thiophenes has been researched along with Schizophrenia in 85 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.35) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (9.41) | 29.6817 |
| 2010's | 49 (57.65) | 24.3611 |
| 2020's | 26 (30.59) | 2.80 |
| Authors | Studies |
|---|---|
| Hibino, H; Inoue, Y; Matsumoto, H; Mikami, K; Suzuki, H; Takaya, A; Yamamoto, K | 2 |
| Fernando, R; Gan, L; Xiao, J; Yun, Y | 1 |
| Schooler, NR | 1 |
| Bellagamba, S; Orsolini, L; Salvi, V; Volpe, U | 1 |
| Picazo Picazo, O; Roldán Roldán, G; Suárez-Santiago, JE | 1 |
| Hishimoto, A; Matsukawa, M; Sekine, D; Yamada, S; Yasui-Furukori, N | 1 |
| Cahill, D; Kohegyi, E; Larsen, F; Raoufinia, A; Wang, X; Wang, Y; Ward, C; Zoubroulis, A | 1 |
| Cheng, CS; Kuo, CJ; Lin, SK | 1 |
| Kumakura, J; Okada, T; Suda, S; Yasuda, M | 1 |
| Futamura, T; Kikuchi, T; Maeda, K; Niidome, K; Suzuki, M; Usami, T | 1 |
| Aoki, S; Shimizu, H; Takeda, T; Washida, K; Yamashita, R; Yoshimura, Y | 1 |
| Crippa, A; Davis, JM; Leucht, S; Orsini, N; Patel, MX; Siafis, S | 1 |
| Broder, MS; Chang, E; Greene, M; Houle, CR; Tarbox, MH; Waters, HC; Yan, T | 1 |
| Ikuta, T; Iwata, N; Kishi, T; Matsuda, Y; Sakuma, K | 1 |
| Antoun Reyad, A; Girgis, E; Mishriky, R | 1 |
| Copolov, D; Hope, J; Keks, N; McLennan, H; Meadows, G; Schwartz, D | 1 |
| Ishigooka, J; Iwashita, S; Kojima, Y; Matsuo, S; Usami, T | 1 |
| Baker, RA; Cox, K; Eramo, A; Kojima, Y; Okame, T; Potkin, SG; van Erp, TG | 1 |
| Markovic, M; Maroney, M; Stummer, L | 1 |
| Ismail, Z; Meade, N; Meehan, SR; Shi, L; Weiss, C | 1 |
| Boku, S; Fujiyama, H; Fukuhara, R; Kanno, T; Kawahara, K; Sugawara, H; Takebayashi, M; Tanaka, H | 1 |
| Kikuchi, T; Otsubo, T; Watanabe, Y; Yamada, S | 1 |
| Aoki, K; Inada, K; Ishigooka, J; Iwashita, S; Kojima, Y; Niidome, K; Yamada, S | 1 |
| Baas, CAJ; Knegtering, H; Spoelstra, SK | 1 |
| Edinoff, AN; Girma, B; Kaye, AD; Kaye, AJ; Kaye, AM; Kaye, JS; Leethy, KN; Maxey, BS; Mychaskiw, G; Odisho, A; Ren, AL; Urits, I; Viswanath, O; Wu, NW | 1 |
| Bruno, CD; Chow, CR; Elmokadem, A; Greenblatt, DJ; Housand, C; Jordie, EB; Lesko, LJ | 1 |
| Dineley, KT; Dunphy, JM; Haydon, PG; Papouin, T; Tolman, M | 1 |
| Briones-Aranda, A; Espinosa-Raya, J; Picazo, O; Suárez-Santiago, JE | 1 |
| Higashi, K; Ishigooka, J; Iwashita, S; Liew, EL; Tadori, Y | 1 |
| Ekinci, A; Ekinci, O | 1 |
| Castle, D; Hope, J; Keks, NA | 1 |
| Forbes, A; Hakala, M; Hobart, M; Ouyang, J; Pfister, S; Shi, L | 1 |
| Ishigooka, J; Iwashita, S; Tadori, Y | 2 |
| Baker, RA; Duffy, RA; Gwin, KK; McQuade, RD; Weiller, E; Weiss, C; Zhang, P | 1 |
| Eriksson, H; Newcomer, JW; Weiller, E; Weiss, C; Zhang, P | 1 |
| Cieślik, P; Kalinowski, L; Kusek, M; Pelikant-Małecka, I; Pilc, A; Płoska, A; Radulska, A; Sławiński, J; Tokarski, K; Wierońska, JM; Woźniak, M; Żołnowska, B | 1 |
| Baker, RA; Correll, CU; Duffy, RA; Eramo, A; Hobart, M; Shi, L; Weiller, E; Weiss, C | 1 |
| Frampton, JE | 1 |
| Limandri, BJ | 1 |
| Bauer, LO; Dgetluck, N; Gawryl, M; Hilt, DC; Palfreyman, M; Preskorn, SH | 1 |
| Parachikova, AI; Pedersen, CS; Plath, N; Sørensen, DB | 1 |
