Page last updated: 2024-08-18

thiophenes and Hypertension, Pulmonary

thiophenes has been researched along with Hypertension, Pulmonary in 99 studies

Research

Studies (99)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (1.01)	18.2507
2000's	65 (65.66)	29.6817
2010's	32 (32.32)	24.3611
2020's	1 (1.01)	2.80

Authors

Authors	Studies
Callan, E; Entringer, B; Joshi, A; Konduri, GG; Michalkiewicz, T; Parchur, AK; Rana, U; Teng, RJ	1
Eba, S; Hoshikawa, Y; Ishida, K; Kondo, T; Mitsuishi, Y; Moriguchi, T; Okada, Y; Satoh, H; Shimizu, T; Shimokawa, H; Watanabe, T; Yamamoto, M	1
Aung, TH; Foo, D; Francis, PJ; Ho, HH; Huang, W; Ong, PJ; Wong, CP; Yeo, D	1
Catalá-López, F; de la Fuente Honrubia, C; Macías Saint-Gerons, D; Montero, D	1
Benza, RL; Dhaun, N; Hwang, LJ; Liu, X; Naeije, R; Teal, S; Vachiery, JL; Webb, DJ	1
Feng, W; Lin, Y; Lu, H; Xi, AM; Yan, CZ; Zhang, Y	1
Howard, LS; Price, LC	1
Ewert, R; Kirch, W; Opitz, CF; Pittrow, D	1
Badesch, DB; Barst, RJ; Benza, RL; Black, CM; Fleming, TR; Frost, A; Galie, N; Girgis, RE; Highland, KB; Naeije, R; Rubin, L; Strange, C	1
Coghlan, G; Kabunga, P	1
Badesch, DB; Despain, DJ; Dufton, C; Frost, AE; Galie, N; Gerber, MJ; McGoon, MD; McLaughlin, VV; Olschewski, H; Oudiz, RJ; Rubin, LJ	1
Stähler, G	1
Dhaun, N; Goddard, J; MacIntyre, IM; Webb, DJ	1
Faruqi, S; Fathi, H; Morice, AH	1
Champion, HC; Girgis, RE; Hassoun, PM; Hummers, LK; Mathai, SC; Wigley, FM; Zaiman, A	1
Preston, IR; Steiner, MK	1
Beghetti, M; Galiè, N	1
Danesi, R; Dei Cas, L; Lombardi, C; Metra, M; Verzura, G; Zacà, V	1
Gutiérrez, R; Lupi, E; Miranda, MT; Peña, H; Pulido, T; Roquet, I; Rueda, T; Sandoval, J; Santos, E	1
Cacoub, P; Langleben, D	1
Argyropoulou, P; Boutou, AK; Chavouzis, N; Nakou, C; Pitsiou, GG; Stanopoulos, I	1
Mucke, HA	1
Dranitsaris, G; Mehta, S	1
Ghofrani, HA	1
Gaine, SP; Kelleher, B; Lavelle, A; Lawler, G; Mulligan, N; Murphy, DM; Sugrue, R	1
Barton, P; Chen, YF; Fry-Smith, A; Gibbs, JS; Hyde, C; Jowett, S; Malottki, K; Moore, D; Pepke-Zaba, J; Roberts, J	1
Corris, PA; Langleben, D	1
Dalton, B; Gabbay, E; Keogh, A; Steele, P; Stewart, S; Strange, G; Wlodarczyk, J	1
Humbert, M; Montani, D	1
Hunsche, E; Lefebvre, MC	1
Abramowicz, D; Faoro, V; Huez, S; Lamotte, M; Naeije, R; Neupane, S; Retailleau, K	1
Al-Mousily, F; Byrne, BJ; Embury, J; Gannon, KS; Germain, S; Jacques, V; Murray, J; Porvasnik, SL; Shacham, S	1
Coghlan, JG; Denton, CP; Handler, CE; Kabunga, P; Smith, CJ; Valerio, CJ	1
Brimioulle, S; Dewachter, C; Dewachter, L; Fesler, P; Franck, S; Hubloue, I; Kerbaul, F; Naeije, R; Remmelink, M; Rondelet, B	1
Derk, CT; Shetty, N	1
Galiè, N; Gibbs, JS; Hoeper, MM; Simonneau, G	1
Fisher, AJ; Johnson, MK; Kirkham, N; Lee, WT; Lordan, JL; Peacock, AJ	1
Galiè, N; Gibbs, R; Hoeper, MM; Simon, J; Simonneau, G	1
Cima, K; Desole, S; Graziadei, I; Kähler, CM; Vogel, W; Vogelsinger, H	1
Safdar, Z	1
Bauleo, C; Catapano, G; Formichi, B; Genovesi, D; Giuntini, C; Mannucci, F; Marini, C; Michelassi, C; Monti, S; Prediletto, R	1
Delbeck, M; Ellinghaus, P; Kast, R; Laux, V; Nickel, KF; Perzborn, E; Schäfer, S; Schermuly, RT; Strassburger, J; von Degenfeld, G	1
