thiophenes and Disease Models, Animal

Topics: Acetylcholine; Acinetobacter baumannii; Actinobacteria; Action Potentials; Adalimumab; Adaptation, Physiological; Adipates; Administration, Oral; Adolescent; Adrenal Glands; Adsorption; Adult; Aged; Aged, 80 and over; Aging; AIDS-Related Opportunistic Infections; Aldosterone; Amino Acids; Ammonia; Amoxicillin; AMP-Activated Protein Kinases; Animals; Antacids; Anti-Bacterial Agents; Antineoplastic Agents; Antirheumatic Agents; Apgar Score; Area Under Curve; ARNTL Transcription Factors; Arterial Pressure; Arthritis, Juvenile; Athletes; Attention; Biodegradation, Environmental; Biofilms; Biofuels; Biological Therapy; Biomass; Biomimetic Materials; Bioreactors; Birth Weight; Bismuth; Blood Flow Velocity; Bone and Bones; Brain Injuries, Traumatic; Calcium; Calcium Channels; Capsaicin; Carbon; Carcinoma, Hepatocellular; Cardiomegaly, Exercise-Induced; Cartilage; Cartilage, Articular; Case-Control Studies; Catalysis; Cats; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Death; Cell Differentiation; Cell Line, Tumor; Cell Membrane; Charcoal; Chemokine CCL2; Child; Child, Preschool; Chondrogenesis; Chronic Disease; Circadian Clocks; Circadian Rhythm Signaling Peptides and Proteins; Clarithromycin; Coccidioides; Coccidioidomycosis; Cognitive Behavioral Therapy; Coinfection; Color; Coloring Agents; Computer Simulation; Computers, Molecular; Consensus; Corticosterone; Cyclic AMP Response Element-Binding Protein; Cytochrome P-450 Enzyme System; Death, Sudden, Cardiac; Density Functional Theory; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Dialysis Solutions; Disease Models, Animal; Dogs; Dopamine Agonists; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Drug Resistance, Bacterial; Drug Therapy, Combination; Electrocardiography; Electrocardiography, Ambulatory; Electrolytes; Endocardium; Endocrine Disruptors; Endocytosis; Endoscopy, Gastrointestinal; Escherichia coli Proteins; Esters; Evolution, Molecular; Executive Function; Feasibility Studies; Female; Ferric Compounds; Fluorescence; Fluorescent Dyes; Fluorine Radioisotopes; Frailty; Free Radical Scavengers; Gabapentin; Geriatric Assessment; Glucaric Acid; Glucocorticoids; Glucose; Glucose Metabolism Disorders; Halogenated Diphenyl Ethers; Heart Rate; Heart Ventricles; HEK293 Cells; Helicobacter Infections; Helicobacter pylori; Hep G2 Cells; Hepatocytes; Humans; Hungary; Hydrogen Sulfide; Hydrogen-Ion Concentration; Immunologic Factors; Immunomodulation; Immunosuppressive Agents; Independent Living; Indocyanine Green; Infant; Infant Formula; Infant Mortality; Infant, Newborn; Infant, Newborn, Diseases; Inflorescence; Insulin Resistance; Insulins; International Agencies; Iron; Isotonic Solutions; Kidney Failure, Chronic; Kinetics; Lactones; Leukocytes, Mononuclear; Liver Neoplasms; Macular Edema; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetosomes; Male; Medical Audit; Mesenchymal Stem Cells; Metabolic Syndrome; Metformin; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Middle Aged; Molecular Conformation; Molecular Targeted Therapy; Motor Activity; Multiple Sclerosis; Mycophenolic Acid; Netherlands; Neuropsychological Tests; Nuclear Energy; Organs at Risk; Osteoarthritis; Osteoarthritis, Hip; Oxidation-Reduction; Palladium; Pericardium; Perinatal Death; Peritoneal Dialysis; Phantoms, Imaging; Pharmaceutical Preparations; Phospholipids; Phosphorylation; Physical Conditioning, Human; Physical Endurance; Pilot Projects; Polyketides; Polymers; Positron-Emission Tomography; Postoperative Period; Potassium; Powders; Pramipexole; Predictive Value of Tests; Pregabalin; Pregnancy; Pregnancy Outcome; Protein Structure, Secondary; Proton Pump Inhibitors; Puberty; Pulmonary Circulation; Quality Assurance, Health Care; Quantum Dots; Radiometry; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Intensity-Modulated; Rats, Sprague-Dawley; Receptors, CCR2; Receptors, Transferrin; Regeneration; Registries; Renal Insufficiency, Chronic; Reproducibility of Results; Research Design; Restless Legs Syndrome; Retina; Retinoid X Receptor alpha; Retrospective Studies; Rhenium; Risk Factors; RNA, Messenger; Severity of Illness Index; Sex Factors; Sodium; Sodium Fluoride; Solvents; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Stroke; Structure-Activity Relationship; Tachycardia, Ventricular; Tetracycline; Tetrahydrofolate Dehydrogenase; Tetrahydronaphthalenes; Thermodynamics; Thiophenes; Time Factors; Tinidazole; Tomography, Optical Coherence; Tomography, X-Ray Computed; Topiramate; Toxoplasma; Toxoplasmosis, Cerebral; Transferrin; Treatment Outcome; Up-Regulation; Upper Extremity; Uremia; Uveitis; Vascular Remodeling; Ventricular Fibrillation; Ventricular Function, Left; Ventricular Function, Right; Ventricular Remodeling; Verapamil; Veterans; Visual Acuity; Vitrectomy; Water Pollutants, Chemical; Zea mays; Zirconium

Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus

Topics: alpha-Methyltyrosine; Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Cohort Studies; Disease Models, Animal; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Exploratory Behavior; Gene Knockdown Techniques; Locomotion; Mice; Mice, Inbred C57BL; Quinolones; Reproducibility of Results; Thiophenes; Tyrosine 3-Monooxygenase; Valproic Acid

Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Disease Models, Animal; Drug Discovery; Humans; Indolizines; Mice; Mitogen-Activated Protein Kinase Kinases; Molecular Targeted Therapy; Neoplasms; Quinolones; Quinoxalines; Thiophenes; Treatment Outcome

Topics: Aldehydes; Animals; Apoptosis; Cell Survival; Coumarins; Disease Models, Animal; Disease Progression; DNA-Binding Proteins; Drug Design; Drug Discovery; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Endoribonucleases; Homeostasis; Humans; Mice; Neoplasms; Neurodegenerative Diseases; Prognosis; Protein Folding; Protein Serine-Threonine Kinases; Quercetin; Regulatory Factor X Transcription Factors; Signal Transduction; Sulfonamides; Thiophenes; Toyocamycin; Transcription Factors; Unfolded Protein Response; X-Box Binding Protein 1

Topics: Anabolic Agents; Animals; Bone Density Conservation Agents; Calcitonin; Denosumab; Diphosphonates; Disease Models, Animal; Evidence-Based Medicine; Fracture Healing; Humans; Osteoporosis; Osteoporotic Fractures; Thiophenes

Topics: Animals; Bone and Bones; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Disease Models, Animal; Humans; Organometallic Compounds; Osteoporosis; Rats; Thiophenes

Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Factor Xa Inhibitors; Fibrinolytic Agents; Humans; Morpholines; Rivaroxaban; Thiophenes; Venous Thrombosis

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Humans; Maleates; Mice; Nerve Growth Factors; Neurites; Neuroprotective Agents; Rats; tau Proteins; Thiophenes

Topics: Animals; Anticoagulants; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Factor Xa Inhibitors; Humans; Intracranial Thrombosis; Macaca fascicularis; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Venous Thrombosis

Topics: Angiotensin Receptor Antagonists; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Hypertension; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Sulfonamides; Thiophenes; Vasodilator Agents

Topics: Animals; Controlled Clinical Trials as Topic; Diphosphonates; Disease Models, Animal; Evidence-Based Medicine; Fractures, Spontaneous; Glycoproteins; Humans; Ibandronic Acid; Imidazoles; Norpregnenes; Osteoporosis; Osteoprotegerin; Piperidines; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Selective Estrogen Receptor Modulators; Thiophenes; Zoledronic Acid

Topics: Animals; Biological Availability; Bone and Bones; Disease Models, Animal; Female; Humans; Male; Organometallic Compounds; Osteoporosis, Postmenopausal; Randomized Controlled Trials as Topic; Thiophenes; Tissue Distribution

Topics: Alzheimer Disease; Animals; Benzodiazepines; Cognition; Cognition Disorders; Disease Models, Animal; GABA Agonists; Haplorhini; Hippocampus; Humans; Mice; Mice, Transgenic; Receptors, GABA-A; Thiazoles; Thiophenes

Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cell Death; Disease Models, Animal; Down-Regulation; Humans; Memory Disorders; Mice; Muscarinic Agonists; Oxidative Stress; Piperidines; Quinuclidines; Receptor, Muscarinic M1; Spiro Compounds; tau Proteins; Thiazoles; Thiophenes

Topics: Adrenergic Uptake Inhibitors; Animals; Cats; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Disease Models, Animal; Duloxetine Hydrochloride; Female; Humans; Nausea; Quality of Life; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Thiophenes; Treatment Outcome; Urinary Incontinence, Stress

Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bone and Bones; Disease Models, Animal; Female; Humans; Ligands; Organometallic Compounds; Osteoporosis; Osteoporosis, Postmenopausal; Receptors, Nicotinic; Thiophenes

Topics: Animals; Bone and Bones; Clinical Trials as Topic; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Organometallic Compounds; Osteoporosis; Osteoporosis, Postmenopausal; Thiophenes

Topics: Adult; Age of Onset; Animals; Biopolymers; Cell Adhesion; Child; Child, Preschool; Chromosomes, Human, X; Diagnosis, Differential; Diagnostic Techniques, Ophthalmological; Disease Models, Animal; Disease Progression; Eye Proteins; Female; Genes, X-Linked; Genetic Carrier Screening; Genetic Counseling; Genetic Therapy; Humans; Infant; Macular Degeneration; Male; Mice; Phenotype; Prevalence; Protein Structure, Tertiary; Retinoschisis; Sulfonamides; Thiophenes

Topics: Animals; Antioxidants; Disease Models, Animal; Humans; Lipid Peroxidation; Lung Diseases; Oxidative Stress; Reactive Oxygen Species; Respiratory System Agents; Thioglycolates; Thiophenes

Topics: Administration, Oral; Animals; Anticoagulants; Bleeding Time; Clinical Trials, Phase II as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Enoxaparin; Factor Xa Inhibitors; Humans; Morpholines; Orthopedics; Rivaroxaban; Thiophenes; Thromboembolism

Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogen Antagonists; Female; Half-Life; Humans; Mammary Neoplasms, Experimental; Models, Biological; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Inbred Strains; Receptors, Estrogen; Tamoxifen; Thiophenes

Topics: Animals; Anticarcinogenic Agents; Clinical Trials as Topic; Disease Models, Animal; Evaluation Studies as Topic; Humans; Liver Neoplasms; Pyrazines; Risk Factors; Schistosomicides; Thiones; Thiophenes

Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; China; Disease Models, Animal; Double-Blind Method; Humans; Liver Neoplasms; Placebos; Pyrazines; Rats; Thiones; Thiophenes; Treatment Outcome

Topics: Animals; Anticarcinogenic Agents; Biomarkers; Brassica; Colitis, Ulcerative; Colorectal Neoplasms; Disease Models, Animal; Enzyme Induction; Gene Expression; Glutathione Transferase; Humans; Inactivation, Metabolic; Mice; Neoplasms; Pyrazines; Risk Factors; Thiones; Thiophenes

Topics: Animals; Basilar Artery; Calcium Signaling; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endothelin Receptor Antagonists; Endothelin-1; Infusions, Intravenous; Ischemic Attack, Transient; Isoxazoles; Male; Rabbits; Receptor, Endothelin A; Subarachnoid Hemorrhage; Thiophenes

Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Disease Models, Animal; Humans; Hypertension; Imidazoles; Rats; Receptors, Angiotensin; Renin-Angiotensin System; Sympathetic Nervous System; Thiophenes

Topics: Animals; Anticarcinogenic Agents; Disease Models, Animal; Humans; Pyrazines; Thiones; Thiophenes

Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Catecholamines; Clonidine; Disease Models, Animal; Ganglia, Sympathetic; Half-Life; Hypothalamus; Models, Neurological; Naloxone; Neurons; Nitroprusside; Norepinephrine; Phenylethanolamine N-Methyltransferase; Pressoreceptors; Propranolol; Rats; Rats, Inbred SHR; Receptors, Opioid; Reflex; Splanchnic Nerves; Thiophenes; Yohimbine

Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus

Topics: Amyloid beta-Peptides; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cell Hypoxia; Cells, Cultured; Cognitive Dysfunction; Disease Models, Animal; Double-Blind Method; Endothelial Cells; Epoetin Alfa; Hippocampus; Humans; Infarction, Middle Cerebral Artery; Locomotion; Male; Peptide Fragments; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Sensory Gating; Sulfonamides; Tetrazoles; Thiophenes

Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; I-kappa B Kinase; Phenylpropionates; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Thiophenes

Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; China; Disease Models, Animal; Double-Blind Method; Humans; Liver Neoplasms; Placebos; Pyrazines; Rats; Thiones; Thiophenes; Treatment Outcome

Topics: Analysis of Variance; Animals; Cardiopulmonary Bypass; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Isoxazoles; Pulmonary Circulation; Receptors, Endothelin; Swine; Thiophenes; Vascular Resistance; Ventricular Function, Left

Topics: Analgesics; Animals; Carrageenan; Corpus Striatum; Disease Models, Animal; Domperidone; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Inflammation; Injections; Male; Microspheres; Naloxone; Narcotic Antagonists; Pain; Periaqueductal Gray; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Stress, Mechanical; Temperature; Tetrahydronaphthalenes; Thiophenes

Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Disease Models, Animal; DNA Damage; Humans; Immunohistochemistry; Melanoma; Melanoma, Experimental; Mice; Reactive Oxygen Species; Thiophenes; Ubiquitin-Specific Peptidase 7

Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose Tolerance Test; Glucosides; Humans; Male; Mice; Renal Elimination; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes

Topics: Aged; Animals; Base Sequence; Benzamides; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Down-Regulation; Female; Fluorocarbons; Humans; Interleukin-6; Male; Mice, Inbred C57BL; Models, Biological; Nuclear Receptor Subfamily 1, Group F, Member 1; Osteoarthritis; Phosphorylation; Promoter Regions, Genetic; RNA, Messenger; Severity of Illness Index; Signal Transduction; STAT3 Transcription Factor; Sulfonamides; Thiophenes

Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Cells, Cultured; Disease Models, Animal; Down-Regulation; Female; Interleukin-17; Intraepithelial Lymphocytes; Mice, Knockout; Nuclear Receptor Subfamily 1, Group D, Member 1; Psoriasis; Pyrrolidines; Signal Transduction; Skin; Thiophenes

Topics: Administration, Oral; Animals; Diabetes Mellitus, Type 1; Disease Models, Animal; Drug Therapy, Combination; Glucose; Glucosides; Infusions, Intravenous; Leptin; Male; Mice, Inbred C57BL; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes

Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Therapy, Combination; Glucagon-Like Peptide-1 Receptor; Glucosides; Hypoglycemic Agents; Insulin-Secreting Cells; Liraglutide; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes

Topics: Animals; Arginine; Chymases; Cricetinae; Disease Models, Animal; Leukocyte Count; Lipase; Male; Matrix Metalloproteinase 9; Neutrophils; Pancreatitis; RNA, Messenger; Signal Transduction; Sulfonamides; Survival Rate; Thiophenes; Treatment Outcome; Tumor Necrosis Factor-alpha

Topics: Aniline Compounds; Animals; Butyrates; Colitis; Disease Models, Animal; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Inflammation; Ligands; Male; Mice; Mice, Inbred BALB C; Naloxone; Narcotic Antagonists; Peroxidase; Receptors, G-Protein-Coupled; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfonamides; Thiophenes; Xanthenes

