Page last updated: 2024-08-18

thiophenes and Neuralgia

thiophenes has been researched along with Neuralgia in 70 studies

Research

Studies (70)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (4.29)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (14.29)	29.6817
2010's	53 (75.71)	24.3611
2020's	4 (5.71)	2.80

Authors

Authors	Studies
Hashizume, H; Hisaoka-Nakashima, K; Kochi, T; Kodama, K; Morioka, N; Nakamura, Y; Tsuruta, M; Zhang, FF	1
Li, J; Liu, Y; Ma, Z; Sun, Z; Wu, Y; Zhu, Y	1
Arima, T; Hamada, Y; Higashiyama, K; Iwase, Y; Kuzumaki, N; Matsumura, S; Matsuzawa, A; Miyano, K; Mori, T; Narita, M; Sasaki, S; Suda, Y; Sugita, K; Takemura, Y; Uezono, Y; Yamauchi, T; Yamazaki, M	1
Baudouin, C; Fakih, D; Mélik Parsadaniantz, S; Réaux-Le Goazigo, A	1
Donahue, RR; Doolen, S; Grachen, CM; Iannitti, T; Shaw, BC; Taylor, BK	1
Hisaoka-Nakashima, K; Kodama, K; Morioka, N; Nakamura, Y; Nakata, Y; Saeki, M; Tomori, M; Yoshikawa, K; Zhang, FF	1
Barboza, A; Beltran, J; Choo, A; Fowler, M; Ghavami, A; Hanania, T; Hu, A; Kwan, MY; Neelagiri, VR; Shea, J; Sucholeiki, I	1
Ahles, T; Bressler, LR; Cirrincione, C; Fadul, CE; Fleishman, S; Gilman, PB; Knox, C; Le-Lindqwister, N; Pang, H; Paskett, ED; Shapiro, CL; Smith, EM	1
Silvestri, NJ; Trivedi, JR; Wolfe, GI	1
Aira, Z; Azkue, JJ; Bilbao, J; Buesa, I; Doñate, F; García Del Caño, G; Zimmermann, M	1
Colvin, L; Fallon, M; Seretny, M	1
Pang, H; Smith, EM	1
Badghisi, H; Meske, DS; Ossipov, MH; Oyarzo, J; Porreca, F; Xie, JY	1
Dickenson, AH	1
Hsu, YC; Tzeng, NS	1
Aoki, T; Enomoto, R; Hamakawa, N; Kakimoto, S; Matsuoka, N; Murai, N; Oe, T; Sekizawa, T; Tamura, S; Tsukamoto, M	1
Hughes, RA; Lunn, MP; Wiffen, PJ	1
Baraldi, PG; Borea, PA; Gessi, S; Merighi, S; Romagnoli, R; Targa, M; Varani, K; Vincenzi, F	1
Aoki, T; Matsuoka, N; Murai, N; Tamura, S; Tsukamoto, M	1
Castagné, V; Le Cudennec, C	1
Engel, CC	1
Bak, K; Bleeker, J; Cavaletti, G; Chauhan, C; Dworkin, RH; Gavin, P; Hershman, DL; Lacchetti, C; Lavino, A; Lavoie Smith, EM; Loprinzi, CL; Lustberg, MB; Paice, J; Schneider, B; Smith, ML; Smith, T; Terstriep, S; Wagner-Johnston, N	1
Bieberich, E; Bryant, L; Chen, C; Chen, Z; Cuzzocrea, S; Doyle, T; Esposito, E; Janes, K; Kamocki, K; Li, C; Little, JW; Neumann, WL; Nicol, G; Obeid, L; Petrache, I; Salvemini, D; Snider, A	1
Chu, SH; Cleeland, CS; Geng, Y; Lee, ES; Lee, YJ; Wang, XS	1
Filipek, B; Sałat, K	1
Baillie, GL; Crowe, M; Damaj, IM; Ghosh, S; Greig, IR; Ignatowska-Jankowska, BM; Kinsey, S; Lichtman, AH; Owens, RA; Poklis, J; Ross, RA; Wiley, JL; Zanato, C; Zanda, M	1
Bhola, RF; Christie, MJ; Christopoulos, A; Imlach, WL; May, LT	1
Davis, SF; Fairchild, DD; Hain, HS; Hanania, T; Henry, MA; Hu, A; Malekiani, SA; Nix, D; Patil, MJ; Sucholeiki, I; Sucholeiki, R	1
Kiss, G	1
Bhatia, A	1
Authier, N; Bertrand, M; Chapuy, E; Chenaf, C; Courteix, C; Eschalier, A; Gabriel, C; Libert, F; Marchand, F; Mocaër, E	1
Berman, K; Fishbain, D; Kajdasz, DK	1
Hawley, P	1