| Carson, WH; Eriksson, H; Hobart, M; Kane, JM; McQuade, RD; Nyilas, M; Ouyang, J; Pfister, S; Sanchez, R; Skuban, A | 1 |
| Ishii, Y; Matsumoto, J; Nakamura, T; Nishijo, H; Ono, T; Sasahara, M; Takamura, Y | 1 |
| Howland, RH | 1 |
| Carson, WH; Correll, CU; Eriksson, H; Hobart, M; McQuade, RD; Nyilas, M; Ouyang, J; Pfister, S; Sanchez, R; Skuban, A | 1 |
| Bryce, DK; Chang, C; Chen, L; Hajós, M; Hoffmann, WE; Hou, XJ; Hurst, RS; Karki, K; Lazzaro, JT; Liu, J; Lotarski, SM; McGinnis, DF; O'Donnell, CJ; Obach, RS; Osgood, SM; Pandit, J; Patel, NC; Schmidt, CJ; Schwarz, J; Scialis, RJ; Seymour, PA; Shaffer, CL; Weber, ML; Wei, Y; Xie, L; Zasadny, KR | 1 |
| Dgetluck, N; Gawryl, M; Hilt, DC; Keefe, RS; Koenig, G; Lombardo, I; Meltzer, HA; Moebius, HJ | 1 |
| Citrome, L | 5 |
| Kibble, A | 1 |
| Greig, SL | 1 |
| Goff, DC | 1 |
| Yee, A | 1 |
| Citrome, L; McEvoy, J | 1 |
| Stahl, SM | 1 |
| Bachhawat, P; Bures, MG; Christopoulos, A; Evans, DA; Felder, CC; Feng, D; Kobilka, BK; Kobilka, TS; Leach, K; Nawaratne, V; Sexton, PM; Sun, B; Thal, DM; Weis, WI | 1 |
| Baker, RA; Citrome, L; Nagamizu, K; Ota, A; Perry, P; Weiller, E | 1 |
| Garnock-Jones, KP | 1 |
| Correll, CU; Hobart, M; Kane, JM; Ouyang, J; Skuban, A; Weiller, E; Weiss, C | 2 |
| Bruijnzeel, D; Tandon, R | 1 |
| Carson, WH; Fleischhacker, WW; Forbes, A; Hobart, M; McQuade, RD; Nyilas, M; Ouyang, J; Pfister, S; Sanchez, R; Weiller, E | 1 |
| Baker, RA; Malla, A; Nagamizu, K; Ota, A; Perry, P; Weiller, E | 1 |
| Hakala, MJ; Hobart, M; Josiassen, MK; Marder, SR; Ouyang, J; Weiller, E; Weiss, C; Zhang, P | 1 |
| Hsu, WY; Lane, HY; Lin, CH | 1 |
| Gallipani, A; Markovic, M; Maroney, M; Patel, KH | 1 |
| Birdsall, NJ; Bose, S; Bymaster, FP; Chan, WY; Christopoulos, A; Felder, CC; Lazareno, S; McKinzie, DL; Mitchell, SN; Thompson, RC; Witkin, JM | 1 |
| Brandon, NJ; Hinchliffe, RM; Huszar, SL; Hutson, PH; Jacobson, MA; Jones, B; Kandebo, M; McNaughton, CH; Mullins, CM; Pascarella, DM; Sachs, N; Smith, SM; Sparey, T; Surles, NO; Uslaner, JM; Venkatraman, S; Yao, L; Young, MB | 1 |
| Williams, M | 1 |
| Cohen, AF; de Boer, P; de Kam, ML; Franson, KL; Liem-Moolenaar, M; Schmidt, M; van Gerven, JM; Zoethout, RW | 1 |
| Bruno, A; D'Arrigo, C; Mallamace, D; Maria Romeo, V; Mico', U; Muscatello, MR; Pandolfo, G; Spina, E; Zoccali, RA | 1 |
| Bencherif, M; Kucinski, A; Stachowiak, EK; Stachowiak, MK; Syposs, C; Wersinger, S | 1 |
| Blobaum, AL; Bridges, TM; Conn, PJ; Daniels, JS; Hopkins, CR; Jones, CK; Lamsal, A; Le, U; Lindsley, CW; Melancon, BJ; Niswender, CM; Rodriguez, AL; Sheffler, DJ; Utley, TJ; Venable, D; Vinson, PN; Wood, MR | 1 |
| Deuschle, M; Knopf, U; Kuwilsky, A; Mase, E; Zink, M | 1 |
| Aubry, JM; Barbe, R; Bertschy, G; Bryois, C; Delini-Stula, A; Gervasoni, N; Merlo, M | 1 |
| Cilia, J; Hatcher, P; Jones, DN; Reavill, C | 1 |
| Honda, Y; Kagono, Y; Kita, S; Saito, M; Suitsu, N | 1 |
| Arnt, J; Didriksen, M; Pouzet, B | 1 |
| Bishop, MP; Gallant, DM; Gallant, J; Shelton, W | 1 |
25 review(s) available for thiophenes and Schizophrenia
| Article | Year |
|---|---|
Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia.
