thiophenes has been researched along with Seizures in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (28.21) | 18.7374 |
| 1990's | 7 (17.95) | 18.2507 |
| 2000's | 11 (28.21) | 29.6817 |
| 2010's | 9 (23.08) | 24.3611 |
| 2020's | 1 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmad, G; Imran, I; Rashid, U; Rasool, N; Rizwan, K; Sadiq, A; Zahoor, AF; Zubair, M | 1 |
| Chen, M; Chen, X; Guo, L; Wang, F; Wu, B; Xu, H; Xu, Y; Yu, F; Yu, J; Zhang, T; Zhou, C | 1 |
| Badolo, L; Bastlund, JF; Crestey, F; Dekermendjian, K; Frederiksen, K; Grunnet, M; Hougaard, C; Jensen, HS; Larsen, PH; Laursen, M; Liu, H; Lu, D; Svenstrup, N; Yang, C; Yang, J | 1 |
| Becker, HM; Deitmer, JW; Forero-Quintero, LS | 1 |
| Moghimi, A; Roohbakhsh, A; Zandi, N; Zaniani, NR | 1 |
| Bryce, DK; Hajós, M; Hanks, AN; Hoffmann, WE; Hurst, RS; Lazzaro, JT; Liu, J; Lotarski, S; Menniti, FS; Osgood, SM; Schmidt, CJ; Scialis, RJ; Shaffer, CL; Weber, ML | 1 |
| Anderson, WH; Bui, HH; Falcone, JF; Gleason, SD; Kato, A; Kuo, MS; Li, X; Stutz, PV; Thompson, LK; Valli, SN; Witkin, JM | 1 |
| Adhikari, AV; Kulandasamy, R; Stables, JP | 2 |
| Chiocchetti, B; Melani, F; Muscas, GC; Rosati, E | 1 |
| Bortolatto, CF; Jesse, CR; Nogueira, CW; Rambo, LM; Ribeiro, LR; Roman, SS; Royes, LF; Wilhelm, EA | 1 |
| Dersch, R; Voderholzer, U; Zwernemann, S | 1 |
| Boissonnet, A; Cloix, JF; Hévor, T; Landemarre, L | 1 |
| Baker, RS; Chamberlain, MJ; Clark, BP; Griffey, K; Harris, JR; Johnson, BG; Johnson, MP; Kelly, G; Kingston, AE; Schoepp, DD; Tizzano, JT; Tomlinson, R; Wright, RA | 1 |
| Atack, JR; Broughton, HB; Chambers, MS; Collinson, N; Cook, S; Dawson, GR; Hobbs, SC; MacLeod, AM; Marshall, G; Maubach, KA; Pillai, GV; Reeve, AJ | 1 |
| Kruszewski, SP | 1 |
| Aladag, MA; Armutcu, F; Boluk, A; Gurel, A; Ilhan, A; Kocer, A | 1 |
| Berger, ML; Buchstaller, HP; Frank, I; Gottschlich, R; Krug, M; Leibrock, J; Noe, CR; Siebert, CD; Steinhilber, D; Steinmetz, R | 1 |
| Maramattom, BV | 1 |
| Kaplan, H; Majkowski, J | 1 |
| Lasoń, W; Machelska, H; Przewłocka, B | 1 |
| Asin, KE; Bednarz, L; Britton, DR; Giardina, WJ; Mahan, L; Mikusa, J; Nikkel, A; Shiosaki, K; Wismer, C | 1 |
| Modica, M; Russo, F; Santagati, A; Santagati, M; Spampinato, S | 1 |
| Blackburn, T; Kennett, G; Middlemiss, D; Stean, T; Upton, N | 1 |
| Bromidge, SM; Brown, AM; Clarke, SE; Gager, T; Hirst, W; Middlemiss, DN; Moss, SF; Newman, H; Price, GW; Riley, G; Routledge, C; Stean, T; Upton, N | 1 |
| Mori, F; Tanji, K; Wakabayashi, K | 1 |
| Andersen, ME; Jenkins, LJ; Jones, RA; Kurlansik, L; Mehl, RG | 1 |
| Dalzell, HC; Dodge, PW; Dren, AT; Handrick, GR; Howes, JF; Plotnikoff, NP; Razdan, RK; Winn, M | 1 |
| del Río, J; Fernándex-Tomé, MP; Fuentes, JA; Madroñero, R | 1 |
| Bansinath, M; Ramabadran, K; Shukla, VK; Turndorf, H | 1 |
| Hashimoto, S; Kasahara, K; Nagatani, T; Sugihara, T; Takao, K; Ueki, S; Yamamoto, T | 1 |
| Corbett, R; Cornfeldt, ML; Dunn, RW; Fielding, S; Laws-Ricker, L; Martin, LL; Payack, JF; Rush, DK; Wilmot, CA | 1 |