Chappell, AS; Desaiah, D; Detke, MJ; Gross, JL; Skljarevski, V; Zhang, Q; Ziegler, D	1
Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT	1
Esfahani, F; Gomori, A; Grossberndt, A; Intrater, H; Klowak, M; Leong, C; Namaka, M; Turcotte, D	1
Acharya, N; Crucitti, A; Hall, JA; Oakes, TM; Utterback, BG; Wang, F	1
Boulanger, L; Chen, S; Fraser, K; Wu, N; Zhao, Y	1
Jefferies, K	1
Finnerup, NB	1
Dijkgraaf, MGW; Heesen, M; Hollmann, MW; Kruis, MR; Pijl, AJ; van der Vegt, MH; Vos, K; Vranken, JH	1
Budhia, S; Gabriel, Z; Plested, M	1
Sun, P; Watson, P; Zhao, Y	1
Courteix, C; Eschalier, A; Fialip, J; Libert, F; Loiodice, S; Privat, AM; Wattiez, AS	1
Barohn, RJ; Dimachkie, MM; Herbelin, L; Khan, S; McVey, A; Mittal, M; Mummaneni, RB; Pasnoor, M; Ridings, L; Saperstein, D; Wang, Y	1
Ahl, J; Irving, GA; Malcolm, SK; Risser, RC; Robinson, MJ; Skljarevski, V; Tanenberg, RJ	1
Andrews, JS; Annedi, SC; Bunton, D; Christie, L; Lee, DK; Maddaford, SP; Mladenova, G; Porreca, F; Rakhit, S; Ramnauth, J; Zhang, D	1
Andrews, JS; Annedi, SC; Dove, P; Felice, MD; Maddaford, SP; Mladenova, G; Porreca, F; Rakhit, S; Ramnauth, J; Renton, P; Silverman, S	1
Anand, KS; Dhikav, V; Prasad, A	1
Andrews, J; Annedi, SC; Dove, P; Lee, DK; Maddaford, SP; Mladenova, G; Porreca, F; Rakhit, S; Ramnauth, J; Renton, P; Silverman, S; Speed, J; Zhang, D; Zinghini, S	1
Dyhr, H; Erichsen, HK; Hansen, MK; Marcher, L; Munro, G; Sheykhzade, M; Storm, A	1
Carroll, WA; Chandran, P; Dart, MJ; Daza, AV; El-Kouhen, OF; Fan, Y; Florjancic, AS; Frost, JM; Garrison, TR; Grayson, GK; Hooker, BA; Hsieh, GC; Meyer, MD; Nelson, DW; Pai, M; Ryther, K; Tietje, KR; Yao, B; Zhu, C	1
Arslanian, A; Best, AE; Duan, RW; Nothaft, W; Pritchett, Y; Rowbotham, MC; Stacey, BR; Zhou, Q	1
Miyazaki, R; Yamamoto, T	1
Andrews, JS; Annedi, SC; Maddaford, SP; Mladenova, G; Porreca, F; Rakhit, S; Ramnauth, J; Zhang, D	1
Granot, M; Granovsky, Y; Khamaisi, M; Nahman-Averbuch, H; Yarnitsky, D	1
Berson, N; Conrath, M; Doly, S; Maroteaux, L; Pohl, M; Truchetto, J; Urtikova, N; Van Steenwinckel, J	1
Fujisaka, Y; Kaneda, H; Koyama, A; Makimura, C; Matsuoka, H; Nakagawa, K; Okamoto, W; Otsuka, M; Tsurutani, J	1
Ardid, D; Chapuy, E; Eschalier, A; Grégoire, S; Michaud, V	1
de Biase, S; Gigli, GL; Lorenzut, S; Merlino, G; Valente, M	1
Green, H; James, JW; Jordan, KG; Letchworth, SR; Loram, LC; Maier, SF; Mazarov, A; Pritchard, RC; Speake, JD; Strand, KA; Taylor, FR; Van Dyke, K; Watkins, LR; Wene, SP	1
Lluch Girbés, E; López Cubas, C; Nijs, J; Torres-Cueco, R	1
Goto, F; Obata, H; Saito, S; Sakurazawa, S; Sasaki, M; Usui, T	1
D'Souza, DN; Iyengar, S; Pritchett, YL; Raskin, J; Tran, P; Waninger, A; Wernicke, JF	1
Terneus, W	1
Chappell, AS; D'Souza, DN; Iyengar, S; Pritchett, YL; Raskin, J; Smith, TR; Wang, F; Wernicke, JF	1
Backonja, MM; Desaiah, D; Farrar, JT; Fishbain, DA; Iyengar, S; Jensen, TS; Kajdasz, DK; McQuay, HJ; Rowbotham, MC; Sang, CN; Ziegler, D	1
Avella, F; Bracale, C; Cacace, R; Graziussi, G; Longhi, P	1
Arthur, G; Hornabrook, RW	1
Eberl, R	1