Topics: Acute Disease; Administration, Oral; Antipsychotic Agents; Aripiprazole; Clozapine; Delayed-Action Preparations; Dose-Response Relationship, Drug; Haloperidol; Humans; Imidazoles; Indoles; Isoxazoles; Lurasidone Hydrochloride; Olanzapine; Paliperidone Palmitate; Piperazines; Piperidines; Quetiapine Fumarate; Quinolones; Risperidone; Schizophrenia; Schizophrenic Psychology; Thiazoles; Thiophenes | 2020 |
Aripiprazole vs. brexpiprazole for acute schizophrenia: a systematic review and network meta-analysis.
Topics: Acute Disease; Akathisia, Drug-Induced; Antipsychotic Agents; Aripiprazole; Humans; Network Meta-Analysis; Quinolones; Randomized Controlled Trials as Topic; Schizophrenia; Thiophenes; Weight Gain | 2020 |
Efficacy and safety of brexpiprazole in acute management of psychiatric disorders: a meta-analysis of randomized controlled trials.
Topics: Antipsychotic Agents; Aripiprazole; Depressive Disorder, Major; Humans; Psychiatric Status Rating Scales; Quetiapine Fumarate; Quinolones; Schizophrenia; Thiophenes; Treatment Outcome | 2020 |
Comparative Tolerability of Dopamine D2/3 Receptor Partial Agonists for Schizophrenia.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Dopamine Agonists; Humans; Piperazines; Quinolones; Receptors, Dopamine D2; Receptors, Dopamine D3; Schizophrenia; Thiophenes | 2020 |
Brexpiprazole for the Treatment of Schizophrenia in Adults: An Overview of Its Clinical Efficacy and Safety and a Psychiatrist's Perspective.
Topics: Adult; Antipsychotic Agents; Dopamine Agonists; Humans; Psychiatry; Quinolones; Receptors, Dopamine D2; Schizophrenia; Thiophenes; Treatment Outcome | 2020 |
Brexpiprazole for the Treatment of Schizophrenia and Major Depressive Disorder: A Comprehensive Review of Pharmacological Considerations in Clinical Practice.
Topics: Antipsychotic Agents; Depressive Disorder, Major; Humans; Quinolones; Schizophrenia; Thiophenes | 2021 |
Brexpiprazole: A Partial Dopamine Agonist for the Treatment of Schizophrenia.
Topics: Dopamine Agonists; Humans; Quinolones; Schizophrenia; Thiophenes; Treatment Outcome | 2018 |
Brexpiprazole: a new leaf on the partial dopamine agonist branch.
Topics: Antipsychotic Agents; Aripiprazole; Depressive Disorder, Treatment-Resistant; Dopamine Agonists; Humans; Quinolones; Schizophrenia; Thiophenes | 2018 |
Changes in metabolic parameters and body weight in brexpiprazole-treated patients with acute schizophrenia: pooled analyses of phase 3 clinical studies.
Topics: Adult; Antipsychotic Agents; Clinical Trials, Phase III as Topic; Double-Blind Method; Glucose; Humans; Longitudinal Studies; Quinolones; Randomized Controlled Trials as Topic; Schizophrenia; Thiophenes; Triglycerides; Weight Gain | 2018 |
Brexpiprazole: A Review in Schizophrenia.
Topics: Antipsychotic Agents; Aripiprazole; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Approval; Humans; Japan; Quinolones; Schizophrenia; Serotonin Receptor Agonists; Thiophenes; United States | 2019 |
Brexpiprazole for schizophrenia and as adjunct for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antipsychotic - what is the number needed to treat, number needed to harm and likelihood to be hel
Topics: Antidepressive Agents; Antipsychotic Agents; Chemotherapy, Adjuvant; Clinical Trials as Topic; Depressive Disorder, Major; Dopamine Agonists; Humans; Quinolones; Schizophrenia; Thiophenes | 2015 |
Brexpiprazole: a new dopamine D₂receptor partial agonist for the treatment of schizophrenia and major depressive disorder.
Topics: Depressive Disorder, Major; Dopamine Agonists; Humans; Quinolones; Receptors, Dopamine D2; Schizophrenia; Thiophenes | 2015 |
Brexpiprazole (Rexulti) for schizophrenia and depression.
Topics: Animals; Depressive Disorder, Major; Dopamine Agonists; Humans; Quinolones; Randomized Controlled Trials as Topic; Schizophrenia; Serotonin Agents; Thiophenes | 2015 |
Brexpiprazole: First Global Approval.
Topics: Depressive Disorder; Drug Approval; Humans; Internationality; Molecular Structure; Quinolones; Schizophrenia; Thiophenes | 2015 |
Brexpiprazole for the treatment of schizophrenia.