| Eigyo, M; Matsushita, A; Murata, S; Shindo, H; Takada, S | 1 |
| Eigyo, M; Kawasaki, K; Matsushita, A; Murata, S; Sasatani, T; Shindo, H; Takada, S | 1 |
| Gordon, CJ; Mohler, FS | 1 |
| Albin, MS; Massopust, LC; Wolin, LR | 1 |
| Kästner, I; Müller, M; Walther, H | 1 |
| Kästner, I; Kermes, U; Rougerie, A | 1 |
| Dadkar, NK; Damle, SK; Gaitonde, B | 1 |
39 other study(ies) available for thiophenes and Seizures
| Article | Year |
|---|---|
Synthesis, in-vitro cholinesterase inhibition, in-vivo anticonvulsant activity and in-silico exploration of N-(4-methylpyridin-2-yl)thiophene-2-carboxamide analogs.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Butyrylcholinesterase; Cholinesterase Inhibitors; Diazepam; Dose-Response Relationship, Drug; Electrophorus; Female; Horses; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Pentylenetetrazole; Seizures; Structure-Activity Relationship; Thiophenes | 2019 |
Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models.
Topics: Acute Disease; Animals; Basic-Leucine Zipper Transcription Factors; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; GABA Plasma Membrane Transport Proteins; GABAergic Neurons; gamma-Aminobutyric Acid; Gene Expression Regulation; Hippocampus; Humans; Inhibitory Postsynaptic Potentials; Isoquinolines; Kindling, Neurologic; Mice, Inbred C57BL; Mice, Knockout; Nuclear Receptor Subfamily 1, Group D, Member 1; RNA, Messenger; Seizures; Small Molecule Libraries; Thiophenes | 2021 |
A small molecule activator of Na
Topics: Action Potentials; Animals; Anticonvulsants; CA1 Region, Hippocampal; Excitatory Postsynaptic Potentials; GABAergic Neurons; HEK293 Cells; Humans; Interneurons; Male; Mice; NAV1.1 Voltage-Gated Sodium Channel; Rats; Rats, Sprague-Dawley; Seizures; Sodium Channel Blockers; Thiophenes | 2017 |
Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters.
Topics: 3-Hydroxybutyric Acid; Animals; Astrocytes; Brain; Diet, Ketogenic; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Glycolysis; Ketone Bodies; Lactic Acid; Mice; Mice, Inbred C57BL; Microtomy; Monocarboxylic Acid Transporters; Neurons; Primary Cell Culture; Seizures; Signal Transduction; Symporters; Thiophenes; Tissue Culture Techniques; Uracil | 2017 |
Protective effects of M8‑B, a TRPM8 antagonist, on febrile‑ and pentylenetetrazol‑induced seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Body Temperature; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Seizures, Febrile; Thiophenes; Time Factors; TRPM Cation Channels | 2019 |
Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574.
Topics: Allosteric Regulation; Animals; Cells, Cultured; Dogs; Excitatory Amino Acid Agonists; Female; HEK293 Cells; Humans; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; Psychomotor Performance; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Seizures; Thiophenes; Treatment Outcome | 2013 |
Inquiries into the Biological Significance of Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8 Through Investigations of TARP γ-8 Null Mice§.
