thiophenes has been researched along with Leukemia in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.34) | 18.7374 |
| 1990's | 6 (20.69) | 18.2507 |
| 2000's | 9 (31.03) | 29.6817 |
| 2010's | 11 (37.93) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MacGregor, GG; Pivovarova, AI | 1 |
| Damoiseaux, R; Gholkar, AA; Lo, YC; Ong, JY; Senese, S; Torres, JZ; Velasquez, EF; Xia, X | 1 |
| Biediger, RJ; Bonig, H; Esguerra, ZA; Gang, EJ; Hsieh, YT; Jang, J; Khazal, S; Kim, HN; Kim, YM; Kwok, E; Osborne, A; Pham, J; Shishido, SN; Vanderslice, P | 1 |
| Cho, YS; Choi, MJ; Keum, G; Kim, SJ; Lee, CS; Min, SJ; Nagarajan, S; Pae, AN | 1 |
| Berges, C; Chatterjee, M; Einsele, H; Topp, MS | 1 |
| Nong, XH; Qi, SH; Wang, J; Wang, QL; Wang, YF; Xu, XY; Zhang, XY | 1 |
| Aubrey, BJ; Balint, B; Blasko, G; Brennan, MS; Bruno, A; Cauquil, N; Chang, C; Chanrion, M; Chen, I; Colland, F; Csekei, M; Davidson, J; Dokurno, P; Galbraith, LC; Geneste, O; Girard, AM; Gong, JN; Graham, C; Gravé, F; Guasconi, G; Guigal-Stephan, N; Herold, MJ; Hickman, JA; Huang, DC; Kelly, GL; Kotschy, A; Le Toumelin-Braizat, G; Lessene, G; Lockhart, B; Lysiak-Auvity, G; Maragno, AL; Matassova, N; Melchiore, F; Moujalled, DM; Murray, J; Ondi, L; Paczal, A; Pedder, C; Pomilio, G; Proszenyak, A; Radics, G; Riffkin, CD; Roberts, AW; Robertson, A; Segal, D; Sipos, S; Smith, J; Strasser, A; Studeny, A; Surgenor, A; Szabo, ZB; Szlavik, Z; Wei, AH | 1 |
| Ikezoe, T; Koeffler, HP; Nishioka, C; Takezaki, Y; Tasaka, T; Togitani, K; Yang, J; Yokoyama, A | 1 |
| Advirao, GM; Nambiar, M; Raghavan, SC; Shahabuddin, MS | 1 |
| Balzarini, J; Baraldi, PG; Brancale, A; Cruz-Lopez, O; Di Cristina, A; Grimaudo, S; Hamel, E; Pipitone, RM; Romagnoli, R; Tolomeo, M | 1 |
| Borisova, O; Ilyinsky, N; Kaluzhny, D; Livshits, M; Shchekotikhin, A; Shchyolkina, A; Shtil, A; Sinkevich, Y; Tsvetkov, PO; Tsvetkov, V; Veselovsky, A | 1 |
| Advirao, GM; Choudhary, B; Giri, R; Panjamurthy, K; Raghavan, SC; Shahabuddin, M; Sharma, S; Srivastava, M | 1 |
| Dallemagne, P; Khanh, LP; Landelle, H; Rault, S | 1 |
| Berg, SL; Bernstein, M; Blaney, SM; Horton, TM; Kamen, B; Kuhn, J; Langevin, AM; Weitman, S | 1 |
| Chen, CJ; Chen, MH; Hsu, MH; Huang, LJ; Huang, PT; Kuo, SC; Lee, KH; Shin, WC; Wen, YF | 1 |
| Gopal, M; Mehta, A; Shenoy, S; Vasania, VS | 1 |
| Gibson, W; Jackman, AL; Kimbell, R; Kobayashi, H; Miyachi, H; Takemura, Y | 2 |
| Cheson, BD; Phillips, PH; Sorensen, JM | 1 |
| Faure, MP; Jolivet, J; Matherly, LH; Taub, JW; Wong, SC | 1 |
| Aherne, GW; Barnes, MJ; Calvete, JA; Estlin, EJ; Hardcastle, A; Lunec, J; McGuire, JJ; Newell, DR; Pearson, AD; Taylor, GA | 1 |