Topics: Antipsychotic Agents; Dopamine Agonists; Humans; Quinolones; Schizophrenia; Serotonin Agents; Thiophenes; Treatment Outcome | 2016 |
Brexpiprazole for the Treatment of Schizophrenia: A Review of this Novel Serotonin-Dopamine Activity Modulator.
Topics: Antipsychotic Agents; Humans; Quinolones; Schizophrenia; Thiophenes | 2016 |
Brexpiprazole: A Review in Schizophrenia.
Topics: Animals; Antipsychotic Agents; Humans; Quinolones; Schizophrenia; Thiophenes | 2016 |
Efficacy of brexpiprazole in patients with acute schizophrenia: Review of three randomized, double-blind, placebo-controlled studies.
Topics: Acute Disease; Antipsychotic Agents; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Quinolones; Randomized Controlled Trials as Topic; Schizophrenia; Thiophenes | 2016 |
Overview of short- and long-term tolerability and safety of brexpiprazole in patients with schizophrenia.
Topics: Antipsychotic Agents; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Quinolones; Randomized Controlled Trials as Topic; Schizophrenia; Thiophenes | 2016 |
Spotlight on brexpiprazole and its potential in the treatment of schizophrenia and as adjunctive therapy for the treatment of major depression.
Topics: Animals; Depressive Disorder, Major; Humans; Quinolones; Schizophrenia; Thiophenes | 2016 |
Brexpiprazole for the treatment of schizophrenia.
Topics: Antipsychotic Agents; Cognition; Dopamine; Humans; Psychomotor Agitation; Quinolones; Receptors, Dopamine D2; Schizophrenia; Serotonin; Thiophenes | 2017 |
Emerging pharmacological therapies in schizophrenia: what's new, what's different, what's next?
Topics: Antipsychotic Agents; Aripiprazole; Delayed-Action Preparations; Humans; Injections, Intramuscular; Paliperidone Palmitate; Piperazines; Quinolones; Schizophrenia; Tetrabenazine; Thiophenes; Valine | 2016 |
Brexpiprazole.
Topics: Antidepressive Agents; Antipsychotic Agents; Clinical Trials, Phase III as Topic; Depressive Disorder, Major; Drug Therapy, Combination; Humans; Quinolones; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Schizophrenia; Thiophenes; Weight Gain | 2017 |
[Psychiatry].
Topics: Adolescent; Antidepressive Agents; Bipolar Disorder; Child; Depression; Duloxetine Hydrochloride; Humans; Mental Disorders; Schizophrenia; Thiophenes | 2007 |
Compelling or irrelevant? Using number needed to treat can help decide.
Topics: Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Data Interpretation, Statistical; Depressive Disorder, Major; Dibenzothiazepines; Duloxetine Hydrochloride; Evidence-Based Medicine; Humans; Outcome Assessment, Health Care; Quetiapine Fumarate; Randomized Controlled Trials as Topic; Schizophrenia; Secondary Prevention; Thiophenes; Treatment Outcome | 2008 |
19 trial(s) available for thiophenes and Schizophrenia
| Article | Year |
|---|---|
Post-hoc analysis investigating the safety and efficacy of brexpiprazole in Japanese patients with schizophrenia who were switched from other antipsychotics in a long-term study (Secondary Publication).
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Dopamine Agonists; Dose-Response Relationship, Drug; Double-Blind Method; Drug Substitution; Female; Headache; Humans; Japan; Longitudinal Studies; Male; Middle Aged; Quinolones; Schizophrenia; Schizophrenic Psychology; Sleep Initiation and Maintenance Disorders; Thiophenes; Treatment Outcome; Young Adult | 2020 |
Effect of brexpiprazole on control of impulsivity in schizophrenia: A randomized functional magnetic resonance imaging study.
Topics: Adult; Cerebral Cortex; Dopamine Agonists; Double-Blind Method; Female; Humans; Impulsive Behavior; Inhibition, Psychological; Magnetic Resonance Imaging; Male; Middle Aged; Quinolones; Schizophrenia; Task Performance and Analysis; Thiophenes; Treatment Outcome; Young Adult | 2020 |
Efficacy and safety of brexpiprazole in patients with schizophrenia presenting with severe symptoms:
Topics: Adult; Double-Blind Method; Female; Humans; Male; Middle Aged; Neurotransmitter Agents; Outcome Assessment, Health Care; Quinolones; Schizophrenia; Severity of Illness Index; Thiophenes | 2020 |
Pharmacokinetics and Safety of Brexpiprazole Following Multiple-Dose Administration to Japanese Patients With Schizophrenia.
Topics: Antipsychotic Agents; Area Under Curve; Asian People; Cytochrome P-450 CYP2D6; Depressive Disorder, Major; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Quinolones; Schizophrenia; Thiophenes | 2018 |
A Long-Term, Open-Label Study to Evaluate the Safety and Tolerability of Brexpiprazole as Maintenance Treatment in Adults with Schizophrenia.
Topics: Adult; Antipsychotic Agents; Double-Blind Method; Female; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Quinolones; Schizophrenia; Secondary Prevention; Thiophenes | 2018 |
Long-term safety and effectiveness of brexpiprazole in Japanese patients with schizophrenia: A 52-week, open-label study.