Reviews

11 review(s) available for thiophenes and Neuralgia

Article	Year
Treatment of painful peripheral neuropathy. Neurologic clinics, 2013, Volume: 31, Issue:2 Topics: Analgesics; Antidepressive Agents; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Humans; Neuralgia; Pain Management; Pregabalin; Randomized Controlled Trials as Topic; Thiophenes	2013
Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia. The Cochrane database of systematic reviews, 2014, Jan-03, Issue:1 Topics: Adult; Analgesics; Chronic Pain; Diabetic Neuropathies; Duloxetine Hydrochloride; Fibromyalgia; Humans; Neuralgia; Randomized Controlled Trials as Topic; Thiophenes	2014
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Jun-20, Volume: 32, Issue:18 Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineoplastic Agents; Baclofen; Comorbidity; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Duloxetine Hydrochloride; Evidence-Based Medicine; Gabapentin; gamma-Aminobutyric Acid; Gels; Humans; Incidence; Ketamine; Neoplasms; Neuralgia; Peripheral Nervous System Diseases; Quality of Life; Randomized Controlled Trials as Topic; Severity of Illness Index; Survivors; Thiophenes; Treatment Outcome; United States	2014
Current use of drugs affecting the central nervous system for chemotherapy-induced peripheral neuropathy in cancer patients: a systematic review. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2015, Volume: 23, Issue:2 Topics: Amitriptyline; Anticonvulsants; Antidepressive Agents; Antineoplastic Agents; Boronic Acids; Bortezomib; Carbamazepine; Central Nervous System; Cyclohexanols; Duloxetine Hydrochloride; Epothilones; Humans; Neoplasms; Neuralgia; Oxcarbazepine; Peripheral Nervous System Diseases; Pyrazines; Taxoids; Thalidomide; Thiophenes; Venlafaxine Hydrochloride; Vinca Alkaloids	2015
[DRUG THERAPY OF NEUROPATHIC PAIN BASED ON THE LATEST RECOMMENDATIONS]. Ideggyogyaszati szemle, 2015, Mar-30, Volume: 68, Issue:3-4 Topics: Amines; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cyclohexanecarboxylic Acids; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Humans; Neuralgia; Practice Guidelines as Topic; Pregabalin; Thiophenes	2015
Duloxetine for neuropathic pain based on recent clinical trials. Current pain and headache reports, 2006, Volume: 10, Issue:3 Topics: Antidepressive Agents; Clinical Trials as Topic; Duloxetine Hydrochloride; Humans; Neuralgia; Thiophenes; Treatment Outcome	2006
A treatment algorithm for neuropathic pain: an update. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2009, Volume: 24, Issue:12 Topics: Algorithms; Analgesics; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Humans; Neuralgia; Pain Measurement; Paroxetine; Pregabalin; Randomized Controlled Trials as Topic; Thiophenes	2009
Safety and tolerability of duloxetine in the acute management of diabetic peripheral neuropathic pain: analysis of pooled data from three placebo-controlled clinical trials. Expert opinion on drug safety, 2010, Volume: 9, Issue:4 Topics: Adrenergic Uptake Inhibitors; Chronic Disease; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Neuralgia; Polypharmacy; Randomized Controlled Trials as Topic; Thiophenes	2010
Treatment of neuropathic pain. Seminars in neurology, 2010, Volume: 30, Issue:4 Topics: Antidepressive Agents, Tricyclic; Duloxetine Hydrochloride; Humans; Neuralgia; Peripheral Nervous System Diseases; Thiophenes	2010
Pregabalin, the lidocaine plaster and duloxetine in patients with refractory neuropathic pain: a systematic review. BMC neurology, 2010, Nov-19, Volume: 10 Topics: Analgesics; Anesthetics, Local; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Humans; Lidocaine; Neuralgia; Pregabalin; Thiophenes; Treatment Outcome	2010
ADMET considerations for restless leg syndrome drug treatments. Expert opinion on drug metabolism & toxicology, 2012, Volume: 8, Issue:10 Topics: Amines; Anticonvulsants; Benzothiazoles; Carbamates; Cyclohexanecarboxylic Acids; Dopamine Agents; Dopamine Agonists; Ergolines; Gabapentin; gamma-Aminobutyric Acid; Humans; Indoles; Levodopa; Neuralgia; Pramipexole; Pregabalin; Randomized Controlled Trials as Topic; Restless Legs Syndrome; Tetrahydronaphthalenes; Thiophenes; Treatment Outcome	2012