French, B; Gabler, NB; Halpern, SD; Kawut, SM; Liu, Z; Palevsky, HI; Strom, BL; Taichman, DB	1
Bartelds, B; Berger, RMF; Boersma, B; Dickinson, MG; Mohaupt, S; Takens, J; van Albada, M; van Loon, RLE; Wijnberg, H	1
Hwang, LJ; Jardim, C; Jerjes-Sánchez Díaz, C; Kurzyna, M; Pulido, T; Ramírez, A; Sandoval, J; Souza, R; Teal, SA; Torbicki, A	1
Cross, DM; Derzi, M; Horsley, E; Owen, K; Stavros, FL	2
Hintz, E; Klein, R; Staehler, G	1
Blenkhorn, F; Eisenberg, MJ; Fox, B; Hirsch, AM; Joyal, D; Langleben, D; Lesenko, L; Schlesinger, RD	1
Luo, N; Ryan, JJ	1
Fang, X; Fung, ML; Huang, Y; Liu, Y; Mao, G; Shyy, JY; Tian, XY; Wang, N	1
Celermajer, DS; Corte, TJ; Don, GW; Joseph, F	1
Colucci, WS; Givertz, MM; Ooi, H	1
Bibova, J; Hampl, V; Herget, J; Novotna, J; Povysilova, V; Vankova, M	1
Apostolopoulou, SC; Rammos, S	1
Barst, RJ; Dixon, RA; Duncan, B; Frost, A; Frumkin, LR; Hill, N; Horn, EM; Langleben, D; McLaughlin, V; Oudiz, R; Robbins, IM; Shapiro, S; Tapson, VF; Zwicke, D	1
Branzi, A; Galié, N; Manes, A	1
Wilkins, MR	1
Barst, RJ; Hirsch, AM; Langleben, D; Lesenko, L; Shalit, E	1
Barst, RJ; Horn, EM; Widlitz, AC	2
Cheng, J; Liu, C	1
Barst, R; Brock, T; Dixon, R; Langleben, D	1
Barst, RJ; DeMarco, T; Frost, AE; Hill, N; Horn, E; Langleben, D; McLaughlin, V; Oudiz, R; Robbins, IM; Rubenfire, M; Schilz, R; Shapiro, S; Tapson, VF; Zwicke, D	1
Channick, RN; Lee, SH	1
Barst, RJ; Garofano, R; Hansen, JE; Oudiz, RJ; Sun, XG; Wasserman, K; Wu, X	1
Arbak, P; Balbay, O; Comunoğlu, NU; Erbaş, M; Güler, S; Nihat Annakkaya, A; Silan, C; Uzun, O; Yavuz, O	1
Gaine, SP; O'Callaghan, DS	1
Badesch, D; Barst, RJ; Frost, A; Galie, N; Langleben, D; Lawrence, EC; Naeije, R; Shapiro, S	1
Archer, SL; Michelakis, ED	1
Abman, SH	1
Chen, J; Liu, C	1
Coyne, TC	1
Ewert, R; Opitz, CF	1
Humbert, M; Simonneau, G	1
Hoeper, MM	1
Barst, RJ	1
Abubakar, A; Wittbrodt, ET	1
Gomberg-Maitland, M; Jacobs, A; Preston, IR	1
Cortopassi, F; Fernandes, CJ; Jardim, C; Martins, BC; Pulido, T; Sandoval, J; Souza, R	1
Barst, RJ; Benza, RL; Keogh, A; Lawrence, EC; Mehta, S; Oudiz, RJ	1
Brimiouille, S; Fesler, P; Hubloue, I; Huez, S; Kerbaul, F; Naeije, R; Remmelink, M; Rondelet, B; Salmon, I; Vivian, GF	1
Langleben, D	1
Scott, LJ	1
Baloira, A	1
Barst, RJ; Frost, AE; Girgis, RE; Hill, NS; Horn, EM; Langleben, D; McLaughlin, VV; Oudiz, RJ; Robbins, IM; Seibold, JR; Shapiro, S; Tapson, VF	1
Waxman, AB	1
Dhaun, N; Goddard, J; Pollock, DM; Webb, DJ	1
Dinh-Xuan, AT; Hoeper, MM	1
Dupuis, J; Hoeper, MM	1
Amoura, Z; Cacoub, P; Langleben, D	1
Batyraliev, TA; Ekinsi, E; Makhmutkhodzhaev, SA; Pataraia, SA; Pershukov, IV; Preobrazhenskiĭ, DV; Sidorenko, BA	1
Park, MH	1
Biediger, RJ; Blok, N; Bourgoyne, AR; Brock, TA; Bui, H; Chen, Q; Decker, ER; Dixon, RA; Dupré, B; Holland, GW; Knowles, V; Kogan, TP; Lin, S; Market, RV; Raju, B; Wu, C	1
Block, N; Brock, TA; Chen, SJ; Chen, YF; Dixon, RA; Munsch, CL; Sherwood, SJ; Tilton, RG; Wu, C	1
Almany, DK; Crawford, FA; Davis, JN; Fary, DJ; Goldberg, AT; Hendrick, JW; Joffs, C; Spinale, FG; Walker, CA	1
Kim, NH; Rubin, LJ	1
Barst, RJ; Horn, EM; McFarlin, J; McLaughlin, V; Rich, S; Widlitz, A	1

