thiopyran has been researched along with Colonic-Neoplasms* in 1 studies
1 other study(ies) available for thiopyran and Colonic-Neoplasms
Article | Year |
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Antiproliferative activity of novel derivative of thiopyran on breast and colon cancer lines and DNA binding.
Dimethyl-5-acetyl-4-methyl-6-(4-methylphenylimino)-6H-thiopyran-2,3-dicarboxylate (4) has been synthesized and its antiproliferative activity is reported here. Compound 4 inhibited the growth of human colon cancer cell line HCT-15 with an IC(50) value of 3.5 μM and of breast cancer cell line MCF-7 with an IC(50) value of 1.5 μM in a dose/time-dependent manner using a sulforhodamine B assay. Moreover, suppression of clonogenic activity occurred after exposure to 4 at a concentration of 4 μM for HCT-15 and 1.7 μM for MCF-7. The results also showed tumor cell invasion through matrigel and cell adhesion. The effect of ligand complexation on DNA structure led to overall affinity constant of K(4-DNA)=9.8×10(4) M(-1). Topics: Antineoplastic Agents; Binding, Competitive; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Collagen; Colonic Neoplasms; DNA; Dose-Response Relationship, Drug; Drug Combinations; Extracellular Matrix Proteins; Female; Humans; Inhibitory Concentration 50; Kinetics; Laminin; Models, Chemical; Molecular Structure; Proteoglycans; Pyrans; Sulfhydryl Compounds; Time Factors | 2012 |