Trials

11 trial(s) available for thiophenes and Neuralgia

Article	Year
Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. JAMA, 2013, Apr-03, Volume: 309, Issue:13 Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Neoplasms; Neuralgia; Peripheral Nervous System Diseases; Quality of Life; Selective Serotonin Reuptake Inhibitors; Thiophenes; Treatment Outcome	2013
Evaluating the maintenance of effect of duloxetine in patients with diabetic peripheral neuropathic pain. Diabetes/metabolism research and reviews, 2009, Volume: 25, Issue:7 Topics: Adrenergic Uptake Inhibitors; Aged; Confidence Intervals; Diabetic Neuropathies; Drug Monitoring; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Neuralgia; Pain Measurement; Thiophenes; Time Factors; Treatment Outcome	2009
Duloxetine in patients with central neuropathic pain caused by spinal cord injury or stroke: a randomized, double-blind, placebo-controlled trial. Pain, 2011, Volume: 152, Issue:2 Topics: Adult; Disability Evaluation; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Hyperalgesia; Male; Middle Aged; Neuralgia; Outcome Assessment, Health Care; Pain Measurement; Pain Threshold; Placebo Effect; Spinal Cord Injuries; Stroke; Thiophenes; Treatment Outcome	2011
Duloxetine, pregabalin, and duloxetine plus gabapentin for diabetic peripheral neuropathic pain management in patients with inadequate pain response to gabapentin: an open-label, randomized, noninferiority comparison. Mayo Clinic proceedings, 2011, Volume: 86, Issue:7 Topics: Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neuralgia; Pain Measurement; Pregabalin; Thiophenes; Treatment Outcome	2011
Efficacy and safety of the α4β2 neuronal nicotinic receptor agonist ABT-894 in patients with diabetic peripheral neuropathic pain. Pain, 2012, Volume: 153, Issue:4 Topics: Aged; Azabicyclo Compounds; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Neuralgia; Nicotinic Agonists; Pain Measurement; Pyridines; Receptors, Nicotinic; Thiophenes; Treatment Outcome	2012
Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy. Pain, 2012, Volume: 153, Issue:6 Topics: Aged; Analgesics; Conditioning, Psychological; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Neuralgia; Pain Threshold; Predictive Value of Tests; Selective Serotonin Reuptake Inhibitors; Thiophenes	2012
Pilot study of duloxetine for cancer patients with neuropathic pain non-responsive to pregabalin. Anticancer research, 2012, Volume: 32, Issue:5 Topics: Adult; Aged; Analgesics; Antidepressive Agents; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neoplasms; Neuralgia; Pilot Projects; Pregabalin; Thiophenes	2012
A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain. Neurology, 2006, Oct-24, Volume: 67, Issue:8 Topics: Acetaminophen; Adrenergic Uptake Inhibitors; Aged; Analgesics, Non-Narcotic; Diabetic Neuropathies; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Neuralgia; Norepinephrine; Pain; Palliative Care; Peripheral Nervous System Diseases; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Thiophenes; Treatment Outcome	2006
An open-label 52-week clinical extension comparing duloxetine with routine care in patients with diabetic peripheral neuropathic pain. Pain medicine (Malden, Mass.), 2007, Volume: 8, Issue:6 Topics: Acetaminophen; Amitriptyline; Analgesics; Carbamazepine; Diabetes Complications; Diabetic Neuropathies; Diclofenac; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Lipids; Male; Meloxicam; Middle Aged; Neuralgia; Pentoxifylline; Selective Serotonin Reuptake Inhibitors; Thiamine; Thiazines; Thiazoles; Thioctic Acid; Thiophenes; Time; Vitamin B 12	2007
Duloxetine for the management of diabetic peripheral neuropathic pain: evidence-based findings from post hoc analysis of three multicenter, randomized, double-blind, placebo-controlled, parallel-group studies. Clinical therapeutics, 2007, Volume: 29 Suppl Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Neuralgia; Peripheral Nervous System Diseases; Selective Serotonin Reuptake Inhibitors; Thiophenes	2007
[Carticaine in the therapie of pain (author's transl)]. Praktische Anasthesie, Wiederbelebung und Intensivtherapie, 1974, Volume: 9, Issue:3 Topics: Adult; Aged; Analgesia; Anesthesia, Conduction; Anesthetics, Local; Blood Pressure; Female; Humans; Joint Diseases; Male; Mepivacaine; Middle Aged; Neuralgia; Pain; Propylamines; Pulse; Thiophenes	1974