Reviews

33 review(s) available for thiophenes and Hypertension, Pulmonary

Article	Year
Endothelin receptor antagonists for pulmonary arterial hypertension: rationale and place in therapy. American journal of cardiovascular drugs : drugs, devices, and other interventions, 2008, Volume: 8, Issue:3 Topics: Antihypertensive Agents; Bosentan; Clinical Trials, Phase III as Topic; Drug Interactions; Endothelin Receptor Antagonists; Endothelins; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes	2008
Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: does selectivity matter? European heart journal, 2008, Volume: 29, Issue:16 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Phenylpropionates; Pulmonary Artery; Pyridazines; Randomized Controlled Trials as Topic; Sulfonamides; Thiophenes; Treatment Outcome; Vascular Resistance; Walking	2008
Endothelin receptor antagonism: role in the treatment of pulmonary arterial hypertension related to scleroderma. Drugs, 2008, Volume: 68, Issue:12 Topics: Antihypertensive Agents; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Receptors, Endothelin; Scleroderma, Systemic; Sulfonamides; Thiophenes; Treatment Outcome	2008
[Specific drugs for the treatment of pulmonary arterial hypertension - current status]. Deutsche medizinische Wochenschrift (1946), 2008, Volume: 133 Suppl 6 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Prostaglandins; Purines; Pyridazines; Sildenafil Citrate; Sulfonamides; Sulfones; Survival Rate; Thiophenes; Vasodilator Agents	2008
Sitaxsentan sodium for pulmonary hypertension. Drugs of today (Barcelona, Spain : 1998), 2008, Volume: 44, Issue:8 Topics: Animals; Clinical Trials as Topic; Drug Interactions; Endothelin Receptor Antagonists; Endothelins; Humans; Hypertension, Pulmonary; Isoxazoles; Receptors, Endothelin; Thiophenes	2008
Optimizing endothelin receptor antagonist use in the management of pulmonary arterial hypertension. Vascular health and risk management, 2008, Volume: 4, Issue:5 Topics: Animals; Antihypertensive Agents; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Patient Compliance; Patient Satisfaction; Phenylpropionates; Pyridazines; Quality of Life; Receptors, Endothelin; Sulfonamides; Thiophenes; Treatment Outcome	2008
Eisenmenger syndrome a clinical perspective in a new therapeutic era of pulmonary arterial hypertension. Journal of the American College of Cardiology, 2009, Mar-03, Volume: 53, Issue:9 Topics: Antihypertensive Agents; Bosentan; Eisenmenger Complex; Endothelin Receptor Antagonists; Epoprostenol; Humans; Hypertension, Pulmonary; Isoxazoles; Phosphodiesterase Inhibitors; Piperazines; Pulmonary Circulation; Purines; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes	2009
Small-molecule endothelin receptor antagonists: a review of patenting activity across therapeutic areas. IDrugs : the investigational drugs journal, 2009, Volume: 12, Issue:6 Topics: Animals; Antihypertensive Agents; Bosentan; Drug Design; Endothelin Receptor Antagonists; Endothelins; Humans; Hypertension, Pulmonary; Isoxazoles; Patents as Topic; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes	2009
Clinical and cost-effectiveness of epoprostenol, iloprost, bosentan, sitaxentan and sildenafil for pulmonary arterial hypertension within their licensed indications: a systematic review and economic evaluation. Health technology assessment (Winchester, England), 2009, Volume: 13, Issue:49 Topics: Antihypertensive Agents; Bosentan; Cost-Benefit Analysis; Endothelin Receptor Antagonists; Epoprostenol; Humans; Hypertension, Pulmonary; Iloprost; Isoxazoles; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes; United States; Vasodilator Agents	2009
Hemodynamics in pulmonary arterial hypertension (PAH): do they explain long-term clinical outcomes with PAH-specific therapy? BMC cardiovascular disorders, 2010, Feb-22, Volume: 10 Topics: Adult; Aged; Antihypertensive Agents; Bosentan; Cohort Studies; Epoprostenol; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Piperazines; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes; Time Factors; Treatment Outcome	2010
Endothelin receptor antagonists as disease modifiers in systemic sclerosis. Inflammation & allergy drug targets, 2011, Volume: 10, Issue:1 Topics: Animals; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelins; Familial Primary Pulmonary Hypertension; Fibrosis; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Receptors, Endothelin; Scleroderma, Systemic; Sulfonamides; Thiophenes; Treatment Outcome	2011
The endothelin system in pulmonary arterial hypertension. Cardiovascular research, 2004, Feb-01, Volume: 61, Issue:2 Topics: Animals; Bosentan; Endothelial Cells; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Humans; Hypertension, Pulmonary; Infant, Newborn; Isoxazoles; Models, Animal; Muscle, Smooth, Vascular; Pulmonary Circulation; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Thiophenes	2004
Endothelin receptor antagonists for pulmonary arterial hypertension. The Cochrane database of systematic reviews, 2005, Jan-25, Issue:1 Topics: Adult; Antihypertensive Agents; Bosentan; Child; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Randomized Controlled Trials as Topic; Sulfonamides; Thiophenes	2005
Endothelin antagonism in pulmonary arterial hypertension. Seminars in respiratory and critical care medicine, 2005, Volume: 26, Issue:4 Topics: Antihypertensive Agents; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Endothelin-1; Epoprostenol; Humans; Hypertension, Pulmonary; Isoxazoles; Piperazines; Pulmonary Artery; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes	2005
Sitaxsentan: a novel endothelin-A receptor antagonist for pulmonary arterial hypertension. Expert review of cardiovascular therapy, 2005, Volume: 3, Issue:6 Topics: Clinical Trials as Topic; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Thiophenes	2005
An evidence-based approach to the management of pulmonary arterial hypertension. Current opinion in cardiology, 2006, Volume: 21, Issue:4 Topics: Antihypertensive Agents; Benzamides; Bosentan; Calcium Channel Blockers; Comorbidity; Dichloroacetic Acid; Drug Therapy, Combination; Epoprostenol; Evidence-Based Medicine; Fluoxetine; Humans; Hypertension, Pulmonary; Iloprost; Imatinib Mesylate; Isoxazoles; Phosphodiesterase Inhibitors; Piperazines; Prostaglandins, Synthetic; Pulmonary Artery; Purines; Pyrimidines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Simvastatin; Sulfonamides; Sulfones; Thiophenes; Vasodilator Agents	2006