Topics: Animals; Antioxidants; Biomarkers; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Expectorants; Inflammation; Kidney; Lung Injury; Male; Oxidative Stress; Particulate Matter; Rats; Rats, Wistar; Spleen; Thioglycolates; Thiophenes

Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Female; Indoles; Male; Mice; Mice, Transgenic; Microglia; Motor Neurons; Nerve Degeneration; Receptor, Serotonin, 5-HT2B; Serotonin; Serotonin 5-HT2 Receptor Agonists; Superoxide Dismutase-1; Thiophenes

Topics: Angiotensin I; Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Fibrosis; Hypertension; Imidazoles; Injections, Intraperitoneal; Losartan; Male; Peptide Fragments; Proto-Oncogene Mas; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiophenes; Tyrosine 3-Monooxygenase

Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Fasting; Gene Expression Profiling; Gene Expression Regulation; Glucosides; Hepatocytes; Hypoglycemic Agents; Interleukin-1beta; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Non-alcoholic Fatty Liver Disease; Signal Transduction; Streptozocin; Superoxide Dismutase; Thiophenes; Tumor Necrosis Factor-alpha

Topics: Animals; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Female; Male; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tetrahydronaphthalenes; Thiophenes; Urinary Bladder

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognitive Dysfunction; Disease Models, Animal; Humans; Imidazoles; Mice; Mice, Transgenic; Neurodegenerative Diseases; Receptor, Angiotensin, Type 2; Stroke; Sulfonamides; Thiophenes

Topics: Animals; Designer Drugs; Disease Models, Animal; gamma-Aminobutyric Acid; Imidazoles; Mice; Sleep; Sulfonamides; Thiophenes

Topics: Amikacin; Aminoglycosides; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cell Culture Techniques; Cells, Cultured; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Hair Cells, Auditory; Humans; Intravital Microscopy; Ion Channels; Male; Mechanotransduction, Cellular; Mice; Ototoxicity; Patch-Clamp Techniques; Protective Agents; Rats; Thiophenes; Time-Lapse Imaging; Urea; Zebrafish

Topics: Acrylamides; Aniline Compounds; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Male; Mice; Neoplastic Stem Cells; Protein Kinase Inhibitors; Quinolones; RNA, Small Interfering; Survivin; Thiophenes; Xenograft Model Antitumor Assays

Topics: Albuminuria; Animals; Antihypertensive Agents; Arteries; Blood Pressure; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Epoprostenol; Hypertension; Isoxazoles; Kidney; Male; Oxidative Stress; Pyrimidines; Rats, Inbred WKY; Receptor, Endothelin A; Receptor, Endothelin B; Signal Transduction; Sulfonamides; Sunitinib; Thiophenes

Topics: Animals; Arcuate Nucleus of Hypothalamus; Blood Glucose; Cytokines; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Echocardiography; I-kappa B Kinase; Inflammation; Male; NF-kappa B; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiophenes

Topics: Animals; Case-Control Studies; Disease Models, Animal; Dopamine Agonists; Humans; Kidney Failure, Chronic; Male; Mice; Mice, Knockout; Muscles; Musculoskeletal Physiological Phenomena; Nerve Tissue Proteins; Renal Dialysis; Restless Legs Syndrome; Serum; Sleep, REM; Tetrahydronaphthalenes; Thiophenes

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; ARNTL Transcription Factors; Cell Line; Circadian Clocks; CLOCK Proteins; Disease Models, Animal; Isoquinolines; Macrophages; Mice; Mice, Knockout; Microglia; Nuclear Receptor Subfamily 1, Group D, Member 1; Plaque, Amyloid; Receptors, Cytoplasmic and Nuclear; Receptors, Purinergic P2Y12; Repressor Proteins; RNA, Small Interfering; Synapses; Thiophenes

Topics: Animals; Apoptosis; Disease Models, Animal; Down-Regulation; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Glucosides; Heat-Shock Proteins; Male; Mice; Non-alcoholic Fatty Liver Disease; Renal Insufficiency, Chronic; Thiophenes; Transcription Factor CHOP; Triglycerides

Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Humans; Ligands; Mice; Mice, Inbred C57BL; Mice, Knockout; Nanoparticles; Optical Imaging; Particle Size; Polymers; Pyridines; Surface Properties; Thiophenes; X-Ray Microtomography

Topics: Animals; Cell Culture Techniques; Cell Line; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Lipid Metabolism; Mice; Monocarboxylic Acid Transporters; Pyrimidinones; Thiophenes

Topics: Animals; Blood Coagulation; Blood Platelets; Carrageenan; Clopidogrel; Cyclic AMP; Disease Models, Animal; Fibrinolytic Agents; Hemorrhage; Male; Mice; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Rats, Wistar; Receptors, Purinergic P2Y12; Thiophenes; Thrombosis

Topics: Administration, Intranasal; alpha-Synuclein; Animals; Blood-Brain Barrier; Cell Line, Tumor; Chitosan; Disease Models, Animal; Dopamine Agonists; Drug Carriers; Female; Haloperidol; Humans; Male; Nanoparticles; Neurons; Oxidopamine; Parkinson Disease, Secondary; Particle Size; Rats; Tetrahydronaphthalenes; Thiophenes; Toxicity Tests, Acute

Topics: Animals; Antineoplastic Agents; Apoptosis; B-Lymphocytes; Bile Ducts, Intrahepatic; Cholestasis; Disease Models, Animal; Epithelial Cell Adhesion Molecule; Epithelial Cells; Humans; Liver Cirrhosis; Mice; Mice, Knockout; Myeloid Cell Leukemia Sequence 1 Protein; Pyrimidines; Signal Transduction; Thiophenes

Topics: Animals; Autoantibodies; B-Lymphocytes; Cell Proliferation; Disease Models, Animal; Female; Immunoglobulin G; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphocyte Activation; Mice, Inbred BALB C; Signal Transduction; Spleen; Sulfonamides; Terpenes; Thiophenes; X-Box Binding Protein 1

Topics: Alzheimer Disease; Angiotensin II Type 2 Receptor Blockers; Animals; Anti-Inflammatory Agents; Cognition; Disease Models, Animal; Imidazoles; Losartan; Mice; Neuroimmunomodulation; Neurovascular Coupling; Plaque, Amyloid; Pyridines; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System; Sulfonamides; Thiophenes; Vasodilation

Topics: Animals; Animals, Newborn; Disease Models, Animal; Endoribonucleases; Hypoxia-Ischemia, Brain; Inflammasomes; MicroRNAs; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Protein Serine-Threonine Kinases; Pyroptosis; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfonamides; Thiophenes

Topics: Animals; Anti-Inflammatory Agents; beta-Alanine; Cell Line; Central Nervous System; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Glutamates; Indans; Interleukin-1beta; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Neostriatum; Oxadiazoles; RNA, Messenger; Sphingosine-1-Phosphate Receptors; Synapses; Synaptic Transmission; T-Lymphocytes; Thiophenes

Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Zebrafish

Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Drug Therapy, Combination; Heart Failure; Heart Rate; Isoproterenol; Male; Myocardium; Rats, Wistar; Receptor, Angiotensin, Type 2; Stroke Volume; Sulfonamides; Thiophenes; Valsartan; Ventricular Function, Left

Topics: Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Constriction; Disease Models, Animal; Gene Expression Regulation; Hepatic Artery; Hormesis; Liver Failure; Male; Membrane Potential, Mitochondrial; Mitochondria, Liver; Oxygen Consumption; Phosphorylation; Portal Vein; Premedication; Pyrimidines; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Solubility; Thiophenes

Topics: Animals; Anti-Inflammatory Agents; Bleomycin; Body Weight; Dinoprostone; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Extracellular Matrix; Female; Gene Expression; Humans; Hydroxyprostaglandin Dehydrogenases; Idiopathic Pulmonary Fibrosis; Inflammation; Lung; Macrophages; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Pyridines; Respiratory Function Tests; Survival Analysis; Thiophenes

Topics: Administration, Oral; Animals; Cell Movement; Cells, Cultured; Disease Models, Animal; Female; Fibroblasts; Fibrosis; Humans; Imidazoles; Injections, Intraperitoneal; Mice; Peritoneum; Postoperative Care; Postoperative Complications; Primary Cell Culture; Receptor, Angiotensin, Type 2; Sulfonamides; Thiophenes; Tissue Adhesions; Transforming Growth Factor beta; Wound Healing

Topics: Animals; Disease Models, Animal; Escitalopram; Fear; Mice; Quinolones; Stress Disorders, Post-Traumatic; Thiophenes

Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Clonal Evolution; Datasets as Topic; Disease Models, Animal; Disease Progression; DNA Copy Number Variations; Humans; Lung; Lung Neoplasms; Mice; Mice, Transgenic; Mutation; Myeloid Cell Leukemia Sequence 1 Protein; Primary Cell Culture; Prospective Studies; Proto-Oncogene Proteins p21(ras); Pyrimidines; Retrospective Studies; RNA-Seq; Spheroids, Cellular; Thiophenes; Tumor Burden; Tumor Suppressor Protein p53; X-Ray Microtomography

Topics: Animals; Behavior, Animal; Disease Models, Animal; Gene Expression Profiling; HEK293 Cells; Humans; Inflammation; Male; MicroRNAs; Neuralgia; Neuroinflammatory Diseases; Oxadiazoles; Rats; Rats, Wistar; Sphingosine-1-Phosphate Receptors; Stress, Mechanical; Thiophenes

Topics: Adult; Aged; Animals; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetic Foot; Disease Models, Animal; Female; Forkhead Box Protein M1; Humans; Inflammation; Male; Mice, Inbred Strains; Middle Aged; Mouth Mucosa; Pyridines; Thiophenes; Transcriptome; Wound Healing

Topics: Animals; Cell Cycle Proteins; Cell Line; Diabetic Nephropathies; Disease Models, Animal; Down-Regulation; Endoplasmic Reticulum Stress; Endoribonucleases; Glucose; Kidney Tubules; Male; MicroRNAs; Models, Biological; Multienzyme Complexes; NLR Family, Pyrin Domain-Containing 3 Protein; Protein Serine-Threonine Kinases; Pyroptosis; Rats, Sprague-Dawley; Sulfonamides; Thiophenes; Up-Regulation

Topics: Animals; Disease Models, Animal; Humans; Inflammation; Lipogenesis; Liver; Liver Cirrhosis; Mice; Non-alcoholic Fatty Liver Disease; Nuclear Receptor Subfamily 1, Group D, Member 1; Obesity; Pyrrolidines; Thiophenes

Topics: Airway Remodeling; Angiotensin I; Angiotensin II; Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Disease Models, Animal; Female; Imidazoles; Inflammation Mediators; Lung; Macrophages, Alveolar; Mice, Inbred BALB C; Neutrophils; Oxidative Stress; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Signal Transduction; Smoke; Sulfonamides; Thiophenes; Tobacco Products

Topics: Allosteric Regulation; AMP-Activated Protein Kinases; Animals; Biphenyl Compounds; Cell Respiration; Cell Survival; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Fibroblasts; Humans; meta-Aminobenzoates; Mice; Mitochondrial Diseases; Oxidative Stress; Oxygen Consumption; Pyrimidines; Pyrones; Thiazoles; Thiophenes

Topics: Acetaminophen; Analgesics; Animals; Behavior, Animal; Carrageenan; Delayed-Action Preparations; Disease Models, Animal; Drug Compounding; Drug Synergism; Drug Therapy, Combination; Hyperalgesia; Locomotion; Male; Microspheres; Nociceptive Pain; Open Field Test; Pain Threshold; Rats, Sprague-Dawley; Tetrahydronaphthalenes; Thiophenes; Tramadol

Topics: Administration, Ophthalmic; Animals; Anti-Inflammatory Agents; Chemokine CCL2; Cold Temperature; Cornea; CX3C Chemokine Receptor 1; Disease Models, Animal; Dry Eye Syndromes; Evoked Potentials, Somatosensory; Ganglia, Parasympathetic; Gene Expression Regulation; Harderian Gland; Hyperalgesia; Interleukin-18; Interleukin-1beta; Lacrimal Apparatus; Male; Mice; Mice, Inbred C57BL; Neuralgia; Nicotinic Acids; Prostaglandin-E Synthases; Thiophenes; Trigeminal Ganglion; TRPM Cation Channels

Topics: Adult; Animals; beta-Glucans; Cell Differentiation; Disease Models, Animal; Female; Humans; Ileitis; Inflammation; Male; Mice; Middle Aged; Osteoblasts; Osteogenesis; Phosphorylation; Positron-Emission Tomography; Spondylitis, Ankylosing; STAT3 Transcription Factor; Stem Cells; Thiophenes; X-Ray Microtomography; Young Adult

Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hepatocytes; Ligands; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Models, Molecular; Molecular Structure; Receptor, Angiotensin, Type 2; Spinal Cord; Structure-Activity Relationship; Sulfonamides; Thiophenes; Vasodilation

Topics: Alendronate; Animals; Bone Density; Bone Density Conservation Agents; Bone Resorption; Disease Models, Animal; Female; Femur; Fracture Healing; Mice; Osteogenesis; Osteogenesis Imperfecta; Thiophenes

Topics: Acute Disease; Animals; Basic-Leucine Zipper Transcription Factors; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; GABA Plasma Membrane Transport Proteins; GABAergic Neurons; gamma-Aminobutyric Acid; Gene Expression Regulation; Hippocampus; Humans; Inhibitory Postsynaptic Potentials; Isoquinolines; Kindling, Neurologic; Mice, Inbred C57BL; Mice, Knockout; Nuclear Receptor Subfamily 1, Group D, Member 1; RNA, Messenger; Seizures; Small Molecule Libraries; Thiophenes

Topics: Animals; Atropine; Cricetinae; Disease Models, Animal; Drug Evaluation, Preclinical; Embryo, Nonmammalian; Hydroxamic Acids; Lumican; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Morpholinos; Myopia; Phenylalanine; Sclera; Thiophenes; Tissue Inhibitor of Metalloproteinase-2; Zebrafish; Zebrafish Proteins

Topics: Analgesics, Opioid; Animals; Behavior, Animal; beta-Arrestin 2; Cells, Cultured; Disease Models, Animal; Drug Tolerance; Female; Ganglia, Spinal; Male; Mice, Knockout; Morphine; Neurons; Nociceptive Pain; Pain Threshold; Receptors, Opioid, mu; Spiro Compounds; Thiophenes; Time Factors

Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Kidney; Phenotype; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Reperfusion Injury; Signal Transduction; Sulfonamides; T-Lymphocytes, Regulatory; Thiophenes; Time Factors

Topics: Animals; Apatites; Bone Regeneration; Bone Transplantation; Cell Differentiation; Cyclohexylamines; Disease Models, Animal; Female; Hedgehog Proteins; Humans; Liposomes; Male; Mesenchymal Stem Cells; Mice; Osteogenesis; Oxysterols; Signal Transduction; Skull; Thiophenes; Tissue Scaffolds; X-Ray Microtomography

Topics: Animals; Cells, Cultured; Chemokines; Disease Models, Animal; Female; Inflammation; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nuclear Receptor Subfamily 1, Group F, Member 1; Shock, Septic; Signal Transduction; Sulfonamides; Thiophenes; Treatment Outcome

Topics: Animals; Calcium Signaling; Colon; Constipation; Diabetes Complications; Disease Models, Animal; Female; Gastrointestinal Motility; Genes, Reporter; Indoles; Interstitial Cells of Cajal; Male; Mice, Inbred C57BL; Mice, Transgenic; Myoelectric Complex, Migrating; Ovariectomy; Proto-Oncogene Proteins c-kit; Receptor, Serotonin, 5-HT2B; Serotonin; Serotonin 5-HT2 Receptor Agonists; Thiophenes; Tryptophan Hydroxylase

Topics: Animals; Cornea; Corneal Injuries; Disease Models, Animal; Expectorants; Male; Ophthalmic Solutions; Oxidative Stress; Rats; Rats, Wistar; Thiophenes; Ultraviolet Rays