Other Studies

48 other study(ies) available for thiophenes and Neuralgia

Article	Year
Stimulation of nuclear receptor REV-ERBs suppresses inflammatory responses in spinal microglia. Neurochemistry international, 2021, Volume: 151 Topics: Animals; Inflammation; Lipopolysaccharides; Microglia; Neuralgia; Pyrrolidines; Rats; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Thiophenes	2021
miR-140 ameliorates neuropathic pain in CCI rats by targeting S1PR1. Journal of receptor and signal transduction research, 2021, Volume: 41, Issue:4 Topics: Animals; Behavior, Animal; Disease Models, Animal; Gene Expression Profiling; HEK293 Cells; Humans; Inflammation; Male; MicroRNAs; Neuralgia; Neuroinflammatory Diseases; Oxadiazoles; Rats; Rats, Wistar; Sphingosine-1-Phosphate Receptors; Stress, Mechanical; Thiophenes	2021
Further investigation of the rapid-onset and short-duration action of the G protein-biased μ-ligand oliceridine. Biochemical and biophysical research communications, 2021, 01-01, Volume: 534 Topics: Analgesics; Animals; Cell Line; GTP-Binding Proteins; Humans; Male; Mice; Mice, Inbred ICR; Neuralgia; Receptors, Opioid, mu; Signal Transduction; Spiro Compounds; Thiophenes; Time Factors	2021
TRPM8: A Therapeutic Target for Neuroinflammatory Symptoms Induced by Severe Dry Eye Disease. International journal of molecular sciences, 2020, Nov-19, Volume: 21, Issue:22 Topics: Administration, Ophthalmic; Animals; Anti-Inflammatory Agents; Chemokine CCL2; Cold Temperature; Cornea; CX3C Chemokine Receptor 1; Disease Models, Animal; Dry Eye Syndromes; Evoked Potentials, Somatosensory; Ganglia, Parasympathetic; Gene Expression Regulation; Harderian Gland; Hyperalgesia; Interleukin-18; Interleukin-1beta; Lacrimal Apparatus; Male; Mice; Mice, Inbred C57BL; Neuralgia; Nicotinic Acids; Prostaglandin-E Synthases; Thiophenes; Trigeminal Ganglion; TRPM Cation Channels	2020
Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central sensitization in the dorsal horn. Pain, 2018, Volume: 159, Issue:2 Topics: Anilides; Animals; Central Nervous System Sensitization; Disease Models, Animal; eIF-2 Kinase; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Motor Activity; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Neuralgia; Organophosphonates; Oxadiazoles; Pain Threshold; Peptide Fragments; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; Spinal Cord; Spinal Nerve Roots; Subcellular Fractions; Thiophenes	2018
Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice. Brain, behavior, and immunity, 2019, Volume: 78 Topics: Animals; Astrocytes; Cytokines; Female; Glial Fibrillary Acidic Protein; Glycine; Hyperalgesia; Inflammation; Interleukin-6; Male; Mice; Neuralgia; Nociceptors; Nuclear Receptor Subfamily 1, Group D, Member 1; Primary Cell Culture; Pyrrolidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Spinal Cord; Spinal Cord Dorsal Horn; Thiophenes; Tumor Necrosis Factor-alpha	2019
Biomarker Analysis of Orally Dosed, Dual Active, Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitor, AQU-118, in the Spinal Nerve Ligation (SNL) Rat Model of Neuropathic Pain. International journal of molecular sciences, 2019, 02-14, Volume: 20, Issue:4 Topics: Animals; Biomarkers; Caspase 3; Ganglia, Spinal; Gene Expression Regulation; Humans; Indoles; Ligation; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neuralgia; Propionates; Rats; Spinal Nerves; Thiophenes	2019
Transient, 5-HT2B receptor-mediated facilitation in neuropathic pain: Up-regulation of PKCγ and engagement of the NMDA receptor in dorsal horn neurons. Pain, 2013, Volume: 154, Issue:9 Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Evoked Potentials; Excitatory Amino Acid Antagonists; HEK293 Cells; Humans; Hyperalgesia; Indoles; Male; Nerve Fibers, Unmyelinated; Neuralgia; Neurons; Physical Stimulation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Receptors, N-Methyl-D-Aspartate; Serotonin Receptor Agonists; Spinal Nerve Roots; Spinal Nerves; Subcellular Fractions; Thiophenes; Time Factors; Up-Regulation	2013
Therapy for chemotherapy-induced peripheral neuropathy. JAMA, 2013, Aug-07, Volume: 310, Issue:5 Topics: Antineoplastic Agents; Female; Humans; Male; Neuralgia; Peripheral Nervous System Diseases; Quality of Life; Selective Serotonin Reuptake Inhibitors; Thiophenes	2013
Therapy for chemotherapy-induced peripheral neuropathy--in reply. JAMA, 2013, Aug-07, Volume: 310, Issue:5 Topics: Antineoplastic Agents; Female; Humans; Male; Neuralgia; Peripheral Nervous System Diseases; Quality of Life; Selective Serotonin Reuptake Inhibitors; Thiophenes	2013
Opioid and noradrenergic contributions of tapentadol in experimental neuropathic pain. Neuroscience letters, 2014, Mar-06, Volume: 562 Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Male; Morphine; Neuralgia; Norepinephrine; Pain Measurement; Phenols; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Nerves; Tapentadol; Thiophenes	2014