Pulmonary hypertension in older children: new approaches and therapies. Paediatric respiratory reviews, 2006, Volume: 7 Suppl 1 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Antihypertensive Agents; Bosentan; Calcium Channel Blockers; Cardiac Catheterization; Child; Cyclic Nucleotide Phosphodiesterases, Type 5; Echocardiography; Endothelin Receptor Antagonists; Epoprostenol; Humans; Hypertension, Pulmonary; Isoxazoles; Phosphodiesterase Inhibitors; Pulmonary Wedge Pressure; Sulfonamides; Thiophenes; Treatment Outcome	2006
Endothelin receptor antagonists for pulmonary arterial hypertension. The Cochrane database of systematic reviews, 2006, Jul-19, Issue:3 Topics: Antihypertensive Agents; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Randomized Controlled Trials as Topic; Sulfonamides; Thiophenes	2006
Dual ET(A)/ET(B) vs. selective ET(A) endothelin receptor antagonism in patients with pulmonary hypertension. European journal of clinical investigation, 2006, Volume: 36 Suppl 3 Topics: Antihypertensive Agents; Bosentan; Cell Division; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hypertension, Pulmonary; Isoxazoles; Lung; Pulmonary Fibrosis; Sulfonamides; Thiophenes; Vasoconstriction; Vasodilation	2006
Drug Insight: endothelin-receptor antagonists for pulmonary arterial hypertension in systemic rheumatic diseases. Nature clinical practice. Rheumatology, 2005, Volume: 1, Issue:2 Topics: Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pulmonary Wedge Pressure; Pyridazines; Rheumatic Diseases; Thiophenes; Treatment Outcome	2005
[Treatment of pulmonary arterial hypertension: endothelin-receptor antagonists]. Deutsche medizinische Wochenschrift (1946), 2006, Dec-08, Volume: 131, Issue:49 Suppl 9 Topics: Algorithms; Antihypertensive Agents; Bosentan; Drug Interactions; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Sulfonamides; Survival Rate; Thiophenes	2006
Sitaxsentan: a selective endothelin-A receptor antagonist, for the treatment of pulmonary arterial hypertension. Expert opinion on pharmacotherapy, 2007, Volume: 8, Issue:1 Topics: Endothelin A Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Receptor, Endothelin A; Thiophenes	2007
Sitaxsentan for treatment of pulmonary hypertension. The Annals of pharmacotherapy, 2007, Volume: 41, Issue:1 Topics: Animals; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Receptors, Endothelin; Thiophenes; Treatment Outcome	2007
Endothelin receptor antagonism in pulmonary arterial hypertension--a role for selective ET(A) inhibition? Current medical research and opinion, 2006, Volume: 22, Issue:12 Topics: Clinical Trials as Topic; Endothelin A Receptor Antagonists; Endothelin-1; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Sulfonamides; Thiophenes	2006
Endothelin receptor antagonists in the treatment of pulmonary arterial hypertension. Clinics in chest medicine, 2007, Volume: 28, Issue:1 Topics: Antihypertensive Agents; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Randomized Controlled Trials as Topic; Sulfonamides; Thiophenes	2007
Sitaxentan: in pulmonary arterial hypertension. Drugs, 2007, Volume: 67, Issue:5 Topics: Endothelin A Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Randomized Controlled Trials as Topic; Receptor, Endothelin A; Thiophenes; Treatment Outcome	2007
A review of sitaxsentan sodium in patients with pulmonary arterial hypertension. Vascular health and risk management, 2007, Volume: 3, Issue:1 Topics: Clinical Trials as Topic; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Pulmonary Wedge Pressure; Thiophenes; Treatment Outcome	2007
Selective and mixed endothelin receptor antagonism in cardiovascular disease. Trends in pharmacological sciences, 2007, Volume: 28, Issue:11 Topics: Animals; Bosentan; Clinical Trials as Topic; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Models, Biological; Sulfonamides; Thiophenes	2007
Endothelin receptor antagonists in pulmonary arterial hypertension. The European respiratory journal, 2008, Volume: 31, Issue:2 Topics: Animals; Bosentan; Clinical Trials, Phase III as Topic; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Prognosis; Pyridazines; Randomized Controlled Trials as Topic; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Severity of Illness Index; Sulfonamides; Survival Rate; Thiophenes; Treatment Outcome	2008
[Treatment of pulmonary arterial hypertension by endothelin receptor antagonists in 2008]. La Revue de medecine interne, 2008, Volume: 29, Issue:4 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes	2008
[Pulmonary hypertension and right ventricular failure. Part XI. Endothelin receptor blockers in the treatment of primary pulmonary arterial hypertension]. Kardiologiia, 2007, Volume: 47, Issue:7 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Heart Failure; Hemodynamics; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes; Ventricular Dysfunction, Right	2007
Advances in diagnosis and treatment in patients with pulmonary arterial hypertension. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2008, Feb-01, Volume: 71, Issue:2 Topics: Antihypertensive Agents; Bosentan; Cardiac Catheterization; Disease Progression; Drug Therapy, Combination; Endothelin Receptor Antagonists; Endothelium, Vascular; Epoprostenol; Heart Failure; Humans; Hypertension, Pulmonary; Iloprost; Isoxazoles; Phosphodiesterase Inhibitors; Piperazines; Platelet Aggregation Inhibitors; Prognosis; Pulmonary Artery; Purines; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes; Vasoconstriction	2008
Endothelin in health and disease: endothelin receptor antagonists in the management of pulmonary artery hypertension. Journal of cardiovascular pharmacology and therapeutics, 2002, Volume: 7, Issue:1 Topics: Antihypertensive Agents; Bosentan; Clinical Trials as Topic; Endothelin Receptor Antagonists; Endothelins; Humans; Hypertension, Pulmonary; Isoxazoles; Pulmonary Artery; Sulfonamides; Thiophenes	2002