Topics: Adult; Aged; Antipsychotic Agents; Female; Humans; Japan; Male; Middle Aged; Outcome Assessment, Health Care; Quinolones; Schizophrenia; Thiophenes | 2018 |
Efficacy and safety of brexpiprazole for the treatment of acute schizophrenia in Japan: A 6-week, randomized, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Japan; Male; Middle Aged; Quinolones; Schizophrenia; Thiophenes; Treatment Outcome; Young Adult | 2018 |
Successful switching of patients with acute schizophrenia from another antipsychotic to brexpiprazole: comparison of clinicians' choice of cross-titration schedules in a post hoc analysis of a randomized, double-blind, maintenance treatment study.
Topics: Adult; Antipsychotic Agents; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Quinolones; Schizophrenia; Thiophenes | 2019 |
Normalizing effects of EVP-6124, an α-7 nicotinic partial agonist, on event-related potentials and cognition: a proof of concept, randomized trial in patients with schizophrenia.
Topics: Adolescent; Adult; alpha7 Nicotinic Acetylcholine Receptor; Antipsychotic Agents; Cognition; Cognition Disorders; Double-Blind Method; Drug Therapy, Combination; Evoked Potentials; Female; Humans; Male; Middle Aged; Quinuclidines; Schizophrenia; Thiophenes; Treatment Outcome; Young Adult | 2014 |
A multicenter, randomized, double-blind, controlled phase 3 trial of fixed-dose brexpiprazole for the treatment of adults with acute schizophrenia.
Topics: Adolescent; Adult; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Psychiatric Status Rating Scales; Quinolones; Schizophrenia; Serotonin Agents; Thiophenes; Treatment Outcome; Young Adult | 2015 |
Efficacy and Safety of Brexpiprazole for the Treatment of Acute Schizophrenia: A 6-Week Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Acute Disease; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Blood Glucose; Double-Blind Method; Female; Humans; Lipids; Male; Psychiatric Status Rating Scales; Quinolones; Schizophrenia; Thiophenes; Treatment Outcome; Weight Gain | 2015 |
Randomized, Double-Blind, Placebo-Controlled Study of Encenicline, an α7 Nicotinic Acetylcholine Receptor Agonist, as a Treatment for Cognitive Impairment in Schizophrenia.
Topics: Adolescent; Adult; alpha7 Nicotinic Acetylcholine Receptor; Antipsychotic Agents; Cognition; Cognition Disorders; Double-Blind Method; Female; Humans; Male; Middle Aged; Nicotinic Agonists; Psychiatric Status Rating Scales; Psychotropic Drugs; Quinuclidines; Schizophrenia; Schizophrenic Psychology; Thiophenes; Treatment Outcome; Young Adult | 2015 |
The effect of brexpiprazole (OPC-34712) and aripiprazole in adult patients with acute schizophrenia: results from a randomized, exploratory study.
Topics: Acute Disease; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Aripiprazole; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Quinolones; Schizophrenia; Serotonin Agents; Thiophenes; Treatment Outcome; Weight Gain | 2016 |
Efficacy and Safety of Brexpiprazole (OPC-34712) as Maintenance Treatment in Adults with Schizophrenia: a Randomized, Double-Blind, Placebo-Controlled Study.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Proportional Hazards Models; Psychiatric Status Rating Scales; Quinolones; Recurrence; Schizophrenia; Thiophenes; Treatment Outcome; Young Adult | 2017 |
The effect of brexpiprazole in adult outpatients with early-episode schizophrenia: an exploratory study.
Topics: Adult; Ambulatory Care; Antipsychotic Agents; Dose-Response Relationship, Drug; Early Diagnosis; Female; Follow-Up Studies; Humans; Male; Outpatients; Quinolones; Schizophrenia; Serotonin Agents; Thiophenes; Treatment Outcome; Young Adult | 2016 |
Brexpiprazole in patients with schizophrenia: overview of short- and long-term phase 3 controlled studies.
Topics: Adult; Antipsychotic Agents; Double-Blind Method; Female; Humans; Male; Middle Aged; Quinolones; Schizophrenia; Thiophenes; Treatment Outcome | 2017 |
The effects of a glycine reuptake inhibitor R231857 on the central nervous system and on scopolamine-induced impairments in cognitive and psychomotor function in healthy subjects.
Topics: Adult; Affect; Attention; Central Nervous System; Cognition; Cross-Over Studies; Double-Blind Method; Electroencephalography; Furans; Glycine Plasma Membrane Transport Proteins; Humans; Male; Middle Aged; Psychomotor Disorders; Psychomotor Performance; Pursuit, Smooth; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Scopolamine; Thiophenes; Young Adult | 2010 |
Duloxetine as adjunctive treatment to clozapine in patients with schizophrenia: a randomized, placebo-controlled trial.