Topics: Acetylcholine; Amphetamines; Animals; Biogenic Monoamines; Body Temperature; Brain; Calcium Channels; Central Nervous System Stimulants; Cyclic AMP; Excitatory Amino Acid Antagonists; Exploratory Behavior; Histamine; Hyperkinesis; Lipids; Maze Learning; Mice; Mice, Transgenic; Motor Activity; Pentylenetetrazole; Phencyclidine; Receptors, AMPA; Seizures; Sulfonamides; Swimming; Thiophenes; Time Factors | 2015 |
Synthesis and anticonvulsant activity of some new bishydrazones derived from 3,4-dipropyloxythiophene.
Topics: Animals; Anticonvulsants; Electroshock; Hydrazones; Male; Mice; Pentylenetetrazole; Rotarod Performance Test; Seizures; Thiophenes | 2009 |
Antidepressant-associated myoclonic status in a patient with symptomatic generalized epilepsy: does risk occur with therapeutic doses?
Topics: Antidepressive Agents; Depression; Duloxetine Hydrochloride; Electroencephalography; Epilepsy, Generalized; Humans; Male; Middle Aged; Paroxetine; Seizures; Thiophenes | 2009 |
A new class of anticonvulsants possessing 6 Hz activity: 3,4-dialkyloxy thiophene bishydrazones.
Topics: Animals; Anticonvulsants; Electroshock; Hydrazones; Male; Mice; Molecular Structure; Motor Activity; Pentylenetetrazole; Seizures; Structure-Activity Relationship; Thiophenes | 2009 |
Protective effect of 2,2'-dithienyl diselenide on kainic acid-induced neurotoxicity in rat hippocampus.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Glutathione Peroxidase; Hippocampus; Kainic Acid; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Organoselenium Compounds; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar; Reaction Time; Seizures; Sodium-Potassium-Exchanging ATPase; Sulfhydryl Compounds; Thiophenes; Thymidine; Trityl Compounds | 2011 |
Partial status epilepticus after electroconvulsive therapy and medical treatment with bupropion.
Topics: Adrenergic Uptake Inhibitors; Adult; Anticonvulsants; Antidepressive Agents, Second-Generation; Bupropion; Depressive Disorder, Major; Duloxetine Hydrochloride; Electroconvulsive Therapy; Electroencephalography; Humans; Male; Seizures; Status Epilepticus; Thiophenes | 2011 |
Monoamines and glycogen levels in cerebral cortices of fast and slow methionine sulfoximine-inbred mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Brain; Disease Models, Animal; Glycogen; Hydroxyindoleacetic Acid; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Seizures; Serotonin; Thiophenes | 2013 |
Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists.
Topics: Alanine; Animals; Benzoates; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Inhibitory Concentration 50; Mice; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Seizures; Structure-Activity Relationship; Thiophenes; Xanthenes | 2002 |
Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.
Topics: Animals; Brain; Cell Line; Cognition; Female; GABA Agonists; Hippocampus; Humans; In Vitro Techniques; Ligands; Male; Maze Learning; Memory; Mice; Nootropic Agents; Oocytes; Patch-Clamp Techniques; Protein Subunits; Radioligand Assay; Rats; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Thiazoles; Thiophenes; Xenopus laevis | 2003 |
Neonatal brain injury.
Topics: Diagnosis, Differential; Duloxetine Hydrochloride; Female; Fetus; Humans; Infant, Newborn; Pregnancy; Prenatal Exposure Delayed Effects; Seizures; Selective Serotonin Reuptake Inhibitors; Thiophenes | 2005 |
Erdosteine ameliorates PTZ-induced oxidative stress in mice seizure model.
Topics: Animals; Anticonvulsants; Brain Chemistry; Cerebral Cortex; Convulsants; Disease Models, Animal; Drug Interactions; Female; Malondialdehyde; Mice; Nitric Oxide; Oxidative Stress; Pentylenetetrazole; Reaction Time; Seizures; Superoxide Dismutase; Thioglycolates; Thiophenes; Xanthine Oxidase | 2005 |
Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor.