| Creutzig, U; Hählen, K; Janka-Schaub, G; Jansen, G; Kaspers, GJ; Mauritz, R; Noordhuis, P; Peters, GJ; Pieters, R; Rots, MG; van Zantwijk, CH; Veerman, AJ; Willey, JC | 1 |
| Andrei, G; Balzarini, J; De Clercq, E; Felder, TM; Snoeck, R; Sowell, JW; Stephens, CE | 1 |
| Alonso, MM; Encío, I; Gil, M; Martínez-Merino, V; Migliaccio, M | 1 |
| Assaraf, YG; Bunni, MA; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Rosowsky, A; Schornagel, JH | 1 |
| Colige, A; Devy, L; Foidart, JM; Garnotel, R; Hollender, P; Jeannesson, P; Munaut, C; Noël, A | 1 |
| Comay, S; Dubovsky, D; Hougaard, M; Jacobs, P | 1 |
| Bodey, GP; Horikoshi, N; Inagaki, J; McCredie, KB; Rodriguez, V | 1 |
| Bodey, GP; Inagaki, J; Rodriguez, V | 1 |
1 trial(s) available for thiophenes and Leukemia
| Article | Year |
|---|---|
Phase I trial and pharmacokinetic study of raltitrexed in children with recurrent or refractory leukemia: a pediatric oncology group study.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; Humans; Infant; Infusions, Intravenous; Leukemia; Male; Maximum Tolerated Dose; Quinazolines; Thiophenes; Treatment Outcome | 2005 |
28 other study(ies) available for thiophenes and Leukemia
| Article | Year |
|---|---|
Glucose-dependent growth arrest of leukemia cells by MCT1 inhibition: Feeding Warburg's sweet tooth and blocking acid export as an anticancer strategy.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Glucose; Growth Inhibitors; Humans; K562 Cells; Leukemia; MCF-7 Cells; Monocarboxylic Acid Transporters; Symporters; Thiophenes; Uracil | 2018 |
Leukemia Cell Cycle Chemical Profiling Identifies the G2-Phase Leukemia Specific Inhibitor Leusin-1.
Topics: Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; Drug Discovery; Flow Cytometry; G2 Phase; Humans; Leukemia; Pyridines; Thiophenes | 2019 |
Effects of the small-molecule inhibitor of integrin α4, TBC3486, on pre-B-ALL cells.
Topics: Animals; Antineoplastic Agents; Coculture Techniques; Drug Resistance, Neoplasm; Humans; Inflammation; Integrin alpha4; Leukemia; Mice; Neoplasm Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cells, B-Lymphoid; Stromal Cells; Thiophenes; Urea | 2014 |
Tubulin inhibitor identification by bioactive conformation alignment pharmacophore-guided virtual screening.
Topics: Antineoplastic Agents; Cell Proliferation; Drug Design; HL-60 Cells; Humans; Leukemia; Models, Molecular; Molecular Conformation; Small Molecule Libraries; Thiophenes; Tubulin; Tubulin Modulators | 2015 |
Targeting polo-like kinase 1 suppresses essential functions of alloreactive T cells.