Topics: Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents; Antipsychotic Agents; Clozapine; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Duloxetine Hydrochloride; Executive Function; Female; Guidelines as Topic; Humans; Male; Middle Aged; Placebos; Psychiatric Status Rating Scales; Schizophrenia; Selective Serotonin Reuptake Inhibitors; Thiophenes; Time Factors; Treatment Outcome; Young Adult | 2011 |
IBD-78: A preliminary evaluation in chronic schizophrenic patients.
Topics: Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Schizophrenia; Thiophenes | 1966 |
41 other study(ies) available for thiophenes and Schizophrenia
| Article | Year |
|---|---|
Continuation rate for asenapine and brexpiprazole treatment in elderly patients with schizophrenia.
Topics: Aged; Antipsychotic Agents; Dibenzocycloheptenes; Humans; Quinolones; Schizophrenia; Thiophenes | 2021 |
Hyperprolactinemia induced by brexpiprazole in patients with schizophrenia: A case report.
Topics: Antipsychotic Agents; Humans; Hyperprolactinemia; Quinolones; Schizophrenia; Thiophenes | 2021 |
Functional Outcomes of an Antipsychotic Medication in Schizophrenia: A Generalizable or Specific Effect?
Topics: Antipsychotic Agents; Humans; Quinolones; Schizophrenia; Thiophenes | 2022 |
A case report of clozapine-treatment-resistant schizophrenia successfully managed with brexpiprazole combination therapy.
Topics: Adult; Antipsychotic Agents; Aripiprazole; Clozapine; Drug Therapy, Combination; Humans; Quinolones; Schizophrenia; Schizophrenia, Treatment-Resistant; Thiophenes; Young Adult | 2022 |
The 5-HT6R agonist E-6837 and the antagonist SB-271046 reverse the psychotic-like behaviors induced by ketamine.
Topics: Animals; Antipsychotic Agents; Humans; Indoles; Ketamine; Memory Disorders; Mice; Mice, Inbred ICR; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Sulfonamides; Thiophenes | 2022 |
Treatment Discontinuation Among Patients with Schizophrenia Treated with Brexpiprazole and Other Oral Atypical Antipsychotics in Japan: A Retrospective Observational Study.
Topics: Antipsychotic Agents; Humans; Japan; Quinolones; Retrospective Studies; Schizophrenia; Thiophenes | 2022 |
Population Pharmacokinetic Analysis of Brexpiprazole to Support its Indication and Dose Selection in Adolescents With Schizophrenia.
Topics: Adolescent; Adult; Antipsychotic Agents; Child; Humans; Quinolones; Schizophrenia; Thiophenes | 2023 |
Brexpiprazole for the Treatment of Tics in a Patient With Schizophrenia.
Topics: Antipsychotic Agents; Humans; Quinolones; Schizophrenia; Thiophenes; Tics | 2023 |
Treatment-resistant schizophrenia successfully maintained with brexpiprazole following abrupt withdrawal of clozapine due to neutropenia.
Topics: Adolescent; Antipsychotic Agents; Clozapine; Female; Humans; Neutropenia; Quinolones; Schizophrenia; Serotonin Agents; Thiophenes | 2020 |
[Preclinical pharmacological profiles and clinical efficacy of the novel antipsychotic drug brexpiprazole (REXULTI
Topics: Antipsychotic Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Quinolones; Schizophrenia; Tablets; Thiophenes; Treatment Outcome | 2019 |
Association between previous high-dose antipsychotic therapy and brexpiprazole discontinuation after the initiation of brexpiprazole in patients with schizophrenia or schizoaffective disorder.
Topics: Antipsychotic Agents; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Psychotic Disorders; Quinolones; Retrospective Studies; Schizophrenia; Serotonin Agents; Thiophenes; Withholding Treatment | 2020 |
Health Care Cost in Patients With Schizophrenia Treated With Brexpiprazole Versus Other Oral Atypical Antipsychotic Therapy.
Topics: Administration, Oral; Adult; Antipsychotic Agents; Aripiprazole; Female; Health Care Costs; Hospitalization; Humans; Lurasidone Hydrochloride; Male; Medicaid; Medicare; Middle Aged; Olanzapine; Paliperidone Palmitate; Piperazines; Quetiapine Fumarate; Quinolones; Risperidone; Schizophrenia; Thiazoles; Thiophenes; United States | 2020 |
Brexpiprazole in the treatment of schizophrenia and agitation in Alzheimer's disease.
Topics: Alzheimer Disease; Antipsychotic Agents; Humans; Quinolones; Schizophrenia; Thiophenes | 2020 |
Combination therapy of brexpiprazole and aripiprazole for an adolescent patient with a first episode of schizophrenia: A case report.
Topics: Adolescent; Antipsychotic Agents; Aripiprazole; Drug Therapy, Combination; Female; Humans; Quinolones; Schizophrenia; Serotonin Agents; Thiophenes | 2020 |
Safety of switching to brexpiprazole in Japanese patients with schizophrenia: A post-hoc analysis of a long-term open-label study.