Trials

17 trial(s) available for thiophenes and Hypertension, Pulmonary

Article	Year
Endothelin antagonism and uric acid levels in pulmonary arterial hypertension: clinical associations. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2014, Volume: 33, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Aged; Bosentan; Child; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin Receptor Antagonists; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Prospective Studies; Sulfonamides; Survival Rate; Thiophenes; Time Factors; Treatment Outcome; United States; Uric Acid; Young Adult	2014
Sitaxsentan for the treatment of pulmonary arterial hypertension: a 1-year, prospective, open-label observation of outcome and survival. Chest, 2008, Volume: 134, Issue:4 Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Endothelin Receptor Antagonists; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Prospective Studies; Survival Rate; Thiophenes; Time Factors; Treatment Outcome	2008
Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities. Chest, 2009, Volume: 135, Issue:1 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Bosentan; Child; Disease-Free Survival; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Liver Function Tests; Male; Middle Aged; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes; Transaminases; Treatment Outcome; Young Adult	2009
Interaction of acenocoumarol and sitaxentan in pulmonary arterial hypertension. European journal of clinical investigation, 2009, Volume: 39 Suppl 2 Topics: Acenocoumarol; Adolescent; Adult; Anticoagulants; Antihypertensive Agents; Drug Administration Schedule; Drug Interactions; Endothelin Receptor Antagonists; Female; Hemorrhage; Humans; Hypertension, Pulmonary; International Normalized Ratio; Isoxazoles; Male; Prospective Studies; Survival Analysis; Thiophenes; Young Adult	2009
Pulmonary artery pressure limits exercise capacity at high altitude. The European respiratory journal, 2010, Volume: 36, Issue:5 Topics: Acute Disease; Adult; Altitude; Blood Pressure; Chronic Disease; Endothelin A Receptor Antagonists; Exercise; Female; Humans; Hypertension, Pulmonary; Hypoxia; Isoxazoles; Kidney; Male; Middle Aged; Oxygen Consumption; Pulmonary Artery; Pulmonary Gas Exchange; Thiophenes; Vascular Resistance; Young Adult	2010
Race and sex differences in response to endothelin receptor antagonists for pulmonary arterial hypertension. Chest, 2012, Volume: 141, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Bosentan; Child; Double-Blind Method; Endothelin Receptor Antagonists; Ethnicity; Exercise Test; Familial Primary Pulmonary Hypertension; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Phenylpropionates; Prevalence; Prospective Studies; Pulmonary Wedge Pressure; Pyridazines; Sex Factors; Sulfonamides; Thiophenes; Treatment Outcome; United States; Walking; Young Adult	2012
Safety and efficacy of sitaxsentan 50 and 100 mg in patients with pulmonary arterial hypertension. Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:1 Topics: Adolescent; Adult; Aged; Blood Pressure; Child; Dose-Response Relationship, Drug; Double-Blind Method; Dyspnea; Endothelin Receptor Antagonists; Endpoint Determination; Female; Humans; Hypertension, Pulmonary; Intention to Treat Analysis; Isoxazoles; Kaplan-Meier Estimate; Liver Function Tests; Male; Middle Aged; Pulmonary Wedge Pressure; Sample Size; Thiophenes; Treatment Outcome; Vascular Resistance; Young Adult	2012
Endothelin mediates increased pulmonary vascular tone in patients with heart failure: demonstration by direct intrapulmonary infusion of sitaxsentan. Circulation, 2002, Sep-24, Volume: 106, Issue:13 Topics: Blood Flow Velocity; Blood Pressure; Endothelin Receptor Antagonists; Endothelins; Female; Heart Failure; Humans; Hypertension, Pulmonary; Infusions, Intra-Arterial; Isoxazoles; Male; Middle Aged; Pulmonary Artery; Pulmonary Circulation; Receptor, Endothelin A; Reference Values; Thiophenes; Vascular Resistance; Vasomotor System; Ventricular Function, Left	2002
Sitaxsentan therapy for pulmonary arterial hypertension. American journal of respiratory and critical care medicine, 2004, Feb-15, Volume: 169, Issue:4 Topics: Adolescent; Adult; Aged; Anaerobic Threshold; Double-Blind Method; Endothelin Receptor Antagonists; Exercise Test; Exercise Tolerance; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Oxygen Consumption; Thiophenes	2004
STRIDE 1: effects of the selective ET(A) receptor antagonist, sitaxsentan sodium, in a patient population with pulmonary arterial hypertension that meets traditional inclusion criteria of previous pulmonary arterial hypertension trials. Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1 Topics: Administration, Oral; Adult; Aged; Antihypertensive Agents; Blood Pressure; Canada; Double-Blind Method; Endothelin A Receptor Antagonists; Exercise Tolerance; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Patient Selection; Severity of Illness Index; Thiophenes; Treatment Outcome; United States; Vascular Resistance; Walking	2004
The 6-min walk test (6MW) as an efficacy endpoint in pulmonary arterial hypertension clinical trials: demonstration of a ceiling effect. Vascular pharmacology, 2005, Volume: 43, Issue:1 Topics: Double-Blind Method; Endothelin Receptor Antagonists; Endpoint Determination; Exercise Test; Heart Diseases; Humans; Hypertension, Pulmonary; Isoxazoles; Research Design; Thiophenes; Walking	2005
Cardiopulmonary exercise testing and six-minute walk correlations in pulmonary arterial hypertension. The American journal of cardiology, 2006, Jan-01, Volume: 97, Issue:1 Topics: Adolescent; Adult; Aged; Clinical Competence; Data Interpretation, Statistical; Endothelin Receptor Antagonists; Exercise Test; Exercise Tolerance; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Oxygen Consumption; Thiophenes; Walking	2006
Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan. Journal of the American College of Cardiology, 2006, May-16, Volume: 47, Issue:10 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Bosentan; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Dyspnea; Endothelin A Receptor Antagonists; Exercise Test; Exercise Tolerance; Female; Health Status Indicators; Hemodynamics; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Risk Assessment; Sulfonamides; Thiophenes; Treatment Outcome	2006
Sitaxsentan treatment for patients with pulmonary arterial hypertension discontinuing bosentan. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2007, Volume: 26, Issue:1 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Bosentan; Child; Double-Blind Method; Endothelin Receptor Antagonists; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Sulfonamides; Thiophenes; Treatment Outcome	2007
Selective endothelin A receptor antagonism with sitaxsentan for pulmonary arterial hypertension associated with connective tissue disease. Annals of the rheumatic diseases, 2007, Volume: 66, Issue:11 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Cardiac Output; Connective Tissue Diseases; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin A Receptor Antagonists; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Quality of Life; Thiophenes; Treatment Outcome; Vascular Resistance; Walking	2007
Endothelin receptor subtype A blockade selectively reduces pulmonary pressure after cardiopulmonary bypass. The Journal of thoracic and cardiovascular surgery, 2001, Volume: 122, Issue:2 Topics: Analysis of Variance; Animals; Cardiopulmonary Bypass; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Isoxazoles; Pulmonary Circulation; Receptors, Endothelin; Swine; Thiophenes; Vascular Resistance; Ventricular Function, Left	2001
Clinical efficacy of sitaxsentan, an endothelin-A receptor antagonist, in patients with pulmonary arterial hypertension: open-label pilot study. Chest, 2002, Volume: 121, Issue:6 Topics: Adolescent; Adult; Aged; Child; Endothelin Receptor Antagonists; Exercise Tolerance; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Pilot Projects; Receptor, Endothelin A; Thiophenes	2002