Topics: Animals; Cardiomegaly; Cardiotonic Agents; Disease Models, Animal; Docosahexaenoic Acids; Gene Expression Regulation; Insulin-Like Growth Factor I; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocytes, Cardiac; Nuclear Receptor Subfamily 1, Group F, Member 1; Paracrine Communication; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Rats; Ribonucleosides; Signal Transduction; Sulfonamides; Thiophenes; Wortmannin

Topics: Animals; Brain-Computer Interfaces; Disease Models, Animal; Elastic Modulus; Electric Conductivity; Electrodes; Electrodes, Implanted; Electronics; Electrophysiology; Epoxy Resins; Fibroins; Hydrogels; Polystyrenes; Pressure; Rats; Silk; Spectroscopy, Fourier Transform Infrared; Stress, Mechanical; Stroke; Thiophenes

Topics: ADAMTS4 Protein; Aged; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Collagen Type II; Disease Models, Animal; Female; Humans; Magnetic Resonance Imaging; Male; Matrix Metalloproteinase 13; Middle Aged; Molecular Docking Simulation; Nuclear Receptor Subfamily 1, Group F, Member 1; Nucleus Pulposus; Phosphorylation; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiophenes; Tumor Necrosis Factor-alpha; Up-Regulation; YAP-Signaling Proteins

Topics: Actins; Animals; Blotting, Western; Cell Proliferation; Conjunctiva; Disease Models, Animal; Female; Fibroblasts; Fibronectins; Fibrosis; Forkhead Box Protein M1; Glaucoma; In Situ Nick-End Labeling; Injections, Intraocular; Intraocular Pressure; Male; Postoperative Complications; Pyridines; Rabbits; Real-Time Polymerase Chain Reaction; Tenon Capsule; Thiophenes; Trabeculectomy; Transforming Growth Factor beta1; Wound Healing

Topics: Abortion, Spontaneous; Animals; Cell Differentiation; Cytokines; Decidua; Disease Models, Animal; Female; Humans; Inflammation; Lipopolysaccharides; Macrophages; Mice; Nuclear Receptor Subfamily 1, Group D, Member 1; Pregnancy; Pyrrolidines; Signal Transduction; Th1 Cells; Thiophenes; U937 Cells

Topics: Amidines; Animals; Cytochrome P-450 CYP4A; Disease Models, Animal; Ethanol; Fatty Acids; Hepatocytes; Humans; Lipid Metabolism; Lipidomics; Liver; Liver Diseases, Alcoholic; Male; Mice; Nuclear Receptor Subfamily 1, Group D, Member 1; Primary Cell Culture; Pyrrolidines; Receptor, EphB2; Receptors, Cytoplasmic and Nuclear; RNA-Seq; Signal Transduction; Thiophenes; Up-Regulation

Topics: Animals; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Gene Knockdown Techniques; Intraocular Pressure; Ischemia; Models, Biological; Phosphorylation; Polycomb Repressive Complex 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrimidines; Retinal Ganglion Cells; RNA, Small Interfering; Signal Transduction; Thiophenes; Tumor Suppressor Protein p53; Up-Regulation

Topics: Animals; Disease Models, Animal; Humans; Lysophospholipids; Male; Oxadiazoles; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sepsis; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiophenes; Tumor Necrosis Factor-alpha

Topics: Animals; Cholesterol, Dietary; Chymases; Diet, High-Fat; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Male; Non-alcoholic Fatty Liver Disease; Rats, Inbred SHR; Sulfonamides; Thiophenes

Topics: 3-Hydroxybutyric Acid; Animals; Astrocytes; Brain; Diet, Ketogenic; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Glycolysis; Ketone Bodies; Lactic Acid; Mice; Mice, Inbred C57BL; Microtomy; Monocarboxylic Acid Transporters; Neurons; Primary Cell Culture; Seizures; Signal Transduction; Symporters; Thiophenes; Tissue Culture Techniques; Uracil

Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Depression; Depressive Disorder, Major; Disease Models, Animal; Hindlimb Suspension; Indoles; Ketamine; Male; Mice; Motor Activity; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Schizophrenia; Sulfonamides; Swimming; Thiophenes

Topics: Animals; Bone Density Conservation Agents; Disease Models, Animal; Hyperalgesia; Male; Osteoarthritis, Knee; Rats; Rats, Wistar; Thiophenes

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Disease Models, Animal; Heme Oxygenase-1; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neurogenesis; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Thiones; Thiophenes

Topics: Animals; Cell Movement; Cell Proliferation; Cytokines; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Myeloid Cells; Neoplasms, Experimental; Oxadiazoles; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; Stomach Neoplasms; T-Lymphocytes, Cytotoxic; Thiophenes; Tumor Cells, Cultured; Tumor Microenvironment

Topics: Acute Disease; Amylases; Animals; Ceruletide; Disease Models, Animal; Edema; Expectorants; Lipase; Male; Necrosis; Pancreas; Pancreatitis; Rats; Rats, Wistar; Thioglycolates; Thiophenes; Treatment Outcome

Topics: Adenine; Animals; Calcimimetic Agents; Cinacalcet; Disease Models, Animal; Endothelin A Receptor Antagonists; Isoxazoles; Male; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Thiophenes

Topics: Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Anti-Inflammatory Agents; Basic Helix-Loop-Helix Transcription Factors; Calcium-Binding Proteins; Cell Proliferation; Cells, Cultured; Cerebellum; Cyclohexylamines; Developmental Disabilities; Disease Models, Animal; Gene Expression Regulation, Developmental; Glucocorticoids; Hedgehog Proteins; Hypoxia, Brain; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Nerve Tissue Proteins; Nervous System Malformations; Neuroprotective Agents; Prednisolone; Purkinje Cells; Thiophenes; Von Hippel-Lindau Tumor Suppressor Protein; Zinc Finger Protein GLI1

Topics: Anilides; Animals; Central Nervous System Sensitization; Disease Models, Animal; eIF-2 Kinase; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Motor Activity; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Neuralgia; Organophosphonates; Oxadiazoles; Pain Threshold; Peptide Fragments; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; Spinal Cord; Spinal Nerve Roots; Subcellular Fractions; Thiophenes

Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Female; Fluorescent Dyes; Frontal Lobe; Gene Expression; Humans; Male; Mice; Occipital Lobe; Peptide Hydrolases; Plaque, Amyloid; Presenilin-1; Protein Aggregates; Protein Binding; Protein Conformation; Proteolysis; Spectrometry, Fluorescence; Temporal Lobe; Thiophenes

Topics: Animals; Disease Models, Animal; Female; Liver; Protective Agents; Rats; Rats, Wistar; Reperfusion Injury; Thioglycolates; Thiophenes

Topics: Animals; Antimalarials; Disease Models, Animal; Echinops Plant; Female; Malaria; Male; Mice; Parasitic Sensitivity Tests; Plant Extracts; Plant Roots; Plasmodium berghei; Thiophenes

Topics: Animals; Benzazepines; Benzothiazoles; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Male; Mice, Inbred C57BL; Pain Threshold; Pramipexole; Receptors, Dopamine D1; Receptors, Dopamine D3; Restless Legs Syndrome; Tetrahydronaphthalenes; Thiophenes

Topics: Animals; Caspase 1; Cells, Cultured; Chemical and Drug Induced Liver Injury; Circadian Rhythm; Cytokines; Disease Models, Animal; Galactosamine; Genetic Predisposition to Disease; Inflammasomes; Lipopolysaccharides; Liver; Liver Failure, Acute; Macrophage Activation; Macrophages, Peritoneal; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein; Nuclear Receptor Subfamily 1, Group D, Member 1; Peritonitis; Phenotype; Pyrrolidines; RNA Interference; Severity of Illness Index; Signal Transduction; Thiophenes; Time Factors; Transfection

Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Aortic Aneurysm; Dilatation, Pathologic; Disease Models, Animal; Disease Progression; Echocardiography; Fibrillin-1; Losartan; Male; Marfan Syndrome; Mice, Inbred C57BL; Mice, Mutant Strains; Mutation; Receptor, Angiotensin, Type 2; Sulfonamides; Thiophenes

Topics: Animals; Blood-Brain Barrier; Cell Line; Cerebrovascular Circulation; Collateral Circulation; Disease Models, Animal; Endothelial Cells; Infarction, Middle Cerebral Artery; Macrophages; Male; Meninges; Mice, Inbred BALB C; Monocytes; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; Oxadiazoles; Phosphorylation; Receptors, Lysosphingolipid; Recovery of Function; Signal Transduction; Sphingosine-1-Phosphate Receptors; Thiophenes; Tight Junction Proteins; Time Factors

Topics: Administration, Intranasal; Animals; Brain; Disease Models, Animal; Dopamine Agonists; Drug Carriers; Drug Delivery Systems; Lactoferrin; Male; Nanoparticles; Neuroprotective Agents; Nose; Parkinson Disease; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tetrahydronaphthalenes; Thiophenes; Tissue Distribution

Topics: Animals; Antiviral Agents; Disease Models, Animal; Enzyme Activation; Epithelium, Corneal; Eye; Herpes Simplex; Herpesvirus 1, Human; Humans; Mice, Inbred BALB C; Proto-Oncogene Proteins c-akt; Pyrimidines; Swine; Thiophenes; Virion

Topics: Animals; Disease Models, Animal; Erythrocyte Deformability; Erythrocytes; Expectorants; Hindlimb; Ischemia; Lower Extremity; Rats, Wistar; Reperfusion Injury; Thioglycolates; Thiophenes

Topics: Animals; Cell Differentiation; Disease Models, Animal; Fibrosis; Humans; Induced Pluripotent Stem Cells; Isoxazoles; Mice; Myocardial Infarction; Myocytes, Cardiac; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stem Cell Transplantation; Thiophenes

Topics: Animals; Behavior, Animal; Disease Models, Animal; Fibrinolytic Agents; Male; Random Allocation; Rats; Rats, Wistar; Recovery of Function; Stroke; Sulfonamides; Thiophenes; Thromboembolism; Tissue Plasminogen Activator

Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Blood Platelets; Disease Models, Animal; Humans; Mice, Knockout; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins c-raf; Pulmonary Embolism; Pyrimidines; Signal Transduction; Thiophenes; Thrombosis; Thromboxanes

Topics: Animals; Central Nervous System; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Macrophage Activation; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Th1 Cells; Th17 Cells; Thiones; Thiophenes

Topics: Age Factors; Animals; Benzamides; Corpus Striatum; Cyclic AMP; Disease Models, Animal; Drosophila; Drosophila Proteins; Exploratory Behavior; Gait; HEK293 Cells; Humans; Huntingtin Protein; Huntington Disease; Induced Pluripotent Stem Cells; Mice; Mice, Transgenic; Mutation; Neurons; Phenotype; Quinoxalines; Receptors, G-Protein-Coupled; Thiophenes; Walking

Topics: Alcohol Oxidoreductases; Animals; ATP-Binding Cassette Transporters; Cell Line, Tumor; Disease Models, Animal; Diterpenes; Female; HEK293 Cells; High-Throughput Screening Assays; Humans; Light; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neuroprotective Agents; NIH 3T3 Cells; Protein Folding; Protein Transport; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Retinaldehyde; Rhodopsin; Thiophenes; Treatment Outcome

Topics: Animals; Body Composition; Diabetes Mellitus, Type 2; Disease Models, Animal; Diuresis; Drinking; Eating; Epithelial Sodium Channels; Glucosides; Male; Natriuresis; Rats, Sprague-Dawley; Sodium; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Sodium-Hydrogen Exchanger 3; Thiophenes; Time Factors; Water-Electrolyte Balance

Topics: Animals; Disease Models, Animal; Gene Knockdown Techniques; Hemochromatosis; Hepcidins; Iron; NF-kappa B; Receptors, Transferrin; Signal Transduction; Thiophenes; Up-Regulation; Zebrafish; Zebrafish Proteins

Topics: Aged; Alendronate; Animals; Core Binding Factor Alpha 1 Subunit; Disease Models, Animal; Female; Humans; Mice; Osteocalcin; Osteoclasts; Osteogenesis; Osteolysis; Osteoporosis; Osteoprotegerin; Prosthesis Failure; Thiophenes

Topics: Action Potentials; Administration, Intravenous; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Rate; Humans; Injections, Intradermal; Isolated Heart Preparation; Male; Mice; Myocytes, Cardiac; Neural Conduction; Pain Threshold; Papio; Pyrroles; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Thiophenes; Time Factors; Xenopus laevis

Topics: Alleles; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Female; Humans; Lymphoma; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Myeloid Cell Leukemia Sequence 1 Protein; Pyrimidines; Thiophenes

Topics: Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Carrageenan; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Free Radical Scavengers; Male; Mice; Molecular Structure; Nitric Oxide; Picrates; Quinazolines; Rats, Wistar; Structure-Activity Relationship; Thiophenes

Topics: Amides; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Proteins; Ciprofloxacin; Disease Models, Animal; Drug Delivery Systems; Drug Design; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen-Ion Concentration; Lung Diseases; Mice; Micelles; Nanoparticles; Peritonitis; Polymers; Proof of Concept Study; Sepsis; Thiophenes

Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Fracture Healing; Fractures, Bone; Humans; Insulin; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Thiophenes

Topics: Allosteric Regulation; Animals; Antipsychotic Agents; Benzamides; Brain; Cyclopentanes; Disease Models, Animal; Drug Therapy, Combination; Excitatory Postsynaptic Potentials; Indoles; Male; Mice; Neurotransmitter Agents; Pyridines; Pyrimidines; Receptors, GABA-B; Receptors, Muscarinic; Schizophrenia; Thiophenes

Topics: Adult; Aged; Aged, 80 and over; Alternative Splicing; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Epoxy Compounds; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Macrolides; Male; Mice; Mice, Transgenic; Middle Aged; Mitochondria; Mutation; Myeloid Cell Leukemia Sequence 1 Protein; Phosphoproteins; Primary Cell Culture; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; RNA Splicing Factors; Spliceosomes; Sulfonamides; Thiophenes

Topics: Analysis of Variance; Animals; Blood Glucose; Cholesterol; Disease Models, Animal; Estrone; Expectorants; Female; Hypoglycemic Agents; Insulin Resistance; Metformin; Ovary; Oxidative Stress; Polycystic Ovary Syndrome; Random Allocation; Rats; Rats, Wistar; Thioglycolates; Thiophenes; Treatment Outcome; Uterus

Topics: Administration, Oral; Aging; Animals; Body Weight; Cognitive Dysfunction; Disease Models, Animal; Double-Blind Method; Drug Evaluation, Preclinical; Male; Motor Activity; Nootropic Agents; Random Allocation; Rats, Wistar; Receptor, Angiotensin, Type 2; Recovery of Function; Stroke; Sulfonamides; Thiophenes; Time Factors

Topics: Animals; Autocrine Communication; Capillary Permeability; Cells, Cultured; Critical Illness; Cyclohexylamines; Cytokines; Disease Models, Animal; Endothelial Cells; Gene Expression Regulation; Hedgehog Proteins; Hindlimb; Human Umbilical Vein Endothelial Cells; Humans; Inflammation Mediators; Ischemia; Kruppel-Like Transcription Factors; Male; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Neovascularization, Physiologic; Regional Blood Flow; Signal Transduction; Stress, Mechanical; Thiophenes

Topics: Adenosine Monophosphate; Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Biphenyl Compounds; Diet, Protein-Restricted; Disease Models, Animal; Energy Metabolism; Fibrosis; Humans; Kidney; Male; Metabolomics; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Myocardium; Pyrones; Renal Insufficiency, Chronic; Signal Transduction; Thiophenes

Topics: Animals; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Cough; Cytokines; Disease Models, Animal; Expectorants; Guinea Pigs; Inflammation; Male; Mucociliary Clearance; Thioglycolates; Thiophenes

Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Cytokines; Disease Models, Animal; Fibrosis; Heart Failure; Inflammation Mediators; Isoproterenol; Myocytes, Cardiac; Oxidative Stress; Pyrazines; Rats, Sprague-Dawley; Recovery of Function; Thiones; Thiophenes; Ventricular Function, Left; Ventricular Remodeling