Topics: Antipsychotic Agents; Aripiprazole; Humans; Japan; Quinolones; Schizophrenia; Thiophenes; Treatment Outcome | 2021 |
[Brexpiprazole for treatment of schizophrenia: a critical literature study].
Topics: Antipsychotic Agents; Belgium; Humans; Netherlands; Quinolones; Randomized Controlled Trials as Topic; Schizophrenia; Thiophenes; Treatment Outcome | 2021 |
Continuation rate for asenapine and brexpiprazole treatment in patients with schizophrenia.
Topics: Antipsychotic Agents; Dibenzocycloheptenes; Humans; Quinolones; Retrospective Studies; Schizophrenia; Thiophenes; Treatment Outcome | 2021 |
Brexpiprazole Pharmacokinetics in CYP2D6 Poor Metabolizers: Using Physiologically Based Pharmacokinetic Modeling to Optimize Time to Effective Concentrations.
Topics: Antipsychotic Agents; Area Under Curve; Cytochrome P-450 CYP2D6; Drug Administration Schedule; Genotype; Half-Life; Humans; Metabolic Clearance Rate; Models, Biological; Phenotype; Quinolones; Schizophrenia; Thiophenes | 2022 |
Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Astrocytes; Behavior, Animal; Chromatography, High Pressure Liquid; Conditioning, Psychological; Electroencephalography; Electromyography; Excitatory Postsynaptic Potentials; Fear; Hippocampus; Immunohistochemistry; Learning; Memory; Mice; Mice, Transgenic; Microdialysis; Neck Muscles; Nicotinic Agonists; Optical Imaging; Optogenetics; Quinuclidines; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine; Synapses; Thiophenes; Wakefulness | 2017 |
Agonist E-6837 and antagonist SB-271046 of 5-HT6 receptors both reverse the depressive-like effect induced in mice by subchronic ketamine administration.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Depression; Depressive Disorder, Major; Disease Models, Animal; Hindlimb Suspension; Indoles; Ketamine; Male; Mice; Motor Activity; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Schizophrenia; Sulfonamides; Swimming; Thiophenes | 2017 |
The effects of brexpiprazole and aripiprazole on body weight as monotherapy in patients with schizophrenia and as adjunctive treatment in patients with major depressive disorder: an analysis of short-term and long-term studies.
Topics: Adult; Antipsychotic Agents; Aripiprazole; Depressive Disorder, Major; Female; Humans; Longitudinal Studies; Male; Meta-Analysis as Topic; Middle Aged; Quinolones; Randomized Controlled Trials as Topic; Schizophrenia; Thiophenes; Weight Gain | 2018 |
Simultaneous activation of muscarinic and GABA
Topics: Allosteric Regulation; Animals; Antipsychotic Agents; Benzamides; Brain; Cyclopentanes; Disease Models, Animal; Drug Therapy, Combination; Excitatory Postsynaptic Potentials; Indoles; Male; Mice; Neurotransmitter Agents; Pyridines; Pyrimidines; Receptors, GABA-B; Receptors, Muscarinic; Schizophrenia; Thiophenes | 2019 |
Clinical Use of Dopamine Modulators as Third-Generation Antipsychotic Agents.
Topics: Antipsychotic Agents; Aripiprazole; Dopamine D2 Receptor Antagonists; Humans; Quinolones; Receptors, Dopamine D2; Schizophrenia; Serotonin Antagonists; Thiophenes | 2019 |
PCP-induced deficits in murine nest building activity: employment of an ethological rodent behavior to mimic negative-like symptoms of schizophrenia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzofurans; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hyperkinesis; Male; Mice; Mice, Inbred C57BL; Phencyclidine; Quinuclidines; Rotarod Performance Test; Schizophrenia; Schizophrenic Psychology; Social Behavior; Thiophenes | 2014 |
Relationships among parvalbumin-immunoreactive neuron density, phase-locked gamma oscillations, and autistic/schizophrenic symptoms in PDGFR-β knock-out and control mice.
Topics: Animals; Autistic Disorder; GABAergic Neurons; Immunohistochemistry; Interpersonal Relations; Male; Maleates; Mice; Mice, Knockout; Models, Animal; Parvalbumins; Prefrontal Cortex; Prepulse Inhibition; Receptor, Platelet-Derived Growth Factor beta; Schizophrenia; Thiophenes | 2015 |
Brexpiprazole: another multipurpose antipsychotic drug?
Topics: Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Depressive Disorder, Major; Humans; Psychomotor Agitation; Quinolones; Schizophrenia; Stress Disorders, Post-Traumatic; Thiophenes | 2015 |
The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242).
Topics: Administration, Oral; Adolescent; Adult; Aged; Animals; Binding Sites; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Drug Stability; Female; Humans; Male; Memory, Short-Term; Mice, Inbred C57BL; Middle Aged; Protein Conformation; Rats, Sprague-Dawley; Receptors, AMPA; Schizophrenia; Structure-Activity Relationship; Sulfonamides; Thiophenes; Young Adult | 2015 |
American Psychiatric Association - 168th Annual Meeting (May 16-20, 2015 - Toronto, Canada).
