-lung cancer agent and research on its anti-tumor mechanism provides new information for chemotherapy drug research. Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; NF-kappa B; Pyrans; Pyroptosis; RAW 264.7 Cells; Signal Transduction; Sulfhydryl Compounds; Toxicity Tests; Xenograft Model Antitumor Assays	2019

Article

Year

A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-κB mediated apoptosis-to-pyroptosis switch.

Apoptosis : an international journal on programmed cell death, 2019, Volume: 24, Issue:1-2

Pyroptosis is a novel manner of cell death that can be mediated by chemotherapy drugs. The awareness of pyroptosis is significantly increasing in the fields of anti-tumor research and chemotherapy drugs. Invoking the occurrence of pyroptosis is an attractive prospect for the treatment of lung cancer. Here, the compound L61H10 was obtained as a thiopyran derivative to compare its activity with curcumin. It was indicated that L61H10 exhibited good anti-tumor activity both in vitro and in vivo via the switch of apoptosis-to-pyroptosis, which was associated with the NF-κB signaling pathway. In addition, L61H10 had no obvious side effects both in vitro and in vivo. In brief, L61H10 is shown to be a potential anti-lung cancer agent and research on its anti-tumor mechanism provides new information for chemotherapy drug research.

Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; NF-kappa B; Pyrans; Pyroptosis; RAW 264.7 Cells; Signal Transduction; Sulfhydryl Compounds; Toxicity Tests; Xenograft Model Antitumor Assays

2019