thiophenes has been researched along with Leukemia L 1210 in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 13 (72.22) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hellmann, K; Marshall, PG; Stayt, S | 1 |
| Aherne, GW; Boyle, FT; Brown, M; Gibson, W; Hardcastle, A; Jackman, AL; Kelland, LR; Kimbell, R | 1 |
| Chong, LK; Tattersall, MH | 1 |
| Harrap, KR | 1 |
| al Shargapi, S; Alsaidi, A; Carreiras, F; Dallemagne, P; Gauduchon, P; Rault, S; Robba, M | 1 |
| Bavetsias, V; Bisset, GM; Calvert, AH; Gibson, W; Harrap, KR; Jackman, AL; Jodrell, DI; Kimbell, R; Smith, MN; Stephens, TC | 1 |
| Aherne, W; Boyle, FT; Hardcastle, A; Jackman, AL; Kimbell, R | 1 |
| Aherne, GW; Brunton, L; Clarke, SJ; Farrugia, DC; Jackman, AL | 1 |
| Blanton, CD; Koebel, RF; Needham, LL | 1 |
| Bader, H; Beardsley, GP; DeYarman, MT; Freisheim, JH; Galivan, J; Kerwar, SS; Moroson, BA; O'Connor, BM; Rosowsky, A; Russello, O | 1 |
| Jackman, AL; Kimbell, R; Ward, WH | 1 |
| Gibson, W; Jackman, AL; Jodrell, DI; Stephens, TC | 1 |
| Brown, M; Calvert, AH; Gibson, W; Hughes, LR; Jackman, AL; Judson, IR; Kimbell, R; Taylor, GA | 1 |
| Bishop, JA; Calvert, AH; Hayter, AJ; Hughes, LR; Jackman, AL; Marsham, PR; O'Connor, BM; Oldfield, J; Wardleworth, JM | 1 |
| Akai, S; Honda, T; Kirihara, M; Kita, Y; Mohri, S; Okunaka, R; Sasho, M; Sekihachi, J; Shimooka, K; Tamura, Y | 1 |
| Hacker, MP; Krapcho, AP; Petry, ME | 1 |
| Chaykovsky, M; Chen, KK; Lin, M; Modest, EJ; Rosowsky, A | 1 |
| Chen, KK; Lin, M; Rosowsky, A | 1 |
1 review(s) available for thiophenes and Leukemia L 1210
| Article | Year |
|---|---|
Initiatives with platinum- and quinazoline-based antitumor molecules--Fourteenth Bruce F. Cain Memorial Award Lecture.
Topics: Animals; Antineoplastic Agents; Cisplatin; Drug Resistance; Female; Humans; Leukemia L1210; Mice; Neoplasm Transplantation; Organoplatinum Compounds; Ovarian Neoplasms; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase | 1995 |
17 other study(ies) available for thiophenes and Leukemia L 1210
| Article | Year |
|---|---|
The antitumour activity of a series of benzothiophenes.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Leukemia L1210; Mice; Neoplasms, Experimental; Nitrogen Mustard Compounds; Sarcoma 180; Sarcoma, Experimental; Thiophenes | 1967 |
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Deoxyuracil Nucleotides; Drug Resistance; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Neoplasm Proteins; Ovarian Neoplasms; Peptide Synthases; Polyglutamic Acid; Proteins; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1995 |
5,10-Dideazatetrahydrofolic acid reduces toxicity and deoxyadenosine triphosphate pool, expansion in cultured L1210 cells treated with inhibitors of thymidylate synthase.
Topics: Animals; Cell Survival; Deoxyadenine Nucleotides; Drug Interactions; Floxuridine; Folic Acid; Hypoxanthine; Hypoxanthines; Leukemia L1210; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
Synthesis and cytotoxic activity against L1210 leukemia of new aminocyclopenta[c]thiophenones.
Topics: Animals; Antineoplastic Agents; Cell Count; Cell Division; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Stereoisomerism; Thiophenes; Tumor Cells, Cultured | 1994 |
Gamma-linked dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8- dideazafolate as antitumour agents.
Topics: Animals; Antineoplastic Agents; Dipeptides; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase | 1993 |
The duration of the inhibition of thymidylate synthase in intact L1210 cells exposed to two different classes of quinazoline analogues.
Topics: Animals; Antineoplastic Agents; Cell Division; Deoxyuracil Nucleotides; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Thymine Nucleotides | 1993 |
Leucovorin rescue from raltitrexed (tomudex)-induced antiproliferative effects: in vitro cell line and in vivo mouse studies.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Cell Division; Cell Line; Drug Interactions; Humans; Intestinal Mucosa; Intestine, Small; Leucovorin; Leukemia L1210; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Neutropenia; Polyglutamic Acid; Quinazolines; Thiophenes; Thrombocytopenia | 2000 |
Synthesis of thieno[2,3-b]azepin-4-ones as potential antineoplastic agents.
Topics: Animals; Antineoplastic Agents; Azepines; Leukemia L1210; Lymphoma; Melanoma; Mice; Neoplasms, Experimental; Thiophenes | 1975 |
Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
Topics: Acyltransferases; Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Leukemia L1210; Male; Methotrexate; Mice; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase.
Topics: Animals; Binding Sites; Cell Division; Kinetics; Leukemia L1210; Mice; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
ICI D1694, an inhibitor of thymidylate synthase for clinical study.
Topics: Animals; Breast Neoplasms; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Female; Folic Acid Antagonists; Humans; Leukemia L1210; Mice; Neoplasms, Experimental; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1991 |
ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
Topics: Animals; Carrier Proteins; Cell Division; Drug Screening Assays, Antitumor; Folate Receptors, GPI-Anchored; Folic Acid; Glutamates; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase | 1991 |
Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications.
Topics: Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1991 |
Synthetic anthracyclines: regiospecific total synthesis of D-ring thiophene analogues of daunomycin.
Topics: Animals; Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry; Daunorubicin; Leukemia L1210; Thiophenes; Tumor Cells, Cultured | 1990 |
Heterosubstituted anthracene-9,10-dione analogues. The synthesis and antitumor evaluation of 5,8-bis[(aminoalkyl)amino]naphtho[2,3-b] thiophene-4,9-diones.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Leukemia L1210; Mice; Naphthalenes; Structure-Activity Relationship; Thiophenes | 1990 |
2,4-Diaminothieno(2,3-d)pyrimidines as antifolates and antimalarials. 1. Synthesis of 2,4-diamino-5,6,7,8-tetrahydrothianaphthena(2,3-d)pyrimidines and related compounds.
Topics: Amines; Animals; Antimalarials; Chickens; Enterococcus faecalis; Folic Acid Antagonists; Leukemia L1210; Malaria; Mice; Mice, Inbred DBA; Mice, Inbred ICR; Naphthalenes; Plasmodium berghei; Pyrimidines; Thiophenes | 1973 |
2,4-Diaminothieno(2,3-d)pyrimidines as antifolates and antimalarials. 3. Synthesis of 5,6-disubstituted derivatives and related tetracyclic analogs.
Topics: Animals; Antimalarials; Chickens; Enterococcus faecalis; Folic Acid Antagonists; Leukemia L1210; Leukemia, Experimental; Malaria; Mice; Mice, Inbred DBA; Mice, Inbred ICR; Plasmodium berghei; Pyrimidines; Structure-Activity Relationship; Thiophenes | 1973 |