Other Studies

49 other study(ies) available for thiophenes and Hypertension, Pulmonary

Article	Year
AMP-Kinase Dysfunction Alters Notch Ligands to Impair Angiogenesis in Neonatal Pulmonary Hypertension. American journal of respiratory cell and molecular biology, 2020, Volume: 62, Issue:6 Topics: AMP-Activated Protein Kinase Kinases; Animals; Animals, Newborn; Biphenyl Compounds; Ductus Arteriosus; Electron Transport; Endothelial Cells; Enzyme Activation; Female; Hypertension, Pulmonary; Intracellular Signaling Peptides and Proteins; Jagged-1 Protein; Ligands; Lung; Membrane Proteins; Metformin; Mitochondria; Neovascularization, Pathologic; Persistent Fetal Circulation Syndrome; Phosphorylation; Pregnancy; Protein Kinases; Pyrones; Receptors, Notch; Sheep; Thiophenes; Threonine; Transfection	2020
The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice. American journal of respiratory cell and molecular biology, 2013, Volume: 49, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Animals; Anticarcinogenic Agents; Cytoskeletal Proteins; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Kelch-Like ECH-Associated Protein 1; Mice; Mice, Knockout; NF-E2-Related Factor 2; Pulmonary Disease, Chronic Obstructive; Pyrazines; Tenascin; Thiones; Thiophenes	2013
Successful treatment of a patient with chronic thromboembolic pulmonary hypertension with rivaroxaban. International journal of cardiology, 2013, Jul-31, Volume: 167, Issue:2 Topics: Adult; Anticoagulants; Chronic Disease; Female; Humans; Hypertension, Pulmonary; Morpholines; Pulmonary Embolism; Rivaroxaban; Thiophenes; Treatment Outcome	2013
Endothelin receptor antagonists-induced hepatotoxicity. Internal medicine journal, 2013, Volume: 43, Issue:5 Topics: Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Safety-Based Drug Withdrawals; Thiophenes	2013
[The changes of vascular active substances in pulmonary embolism rats and a comparative study of anticoagulant drugs]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2015, Volume: 31, Issue:2 Topics: Animals; Anticoagulants; Disease Models, Animal; Endothelin-1; Heparin, Low-Molecular-Weight; Hypertension, Pulmonary; Lung; Morpholines; Pulmonary Embolism; Rats; Rivaroxaban; Thiophenes; Warfarin	2015
Sitaxentan: new drug. Pulmonary hypertension: better to continue to use bosentan. Prescrire international, 2008, Volume: 17, Issue:95 Topics: Administration, Oral; Drug Approval; Endothelin Receptor Antagonists; Europe; Humans; Hypertension, Pulmonary; Isoxazoles; Randomized Controlled Trials as Topic; Sulfonamides; Thiophenes	2008
Combination of sitaxentan and tadalafil for idiopathic pulmonary arterial hypertension following relapse on bosentan. International journal of cardiology, 2010, Oct-29, Volume: 144, Issue:3 Topics: Adult; Antihypertensive Agents; Bosentan; Carbolines; Drug Therapy, Combination; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Sulfonamides; Tadalafil; Thiophenes; Treatment Outcome; Vasodilator Agents	2010
Survival in pulmonary hypertension associated with the scleroderma spectrum of diseases: impact of interstitial lung disease. Arthritis and rheumatism, 2009, Volume: 60, Issue:2 Topics: Bosentan; Cohort Studies; Comorbidity; Endothelin Receptor Antagonists; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Isoxazoles; Lung Diseases, Interstitial; Male; Maryland; Middle Aged; Piperazines; Prognosis; Proportional Hazards Models; Purines; Receptors, Endothelin; Scleroderma, Diffuse; Scleroderma, Systemic; Sildenafil Citrate; Sulfonamides; Sulfones; Survival Rate; Thiophenes; Vasodilator Agents	2009
Successful switch to sitaxsentan in a patient with HIV-related pulmonary arterial hypertension and late intolerance to nonselective endothelin receptor blockade. Therapeutic advances in respiratory disease, 2009, Volume: 3, Issue:1 Topics: Endothelin Receptor Antagonists; Follow-Up Studies; HIV; HIV Infections; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Pulmonary Wedge Pressure; Receptors, Endothelin; Thiophenes	2009
A review of STRIDE-2 and STRIDE-2X: the case for selective endothelin receptor blockade. European journal of clinical investigation, 2009, Volume: 39 Suppl 2 Topics: Adult; Aged; Antihypertensive Agents; Bosentan; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Liver; Male; Middle Aged; Randomized Controlled Trials as Topic; Sulfonamides; Survival Analysis; Thiophenes; Transaminases; Treatment Outcome	2009
Successful up-front combination therapy in a patient with idiopathic pulmonary hypertension and patent foramen ovale: an alternative to epoprostenol therapy? The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2009, Volume: 28, Issue:6 Topics: Adult; Antihypertensive Agents; Drug Therapy, Combination; Endothelin A Receptor Antagonists; Epoprostenol; Female; Foramen Ovale, Patent; Humans; Hypertension, Pulmonary; Iloprost; Isoxazoles; Piperazines; Purines; Sildenafil Citrate; Sulfones; Thiophenes; Treatment Outcome; Vasodilator Agents	2009
Oral therapies for the treatment of pulmonary arterial hypertension: a population-based cost-minimization analysis. Applied health economics and health policy, 2009, Volume: 7, Issue:1 Topics: Administration, Oral; Antihypertensive Agents; Bosentan; Canada; Costs and Cost Analysis; Drug Costs; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Piperazines; Placebos; Purines; Pyridazines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes; Treatment Outcome	2009
[Endothelin-receptor antagonists in therapy of pulmonary arterial hypertension]. Deutsche medizinische Wochenschrift (1946), 2009, Volume: 134 Suppl 5 Topics: Antihypertensive Agents; Bosentan; Cell Proliferation; Endothelial Cells; Endothelin Receptor Antagonists; Endothelium, Vascular; Humans; Hypertension, Pulmonary; Isoxazoles; Sulfonamides; Thiophenes; Vasoconstriction; Vasodilation	2009
Sitaxentan-induced hepatic failure in two patients with pulmonary arterial hypertension. The European respiratory journal, 2009, Volume: 34, Issue:3 Topics: Aged; Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Thiophenes	2009
The Achilles heel of endothelin receptor therapy for pulmonary arterial hypertension. The European respiratory journal, 2010, Volume: 35, Issue:2 Topics: Bosentan; Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Liver; Phenotype; Receptors, Endothelin; Sulfonamides; Thiophenes	2010
[Endothelin receptor antagonists in the new European guidelines on pulmonary hypertension]. Revue des maladies respiratoires, 2010, Volume: 27, Issue:2 Topics: Administration, Oral; Antihypertensive Agents; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Europe; Evidence-Based Medicine; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Practice Guidelines as Topic; Purines; Pyridazines; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes	2010