Topics: Animals; Binding, Competitive; Blood-Brain Barrier; Cell Line; Cytoprotection; Electroshock; Glycine; Humans; In Vitro Techniques; Male; Mice; Protein Subunits; Pyridones; Quantitative Structure-Activity Relationship; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Seizures; Thiophenes; Transfection | 2006 |
Duloxetine-induced syndrome of inappropriate antidiuretic hormone secretion and seizures.
Topics: Antidepressive Agents; Depression; Drug Administration Schedule; Duloxetine Hydrochloride; Female; Humans; Inappropriate ADH Syndrome; Medical Errors; Middle Aged; Seizures; Thiophenes; Treatment Outcome | 2006 |
Value of Mongolian gerbils in antiepileptic drug evaluation.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation; Epilepsy; Gerbillinae; Seizures; Thiophenes; Valproic Acid | 1983 |
Kappa opioid receptor agonists inhibit the pilocarpine-induced seizures and toxicity in the mouse.
Topics: Analgesics; Animals; Benzeneacetamides; Brain; Injections, Intraperitoneal; Mice; Naltrexone; Pilocarpine; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Seizures; Thiophenes | 1994 |
Hyperactivity and behavioral seizures in rodents following treatment with the dopamine D1 receptor agonists A-86929 and ABT-431.
Topics: Animals; Behavior, Animal; Benzazepines; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Mice; Motor Activity; Oxidopamine; Prodrugs; Pyridines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Seizures; Sympathectomy, Chemical; Tetrahydronaphthalenes; Thiophenes | 1996 |
Synthesis of aminothienopyrimidine and thienotriazolopyrimidine derivatives as potential anticonvulsant agents.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Male; Mice; Motor Activity; Pyrimidines; Rats; Seizures; Thiophenes; Triazoles | 1996 |
Studies on the role of 5-HT2C and 5-HT2B receptors in regulating generalised seizure threshold in rodents.
Topics: Animals; Drug Interactions; Electric Stimulation; Indoles; Male; Mice; Pentylenetetrazole; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Seizures; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes | 1998 |
Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist.
Topics: Adenylyl Cyclases; Administration, Oral; Animals; Binding, Competitive; Brain; Cognition; Disease Models, Animal; Electric Stimulation; HeLa Cells; Humans; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Recombinant Proteins; Seizures; Serotonin Antagonists; Sulfonamides; Thiophenes; Transfection | 2000 |
Convulsive effects of thiophene, a heterocyclic hydrocarbon: behavioral, electrographic and c-Fos immunocytochemical studies.
Topics: Animals; Behavior, Animal; Brain; Electroencephalography; Hippocampus; Hydrocarbons; Male; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred WKY; Seizures; Thiophenes | 2000 |
Sulfolane-induced convulsions in rodents.
Topics: Administration, Oral; Animals; Cyclic S-Oxides; Dogs; Drug Interactions; Guinea Pigs; Haplorhini; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Lethal Dose 50; Male; Mice; Pentobarbital; Pentylenetetrazole; Rabbits; Rats; Saimiri; Seizures; Sleep; Thiophenes; Time Factors | 1976 |
Drugs derived from cannabinoids. 4. Effect of alkyl substitution in sulfur and carbocyclic analogs.
Topics: Acoustic Stimulation; Aggression; Analgesics; Animals; Ataxia; Cannabis; Cats; Cyclohexanes; Cyclopentanes; Dihydroxyphenylalanine; Dogs; Humans; Hypnotics and Sedatives; Mice; Motor Activity; Phytotherapy; Rats; Reaction Time; Seizures; Structure-Activity Relationship; Thiophenes | 1976 |
Pharmacological properties of 6,7-tetramethylene-5-phenyl-1,2-dihydro-3H-thieno[2,3-e](1,4)-diazepin-2-one (QM-6008, thiadipone), a new psychotropic drug.