Commentary on: Opioid and noradrenergic contributions of tapentadol in experimental neuropathic pain. Neuroscience letters, 2014, Mar-06, Volume: 562 Topics: Analgesics, Opioid; Animals; Duloxetine Hydrochloride; Male; Morphine; Neuralgia; Phenols; Spinal Nerves; Tapentadol; Thiophenes	2014
Can topical duloxetine be used for neuropathic pain? Medical hypotheses, 2014, Volume: 82, Issue:2 Topics: Administration, Topical; Analgesia; Analgesics; Animals; Duloxetine Hydrochloride; Humans; Models, Theoretical; Neuralgia; Rats; Selective Serotonin Reuptake Inhibitors; Thiophenes	2014
AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in a rat model of neuropathic pain with unique characteristics in spinal monoamine turnover. The Journal of pharmacology and experimental therapeutics, 2014, Volume: 348, Issue:3 Topics: Amitriptyline; Analgesics; Animals; Biogenic Monoamines; Dopamine; Dopamine Plasma Membrane Transport Proteins; Duloxetine Hydrochloride; Gastric Emptying; HEK293 Cells; Humans; Male; Morpholines; Motor Activity; Neuralgia; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Binding; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Spinal Cord; Stereoisomerism; Thiophenes	2014
TRR469, a potent A(1) adenosine receptor allosteric modulator, exhibits anti-nociceptive properties in acute and neuropathic pain models in mice. Neuropharmacology, 2014, Volume: 81 Topics: Acetic Acid; Allosteric Regulation; Analgesics; Animals; Catalepsy; CHO Cells; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Motor Activity; Neuralgia; Pain Measurement; Pain Threshold; Piperazines; Protein Binding; Purinergic Agents; Thiophenes	2014
Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: comparison with duloxetine and amitriptyline. European journal of pharmacology, 2014, Jun-15, Volume: 733 Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Hyperalgesia; Injections, Spinal; Male; Mice, Inbred ICR; Morpholines; Neuralgia; Prostaglandins; Spinal Cord; Stereoisomerism; Thiophenes	2014
Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine. European journal of pharmacology, 2014, Jul-15, Volume: 735 Topics: Analgesics; Animals; Cold Temperature; Disease Models, Animal; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Male; Neuralgia; Physical Stimulation; Pregabalin; Rats, Wistar; Sciatic Nerve; Thiophenes; Tramadol	2014
ACP Journal Club. Review: In neuropathy, fibromyalgia, or chronic pain, duloxetine reduces pain but increases adverse events. Annals of internal medicine, 2014, Apr-15, Volume: 160, Issue:8 Topics: Analgesics; Chronic Pain; Diabetic Neuropathies; Duloxetine Hydrochloride; Fibromyalgia; Humans; Neuralgia; Thiophenes	2014
The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. The Journal of biological chemistry, 2014, Jul-25, Volume: 289, Issue:30 Topics: Anilides; Animals; Antineoplastic Agents, Phytogenic; Cytokines; Enzyme Activation; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Indans; Lysophospholipids; Male; Neuralgia; Organophosphonates; Oxadiazoles; Paclitaxel; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiazoles; Thiophenes	2014
Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice. Journal of Zhejiang University. Science. B, 2015, Volume: 16, Issue:3 Topics: Acetanilides; Analgesics; Animals; Benzamides; Capsaicin; Cold Temperature; Disease Models, Animal; Formaldehyde; Hyperalgesia; Isothiocyanates; Male; Mice; Neuralgia; Oximes; Paclitaxel; Pain Measurement; Purines; Thiophenes; Touch; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels	2015
A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:13 Topics: Allosteric Regulation; Amidohydrolases; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Brain; Cannabinoid Receptor Modulators; Carrageenan; CHO Cells; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Indoles; Male; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Receptor, Cannabinoid, CB1; Thiophenes	2015
A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model. Molecular pharmacology, 2015, Volume: 88, Issue:3 Topics: Adenosine A1 Receptor Agonists; Allosteric Regulation; Animals; Excitatory Postsynaptic Potentials; Hyperalgesia; Male; Neuralgia; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Thiophenes; Xanthines	2015
Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain. Journal of oral & facial pain and headache, 2015,Summer, Volume: 29, Issue:3 Topics: Administration, Oral; Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Indoles; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neuralgia; Propionates; Rats; Rats, Sprague-Dawley; Spinal Nerves; Thiophenes; Trigeminal Nerve	2015