Oral Therapies for the treatment of pulmonary arterial hypertension: a population-based cost-minimization analysis. Applied health economics and health policy, 2010, Volume: 8, Issue:1 Topics: Administration, Oral; Antihypertensive Agents; Bosentan; Canada; Cost Control; Drug Costs; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Piperazines; Purines; Pyridazines; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes	2010
PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 334, Issue:2 Topics: Animals; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Magnetic Resonance Imaging; Male; Monocrotaline; Myocardium; Organ Size; Pulmonary Artery; Pyrimidines; Rats; Rats, Sprague-Dawley; Serotonin 5-HT2 Receptor Antagonists; Thiophenes	2010
Clinical experience with bosentan and sitaxentan in connective tissue disease-associated pulmonary arterial hypertension. Rheumatology (Oxford, England), 2010, Volume: 49, Issue:11 Topics: Aged; Antihypertensive Agents; Bosentan; Clinical Trials as Topic; Connective Tissue Diseases; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Statistics as Topic; Sulfonamides; Thiophenes; Treatment Outcome	2010
Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension. American journal of physiology. Heart and circulatory physiology, 2010, Volume: 299, Issue:4 Topics: Angiopoietin-1; Animals; Bone Morphogenetic Protein Receptors, Type II; Disease Models, Animal; Drug Therapy, Combination; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Isoxazoles; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Pulmonary Circulation; Purines; Sildenafil Citrate; Subclavian Artery; Sulfones; Thiophenes; Treatment Outcome	2010
Liver toxicity of sitaxentan in pulmonary arterial hypertension. The European respiratory journal, 2011, Volume: 37, Issue:2 Topics: Chemical and Drug Induced Liver Injury; Contraindications; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Isoxazoles; Liver Failure; Practice Guidelines as Topic; Thiophenes	2011
Sitaxentan-related acute liver failure in a patient with pulmonary arterial hypertension. The European respiratory journal, 2011, Volume: 37, Issue:2 Topics: Chemical and Drug Induced Liver Injury; Contraindications; Endothelin A Receptor Antagonists; Familial Primary Pulmonary Hypertension; Fatal Outcome; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Jaundice; Liver Failure, Acute; Piperazines; Purines; Sildenafil Citrate; Sulfones; Thiophenes; Vasodilator Agents; Young Adult	2011
Liver toxicity of sitaxentan in pulmonary arterial hypertension. European heart journal, 2011, Volume: 32, Issue:4 Topics: Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Early Termination of Clinical Trials; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Isoxazoles; Safety-Based Drug Withdrawals; Thiophenes	2011
Successful treatment of portopulmonary hypertension with the selective endothelin receptor antagonist Sitaxentan. Wiener klinische Wochenschrift, 2011, Volume: 123, Issue:7-8 Topics: Endothelin Receptor Antagonists; Humans; Hypertension, Portal; Hypertension, Pulmonary; Isoxazoles; Male; Pilot Projects; Syndrome; Thiophenes; Treatment Outcome; Young Adult	2011
Effect of transition from sitaxsentan to ambrisentan in pulmonary arterial hypertension. Vascular health and risk management, 2011, Volume: 7 Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Drug Substitution; Dyspnea; Edema; Endothelin A Receptor Antagonists; Exercise Test; Exercise Tolerance; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Liver Function Tests; Male; Middle Aged; Natriuretic Peptide, Brain; Oxygen; Phenylpropionates; Pyridazines; Retrospective Studies; Texas; Thiophenes; Time Factors; Treatment Outcome; Walking	2011
Improved survival in patients with inoperable chronic thromboembolic pulmonary hypertension. Internal and emergency medicine, 2013, Volume: 8, Issue:4 Topics: Acid-Base Equilibrium; Aged; Antihypertensive Agents; Blood Gas Analysis; Bosentan; Cardiac Output; Chronic Disease; Drug Therapy, Combination; Exercise Test; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Oxygen Consumption; Oxygen Inhalation Therapy; Piperazines; Purines; Severity of Illness Index; Sildenafil Citrate; Sulfonamides; Sulfones; Survival Rate; Thiophenes; Thromboembolism; Treatment Outcome; Vascular Resistance; Vasodilator Agents	2013
A role for coagulation factor Xa in experimental pulmonary arterial hypertension. Cardiovascular research, 2011, Oct-01, Volume: 92, Issue:1 Topics: Animals; Blood Coagulation; Enoxaparin; Factor Xa; Factor Xa Inhibitors; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Morpholines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Rivaroxaban; Thiophenes; Thrombosis; Warfarin	2011
Mast cell inhibition improves pulmonary vascular remodeling in pulmonary hypertension. Chest, 2012, Volume: 141, Issue:3 Topics: Animals; Cell Proliferation; Chymases; Cromolyn Sodium; Disease Models, Animal; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Mast Cells; Monocrotaline; Muscle, Smooth, Vascular; Neovascularization, Pathologic; Rats; Rats, Wistar; Sulfonamides; Thiophenes	2012
Evaluation of sitaxentan (Thelin®) toxicity in juvenile rats and regulatory interactions during the development of a European Medicines Agency pediatric investigation plan. Regulatory toxicology and pharmacology : RTP, 2012, Volume: 64, Issue:1 Topics: Animals; Antihypertensive Agents; Behavior, Animal; Child; Dose-Response Relationship, Drug; Drug and Narcotic Control; Endothelin Receptor Antagonists; Europe; Female; Government Agencies; Humans; Hypertension, Pulmonary; Isoxazoles; Male; No-Observed-Adverse-Effect Level; Pediatrics; Rats; Reproduction; Thiophenes; Toxicity Tests	2012
An overview of the preclinical toxicity and potential carcinogenicity of sitaxentan (Thelin®), a potent endothelin receptor antagonist developed for pulmonary arterial hypertension. Regulatory toxicology and pharmacology : RTP, 2012, Volume: 64, Issue:1 Topics: Alkaline Phosphatase; Animals; Antihypertensive Agents; Blood Coagulation; Carcinogenicity Tests; Carcinogens; Chemical and Drug Induced Liver Injury, Chronic; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endothelin Receptor Antagonists; Erythrocyte Indices; Female; Hypertension, Pulmonary; Hypertrophy; Isoxazoles; Liver; Liver Function Tests; Male; Mice; Mice, Inbred Strains; Organ Size; Rats; Rats, Sprague-Dawley; Risk Assessment; Species Specificity; Thiophenes	2012
Exacerbation of AIH in a patient with an AIH/systemic sclerosis overlap syndrome and pulmonary arterial hypertension treated with the endothelin-1 receptor antagonist sitaxentan. BMJ case reports, 2012, Jul-13, Volume: 2012 Topics: Autoantibodies; Autoantigens; Disease Progression; Endothelin A Receptor Antagonists; Familial Primary Pulmonary Hypertension; Female; Hepatitis, Autoimmune; Humans; Hypertension, Pulmonary; Isoxazoles; Middle Aged; Scleroderma, Systemic; Thiophenes; Treatment Outcome	2012