Topics: Animals; Blood Pressure; Cardiomegaly; Cardiovascular Agents; Disease Models, Animal; Fibrosis; Hypertension; Male; Myocytes, Cardiac; Rats, Wistar; Receptor, Angiotensin, Type 2; Signal Transduction; Sodium Chloride, Dietary; Sulfonamides; Thiophenes; Ventricular Remodeling; Weight Gain

Topics: Adrenergic beta-Antagonists; Adrenergic Fibers; Animals; Bone and Bones; Bone Density; Bone Regeneration; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Feedback, Physiological; Female; Humans; Hydroxyprostaglandin Dehydrogenases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteoblasts; Osteoporosis; Propranolol; Pyridines; Receptors, Prostaglandin E, EP4 Subtype; Sensory Receptor Cells; Thiophenes

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognitive Dysfunction; Disease Models, Animal; Disks Large Homolog 4 Protein; Hippocampus; Male; Mice; Nuclear Receptor Subfamily 1, Group D, Member 1; Peptide Fragments; Pyrrolidines; Thiophenes

Topics: Animals; Animals, Newborn; Anticonvulsants; Body Temperature; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Seizures, Febrile; Thiophenes; Time Factors; TRPM Cation Channels

Topics: Animals; Brain Ischemia; Disease Models, Animal; Mice; Oxazoles; PPAR alpha; PPAR gamma; Stroke; Thiophenes

Topics: Adipocytes; Adipogenesis; Adipose Tissue; Adiposity; Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Fibrosis; Glucosides; Inflammation Mediators; Insulin Resistance; Macrophages; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Obesity; Paracrine Communication; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Vascular Remodeling; Vascular System Injuries

Topics: Animals; Benzhydryl Compounds; Blood Glucose; Canagliflozin; Diet, High-Fat; Disease Models, Animal; Glucose Transporter Type 4; Glucosides; Insulin Resistance; Isolated Heart Preparation; Male; Mice, Inbred C57BL; Myocardial Reperfusion Injury; Myocytes, Cardiac; Obesity; Phlorhizin; Signal Transduction; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes

Topics: Amyloid beta-Peptides; Animals; Disease Models, Animal; Fluorescent Dyes; Ligands; Mice; Mice, Transgenic; Peptide Fragments; Porphyrins; Protein Multimerization; Thiophenes

Topics: Animals; Biomarkers; Crystallins; Disease Models, Animal; Drug Combinations; Gene Expression Profiling; Gene Expression Regulation; Glaucoma; Intraocular Pressure; Ophthalmic Solutions; Optic Nerve Diseases; Proteome; Proteomics; Rats; Real-Time Polymerase Chain Reaction; Retina; Retinal Ganglion Cells; Sulfonamides; Thiophenes; Timolol

Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cell Count; Cells, Cultured; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Female; Glial Fibrillary Acidic Protein; Humans; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Parkinsonian Disorders; PPAR delta; Rats; Sulfones; Thiazoles; Thiophenes; Tyrosine 3-Monooxygenase

Topics: Adaptor Proteins, Signal Transducing; Animals; Anticarcinogenic Agents; Cytoskeletal Proteins; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Kelch-Like ECH-Associated Protein 1; Mice; Mice, Knockout; NF-E2-Related Factor 2; Pulmonary Disease, Chronic Obstructive; Pyrazines; Tenascin; Thiones; Thiophenes

Topics: Analysis of Variance; Animals; CD11b Antigen; Disease Models, Animal; Ectodysplasins; Gene Expression Regulation, Enzymologic; Glial Fibrillary Acidic Protein; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Microglia; Minocycline; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar; Stroke; Stroke, Lacunar; Thiophenes; Time Factors

Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Formaldehyde; Granuloma; Male; Molecular Structure; Pain Measurement; Pyrimidines; Rats; Rats, Wistar; Tail; Thiophenes; Turpentine

Topics: Animals; Cell Cycle Proteins; Disease Models, Animal; Endoplasmic Reticulum; Glaucoma, Open-Angle; Gliosis; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Membrane Transport Proteins; Mice; Mice, Transgenic; Protein Serine-Threonine Kinases; Pyrimidines; Retina; Thiophenes; Transcription Factor TFIIIA

Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Antihypertensive Agents; Aqueous Humor; Blood Pressure; Caspase 3; Cell Count; Diminazene; Disease Models, Animal; Enzyme Activation; Fluorescent Antibody Technique, Indirect; Glaucoma; Immunoenzyme Techniques; Intraocular Pressure; Male; Nerve Fibers; Ophthalmic Solutions; Optic Nerve; Peptide Fragments; Peptidyl-Dipeptidase A; Radionuclide Imaging; Rats; Rats, Wistar; Renin-Angiotensin System; Retina; Retinal Ganglion Cells; Sulfonamides; Thiophenes; Tonometry, Ocular

Topics: Animals; Anticestodal Agents; Cells, Cultured; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; Echinococcosis, Pulmonary; Echinococcus multilocularis; Female; Fibroblasts; Furans; Guanidine; Guanidines; Humans; Mice; Mice, Inbred BALB C; Parasitic Sensitivity Tests; Rats; Thiophenes; Vero Cells

Topics: Angiogenesis Inhibitors; Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Humans; Oxygen; PPAR delta; PPAR-beta; Rats; Retinal Diseases; Retinal Neovascularization; Retinal Vessels; Sulfones; Thiazoles; Thiophenes

Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Evoked Potentials; Excitatory Amino Acid Antagonists; HEK293 Cells; Humans; Hyperalgesia; Indoles; Male; Nerve Fibers, Unmyelinated; Neuralgia; Neurons; Physical Stimulation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Receptors, N-Methyl-D-Aspartate; Serotonin Receptor Agonists; Spinal Nerve Roots; Spinal Nerves; Subcellular Fractions; Thiophenes; Time Factors; Up-Regulation

Topics: Animals; Aquaporin 1; Aquaporin 3; Aquaporin 4; Aquaporin 5; Aquaporins; Disease Models, Animal; Immunohistochemistry; Mice; Muscarinic Agonists; Parotid Gland; Quinuclidines; Salivation; Sjogren's Syndrome; Sublingual Gland; Submandibular Gland; Thiophenes; Time Factors

Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Male; Morphine; Neuralgia; Norepinephrine; Pain Measurement; Phenols; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Nerves; Tapentadol; Thiophenes

Topics: Animals; Behavior, Animal; Cerebellum; Cognition Disorders; Cyclohexylamines; Disease Models, Animal; Down Syndrome; Electrophysiology; Hedgehog Proteins; Hippocampus; Long-Term Synaptic Depression; Male; Maze Learning; Memory; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neuronal Plasticity; Phenotype; Purkinje Cells; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Thiophenes

Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dopamine Agonists; Drug Delivery Systems; Female; Male; Motor Activity; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Tetrahydronaphthalenes; Thiophenes; Treatment Outcome

Topics: Animals; Atherosclerosis; Cholesterol, LDL; Cholesterol, VLDL; Diet, Atherogenic; Disease Models, Animal; Hydrazones; Male; Malondialdehyde; Molecular Targeted Therapy; Nitric Oxide Synthase; Rats; Rats, Wistar; Thiophenes; Triglycerides

Topics: Acetic Acid; Adrenergic Uptake Inhibitors; Anesthesia; Animals; Blood Pressure; Cats; Chloralose; Disease Models, Animal; Duloxetine Hydrochloride; Electromyography; Female; Heart Rate; Humans; Hypnotics and Sedatives; Muscle Contraction; Respiration; Thiophenes; Time Factors; Urethra; Urinary Bladder; Urinary Bladder Diseases; Urination

Topics: Acute Pain; Analgesics; Animals; Disease Models, Animal; Drug Discovery; GTP-Binding Proteins; HEK293 Cells; Humans; Mice; Models, Chemical; Molecular Structure; Rats; Receptors, Opioid, mu; Severity of Illness Index; Spiro Compounds; Structure-Activity Relationship; Thiophenes

Topics: Animals; Cerebellum; Cyclohexylamines; Disease Models, Animal; Down Syndrome; Hedgehog Proteins; Learning; Memory; Mice; Purkinje Cells; Reflex, Vestibulo-Ocular; Synapses; Thiophenes

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Atrophy; CA1 Region, Hippocampal; Disease Models, Animal; In Vitro Techniques; Long-Term Potentiation; Male; Maleates; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Neuroprotective Agents; Synapses; Thiophenes

Topics: Animals; Cats; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Duloxetine Hydrochloride; Electric Stimulation Therapy; Female; Foot; Male; Piperazines; Pyridines; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Thiophenes; Urinary Bladder; Urinary Bladder, Overactive

Topics: Animals; Caffeine; Calcium; Disease Models, Animal; Exercise Tolerance; Homeostasis; Hydrazones; Male; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Myocardial Infarction; Physical Conditioning, Animal; Rats; Rats, Wistar; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thiophenes; Time Factors

Topics: 5-Hydroxytryptophan; Animals; Carbidopa; Citalopram; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Exploratory Behavior; Female; Hippocampus; Maze Learning; Memory Disorders; Phenylalanine; Piperazines; Protein Binding; Rats; Rats, Long-Evans; Recognition, Psychology; Selective Serotonin Reuptake Inhibitors; Serotonin; Sulfides; Thiophenes; Vortioxetine

Topics: Animals; Anticoagulants; Blood-Brain Barrier; Brain Ischemia; Cerebral Hemorrhage; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Morpholines; Rats; Rats, Wistar; Rivaroxaban; Stroke; Thiophenes; Thrombolytic Therapy; Time Factors

Topics: Amphetamine; Animals; Antipsychotic Agents; Blood Pressure; Brain; Cell Line, Transformed; Central Nervous System Stimulants; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Fear; Heart Rate; Humans; Hyperkinesis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Protein Binding; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M4; Reflex, Startle; Thiophenes

Topics: Anemia, Sickle Cell; Animals; Anticoagulants; Antithrombins; Benzimidazoles; beta-Alanine; Bone Marrow Transplantation; Dabigatran; Disease Models, Animal; Factor Xa; Factor Xa Inhibitors; Female; Immunoenzyme Techniques; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Receptor, PAR-1; Receptor, PAR-2; Rivaroxaban; Thiophenes; Thrombin; Vascular Diseases

Topics: Animals; Apolipoproteins E; Atherosclerosis; Case-Control Studies; Cell Movement; Cell Proliferation; Cells, Cultured; Coronary Artery Disease; Disease Models, Animal; Endothelial Cells; Hindlimb; Humans; Ischemia; Liver; Male; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; Oxazoles; PPAR alpha; PPAR gamma; Signal Transduction; Stem Cells; Thiophenes

Topics: Acetic Acid; Allosteric Regulation; Analgesics; Animals; Catalepsy; CHO Cells; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Motor Activity; Neuralgia; Pain Measurement; Pain Threshold; Piperazines; Protein Binding; Purinergic Agents; Thiophenes

Topics: Adiposity; Animals; Anti-Obesity Agents; Biomarkers; Blood Glucose; Diet, High-Fat; Disease Models, Animal; Energy Metabolism; Fatty Acids; Glucosides; Glycosuria; Hypoglycemic Agents; Lipid Metabolism; Obesity; Oxidation-Reduction; Rats; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Time Factors; Up-Regulation; Weight Loss

Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Acoustic Stimulation; Analysis of Variance; Animals; Conditioning, Psychological; Corticosterone; Cues; Disease Models, Animal; Enzyme Inhibitors; Fear; Hippocampus; In Vitro Techniques; Learning Disabilities; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Pyrazoles; Stress, Psychological; Thiophenes

Topics: Angiotensin II Type 2 Receptor Blockers; Animals; Brain Infarction; Brain Ischemia; CD11b Antigen; Cerebrovascular Circulation; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Glial Fibrillary Acidic Protein; Imidazoles; Male; Nitric Oxide Synthase Type II; Peroxidase; Pyridines; Rats; Rats, Sprague-Dawley; Stroke; Sulfonamides; Thiophenes; Time Factors

Topics: Analgesics; Analgesics, Opioid; Animals; Carrageenan; Cold Temperature; Conditioning, Psychological; Disease Models, Animal; Duloxetine Hydrochloride; Hot Temperature; Hyperalgesia; Male; Morphine; Organoplatinum Compounds; Oxaliplatin; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Space Perception; Temperature; Thiophenes

Topics: Allografts; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Garlic; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Mice; Models, Molecular; Molecular Conformation; Mutation; Neoplasms; Peroxiredoxin VI; Plant Extracts; Protein Binding; Thiophenes; Tumor Burden

Topics: Aminoimidazole Carboxamide; Animals; Antineoplastic Agents; Disease Models, Animal; Enzyme Activation; Humans; Janus Kinase 2; Leukemia, Myeloid, Acute; Microsomes; Models, Biological; Molecular Structure; Protein Kinase Inhibitors; Rats; Thiophenes

Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Hyperalgesia; Injections, Spinal; Male; Mice, Inbred ICR; Morpholines; Neuralgia; Prostaglandins; Spinal Cord; Stereoisomerism; Thiophenes

Topics: Analgesics; Animals; Cold Temperature; Disease Models, Animal; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Male; Neuralgia; Physical Stimulation; Pregabalin; Rats, Wistar; Sciatic Nerve; Thiophenes; Tramadol

Topics: Animals; Disease Models, Animal; Enoxaparin; Fibrinolytic Agents; Inflammation; Male; Morpholines; Necrosis; Rats; Rats, Sprague-Dawley; Rivaroxaban; Skin; Soft Tissue Injuries; Thiophenes; Tissue Survival; Trauma Severity Indices; Treatment Outcome

Topics: Acrylates; Animals; Blood Pressure; Disease Models, Animal; Heart Function Tests; Heart Ventricles; Imidazoles; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Perfusion; Swine; Thiophenes

Topics: Acute Lung Injury; Animals; Antioxidants; Apoptosis; Cytokines; Disease Models, Animal; Hyperoxia; Lung; Male; MAP Kinase Signaling System; Neuroprotective Agents; NF-kappa B; PPAR delta; PPAR-beta; Pressure; Random Allocation; Rats, Sprague-Dawley; Respiratory System Agents; Sulfones; Thiazoles; Thiophenes; Time Factors

Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Duloxetine Hydrochloride; Gait; Iodoacetic Acid; Male; Morphine; Movement; Osteoarthritis; Pain; Rats; Rest; Thiophenes; Tramadol; Weight-Bearing

Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzofurans; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hyperkinesis; Male; Mice; Mice, Inbred C57BL; Phencyclidine; Quinuclidines; Rotarod Performance Test; Schizophrenia; Schizophrenic Psychology; Social Behavior; Thiophenes

Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; Enzyme Activation; Erlotinib Hydrochloride; Female; Humans; Lung Neoplasms; Mice; Protein Kinase Inhibitors; Pyrones; Quinazolines; Signal Transduction; Thiophenes; TOR Serine-Threonine Kinases; Tumor Burden; Xenograft Model Antitumor Assays

Topics: Animals; Antioxidants; Disease Models, Animal; Male; Nasal Decongestants; Nasal Mucosa; Oxidative Stress; Rats; Rats, Wistar; Rhinitis, Vasomotor; Thioglycolates; Thiophenes

Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Antioxidants; Benzofurans; Binding Sites; Caenorhabditis elegans; Chalcone; Chalcones; Crystallography, X-Ray; Disease Models, Animal; Humans; Microscopy, Fluorescence; Molecular Conformation; Molecular Docking Simulation; Oxidative Stress; Protein Structure, Tertiary; Structure-Activity Relationship; Thiophenes

Topics: Animals; Biological Transport; Cell Line, Tumor; Cluster Analysis; Disease Models, Animal; Female; Glycolysis; Humans; Lactates; Metabolomics; Monocarboxylic Acid Transporters; Neoplasms; Oxidative Stress; Pyrimidinones; Radiation Tolerance; Symporters; Thiophenes; Tumor Burden; Xenograft Model Antitumor Assays