Questions Regarding "Efficacy of Duloxetine in Chronic Low Back Pain with a Neuropathic Component". Anesthesiology, 2016, Volume: 125, Issue:1 Topics: Analgesics; Chronic Pain; Duloxetine Hydrochloride; Humans; Low Back Pain; Neuralgia; Pain Measurement; Peripheral Nervous System Diseases; Thiophenes	2016
Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence. Pain, 2017, Volume: 158, Issue:1 Topics: Acetamides; Adrenergic alpha-2 Receptor Antagonists; Amines; Animals; Antineoplastic Agents; Constriction, Pathologic; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Hypnotics and Sedatives; Idazoxan; Male; Motor Activity; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes	2017
Nontricyclic antidepressants for neuropathic pain #187. Journal of palliative medicine, 2009, Volume: 12, Issue:5 Topics: Antidepressive Agents, Second-Generation; Bupropion; Cyclohexanols; Duloxetine Hydrochloride; Humans; Neuralgia; Selective Serotonin Reuptake Inhibitors; Thiophenes; Venlafaxine Hydrochloride	2009
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models. Brain research, 2009, Oct-27, Volume: 1295 Topics: Amines; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axotomy; Carrageenan; Cyclohexanecarboxylic Acids; Duloxetine Hydrochloride; Edema; Freund's Adjuvant; Gabapentin; Gait; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Indomethacin; Inflammation; Male; Morphine; Neuralgia; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Thiophenes	2009
Opioid use and healthcare costs among patients with DPNP initiating duloxetine versus other treatments. Current medical research and opinion, 2010, Volume: 26, Issue:10 Topics: Adolescent; Adult; Analgesics; Analgesics, Opioid; Case-Control Studies; Cohort Studies; Cost-Benefit Analysis; Duloxetine Hydrochloride; Female; Health Care Costs; Humans; Male; Middle Aged; Neuralgia; Retrospective Studies; Thiophenes; Young Adult	2010
Is duloxetine useful for central neuropathic pain? Pain, 2011, Volume: 152, Issue:2 Topics: Duloxetine Hydrochloride; Female; Humans; Male; Neuralgia; Spinal Cord Injuries; Stroke; Thiophenes	2011
Medication adherence and healthcare costs among patients with diabetic peripheral neuropathic pain initiating duloxetine versus pregabalin. Current medical research and opinion, 2011, Volume: 27, Issue:4 Topics: Adolescent; Adult; Analgesics; Cohort Studies; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Health Care Costs; Humans; Male; Medication Adherence; Middle Aged; Neuralgia; Pregabalin; Retrospective Studies; Thiophenes; Young Adult	2011
Evidence for a differential opioidergic involvement in the analgesic effect of antidepressants: prediction for efficacy in animal models of neuropathic pain? British journal of pharmacology, 2011, Volume: 163, Issue:4 Topics: Analgesics; Animals; Antidepressive Agents; Clomipramine; Cyclopropanes; Diabetes Mellitus, Experimental; Disease Models, Animal; Duloxetine Hydrochloride; Hyperalgesia; Male; Milnacipran; Naloxone; Neuralgia; Rats; Rats, Sprague-Dawley; Thiophenes	2011
Retrospective chart review of duloxetine and pregabalin in the treatment of painful neuropathy. The International journal of neuroscience, 2011, Volume: 121, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Analgesics; Dopamine Uptake Inhibitors; Duloxetine Hydrochloride; Female; Follow-Up Studies; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neuralgia; Pregabalin; Retrospective Studies; Thiophenes; Treatment Outcome	2011
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain. Journal of medicinal chemistry, 2011, Oct-27, Volume: 54, Issue:20 Topics: Analgesics; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Hot Temperature; Humans; Hyperalgesia; Indoles; Ligation; Neuralgia; Nitric Oxide Synthase Type I; Pain; Pyridines; Spinal Nerves; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Vascular Resistance; Vasoconstriction	2011
Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities. Journal of medicinal chemistry, 2012, Jan-26, Volume: 55, Issue:2 Topics: Analgesics; Animals; Arteries; Cardiovascular System; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; HEK293 Cells; High-Throughput Screening Assays; Humans; In Vitro Techniques; Indoles; Neuralgia; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Patch-Clamp Techniques; Rats; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Vascular Resistance; Vasoconstriction	2012
Efficacy, safety and tolerability of duloxetine in idiopathic trigeminal neuralgia. Journal of the Indian Medical Association, 2011, Volume: 109, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Neuralgia; Pain Measurement; Selective Serotonin Reuptake Inhibitors; Thiophenes; Trigeminal Neuralgia	2011