Topics: Acute Disease; Cell Cycle Proteins; Cell Growth Processes; Cell Line, Tumor; Graft vs Host Disease; HSP90 Heat-Shock Proteins; Humans; Immunologic Memory; Isoantigens; Leukemia; Lymphocyte Activation; Lymphocyte Depletion; Molecular Targeted Therapy; Polo-Like Kinase 1; Postoperative Complications; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Stem Cell Transplantation; T-Lymphocyte Subsets; T-Lymphocytes; Thiophenes; Transplantation, Homologous | 2016 |
Oxalicumone A, a new dihydrothiophene-condensed sulfur chromone induces apoptosis in leukemia cells through endoplasmic reticulum stress pathway.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chromones; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Humans; Leukemia; MAP Kinase Signaling System; Thiophenes | 2016 |
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cell Line, Tumor; Female; Humans; Leukemia; Lymphoma; Male; Mice; Models, Biological; Models, Molecular; Multiple Myeloma; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasms; Pyrimidines; Thiophenes; Xenograft Model Antitumor Assays | 2016 |
A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies.
Topics: Apoptosis; Benzimidazoles; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cell Proliferation; G2 Phase; Humans; Leukemia; Phosphorylation; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; RNA, Messenger; Thiophenes; Vincristine | 2009 |
Intercalative pyrimido[4',5':4,5]thieno(2,3-b)quinolines induce apoptosis in leukemic cells: a comparative study of methoxy and morpholino substitution.
Topics: Annexin A5; Apoptosis; Cell Death; Cell Line, Tumor; Cell Membrane; Cell Proliferation; DNA Fragmentation; DNA Replication; Drug Screening Assays, Antitumor; G1 Phase; Humans; Intercalating Agents; Leukemia; Microscopy, Confocal; Morpholinos; Phosphatidylserines; Quinolines; Thiophenes | 2011 |
Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives.
Topics: Animals; Antimitotic Agents; Cell Line, Tumor; Cell Proliferation; Female; Humans; Leukemia; Mice; Molecular Structure; Structure-Activity Relationship; Thiophenes; Uterine Cervical Neoplasms | 2011 |
Disordering of human telomeric G-quadruplex with novel antiproliferative anthrathiophenedione.
Topics: Anthraquinones; Cell Proliferation; Circular Dichroism; Colonic Neoplasms; G-Quadruplexes; Humans; Leukemia; Models, Molecular; Molecular Dynamics Simulation; Nucleic Acid Conformation; Oligonucleotides; Potassium; Sodium; Telomere; Thiophenes; Tumor Cells, Cultured | 2011 |
A novel DNA intercalator, 8-methoxy pyrimido[4',5':4,5]thieno (2,3-b)quinoline-4(3H)-one induces apoptosis in cancer cells, inhibits the tumor progression and enhances lifespan in mice with tumor.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; DNA; DNA Breaks, Double-Stranded; Humans; Intercalating Agents; Leukemia; Mice; Mice, Inbred BALB C; Neoplasms; Quinolines; Reactive Oxygen Species; Signal Transduction; Thiophenes | 2013 |
A first cyclopenta[c]thiophene dimer as a new bivalent potent cytotoxic derivative.
Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Leukemia; Structure-Activity Relationship; Thiophenes; Tumor Cells, Cultured | 2002 |
Cell differentiation enhancement by hydrophilic derivatives of 4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-diones in HL-60 leukemia cells.
Topics: Antineoplastic Agents; Cell Differentiation; HL-60 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Leukemia; Molecular Structure; Structure-Activity Relationship; Thiophenes; Tumor Cells, Cultured | 2007 |
8-Methyl-4-(3-diethylaminopropylamino) pyrimido [4',5';4,5] thieno (2,3-b) quinoline (MDPTQ), a quinoline derivate that causes ROS-mediated apoptosis in leukemia cell lines.
Topics: Annexin A5; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle; Cell Line, Tumor; DNA Damage; Ellipticines; Flow Cytometry; Humans; Leukemia; Membrane Potentials; Mitochondrial Membranes; Phosphatidylserines; Quinolines; Reactive Oxygen Species; Thiophenes; Tumor Stem Cell Assay | 2007 |
The influence of drug-exposure conditions on the development of resistance to methotrexate or ZD1694 in cultured human leukaemia cells.