Topics: Animals; Bacterial Proteins; Brain Injuries; Cell Differentiation; Cerebral Cortex; Cerebral Ventricles; Cyclohexylamines; Disease Models, Animal; Gene Expression Regulation; Hedgehog Proteins; Kruppel-Like Transcription Factors; Luminescent Proteins; Mice; Mice, Transgenic; Microinjections; Nerve Tissue Proteins; Oligodendroglia; Signal Transduction; Stem Cells; Thiophenes; Transduction, Genetic; White Matter; Zinc Finger Protein GLI1

Topics: Animals; Binding Sites; Cell Line; Cell Proliferation; Disease Models, Animal; Dopaminergic Neurons; Drug Evaluation, Preclinical; Forkhead Box Protein O3; Forkhead Transcription Factors; Histone Deacetylase Inhibitors; Humans; MCF-7 Cells; Molecular Docking Simulation; Neuroprotective Agents; Parkinson Disease; Protein Binding; Protein Structure, Tertiary; Pyrimidinones; Rats; Sirtuin 2; Structure-Activity Relationship; Thiophenes

Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Catalase; Dexamethasone; Disease Models, Animal; Female; Glutathione; Intraocular Pressure; Latanoprost; Male; Ocular Hypertension; Oxidative Stress; Pilocarpine; Prostaglandins F, Synthetic; Quinoxalines; Rats, Sprague-Dawley; Retina; Sulfonamides; Superoxide Dismutase; Thiophenes; Timolol

Topics: Animals; Apoptosis; Blood-Brain Barrier; Cerebellum; Cerebral Hemorrhage; Chemokines; Cytokines; Dentate Gyrus; Disease Models, Animal; Female; Kaplan-Meier Estimate; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Meningitis, Meningococcal; Mice; Phenylalanine; Thiophenes

Topics: Animals; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Femoral Artery; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth, Vascular; Myography; Neointima; Pyrrolidines; Thiophenes

Topics: Animals; Antioxidants; Blotting, Western; Corpus Striatum; Cytokines; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Microspheres; MPTP Poisoning; Neuroprotective Agents; Oxidative Stress; Parkinsonian Disorders; Tetrahydronaphthalenes; Thiophenes

Topics: Amniotic Fluid; Animals; Anti-Inflammatory Agents; Biomarkers; Catheters, Indwelling; Chorioamnionitis; Disease Models, Animal; Female; Fetal Blood; I-kappa B Kinase; Lipopolysaccharides; Lung; MAP Kinase Kinase Kinases; Phenylurea Compounds; Pregnancy; Premature Birth; Protein Kinase Inhibitors; Sheep, Domestic; Signal Transduction; Thiophenes; Western Australia; Zearalenone

Topics: Animals; Anti-Anxiety Agents; Anxiety; Cells, Cultured; Citalopram; Diazepam; Disease Models, Animal; Drug Synergism; Humans; Isoindoles; Male; Piperazines; Prefrontal Cortex; Pyridines; Pyrimidines; Rats; Receptors, Serotonin; Serotonin; Serotonin 5-HT1 Receptor Agonists; Synaptic Transmission; Thiophenes

Topics: Acetanilides; Analgesics; Animals; Benzamides; Capsaicin; Cold Temperature; Disease Models, Animal; Formaldehyde; Hyperalgesia; Isothiocyanates; Male; Mice; Neuralgia; Oximes; Paclitaxel; Pain Measurement; Purines; Thiophenes; Touch; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels

Topics: Animals; Benzimidazoles; Brain; Carotid Stenosis; Cerebral Cortex; Chemokine CCL2; Dementia, Vascular; Disease Models, Animal; Drug Evaluation, Preclinical; Maze Learning; Mice, Inbred C57BL; Oxadiazoles; Receptor, Angiotensin, Type 2; Regional Blood Flow; RNA, Messenger; Sulfonamides; Thiophenes; Tumor Necrosis Factor-alpha

Topics: Amides; Animals; Choroidal Neovascularization; Disease Models, Animal; Drug Carriers; Female; I-kappa B Kinase; Lactic Acid; Macrophages; Male; Mice; Mice, Inbred C57BL; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Protein Kinase Inhibitors; Thiophenes

Topics: Analysis of Variance; Animals; Cell Count; Disease Models, Animal; Female; Mice, Inbred C57BL; Osteoclasts; Osteolysis; Particle Size; Polyethylenes; Skull; Thiophenes; X-Ray Microtomography

Topics: Animals; Benzamides; Cold Temperature; Disease Models, Animal; Female; Hypothermia, Induced; Injections, Intraperitoneal; Mice, Inbred C57BL; Mice, Knockout; Pressure; Rats, Sprague-Dawley; Reflex; Signal Transduction; Skin; Thiophenes; Time Factors; TRPM Cation Channels; Urinary Bladder; Urinary Incontinence, Urge; Urination; Urodynamics

Topics: Animals; Antihypertensive Agents; Carbon Disulfide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Disease Models, Animal; Glaucoma; Humans; Intraocular Pressure; Male; Molecular Docking Simulation; Morpholines; Piperazines; Piperidines; Quinuclidines; Rabbits; Structure-Activity Relationship; Substrate Specificity; Sulfonamides; Thiocarbamates; Thiophenes

Topics: Administration, Oral; Adolescent; Adult; Aged; Animals; Binding Sites; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Drug Stability; Female; Humans; Male; Memory, Short-Term; Mice, Inbred C57BL; Middle Aged; Protein Conformation; Rats, Sprague-Dawley; Receptors, AMPA; Schizophrenia; Structure-Activity Relationship; Sulfonamides; Thiophenes; Young Adult

Topics: Animals; Autoantibodies; Collagen Type VII; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Partial Agonism; Epidermolysis Bullosa Acquisita; Genetic Predisposition to Disease; Genomics; Haplotypes; Heterozygote; Homozygote; Immunoglobulin G; Mice, Knockout; Neutrophil Activation; Neutrophils; Nuclear Receptor Subfamily 1, Group F, Member 1; Phenotype; Reactive Oxygen Species; Signal Transduction; Skin; Species Specificity; Sulfonamides; Thiophenes; Time Factors

Topics: Animals; Benzamides; Chlorocebus aethiops; Disease Models, Animal; Disease Outbreaks; Enterohemorrhagic Escherichia coli; Escherichia coli Infections; Europe; HeLa Cells; Hemolytic-Uremic Syndrome; Humans; Mice; Mice, Inbred BALB C; Shiga Toxin 2; Thiophenes; Vero Cells

Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Antioxidants; Disease Models, Animal; DNA; Enzyme Activation; Glutathione; Lipid Peroxidation; Memory Disorders; Mice, Transgenic; Mitogen-Activated Protein Kinases; Mutation; Neurons; NF-kappa B; Oxidative Stress; Peroxiredoxin VI; Presenilin-1; Protein Binding; Protein Carbonylation; Rats, Sprague-Dawley; Thiophenes

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apolipoproteins E; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Cognition; Disease Models, Animal; Gene Expression Regulation; HEK293 Cells; Humans; Lipoproteins; Mice; Mice, Transgenic; Nesting Behavior; Plaque, Amyloid; Retinoid X Receptor alpha; Thiophenes

Topics: Anemia, Sickle Cell; Animals; beta-Globins; Blotting, Western; Cells, Cultured; Disease Models, Animal; Fetal Hemoglobin; Flow Cytometry; Histone Demethylases; Humans; Immunoenzyme Techniques; Mice; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Rhodamines; RNA, Messenger; Spiro Compounds; Splenomegaly; Thiophenes

Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Animals; Bupivacaine; Cells, Cultured; Dermatologic Surgical Procedures; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Hyperalgesia; Injections, Intraperitoneal; Male; Pain Measurement; Pain, Postoperative; Pituitary Gland; Rats, Sprague-Dawley; Sciatic Nerve; Sodium Channel Blockers; Sodium Channels; Thiophenes; Time Factors

Topics: Allosteric Regulation; Amidohydrolases; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Brain; Cannabinoid Receptor Modulators; Carrageenan; CHO Cells; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Indoles; Male; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Receptor, Cannabinoid, CB1; Thiophenes

Topics: Animals; Bone Density Conservation Agents; Disease Models, Animal; Female; Fracture Healing; Humans; Osteoporosis, Postmenopausal; Osteoporotic Fractures; Osteotomy; Ovariectomy; Rats; Rats, Sprague-Dawley; Thiophenes; X-Ray Microtomography

Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Binding, Competitive; Cardiac Pacing, Artificial; Cerebellum; Coronary Occlusion; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Guinea Pigs; Heart Conduction System; Heart Rate; Heart Ventricles; Isolated Heart Preparation; Ligands; Male; Mice, Inbred BALB C; Myocardial Contraction; Pain; Pain Threshold; Potassium Channel Blockers; Potassium Channels; Protein Binding; Pyrroles; Radioligand Assay; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sodium Channel Blockers; Sodium Channels; Thiophenes; Ventricular Function, Left; Ventricular Pressure

Topics: Administration, Oral; Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Indoles; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neuralgia; Propionates; Rats; Rats, Sprague-Dawley; Spinal Nerves; Thiophenes; Trigeminal Nerve

Topics: Animals; Disease Models, Animal; Drug Combinations; Glaucoma; Intraocular Pressure; Ophthalmic Solutions; Platelet Activating Factor; Platelet Aggregation; Rabbits; Sulfonamides; Thiophenes; Timolol

Topics: Animals; Asthma; Disease Models, Animal; Dogs; Female; Guinea Pigs; Humans; Male; Prostaglandins; Rats; Rats, Inbred BN; Receptors, Prostaglandin; Respiratory Hypersensitivity; Rhinitis, Allergic; Sheep; Thiophenes; Treatment Outcome

Topics: Animals; Anticoagulants; Disease Models, Animal; Endothelin-1; Heparin, Low-Molecular-Weight; Hypertension, Pulmonary; Lung; Morpholines; Pulmonary Embolism; Rats; Rivaroxaban; Thiophenes; Warfarin

Topics: Animals; Calcium-Transporting ATPases; Disease Models, Animal; Hydrazones; Hypercholesterolemia; Male; Myocardium; Rats; Rats, Wistar; Thiophenes

Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Cerebral Cortex; Cognition; Disease Models, Animal; Humans; Insulysin; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Plaque, Amyloid; Pyrazoles; Thiophenes

Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Binding Sites; Carcinoma, Ehrlich Tumor; Catalytic Domain; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; HeLa Cells; Humans; Inflammation; Isoxazoles; Lipoxygenase; Lipoxygenase Inhibitors; Mice; Molecular Docking Simulation; Thiophenes

Topics: Animals; Dimethyl Sulfoxide; Disease Models, Animal; Endothelial Cells; Male; Mice; Oxadiazoles; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; Stroke; Thiophenes; Time Factors

Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Chemistry, Pharmaceutical; Disease Models, Animal; Disease Progression; Drug Carriers; Elastin; Immunoconjugates; Macrophages; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Nanoparticles; Phenylalanine; Polyesters; Proteolysis; Rats, Sprague-Dawley; RAW 264.7 Cells; Thiophenes; Time Factors; Vascular Calcification

Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Structure-Activity Relationship; Thiophenes; Thiosemicarbazones

Topics: Animals; Anterior Chamber; Apoptosis; Corneal Edema; Disease Models, Animal; Drug Combinations; Endothelium, Corneal; In Situ Nick-End Labeling; Ophthalmic Solutions; Rabbits; Sulfonamides; Thiophenes; Timolol

Topics: Animals; Bone Density Conservation Agents; Disease Models, Animal; Femoral Fractures; Fracture Healing; Fractures, Malunited; Osteotomy; Peptide Fragments; Rats; Rats, Sprague-Dawley; Teriparatide; Thiophenes; Treatment Outcome

Topics: Animals; Bone Density; Bone Density Conservation Agents; Disease Models, Animal; Female; Femur; Rats; Rats, Wistar; Thiophenes; Wound Healing; X-Ray Microtomography

Topics: Animals; Antiparkinson Agents; Apomorphine; Azepines; Benzothiazoles; Cabergoline; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Ergolines; Indoles; Injections, Intraventricular; Male; Mice; Motor Activity; Oxidopamine; Parkinsonian Disorders; Pramipexole; Quinolines; Receptors, Dopamine D2; Tetrahydronaphthalenes; Thiophenes

Topics: Acid-Base Imbalance; Acidosis, Renal Tubular; Aged; Air Pollution, Indoor; Amino Acid Substitution; Animals; Animals, Newborn; Anti-Bacterial Agents; Antibodies, Neutralizing; Apoptosis; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Bone Marrow Transplantation; Carbonic Anhydrase Inhibitors; Castleman Disease; Cat Diseases; Cats; Cell Proliferation; Cell- and Tissue-Based Therapy; Chemical and Drug Induced Liver Injury; Chemotaxis, Leukocyte; Clinical Trials as Topic; Coated Materials, Biocompatible; Diagnosis, Differential; Disease Models, Animal; Environmental Monitoring; Female; Gas Chromatography-Mass Spectrometry; Genotype; Granuloma, Foreign-Body; Heart Failure; Hepacivirus; Hepatitis C; Horse Diseases; Horses; Housing; Humans; Hypercalcemia; Hypokalemia; Immunophenotyping; In Vitro Techniques; Liver; Liver Function Tests; Lymphocytes; Macrophages; Male; Medicine, Chinese Traditional; Metabolomics; Mice; Mice, Inbred C57BL; Middle Aged; Models, Animal; Mutation; Myocardial Ischemia; Neovascularization, Physiologic; Neutrophil Infiltration; Ocular Hypertension; Ophthalmic Solutions; Parathyroid Hormone; Particulate Matter; Polyethylene Terephthalates; Prednisolone; Prospective Studies; Prosthesis Design; Prosthesis-Related Infections; Rats; Rats, Wistar; Reactive Oxygen Species; Rifampin; Saponins; Sepsis; Skin; Stem Cells; Stroke Volume; Sulfonamides; Texas; Thiophenes; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left; Viral Hepatitis Vaccines; Viral Nonstructural Proteins; Viral Proteins; Vitamin D; Wound Healing

Topics: Animals; Apoptosis; Benzimidazoles; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Chromosomal Instability; Disease Models, Animal; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Humans; Lung Neoplasms; Mice; Mutation; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pteridines; Thiophenes; Tumor Burden; Xenograft Model Antitumor Assays

Topics: Animals; Disease Models, Animal; Fractures, Bone; Incidence; Mice; Mice, Mutant Strains; Osteogenesis Imperfecta; Thiophenes; X-Ray Microtomography

Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucosides; Hypoglycemic Agents; Insulin Resistance; Mice; Non-alcoholic Fatty Liver Disease; Obesity; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Treatment Outcome

Topics: Animals; Caco-2 Cells; Cell Proliferation; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Histone-Lysine N-Methyltransferase; Humans; Injections, Intraventricular; Leukemia, Myeloid, Acute; Mice; Mice, Inbred C57BL; Mice, SCID; Models, Molecular; Molecular Structure; Myeloid-Lymphoid Leukemia Protein; Protein Binding; Proto-Oncogene Proteins; Pyrimidines; Small Molecule Libraries; Structure-Activity Relationship; Thiophenes

Topics: Animals; Colitis; Colon; Dipeptides; Disease Models, Animal; Female; Guinea Pigs; Hyperalgesia; Male; Receptors, Neurokinin-2; Sex Characteristics; Thiophenes; Trinitrobenzenesulfonic Acid; Visceral Pain

Topics: Animals; Bone Density; Disease Models, Animal; Female; Femur; Lumbar Vertebrae; Osteoporosis; Parathyroid Hormone; Rats; Rats, Sprague-Dawley; Thiophenes; Vibration

Topics: Animals; Anti-Inflammatory Agents; Chymases; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Female; Forkhead Transcription Factors; Inflammation Mediators; Interleukin-10; Interleukin-17; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Severity of Illness Index; Sulfonamides; T-Lymphocytes, Regulatory; Thiophenes; Time Factors; Transforming Growth Factor beta1