1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a p Journal of medicinal chemistry, 2012, Mar-22, Volume: 55, Issue:6 Topics: Administration, Oral; Analgesics; Animals; Biological Availability; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; High-Throughput Screening Assays; Humans; Neuralgia; Nitric Oxide Synthase Type I; Patch-Clamp Techniques; Quinolines; Rats; Small Molecule Libraries; Structure-Activity Relationship; Thiophenes	2012
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function. Pharmacology, biochemistry, and behavior, 2012, Volume: 101, Issue:3 Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Locomotion; Male; Morphine; Neuralgia; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes	2012
Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB₂ receptor agonists for pain management. Bioorganic & medicinal chemistry letters, 2012, Apr-01, Volume: 22, Issue:7 Topics: Amides; Analgesics; Animals; Biological Availability; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Hyperalgesia; Neuralgia; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship; Thiophenes	2012
The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. Anesthesia and analgesia, 2012, Volume: 115, Issue:1 Topics: Administration, Oral; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Morphine; Neuralgia; Neuroma; Pain Measurement; Pain Threshold; Pregabalin; Rats; Rats, Sprague-Dawley; Thiophenes; Time Factors	2012
First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain. Journal of medicinal chemistry, 2012, Apr-12, Volume: 55, Issue:7 Topics: Adrenergic Uptake Inhibitors; Analgesics; Animals; CHO Cells; Coronary Vessels; Cricetinae; Cricetulus; Cyclohexanes; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; HEK293 Cells; High-Throughput Screening Assays; Humans; In Vitro Techniques; Indoles; Muscle Contraction; Muscle, Smooth, Vascular; Neuralgia; Nitric Oxide Synthase Type I; Norepinephrine Plasma Membrane Transport Proteins; Rats; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Vascular Resistance	2012
Antinociceptive effect of peripheral serotonin 5-HT2B receptor activation on neuropathic pain. Pain, 2012, Volume: 153, Issue:6 Topics: Animals; Disease Models, Animal; Ganglia, Spinal; Indoles; Male; Neuralgia; Nociceptors; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Sciatic Nerve; Sciatic Neuropathy; Serotonin; Serotonin 5-HT2 Receptor Agonists; Thiophenes	2012
Study of emotional and cognitive impairments in mononeuropathic rats: effect of duloxetine and gabapentin. Pain, 2012, Volume: 153, Issue:8 Topics: Affective Symptoms; Amines; Analgesics; Animals; Antidepressive Agents; Cognition; Cognition Disorders; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Therapy, Combination; Duloxetine Hydrochloride; Emotions; Gabapentin; gamma-Aminobutyric Acid; Male; Neuralgia; Rats; Rats, Sprague-Dawley; Thiophenes; Treatment Outcome	2012
Systemic administration of an alpha-7 nicotinic acetylcholine agonist reverses neuropathic pain in male Sprague Dawley rats. The journal of pain, 2012, Volume: 13, Issue:12 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Ganglia, Spinal; Male; Neuralgia; Nicotinic Agonists; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Thiophenes	2012
Pain treatment for patients with osteoarthritis and central sensitization. Physical therapy, 2013, Volume: 93, Issue:6 Topics: Brain Mapping; Cognitive Behavioral Therapy; Duloxetine Hydrochloride; Exercise Therapy; Humans; Hyperalgesia; Magnetic Resonance Imaging; Neuralgia; Neuroglia; Nociception; Osteoarthritis; Pain Management; Physical Therapy Modalities; Selective Serotonin Reuptake Inhibitors; Thiophenes	2013
Antiallodynic effects of intrathecally administered 5-HT(2C) receptor agonists in rats with nerve injury. Pain, 2004, Volume: 108, Issue:1-2 Topics: Amphetamines; Animals; Indoles; Injections, Spinal; Ketanserin; Ligation; Lumbar Vertebrae; Male; Neuralgia; Nociceptors; Piperazines; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Nerves; Spiro Compounds; Sulfonamides; Thiophenes	2004
Pregabalin and duloxetine for the treatment of neuropathic pain disorders. Journal of pain & palliative care pharmacotherapy, 2007, Volume: 21, Issue:1 Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Humans; Neuralgia; Pain; Pregabalin; Randomized Controlled Trials as Topic; Thiophenes	2007
Pizotifene treatment of Sluder's syndrome. A report of three cases. Acta neurologica, 1979, Volume: 1, Issue:1 Topics: Adult; Ganglia, Autonomic; Humans; Lacrimal Apparatus; Male; Middle Aged; Neuralgia; Palate; Pizotyline; Syndrome; Thiophenes	1979
Trial of a serotonin inhibitor BC 105 in the prevention of migraine. The New Zealand medical journal, 1969, Volume: 70, Issue:451 Topics: Adolescent; Adult; Aged; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Migraine Disorders; Neuralgia; Serotonin Antagonists; Thiophenes	1969