Topics: Aggression; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Benzodiazepinones; Cats; Chlordiazepoxide; Conditioning, Operant; Discrimination Learning; Dogs; Electroencephalography; Female; Guinea Pigs; Humans; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Motor Activity; Motor Skills; Rabbits; Rats; Reinforcement Schedule; Seizures; Sleep; Thiophenes | 1975 |
Intracerebroventricular administration of kappa-agonists induces convulsions in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Baclofen; Benzeneacetamides; Benzomorphans; Cerebral Ventricles; Convulsants; Dizocilpine Maleate; Injections, Intraventricular; Ketamine; Mice; Mice, Inbred Strains; Muscimol; Naloxone; Narcotic Antagonists; Narcotics; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Seizures; Stereoisomerism; Thiophenes | 1991 |
Pharmacological profile of a potential anxiolytic: AP159, a new benzothieno-pyridine derivative.
Topics: Aggression; Animals; Anti-Anxiety Agents; Avoidance Learning; Conflict, Psychological; Drinking Behavior; Ethanol; Flumazenil; Hydroxyindoleacetic Acid; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Motor Activity; Muscle Relaxants, Central; Postural Balance; Pyridines; Rats; Rats, Inbred Strains; Seizures; Serotonin; Thienopyridines; Thiopental; Thiophenes | 1991 |
Preclinical anxiolytic profiles of 7189 and 8319, novel non-competitive NMDA antagonists.
Topics: Aniline Compounds; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Binding, Competitive; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Learning; Male; Mice; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Seizures; Thiophenes; Tritium; Yohimbine | 1990 |
Thienylpyrazoloquinolines with high affinity to benzodiazepine receptors: continuous shift from inverse agonist to agonist properties depending on the size of the alkyl substituent.
Topics: Animals; Chemical Phenomena; Chemistry; Diazepam; Drug Synergism; Male; Mice; Molecular Structure; Pentylenetetrazole; Pyrazoles; Quinolines; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Thiophenes | 1989 |
A new thienylpyrazoloquinoline: a potent and orally active inverse agonist to benzodiazepine receptors.
Topics: Administration, Oral; Animals; Anticonvulsants; Indicators and Reagents; Male; Mice; Pentylenetetrazole; Pyrazoles; Quinolines; Receptors, GABA-A; Seizures; Thiophenes | 1987 |
Thermoregulatory responses of the rabbit to subcutaneous injection of sulfolane.
Topics: Animals; Basal Metabolism; Body Temperature Regulation; Dose-Response Relationship, Drug; Male; Rabbits; Seizures; Species Specificity; Thiophenes | 1988 |
The effects of a new phencyclidine derivative and diazepinone derivative on the electroencephalographic and behavioral responses in the cat.
Topics: Anesthetics; Animals; Antidepressive Agents; Azepines; Behavior, Animal; Brain; Cats; Cyclohexanes; Electroencephalography; Ethylamines; Female; Fluorobenzenes; Heart Rate; Male; Muscle Contraction; Pyrazoles; Respiration; Seizures; Thiophenes; Tranquilizing Agents | 1973 |
[Rhythmic activity in the rat electroencephalogram generated by 2,4-dimethylsulfolan].
Topics: Animals; Brain; Cyclic S-Oxides; Electrodes, Implanted; Electroencephalography; Evoked Potentials; Male; Motor Activity; Pulse; Rats; Rats, Inbred Strains; Reflex, Startle; Respiration; Seizures; Thiophenes; Time Factors | 1972 |
[Effect of phenytoin and ethosuximide on the convulsive action of 2,4-dimethylsulfolan].
Topics: Acoustic Stimulation; Animals; Cyclic S-Oxides; Electrodes, Implanted; Ethosuximide; Male; Motor Activity; Phenytoin; Photic Stimulation; Rats; Seizures; Thiophenes | 1971 |
The convulsive action of 2,5-dicarbethoxy 3,4-dihydroxythiophane (dicetol).
Topics: Acetylcholine; Animals; Blood Pressure; Brain Chemistry; Cats; Depression, Chemical; Guinea Pigs; Heart; Ileum; In Vitro Techniques; Mice; Muscles; Pentobarbital; Picrotoxin; Rabbits; Rats; Reserpine; Respiration; Seizures; Sleep; Thiophenes | 1968 |