Topics: Animals; Antihypertensive Agents; Blood Pressure; Choroid; Disease Models, Animal; Glaucoma; Intraocular Pressure; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Regional Blood Flow; Retina; Sulfonamides; Thiophenes; Treatment Outcome

Topics: Animals; Apoptosis; Disease Models, Animal; Endoplasmic Reticulum Stress; Endoribonucleases; Enzyme Inhibitors; Heat-Shock Proteins; Locus Coeruleus; Male; Multienzyme Complexes; Neurons; Protein Serine-Threonine Kinases; Random Allocation; Rats, Wistar; Signal Transduction; Stress Disorders, Post-Traumatic; Sulfonamides; Thiophenes; Transcription Factor CHOP; X-Box Binding Protein 1

Topics: Animals; Biomechanical Phenomena; Disease Models, Animal; Endothelial Cells; Endothelin Receptor Antagonists; Endothelin-1; Fluorescent Antibody Technique; Gene Knockdown Techniques; Glomerular Basement Membrane; Hypertension; Isoxazoles; Laminin; Mesangial Cells; Mice; Mice, Inbred C57BL; Nephritis, Hereditary; Podocytes; Proteinuria; Pseudopodia; Receptor, Endothelin A; RNA Interference; RNA, Small Interfering; Signal Transduction; Thiophenes; Up-Regulation

Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Animals; Anti-Bacterial Agents; Burkholderia pseudomallei; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Francisella tularensis; Humans; Klebsiella Infections; Klebsiella pneumoniae; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Molecular Conformation; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship; Thiophenes; Yersinia pestis

Topics: Analysis of Variance; Animals; Antidepressive Agents; Benzodioxoles; Calcium; Cyclic AMP; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; HEK293 Cells; Helplessness, Learned; Hindlimb Suspension; Humans; Inhibitory Concentration 50; Locomotion; Male; Mice; Mice, Inbred ICR; Protein Binding; Rats; Rats, Sprague-Dawley; Serotonin and Noradrenaline Reuptake Inhibitors; Swimming; Thiophenes

Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Fatty Acid Synthase, Type I; Female; Humans; Injections, Intraperitoneal; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Pyrimidines; Receptor, ErbB-2; Swine; Thiophenes

Topics: Animals; Brain Injuries, Traumatic; Cognition Disorders; Conditioning, Classical; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Fear; Hippocampus; Interleukin-1beta; Long-Term Potentiation; Male; Maze Learning; Memory, Short-Term; Nerve Tissue Proteins; Phenylacetates; Phosphodiesterase 4 Inhibitors; Rats; Rats, Sprague-Dawley; Reaction Time; Thiophenes; Tumor Necrosis Factor-alpha

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents; Astrocytes; Behavioral Symptoms; Cell Line; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Humans; Imidazoles; Inflammation; Male; Mice; Mice, Inbred ICR; Microglia; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Substantia Nigra; Thiophenes

Topics: Animals; Basement Membrane; Body Temperature; Capillaries; Cell Line; Collagen Type IV; Disease Models, Animal; Endothelin-1; Extracellular Matrix; Gene Expression Regulation; Hypoxia; Isoxazoles; Laminin; Mice; Nephritis, Hereditary; Oxidative Stress; Phenotype; Stria Vascularis; Thiophenes

Topics: Alzheimer Disease; Amyloid beta-Peptides; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Behavior, Animal; Blood Pressure; Brain; Cerebrovascular Circulation; Disease Models, Animal; Hypertension; Imidazoles; Maze Learning; Mice, Transgenic; Spatial Learning; Thiophenes

Topics: Alkaline Phosphatase; Alveolar Bone Loss; Animals; Biomarkers; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Interleukin-1beta; Male; Osteoclasts; Osteoprotegerin; Periodontitis; Random Allocation; RANK Ligand; Rats; Rats, Wistar; Thiophenes

Topics: Animals; Bone Density; Bony Callus; Chondrocytes; Cyclohexylamines; Disease Models, Animal; Fracture Healing; Hedgehog Proteins; Imaging, Three-Dimensional; Male; Mice; Mice, Inbred C57BL; Thiophenes; Tibial Fractures; X-Ray Microtomography

Topics: Acetamides; Adrenergic alpha-2 Receptor Antagonists; Amines; Animals; Antineoplastic Agents; Constriction, Pathologic; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Hypnotics and Sedatives; Idazoxan; Male; Motor Activity; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes

Topics: Animals; Antidepressive Agents; Azepines; Behavior, Animal; Benzamides; Brain-Derived Neurotrophic Factor; Dendritic Spines; Depressive Disorder, Major; Disease Models, Animal; Drug Therapy, Combination; Fluoxetine; Male; Mice; Mice, Inbred C57BL; Phenotype; Quinolones; Receptor, trkB; Selective Serotonin Reuptake Inhibitors; Signal Transduction; Thiophenes

Topics: Animals; Biomechanical Phenomena; Bone Density; Calcium; Disease Models, Animal; Female; Osteoporosis; Peptide Fragments; Procollagen; Rats, Sprague-Dawley; Spinal Fusion; Strontium; Tartrate-Resistant Acid Phosphatase; Thiophenes; X-Ray Microtomography

Topics: Animals; Antioxidants; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Mice; NF-E2-Related Factor 2; Reactive Oxygen Species; Signal Transduction; Stroke; Thiones; Thiophenes

Topics: Animals; Behavior, Animal; Bipolar Disorder; Choice Behavior; Disease Models, Animal; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Exploratory Behavior; Female; Gene Knockdown Techniques; Impulsive Behavior; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenotype; Quinolones; Receptor, Serotonin, 5-HT1A; Risk-Taking; Serotonin Agents; Thiophenes

Topics: Animals; Bone Density Conservation Agents; Disease Models, Animal; Guinea Pigs; Male; Osteoarthritis; Osteophyte; Thiophenes

Topics: Alkaloids; Amphetamines; Animals; Discrimination Learning; Disease Models, Animal; Dose-Response Relationship, Drug; Illicit Drugs; Locomotion; Male; Methamphetamine; Mice; Propiophenones; Psychotropic Drugs; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiophenes

Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antigens, Ly; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Biphenyl Compounds; Cell Line; Cell Migration Inhibition; Chemotaxis; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Genetic Predisposition to Disease; Humans; Macrophages; Metformin; Mice, Knockout; Phenotype; Pyrones; Receptors, CCR2; Ribonucleotides; Signal Transduction; Thiophenes

Topics: Anemia, Sickle Cell; Animals; Disease Models, Animal; Erythrocytes; Histone Demethylases; Humans; Mice; Mitochondria; Models, Biological; Reactive Oxygen Species; Rhodamines; Sirolimus; Spiro Compounds; Thiophenes; TOR Serine-Threonine Kinases

Topics: Adenosine A2 Receptor Agonists; Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Failure; Hydrazones; Male; Myocardial Infarction; Rats; Rats, Inbred SHR; Thiophenes

Topics: 2-Amino-5-phosphonovalerate; Animals; Cinanserin; Disease Models, Animal; Dose-Response Relationship, Radiation; Drug Administration Routes; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Fenfluramine; Hippocampus; Indoles; Long-Term Potentiation; Male; Neural Inhibition; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT2; Restraint, Physical; Serotonin Agents; Stress, Psychological; Thiophenes

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Brain; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Lipid Peroxidation; Male; Maleates; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Neuroprotective Agents; Rotarod Performance Test; Thiophenes

Topics: Animals; Cholinesterase Inhibitors; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Drug Administration Schedule; Drug Therapy, Combination; Galantamine; Male; Maze Learning; Motor Activity; Rats; Rats, Wistar; Receptors, Serotonin; Scopolamine; Serotonin Antagonists; Sulfonamides; Thiophenes; Yawning

Topics: Amides; Animals; Cells, Cultured; Collagen Type I; Cornea; Corneal Ulcer; Disease Models, Animal; Fibroblasts; Gene Expression; I-kappa B Kinase; Immunoblotting; Immunohistochemistry; Interleukin-1beta; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Microscopy, Fluorescence; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrophotometry; Thiophenes

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Behavior, Animal; Benzazepines; Biperiden; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Female; Levodopa; Macaca nemestrina; Muscarinic Antagonists; Parkinsonian Disorders; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydronaphthalenes; Thiophenes

Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Mice; Mice, Transgenic; Models, Molecular; Molecular Conformation; Receptor, Notch1; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Thiophenes

Topics: Adenosine Deaminase; Administration, Oral; Animals; Antioxidants; Antitubercular Agents; Caffeic Acids; Disease Models, Animal; Drinking; Drug Therapy, Combination; Erythrocytes; Injections, Intraperitoneal; Isoniazid; Male; Nitric Oxide; Oxidative Stress; Phenylethyl Alcohol; Purines; Rats; Rats, Wistar; Thioglycolates; Thiophenes; Xanthine Oxidase

Topics: Animals; bcl-X Protein; Cell Survival; Disease Models, Animal; Drug Combinations; Glial Fibrillary Acidic Protein; Intraocular Pressure; Male; Ocular Hypertension; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; RNA, Messenger; Sulfonamides; Thiophenes; Timolol

Topics: Acetylcysteine; Animals; Antioxidants; Constriction; Disease Models, Animal; Glutathione Peroxidase; Ileum; Lipid Peroxidation; Male; Malondialdehyde; Mesenteric Artery, Superior; Oxidative Stress; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sexual Development; Sulfhydryl Compounds; Superoxide Dismutase; Thioctic Acid; Thioglycolates; Thiophenes

Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hindlimb Suspension; Male; Microdialysis; Motor Activity; Oxidopamine; Parkinsonian Disorders; Piperazines; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Substantia Nigra; Thiophenes; Time Factors

Topics: Alkaline Phosphatase; Amino Acids; Animals; Bone Density Conservation Agents; Bone Remodeling; Compressive Strength; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Lumbar Vertebrae; Organometallic Compounds; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Strontium; Thiophenes; X-Ray Microtomography

Topics: ADAM Proteins; ADAM17 Protein; Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Encephalitis; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gliosis; Hippocampus; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neuroprotective Agents; Phenylalanine; Receptors, Tumor Necrosis Factor, Type I; Reperfusion Injury; Thiophenes; Tissue Inhibitor of Metalloproteinase-3; Tumor Necrosis Factor-alpha

Topics: Adenosine Diphosphate; Administration, Oral; Animals; Binding, Competitive; Bleeding Time; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Hemorrhage; Hemostasis; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rabbits; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides; Thiophenes; Thrombosis; Ticlopidine

Topics: Animals; Anti-Obesity Agents; Antidepressive Agents; Autoradiography; Behavior, Animal; Body Weight; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Mice; Mice, Knockout; Motor Activity; Obesity; Protein Binding; Pyrimidinones; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, Somatostatin; Social Dominance; Swimming; Thiophenes

Topics: Animals; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocytes, Cardiac; Oxadiazoles; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; RNA, Messenger; Signal Transduction; Sphingolipids; Thiophenes; Ventricular Remodeling

Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Behavior, Animal; Codeine; Depression; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Duloxetine Hydrochloride; Enzyme Inhibitors; Hindlimb Suspension; Male; Mice; Motor Activity; Selective Serotonin Reuptake Inhibitors; Serotonin; Thiophenes; Tramadol

Topics: Animals; Cerebral Arterial Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Peripheral Vascular Diseases; Piperazines; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Thiophenes

Topics: Animals; Cyclic Nucleotide Phosphodiesterases, Type 7; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Epidermis; Female; Gene Expression Regulation; Humans; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; Pyrazoles; Skin; Tetradecanoylphorbol Acetate; Thiophenes; Tumor Necrosis Factor-alpha

Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Cholestasis, Intrahepatic; Constitutive Androstane Receptor; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cell Leukemia Sequence 1 Protein; Phenobarbital; Pregnenolone Carbonitrile; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiones; Thiophenes; Transcription Factors

Topics: Adipogenesis; Administration, Oral; Animals; Blood Glucose; Blood Volume; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Partial Agonism; Genes, Reporter; Humans; Hypoglycemic Agents; Isoxazoles; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred ICR; PPAR gamma; Propionates; Rosiglitazone; Thiazolidinediones; Thiophenes; Transfection; Water-Electrolyte Balance

Topics: Acetates; Allergens; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cyclic AMP; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Prostaglandin D2; Quinolines; Receptors, Immunologic; Receptors, Prostaglandin; Sulfides; Thiophenes; Time Factors

Topics: Animals; Animals, Newborn; Cell Proliferation; Choroid; Choroidal Neovascularization; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Humans; Laser Coagulation; Male; Mice; Neuroglia; Oxygen; Rats; Rats, Inbred BN; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Retinal Neovascularization; Retinal Vessels; Thiophenes; Triazoles; Vascular Endothelial Growth Factor A

Topics: Analysis of Variance; Animals; Antiparkinson Agents; Callithrix; Disease Models, Animal; Drug Administration Schedule; Drug Delivery Systems; Dyskinesia, Drug-Induced; Female; Levodopa; Male; Motor Activity; Motor Skills; MPTP Poisoning; Tetrahydronaphthalenes; Thiophenes

Topics: Acetates; Amyloid beta-Peptides; Amyloidosis; Animals; Brain Diseases; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Molecular Structure; Neurodegenerative Diseases; Thiophenes

Topics: Adenosine; Animals; CHO Cells; Clopidogrel; Cricetinae; Cricetulus; Disease Models, Animal; Dogs; Hemostasis; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine; Transfection

Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Celecoxib; Central Nervous System Agents; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Escape Reaction; Fluoxetine; Inflammation; Male; Motor Activity; Neuropsychological Tests; Pain; Pain Measurement; Physical Stimulation; Pyrazoles; Rats; Rats, Sprague-Dawley; Scopolamine; Sulfonamides; Thiophenes; Treatment Outcome

Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta, Abdominal; Aortic Diseases; Atherosclerosis; Cholesterol; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Induction; Epoprostenol; Hypercholesterolemia; Indomethacin; Male; Norepinephrine; Rabbits; Thiophenes; Vasoconstriction; Vasoconstrictor Agents

Topics: Animals; B-Lymphocytes; beta-Alanine; Chemotaxis, Leukocyte; Disease Models, Animal; Guillain-Barre Syndrome; Immunologic Factors; Interleukin-17; Macrophages; Male; Matrix Metalloproteinase 9; Neuritis, Autoimmune, Experimental; Paraparesis; Rats; Rats, Inbred Lew; Receptors, Lysosphingolipid; Sciatic Nerve; T-Lymphocytes; Thiophenes; Treatment Outcome

Topics: Animals; Caspase 3; Cell Death; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Ischemic Attack, Transient; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Phenylalanine; Thiophenes; Time Factors

Topics: Animals; Callithrix; Disability Evaluation; Disease Models, Animal; Dopamine Agents; Drug Administration Schedule; Drug Delivery Systems; Dyskinesia, Drug-Induced; Female; Levodopa; Male; Motor Activity; MPTP Poisoning; Statistics, Nonparametric; Tetrahydronaphthalenes; Thiophenes; Time Factors

Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Fingolimod Hydrochloride; Immunosuppressive Agents; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; MAP Kinase Signaling System; Nerve Degeneration; Neuroprotective Agents; Oxadiazoles; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Stroke; Thiophenes; Treatment Outcome

Topics: Animals; Biomechanical Phenomena; Bone Density Conservation Agents; Bone Regeneration; Bony Callus; Diaphyses; Disease Models, Animal; Female; Femur; Fractures, Bone; Humans; Organometallic Compounds; Osteoporosis, Postmenopausal; Ovariectomy; Peptide Fragments; Rats; Rats, Sprague-Dawley; Teriparatide; Thiophenes; Treatment Outcome; Wound Healing; X-Ray Microtomography

Topics: Animals; Atrial Natriuretic Factor; Biomarkers; Cardiovascular Agents; Disease Models, Animal; Echocardiography; Female; Heart; Hypertrophy, Left Ventricular; Magnetic Resonance Imaging; Male; Myocardium; Natriuretic Peptide, Brain; Organ Size; Peptide Fragments; Phenylpropionates; PPAR alpha; PPAR gamma; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiophenes; Troponin T

Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzodiazepines; Chronic Disease; Depression; Depressive Disorder; Disease Models, Animal; Emotions; Fluoxetine; Hindlimb Suspension; Male; Mice; Mice, Inbred BALB C; Motor Activity; Receptors, AMPA; Stress, Psychological; Sulfonamides; Thiophenes

Topics: Administration, Cutaneous; Animals; Bucladesine; Cell Proliferation; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 7; Disease Models, Animal; Epidermis; Female; Humans; Keratinocytes; Mice; Mice, Inbred BALB C; Phosphodiesterase Inhibitors; Psoriasis; Pyrazoles; Skin; Tetradecanoylphorbol Acetate; Thiophenes

Topics: Animals; Antigens, CD; Apolipoproteins E; Apoptosis; Atherosclerosis; Cadherins; Caspase 3; Cells, Cultured; Disease Models, Animal; Fas Ligand Protein; Humans; Matrix Metalloproteinase 7; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylalanine; Protease Inhibitors; Recombinant Proteins; Rupture; Thiophenes; Time Factors

Topics: Animals; Anticoagulants; Benzimidazoles; Dabigatran; Disease Models, Animal; Factor Xa Inhibitors; Humans; Mice; Mice, Knockout; Morpholines; Pyridines; Rivaroxaban; Thiophenes; Thrombin; Venous Thrombosis

Topics: Animals; Antihypertensive Agents; Aqueous Humor; Carteolol; Chromatography, High Pressure Liquid; Ciliary Body; Disease Models, Animal; Humans; Male; Ocular Hypertension; Rabbits; Spectrometry, Mass, Electrospray Ionization; Sulfonamides; Thiophenes

Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cell Adhesion; Cell Proliferation; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Lymphocyte Culture Test, Mixed; Lymphocyte Function-Associated Antigen-1; Mice; Spiro Compounds; Thiophenes

Topics: Animals; Bone Density Conservation Agents; Calcium; Cauda Equina; Core Binding Factor Alpha 1 Subunit; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Fractures, Spontaneous; Lumbar Vertebrae; Mice; Mice, Transgenic; Organometallic Compounds; Osteoporosis; Osteoporotic Fractures; Spinal Fractures; Stress, Mechanical; Strontium; Thiophenes; Tibia

Topics: Acute Lung Injury; Animals; Cardiopulmonary Bypass; Disease Models, Animal; Dogs; Lung; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Phenylalanine; Postoperative Complications; Thiophenes

Topics: Acute Kidney Injury; Animals; Apoptosis; Cell Movement; Disease Models, Animal; Epithelial Cells; Fingolimod Hydrochloride; Homeodomain Proteins; Kidney Tubules, Proximal; Leukocytes; Lipopolysaccharides; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Reperfusion Injury; RNA, Messenger; Signal Transduction; Sphingosine; Thiophenes

Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Newborn; Area Under Curve; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Agonists; Ketamine; Macaca fascicularis; Macaca mulatta; Memory Disorders; Memory, Short-Term; Motor Activity; Neuropsychological Tests; Reaction Time; Sulfonamides; Thiophenes; Time Factors

Topics: Animals; Disease Models, Animal; Glaucoma; Haplorhini; HeLa Cells; Humans; Intraocular Pressure; Ocular Hypertension; Protein Kinase Inhibitors; rho-Associated Kinases; Thiophenes

Topics: Animals; Disease Models, Animal; Dystrophin; Fibrosis; Gene Expression Regulation; Humans; Inflammation; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Phenylalanine; Protease Inhibitors; Thiophenes; Transcription Factor AP-1

Topics: Animals; Aquaporin 5; Disease Models, Animal; Female; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Inbred MRL lpr; Microscopy, Electron; Muscarinic Agonists; Quinuclidines; Sjogren's Syndrome; Submandibular Gland; Thiophenes

Topics: Amines; Analgesics; Animals; Azetidines; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Duloxetine Hydrochloride; Exploratory Behavior; Gabapentin; gamma-Aminobutyric Acid; Male; Mecamylamine; Morphine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Thiophenes

Topics: Adrenergic Uptake Inhibitors; Analgesics; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Facial Pain; Hyperalgesia; Ligation; Male; Masseter Muscle; Neuroglia; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tendons; Thiophenes; Trigeminal Nucleus, Spinal

Topics: Animals; Anti-Obesity Agents; Blood-Brain Barrier; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Inverse Agonism; Humans; Hypothermia; Male; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship; Thiophenes

Topics: Animals; Blood Pressure; Calcium; Cardiomegaly; Cardiotonic Agents; Disease Models, Animal; Hydrazones; Male; Myocardial Contraction; Myocardial Infarction; Myocytes, Cardiac; Rats; Rats, Wistar; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thiophenes; Ventricular Remodeling

Topics: Animals; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide Synthase Type II; Phosphorylation; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-akt; Shock, Septic; Signal Transduction; Sulfones; Thiazoles; Thiophenes

Topics: Angiopoietin-1; Animals; Bone Morphogenetic Protein Receptors, Type II; Disease Models, Animal; Drug Therapy, Combination; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Isoxazoles; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Pulmonary Circulation; Purines; Sildenafil Citrate; Subclavian Artery; Sulfones; Thiophenes; Treatment Outcome

Topics: Animals; Biomechanical Phenomena; Bone Density; Bone Density Conservation Agents; Disease Models, Animal; Female; Fracture Healing; Organometallic Compounds; Osteoporotic Fractures; Rats; Rats, Sprague-Dawley; Thiophenes

Topics: Amyloid; Animals; Brain; Cattle; Disease Models, Animal; Encephalopathy, Bovine Spongiform; Female; Glial Fibrillary Acidic Protein; Male; Mice; Mice, Transgenic; Polymers; Prion Diseases; Prions; Protein Structure, Quaternary; Saccharomyces cerevisiae Proteins; Scrapie; Severity of Illness Index; Sheep; Species Specificity; Spectrum Analysis; Statistics as Topic; Structure-Activity Relationship; Survival Analysis; Thiophenes

Topics: Animals; Apoptosis; Carrier Proteins; Chemotaxis; Colitis; Disease Models, Animal; Furans; Homeostasis; Immunity, Innate; Inflammasomes; Interleukin-10; Interleukin-1beta; Intestines; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Thiophenes; Transforming Growth Factor beta

Topics: Anesthesia; Anesthetics; Animals; Atomoxetine Hydrochloride; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Electromyography; Female; Halothane; Humans; Indoles; Muscle, Smooth; Norepinephrine; Prazosin; Propylamines; Pyridines; Rabbits; Retrospective Studies; Thiophenes; Urinary Tract; Urinary Tract Infections; Urodynamics

Topics: Acetophenones; Anilides; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Hyperalgesia; Lysophospholipids; Male; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Organophosphonates; Oxadiazoles; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Time Factors

Topics: Administration, Oral; Animals; Apolipoprotein A-I; Apolipoprotein A-II; Biomarkers; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Disease Models, Animal; Eating; Glycated Hemoglobin; Hypertriglyceridemia; Hypoglycemic Agents; Hypolipidemic Agents; Insulin Resistance; Macaca mulatta; Male; Metabolic Syndrome; Obesity; Oxazoles; PPAR alpha; PPAR gamma; Prediabetic State; Thiophenes; Time Factors; Triglycerides; Weight Loss

Topics: Animals; Carbon Dioxide; Disease Models, Animal; Expectorants; Female; Laparoscopy; Lung Injury; Oxidative Stress; Pneumoperitoneum, Artificial; Rats; Rats, Wistar; Thioglycolates; Thiophenes; Treatment Outcome

Topics: Analgesics; Animals; Antidepressive Agents; Clomipramine; Cyclopropanes; Diabetes Mellitus, Experimental; Disease Models, Animal; Duloxetine Hydrochloride; Hyperalgesia; Male; Milnacipran; Naloxone; Neuralgia; Rats; Rats, Sprague-Dawley; Thiophenes

Topics: AMP-Activated Protein Kinases; Animals; Biphenyl Compounds; Cells, Cultured; Diabetes Mellitus; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Microtubule-Associated Proteins; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphorylation; Pyrones; Rats; Rats, Inbred Strains; Rats, Wistar; Thiophenes

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biological Transport; Brain; Contrast Media; Disease Models, Animal; Female; Humans; Iodine Radioisotopes; Ligands; Mice; Mice, Transgenic; Peptide Fragments; Plaque, Amyloid; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Thiophenes; Tomography, Emission-Computed, Single-Photon

Topics: Analgesia; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Disease Models, Animal; Duloxetine Hydrochloride; Humans; Low Back Pain; Osteoarthritis; Pain; Retrospective Studies; Thiophenes; Treatment Outcome

Topics: Animals; Carbonic Anhydrase Inhibitors; Crystallography, X-Ray; Disease Models, Animal; Glaucoma; Humans; Models, Molecular; Molecular Structure; Nitric Oxide; Ocular Hypertension; Protein Isoforms; Rabbits; Sulfonamides; Thiophenes

Topics: Animals; Blood Platelets; Blood Pressure; Coronary Occlusion; Coronary Thrombosis; Disease Models, Animal; Drug Evaluation, Preclinical; Electrocardiography; Heart Rate; Male; Myocardial Infarction; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Protein Binding; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2Y12; Thiophenes

Topics: Animals; Biomechanical Phenomena; Bone and Bones; Bone Density; Calcium; Disease Models, Animal; Drug Therapy, Combination; Female; Goats; Humans; Lumbar Vertebrae; Organometallic Compounds; Osteoporosis; Ovariectomy; Random Allocation; Strontium; Thiophenes; Treatment Outcome; X-Ray Microtomography

Topics: Analysis of Variance; Animals; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Glutathione Peroxidase; Hippocampus; Kainic Acid; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Organoselenium Compounds; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar; Reaction Time; Seizures; Sodium-Potassium-Exchanging ATPase; Sulfhydryl Compounds; Thiophenes; Thymidine; Trityl Compounds

Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Indomethacin; Male; Milnacipran; Rats; Rats, Wistar; Thiophenes

Topics: Animals; Body Weight; Brain; Disease Models, Animal; Enzyme Inhibitors; Female; HeLa Cells; Humans; Infarction, Middle Cerebral Artery; Isoquinolines; Male; Motor Activity; Neuroprotective Agents; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stroke; Thiophenes; Tumor Cells, Cultured

Topics: Animals; Cell Proliferation; Chymases; Cromolyn Sodium; Disease Models, Animal; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Mast Cells; Monocrotaline; Muscle, Smooth, Vascular; Neovascularization, Pathologic; Rats; Rats, Wistar; Sulfonamides; Thiophenes

Topics: Administration, Oral; Animals; Anticoagulants; Blood Coagulation; Carotid Artery Injuries; Coronary Occlusion; Coronary Thrombosis; Disease Models, Animal; Electrolytes; Enoxaparin; Factor Xa; Factor Xa Inhibitors; Fibrinolytic Agents; Injections, Intravenous; Male; Morpholines; Partial Thromboplastin Time; Prothrombin Time; Rats; Rats, Sprague-Dawley; Rivaroxaban; Thiophenes

Topics: Animals; Antimalarials; Disease Models, Animal; Malaria, Falciparum; Mice; Plasmodium berghei; Plasmodium falciparum; Thiophenes; Trophozoites

Topics: Analgesics, Non-Narcotic; Animals; Arabidopsis Proteins; Area Under Curve; Carbamazepine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Disease Models, Animal; Drug Interactions; Epoxide Hydrolases; Heterocyclic Compounds, 4 or More Rings; Hyperlipidemias; Intramolecular Transferases; Male; Microsomes, Liver; Poloxamer; Rats; Rats, Sprague-Dawley; Surface-Active Agents; Thiophenes; Time Factors

Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Collagen; Disease Models, Animal; Fibronectins; Fibrosis; Hypertension; Losartan; Macrophages; Male; Myocardium; Oxidative Stress; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 2; Stroke; Sulfonamides; Superoxides; Thiophenes; Vascular Stiffness

Topics: Analysis of Variance; Animals; Carbenoxolone; Connexin 43; Disease Models, Animal; Duloxetine Hydrochloride; Electroshock; Exploratory Behavior; Fluoxetine; Food Deprivation; Food Preferences; Gap Junctions; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hormone Antagonists; Inhibition, Psychological; Isoquinolines; Male; Microscopy, Electron, Transmission; Mifepristone; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Restraint, Physical; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Social Isolation; Stress, Psychological; Sucrose; Sweetening Agents; Swimming; Thiophenes

Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Flow Velocity; Blood Pressure; Body Weight; Collagen; Disease Models, Animal; Hydroxyproline; Hypertension; Imidazoles; Male; NG-Nitroarginine Methyl Ester; Olmesartan Medoxomil; Pulsatile Flow; Rats; Rats, Wistar; Receptor, Angiotensin, Type 2; Sulfonamides; Tetrazoles; Thiophenes; Vascular Stiffness

Topics: Animals; Biomechanical Phenomena; Biomedical Engineering; Bone Density; Bone Density Conservation Agents; Botulinum Toxins; Disease Models, Animal; Elastic Modulus; Female; Organometallic Compounds; Osteoporosis; Paralysis; Rats; Rats, Sprague-Dawley; Thiophenes; X-Ray Microtomography

Topics: Animals; Anticoagulants; Apolipoproteins E; Blood Coagulation; Disease Models, Animal; Factor Xa Inhibitors; Fibrinolytic Agents; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Rivaroxaban; Thiophenes; Thrombosis

Topics: Amiloride; Angiotensin II Type 1 Receptor Blockers; Animals; Bendroflumethiazide; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Sodium Channels; Imidazoles; Male; Natriuresis; Natriuretic Agents; Obesity; Pyridines; Rats; Rats, Zucker; Receptor, Angiotensin, Type 2; Sodium; Sodium Chloride Symporter Inhibitors; Sodium Chloride Symporters; Sulfonamides; Thiophenes; Urination

Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Animals, Newborn; Anti-Inflammatory Agents; Astrocytes; Avoidance Learning; Brain; Cell Survival; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Exploratory Behavior; Gene Expression Regulation; Inflammation; Lipopolysaccharides; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Nitric Oxide; Peptide Fragments; Reactive Oxygen Species; Thiophenes

Topics: Acetamides; Analysis of Variance; Animals; Animals, Newborn; Arousal; Autoradiography; Chronobiology Disorders; Disease Models, Animal; Drug Administration Schedule; Electroencephalography; Electromyography; Female; Hippocampus; Hypnotics and Sedatives; Male; Movement Disorders; Pregnancy; Prenatal Exposure Delayed Effects; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Melatonin; Restraint, Physical; Sleep Wake Disorders; Thiophenes

Topics: Animals; Anti-Bacterial Agents; Cell Survival; Chlorocebus aethiops; Disease Models, Animal; Female; Methane; Mice; Mice, Inbred BALB C; Mycobacterium fortuitum; Mycobacterium Infections; Survival Analysis; Thiophenes; Treatment Outcome; Vero Cells

Topics: Acute Pain; Adrenergic Uptake Inhibitors; Amines; Amphetamine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Central Nervous System Stimulants; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Ibuprofen; Lameness, Animal; Male; Morphine; Motor Activity; Neuritis; Rats; Rats, Sprague-Dawley; Thiophenes

Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Locomotion; Male; Morphine; Neuralgia; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes

Topics: Animals; Avoidance Learning; Cholinergic Antagonists; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Memory Disorders; Memory, Short-Term; Mice; Receptors, Serotonin; Scopolamine; Serotonin Antagonists; Sulfonamides; Thiophenes

Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cell Line; Chemical and Drug Induced Liver Injury; Concanavalin A; Cytokines; Disease Models, Animal; Female; I-kappa B Proteins; Inflammation; Interleukin-6; Lipopolysaccharides; Liver; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Thiophenes; Tumor Necrosis Factor-alpha