Topics: Antimetabolites, Antineoplastic; Drug Resistance; gamma-Glutamyl Hydrolase; Gene Expression Regulation, Enzymologic; Humans; Leukemia; Methotrexate; Peptide Synthases; Pteroylpolyglutamic Acids; Quinazolines; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1996 |
Biological activity and intracellular metabolism of ZD1694 in human leukemia cell lines with different resistance mechanisms to antifolate drugs.
Topics: Antimetabolites, Antineoplastic; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Polyglutamic Acid; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Tumor Cells, Cultured | 1996 |
Clinical trials referral resource. Clinical trials with tomudex.
Topics: Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Clinical Trials as Topic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Leukemia; Male; Prostatic Neoplasms; Quinazolines; Thiophenes; Thymidylate Synthase | 1996 |
Confocal microscopy visualization of antifolate uptake by the reduced folate carrier in human leukaemic cells.
Topics: Biological Transport; Carrier Proteins; Folic Acid Antagonists; Humans; Leukemia; Membrane Proteins; Membrane Transport Proteins; Microscopy, Confocal; Quinazolines; Reduced Folate Carrier Protein; Thiophenes; Tumor Cells, Cultured | 1997 |
Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.
Topics: Biological Transport; Cell Division; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Growth Inhibitors; Humans; Inhibitory Concentration 50; Leukemia; Methotrexate; Peptide Synthases; Purines; Quinazolines; RNA, Messenger; Thiophenes; Thymidine Monophosphate; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Circumvention of methotrexate resistance in childhood leukemia subtypes by rationally designed antifolates.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Resistance, Neoplasm; Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Quinazolines; Thiophenes; Treatment Outcome; Trimetrexate | 1999 |
Synthesis and antiviral/antitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones.
Topics: Anti-HIV Agents; Antineoplastic Agents; Antiviral Agents; Arylsulfonic Acids; Breast Neoplasms; Cells, Cultured; Colonic Neoplasms; Cytomegalovirus; HIV-1; HIV-2; Humans; Inhibitory Concentration 50; Leukemia; Simplexvirus; Thiophenes | 2001 |
New cytotoxic benzo(b)thiophenilsulfonamide 1,1-dioxide derivatives inhibit a NADH oxidase located in plasma membranes of tumour cells.
Topics: Antineoplastic Agents; Cell Membrane; Culture Media; Drug Screening Assays, Antitumor; Humans; Kinetics; Leukemia; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Sulfonylurea Compounds; Thiophenes; Tumor Cells, Cultured | 2001 |
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Topics: Biological Transport; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Glutamates; Guanine; Homeostasis; Humans; Leukemia; Methotrexate; Ornithine; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Pterins; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
Matrix and serine protease expression during leukemic cell differentiation induced by aclacinomycin and all-trans-retinoic acid.
Topics: Aclarubicin; Antineoplastic Agents; Cell Differentiation; Cell Movement; HL-60 Cells; Humans; Leukemia; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Phenylalanine; Serine Endopeptidases; Thiophenes; Tissue Inhibitor of Metalloproteinases; Tretinoin; Tumor Cells, Cultured | 2002 |
Letter: Epipodophyllotoxin VP 16213 in acute non-lymphoblastic leukaemia.
Topics: Cytarabine; Doxorubicin; Drug Therapy, Combination; Humans; Leukemia; Podophyllotoxin; Thiophenes | 1975 |
Ticarcillin therapy of infections.
Topics: Adult; Bacterial Infections; Carboxylic Acids; Humans; Leukemia; Neoplasms; Penicillins; Pseudomonas Infections; Thiophenes | 1973 |
Clinical pharmacology of ticarcillin (alpha-carboxyl-3-thienylmethyl penicillin, BRL-2288).
Topics: Adolescent; Adult; Aged; Carboxylic Acids; Humans; Injections, Intramuscular; Injections, Intravenous; Kidney Diseases; Leukemia; Middle Aged; Neoplasms; Penicillins; Thiophenes; Time Factors | 1973 |