Topics: Alcoholism; Benzofurans; Canada; Drug Discovery; Humans; Indoles; Mental Disorders; Piperazines; Psychiatry; Quinolones; Schizophrenia; Thiophenes; Vilazodone Hydrochloride | 2015 |
Brexpiprazole: A New Antipsychotic Following in the Footsteps of Aripiprazole.
Topics: Antipsychotic Agents; Female; Humans; Male; Quinolones; Schizophrenia; Thiophenes | 2015 |
The ABC's of dopamine receptor partial agonists - aripiprazole, brexpiprazole and cariprazine: the 15-min challenge to sort these agents out.
Topics: Antipsychotic Agents; Aripiprazole; Bipolar Disorder; Depressive Disorder, Major; Dopamine Agonists; Drug Administration Schedule; Drug Interactions; Humans; Piperazines; Quinolones; Schizophrenia; Thiophenes | 2015 |
Mechanism of action of brexpiprazole: comparison with aripiprazole.
Topics: Adrenergic alpha-1 Receptor Antagonists; Antipsychotic Agents; Aripiprazole; Depressive Disorder, Major; Dopamine Agonists; Humans; Quinolones; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D2; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Agents; Thiophenes | 2016 |
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
Topics: Acetylcholine; Allosteric Regulation; Allosteric Site; Alzheimer Disease; Crystallization; Crystallography, X-Ray; Drug Inverse Agonism; Humans; Models, Molecular; Nicotinic Acids; Receptor, Muscarinic M1; Receptor, Muscarinic M4; Schizophrenia; Static Electricity; Substrate Specificity; Surface Properties; Thiophenes; Tiotropium Bromide | 2016 |
Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia.
Topics: Allosteric Regulation; Antipsychotic Agents; Cell Line; DNA Mutational Analysis; Humans; Nicotinic Acids; Radioligand Assay; Receptor, Muscarinic M4; Schizophrenia; Signal Transduction; Small Molecule Libraries; Thiophenes | 2008 |
The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine.
Topics: Aged; Animals; D-Amino-Acid Oxidase; Dizocilpine Maleate; Habituation, Psychophysiologic; Humans; Male; Models, Molecular; Pyrroles; Rats; Rats, Wistar; Recognition, Psychology; Schizophrenia; Serine; Thiophenes | 2009 |
Commentary: genome-based CNS drug discovery: D-amino acid oxidase (DAAO) as a novel target for antipsychotic medications: progress and challenges.
Topics: Animals; Antipsychotic Agents; D-Amino-Acid Oxidase; Enzyme Activators; Genome, Human; Humans; Isoxazoles; Pyrazoles; Pyrroles; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Thiophenes | 2009 |
α7 neuronal nicotinic receptor agonist (TC-7020) reverses increased striatal dopamine release during acoustic PPI testing in a transgenic mouse model of schizophrenia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acoustic Stimulation; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Homovanillic Acid; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microdialysis; Neural Inhibition; Nicotinic Agonists; Quinuclidines; Receptor, Fibroblast Growth Factor, Type 1; Reflex, Startle; Schizophrenia; Sensory Gating; Thiophenes | 2012 |
Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.
Topics: Allosteric Regulation; Amides; Animals; Brain; Cholinergic Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Half-Life; Humans; Protein Binding; Pyridines; Rats; Receptor, Muscarinic M4; Schizophrenia; Structure-Activity Relationship; Thiophenes | 2013 |
Duloxetine treatment of major depressive episodes in the course of psychotic disorders.
Topics: Adult; Aged; Antidepressive Agents; Antipsychotic Agents; Depressive Disorder, Major; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; Humans; Male; Personality Inventory; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Schizophrenic Psychology; Thiophenes; Treatment Outcome | 2006 |
(+/-) Ketamine-induced prepulse inhibition deficits of an acoustic startle response in rats are not reversed by antipsychotics.
Topics: Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Ketamine; Lamotrigine; Male; Pyridines; Rats; Rats, Sprague-Dawley; Reflex, Startle; Risperidone; Schizophrenia; Sulfonamides; Thiophenes; Triazines | 2007 |
Computerized EEG study on drug-induced extrapyramidalism in schizophrenic patients.
Topics: Adolescent; Amantadine; Brain; Computers; Electroencephalography; Female; Glycolates; Haloperidol; Humans; Levodopa; Male; Middle Aged; Parasympatholytics; Pyramidal Tracts; Reference Values; Schizophrenia; Thiophenes; Trihexyphenidyl | 1982 |
Effects of the 5-HT(6) receptor antagonist, SB-271046, in animal models for schizophrenia.
Topics: Animals; Catalepsy; Central Nervous System Stimulants; Clozapine; Dextroamphetamine; Dose-Response Relationship, Drug; Hyperkinesis; Male; Rats; Rats, Wistar; Receptors, Serotonin; Reflex, Startle; Schizophrenia; Serotonin Antagonists; Social Behavior; Sulfonamides; Thiophenes | 2002 |