Hemodynamic stability after transitioning between endothelin receptor antagonists in patients with pulmonary arterial hypertension. The Canadian journal of cardiology, 2013, Volume: 29, Issue:6 Topics: Administration, Oral; Aged; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Middle Aged; Phenylpropionates; Pulmonary Wedge Pressure; Pyridazines; Retrospective Studies; Sulfonamides; Thiophenes; Treatment Outcome; Vascular Resistance	2013
Transitioning between endothelin receptor blockers: monitoring to ensure a smooth transition. The Canadian journal of cardiology, 2013, Volume: 29, Issue:6 Topics: Bosentan; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pulmonary Wedge Pressure; Pyridazines; Sulfonamides; Thiophenes; Vascular Resistance	2013
Peroxisome proliferator-activated receptor-γ ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor. Hypertension (Dallas, Tex. : 1979), 2012, Volume: 60, Issue:6 Topics: Animals; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypoxia; Indoles; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Pulmonary Artery; Receptor, Serotonin, 5-HT2B; Rosiglitazone; Serotonin 5-HT2 Receptor Agonists; Thiazolidinediones; Thiophenes; Transcription Factor AP-1; Up-Regulation	2012
Ironic case of hepatic dysfunction following the global withdrawal of sitaxentan. Internal medicine journal, 2012, Volume: 42, Issue:12 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Liver; Liver Function Tests; Middle Aged; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Safety-Based Drug Withdrawals; Scleroderma, Systemic; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes	2012
Metalloproteinase inhibition by Batimastat attenuates pulmonary hypertension in chronically hypoxic rats. American journal of physiology. Lung cellular and molecular physiology, 2003, Volume: 285, Issue:1 Topics: Animals; Chronic Disease; Collagen; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Pulmonary Circulation; Rats; Rats, Wistar; Specific Pathogen-Free Organisms; Thiophenes	2003
Sitaxsentan in pulmonary arterial hypertension. Chest, 2003, Volume: 123, Issue:5 Topics: Endothelin Receptor Antagonists; Hemodynamics; Humans; Hypertension, Pulmonary; Isoxazoles; Receptor, Endothelin A; Thiophenes	2003
Selective or nonselective endothelin receptor blockade in pulmonary arterial hypertension. American journal of respiratory and critical care medicine, 2004, Feb-15, Volume: 169, Issue:4 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Exercise Test; Humans; Hypertension, Pulmonary; Isoxazoles; Sulfonamides; Thiophenes	2004
Sustained symptomatic, functional, and hemodynamic benefit with the selective endothelin-A receptor antagonist, sitaxsentan, in patients with pulmonary arterial hypertension: a 1-year follow-up study. Chest, 2004, Volume: 126, Issue:4 Topics: Adult; Endothelin Receptor Antagonists; Female; Follow-Up Studies; Hemodynamics; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Thiophenes	2004
Sitaxsentan, a selective endothelin-A receptor antagonist for the treatment of pulmonary arterial hypertension. Expert opinion on investigational drugs, 2004, Volume: 13, Issue:11 Topics: Adult; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Receptor, Endothelin A; Receptor, Endothelin B; Substrate Specificity; Thiophenes	2004
Hypobaric-hypoxia-induced pulmonary damage in rats ameliorated by antioxidant erdosteine. Acta histochemica, 2006, Volume: 108, Issue:1 Topics: Animals; Antibodies, Monoclonal; Antioxidants; Atmosphere Exposure Chambers; Atmospheric Pressure; Endothelial Cells; Hematocrit; Hemorrhage; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Immunohistochemistry; Lung; Malondialdehyde; Pulmonary Artery; Random Allocation; Rats; Thioglycolates; Thiophenes	2006
Sitaxsentan: an endothelin-A receptor antagonist for the treatment of pulmonary arterial hypertension. International journal of clinical practice, 2006, Volume: 60, Issue:4 Topics: Endothelin A Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Thiophenes; Treatment Outcome	2006
An evidence-based approach to the management of pulmonary arterial hypertension. Current opinion in cardiology, 2006, Volume: 21, Issue:5 Topics: Antihypertensive Agents; Bosentan; Disease Management; Drug Interactions; Endothelin Receptor Antagonists; Evidence-Based Medicine; Humans; Hypertension, Pulmonary; Isoxazoles; Piperazines; Purines; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes; Vasodilator Agents; Walking	2006
Effect of sitaxsentan treatment on quality of life in pulmonary arterial hypertension. International journal of clinical practice, 2007, Volume: 61, Issue:1 Topics: Administration, Oral; Adult; Antihypertensive Agents; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Quality of Life; Thiophenes	2007
Sitaxsentan for the prevention of experimental shunt-induced pulmonary hypertension. Pediatric research, 2007, Volume: 61, Issue:3 Topics: Anastomosis, Surgical; Angiopoietin-1; Animals; Bone Morphogenetic Protein Receptors; Brachiocephalic Trunk; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Isoxazoles; Pulmonary Artery; RNA, Messenger; Swine; Thiophenes	2007
[Pulmonary hypertension treatment: future prospects]. Archivos de bronconeumologia, 2007, Volume: 43, Issue:3 Topics: Administration, Intranasal; Administration, Oral; Animals; Bosentan; Drug Evaluation, Preclinical; Endothelin A Receptor Antagonists; Epoprostenol; Forecasting; Humans; Hypertension, Pulmonary; Iloprost; Infusions, Intravenous; Isoxazoles; Life Expectancy; Lung Transplantation; Monocrotaline; Piperazines; Platelet-Derived Growth Factor; Purines; Randomized Controlled Trials as Topic; Rats; Sheep; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes; Vasodilator Agents	2007
Pulmonary hypertension: basic concepts and practical management. The European respiratory journal, 2008, Volume: 31, Issue:2 Topics: Bosentan; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Receptors, Endothelin; Sensitivity and Specificity; Sulfonamides; Survival Analysis; Thiophenes; Treatment Outcome	2008
Endothelin antagonists: substituted mesitylcarboxamides with high potency and selectivity for ET(A) receptors. Journal of medicinal chemistry, 1999, Nov-04, Volume: 42, Issue:22 Topics: Administration, Oral; Animals; Biological Availability; Drug Evaluation, Preclinical; Endothelin Receptor Antagonists; Half-Life; Hypertension, Pulmonary; Models, Molecular; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Structure-Activity Relationship; Sulfonamides; Thiophenes	1999
Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist. Pulmonary pharmacology & therapeutics, 2000, Volume: 13, Issue:2 Topics: Animals; Cardiomegaly; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Hypertrophy; Hypoxia; Isoxazoles; Male; Monocrotaline; Oxygen; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Thiophenes; Vasoconstriction; Weight Gain	2000