Topics: Administration, Oral; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Morphine; Neuralgia; Neuroma; Pain Measurement; Pain Threshold; Pregabalin; Rats; Rats, Sprague-Dawley; Thiophenes; Time Factors

Topics: Animals; Anti-Inflammatory Agents; Aspirin; Biomarkers; Blood Platelets; Disease Models, Animal; Down-Regulation; Humans; Inflammation Mediators; Leukocytes; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Piperazines; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Selenoprotein P; Shock, Septic; Thiophenes; Thromboxane B2; Tumor Necrosis Factor-alpha

Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Drug Interactions; Duloxetine Hydrochloride; Etodolac; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mexiletine; Mice; Paclitaxel; Peripheral Nervous System Diseases; Pregabalin; Thiophenes; Tissue Distribution

Topics: Adipose Tissue; Animals; Biological Clocks; Circadian Rhythm; Disease Models, Animal; Energy Metabolism; HEK293 Cells; Humans; Hypothalamus; Liver; Metabolome; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Muscle, Skeletal; Nuclear Receptor Subfamily 1, Group D, Member 1; Obesity; Pyrrolidines; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Thiophenes

Topics: Animals; Blood Glucose; CHO Cells; Cricetinae; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Glucosides; Humans; Hypoglycemic Agents; Inhibitory Concentration 50; Male; Mice; Molecular Structure; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes

Topics: Animals; Disease Models, Animal; Ganglia, Spinal; Indoles; Male; Neuralgia; Nociceptors; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Sciatic Nerve; Sciatic Neuropathy; Serotonin; Serotonin 5-HT2 Receptor Agonists; Thiophenes

Topics: Administration, Oral; Animals; Bone Density; Bone Density Conservation Agents; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Femur; Immunohistochemistry; Organometallic Compounds; Ovariectomy; Random Allocation; Rats; Rats, Wistar; Reference Values; Stress, Mechanical; Thiophenes; Treatment Outcome

Topics: Administration, Topical; Animals; Benzamides; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ointments; PPAR gamma; PPAR-beta; Psoriasis; Recombinant Proteins; Skin; Skin Absorption; Sulfones; Thiophenes

Topics: Administration, Oral; Animals; Antioxidants; Bone Density Conservation Agents; Catalase; Disease Models, Animal; Drug Administration Schedule; Female; Glutathione Peroxidase; Humans; Kidney; Lipid Peroxidation; Liver; Organometallic Compounds; Osteoporosis; Osteoporosis, Postmenopausal; Ovariectomy; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Thiophenes

Topics: Animals; Atherosclerosis; Benzimidazoles; CD36 Antigens; Cell Line; Diabetes Complications; Disease Models, Animal; Dyslipidemias; Humans; Hypertriglyceridemia; Insulin Resistance; Male; Mice; Postprandial Period; Rats; Rats, Wistar; Thiophenes

Topics: Analysis of Variance; Animals; Anti-Obesity Agents; Blood Glucose; Body Mass Index; Body Weight; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Antagonists; Cholesterol; Dietary Fats; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation; Hypothalamus; Indazoles; Intra-Abdominal Fat; Liver; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin Plasma Membrane Transport Proteins; Thiophenes; Transaminases; Triglycerides

Topics: Amitriptyline; Animals; Anti-Ulcer Agents; Antidepressive Agents; Disease Models, Animal; Duloxetine Hydrochloride; Fluoxetine; Immersion; Indomethacin; Male; Mianserin; Mirtazapine; Rats; Rats, Sprague-Dawley; Reserpine; Restraint, Physical; Stomach Ulcer; Stress, Psychological; Thiophenes; Water

Topics: Animals; Calmodulin; Carbonic Anhydrase II; Cloprostenol; Disease Models, Animal; Glaucoma; HMGB1 Protein; HSP70 Heat-Shock Proteins; Intraocular Pressure; Ophthalmic Solutions; Peptide Mapping; Proteome; Proteomics; Rats; Retina; Sulfonamides; Thiophenes; Travoprost

Topics: Alkylating Agents; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Chronic Disease; Dexamethasone; Dinoprostone; Disease Models, Animal; Duloxetine Hydrochloride; Hindlimb; Iodoacetates; Male; Morphine; Muscle Fibers, Skeletal; Naproxen; Neurons, Afferent; Pain Measurement; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Restraint, Physical; Synovial Fluid; Thiophenes; Weight-Bearing

Topics: Administration, Oral; Animals; Anticoagulants; Azepines; Benzamides; Disease Models, Animal; Factor Xa Inhibitors; Femoral Artery; Lipids; Male; Morpholines; Plaque, Atherosclerotic; Prothrombin Time; Rabbits; Rivaroxaban; Thiophenes; Thrombosis

Topics: Animals; Antirheumatic Agents; Cartilage, Articular; Disease Models, Animal; Disease Progression; Dogs; Female; Gene Expression; Interleukin-1beta; Organometallic Compounds; Osteoarthritis; Peptide Hydrolases; Real-Time Polymerase Chain Reaction; Synovial Membrane; Thiophenes

Topics: Administration, Oral; Animals; Chronic Pain; Disease Models, Animal; Heterocyclic Compounds, 3-Ring; Humans; Pyrimidinones; Rats; Receptors, Metabotropic Glutamate; Structure-Activity Relationship; Thiophenes

Topics: Allosteric Regulation; Amides; Animals; Brain; Cholinergic Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Half-Life; Humans; Protein Binding; Pyridines; Rats; Receptor, Muscarinic M4; Schizophrenia; Structure-Activity Relationship; Thiophenes

Topics: Animals; Antibodies, Monoclonal; Bacterial Load; Blood Coagulation; Burkholderia pseudomallei; Cytokines; Cytoprotection; Disease Models, Animal; Female; Inflammation; Inflammation Mediators; Liver; Lung; Lysophospholipids; Melioidosis; Mice; Mice, Inbred C57BL; Oxadiazoles; Protein C; Receptor, PAR-1; Sepsis; Signal Transduction; Sphingosine; Thiophenes; Time Factors

Topics: Animals; Apoptosis; Bone Density Conservation Agents; Bone Remodeling; Chondrocytes; Disease Models, Animal; Dose-Response Relationship, Drug; Immunohistochemistry; In Situ Nick-End Labeling; Male; Menisci, Tibial; Osteoarthritis; Rats; Rats, Sprague-Dawley; SOX9 Transcription Factor; Spectrum Analysis, Raman; Thiophenes; Tibial Meniscus Injuries; Time Factors

Topics: Amides; Animals; Cells, Cultured; Disease Models, Animal; Epithelial Cells; Gene Expression; Humans; I-kappa B Kinase; Immunohistochemistry; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Nicotiana; Pulmonary Disease, Chronic Obstructive; Respiratory Tract Diseases; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smoke; Smoking; Thiophenes; Time Factors; Transcription Factor RelA

Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Brain; Disease Models, Animal; Glycogen; Hydroxyindoleacetic Acid; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Seizures; Serotonin; Thiophenes

Topics: Animals; Arthritis, Experimental; Bridged Bicyclo Compounds; Disease Models, Animal; Inhibitory Concentration 50; Lipopolysaccharides; Pyridines; Rats; Structure-Activity Relationship; Thiophenes; Tumor Necrosis Factor-alpha

Topics: Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Enzyme Inhibitors; Extracellular Matrix; Female; Glycine; Hemodynamics; Humans; Hydroxamic Acids; Infarction, Middle Cerebral Artery; Intracranial Arteriosclerosis; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Phenylalanine; Thiophenes; Treatment Outcome

Topics: Adipocytes; Animals; Blood Vessels; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Diet; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Male; Matrix Metalloproteinase 12; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Matrix Metalloproteinases, Membrane-Associated; Matrix Metalloproteinases, Secreted; Metalloendopeptidases; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Mice, Obese; Mitosis; Obesity; Phenylalanine; Protease Inhibitors; RNA, Messenger; Rosiglitazone; Stromal Cells; Thiazoles; Thiazolidinediones; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-3

Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Design; Edema; Formaldehyde; Inflammation; Molecular Structure; Pyridines; Rats; Thiophenes

Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Chi-Square Distribution; Disease Models, Animal; Drug Therapy, Combination; Endothelial Growth Factors; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Male; Matrix Metalloproteinases; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Pancreatic Neoplasms; Phenylalanine; Probability; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric; Thiophenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Animals; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Isoquinolines; Mice; Neuroprotective Agents; Phenanthrenes; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Thiophenes

Topics: Amphetamines; Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylamines; Indoles; Ketanserin; Male; Maze Learning; Mice; Motor Activity; Naphthyridines; Piperazine; Piperazines; Psychomotor Performance; Pyridines; Reaction Time; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfonamides; Thiophenes

Topics: Animals; Anticarcinogenic Agents; Carcinogens; Colon; Colonic Neoplasms; Dimethyl Fumarate; Disease Models, Animal; Enzyme Induction; Fumarates; Glucuronosyltransferase; Glutathione Transferase; Inactivation, Metabolic; Intestinal Mucosa; Liver; Male; NAD(P)H Dehydrogenase (Quinone); NADP; Pyrazines; Radiation-Sensitizing Agents; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes

Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Biogenic Monoamines; Brain; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Male; Mice; Neurons; Receptors, AMPA; Selective Serotonin Reuptake Inhibitors; Sulfonamides; Thiophenes

Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Infarction, Middle Cerebral Artery; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Phenylalanine; Rats; Rats, Wistar; Recombinant Proteins; Reperfusion; Sucrose; Survival Rate; Thiophenes; Time Factors; Tissue Plasminogen Activator; Treatment Outcome; Water

Topics: Acute Disease; Aniline Compounds; Animals; Blood Gas Analysis; Bronchoalveolar Lavage; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Fibrinogen; Injections, Intravenous; Intubation, Intratracheal; Lung; Male; Microscopy, Confocal; Pulmonary Surfactants; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Respiratory Distress Syndrome; Thiophenes

Topics: Acrylates; Animals; Antihypertensive Agents; Aspartic Acid Endopeptidases; Blood Pressure; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Glomerulosclerosis, Focal Segmental; Hypertension, Renal; Imidazoles; Kidney; Male; Metalloendopeptidases; Models, Cardiovascular; Nephritis, Interstitial; Organ Size; Osteopontin; Proteinuria; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Renin; Renin-Angiotensin System; RNA, Messenger; Sialoglycoproteins; Systole; Thiophenes

Topics: Animals; Dipeptides; Disease Models, Animal; Disease Progression; Hippocampus; Immunohistochemistry; Ischemic Attack, Transient; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Knockout; Neurons; Neuroprotective Agents; Phenylalanine; Protease Inhibitors; Thiophenes

Topics: Animals; Cell Count; Cell Death; Cell Survival; Diethylamines; Disease Models, Animal; Intraocular Pressure; Male; Nerve Crush; Neuroprotective Agents; Ocular Hypertension; Optic Nerve; Optic Nerve Diseases; Rats; Rats, Wistar; Retinal Ganglion Cells; Thiophenes

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Disease Models, Animal; Drug Design; Edema; Esters; Free Radical Scavengers; Hydrocarbons, Aromatic; Molecular Structure; Oximes; Picrates; Rats; Structure-Activity Relationship; Thiophenes

Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cyclohexanols; Cyclopropanes; Disease Models, Animal; Drug Therapy, Combination; Duloxetine Hydrochloride; Fluoxetine; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Male; Methyltyrosines; Milnacipran; Neuromuscular Junction; Norepinephrine; p-Chloroamphetamine; Pain; Paroxetine; Rats; Rats, Sprague-Dawley; Serotonin; Thiophenes; Venlafaxine Hydrochloride

Topics: Adenosine Triphosphate; Amides; Animals; Anti-Asthmatic Agents; Arthritis, Experimental; Binding, Competitive; Cell Proliferation; Chemokines; Collagen; Cytokines; Disease Models, Animal; Humans; I-kappa B Kinase; Interleukin-6; Interleukin-8; Lipopolysaccharides; Male; Mice; Mice, Inbred DBA; Monocytes; NF-kappa B; Protein Serine-Threonine Kinases; T-Lymphocytes; Thiophenes; Transcription Factor RelA; Tumor Necrosis Factor-alpha

Topics: Adenosine Deaminase; Animals; Aorta, Abdominal; Biomarkers; Disease Models, Animal; Expectorants; Glutathione Peroxidase; Malondialdehyde; Models, Cardiovascular; Motor Neurons; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Psychomotor Performance; Rabbits; Reperfusion Injury; Spinal Cord; Spinal Cord Ischemia; Superoxide Dismutase; Thioglycolates; Thiophenes; Treatment Outcome; Xanthine Oxidase

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Drug Design; Edema; Ibuprofen; Morpholines; Pyridines; Rats; Structure-Activity Relationship; Sulfhydryl Compounds; Sulfones; Thiophenes

Topics: Animals; Anticarcinogenic Agents; Bexarotene; Breast Neoplasms; Clinical Trials as Topic; Disease Models, Animal; Female; Humans; Nicotinic Acids; Piperidines; Retinoid X Receptors; Tetrahydronaphthalenes; Thiophenes

Topics: Acute Disease; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Citalopram; Disease Models, Animal; Duloxetine Hydrochloride; Male; Mianserin; Mirtazapine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes

Topics: Animals; Blood Coagulation Tests; Disease Models, Animal; Dose-Response Relationship, Drug; Factor Xa Inhibitors; Fibrinolytic Agents; Humans; Inhibitory Concentration 50; Morpholines; Rabbits; Rats; Rivaroxaban; Serine Proteinase Inhibitors; Species Specificity; Thiophenes; Thromboplastin; Venous Thrombosis

Topics: Animals; Antihypertensive Agents; Cell Count; Cell Survival; Cytoprotection; Disease Models, Animal; Glaucoma; Intraocular Pressure; Male; Ophthalmic Solutions; Rats; Rats, Wistar; Retinal Ganglion Cells; Sulfonamides; Thiophenes; Timolol

Topics: Animals; Anticonvulsants; Brain Chemistry; Cerebral Cortex; Convulsants; Disease Models, Animal; Drug Interactions; Female; Malondialdehyde; Mice; Nitric Oxide; Oxidative Stress; Pentylenetetrazole; Reaction Time; Seizures; Superoxide Dismutase; Thioglycolates; Thiophenes; Xanthine Oxidase

Topics: Acrylates; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Arteriovenous Fistula; Carboxypeptidases; Cardiomegaly; Disease Models, Animal; Heart Failure; Imidazoles; Male; Mineralocorticoid Receptor Antagonists; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Spironolactone; Thiophenes; Ventricular Remodeling

Topics: Acetylcysteine; Animals; Antioxidants; Bleomycin; Disease Models, Animal; Drug Interactions; Male; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Thioglycolates; Thiophenes

Topics: Amides; Animals; Anti-Inflammatory Agents; Asthma; Budesonide; Cells, Cultured; Chemokine CCL11; Chemokines, CC; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Expression; Granulocyte Colony-Stimulating Factor; Humans; I-kappa B Kinase; Inflammation; Interleukin-8; Muscle, Smooth; NF-kappa B; Rats; Respiratory System; Thiophenes

Topics: Age Factors; Anabolic Agents; Animals; Bone Density; Calcium; Contraceptives, Oral; Diphosphonates; Disease Models, Animal; Estrogen Replacement Therapy; Female; Fractures, Bone; Humans; Norpregnenes; Organometallic Compounds; Osteoporosis, Postmenopausal; Risk Factors; Selective Estrogen Receptor Modulators; Spinal Fractures; Thiophenes; Vitamin D

Topics: Acetylglucosaminidase; Administration, Oral; Animals; Anti-Bacterial Agents; Catalase; Disease Models, Animal; Drug Antagonism; Drug Therapy, Combination; Injections, Intraperitoneal; Kidney; Kidney Diseases; Kidney Tubules; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Thioglycolates; Thiophenes; Vancomycin

Topics: Acetamides; Animals; Anti-Anxiety Agents; Arousal; Brain; Buspirone; Chronotherapy; Conditioning, Classical; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroshock; Exploratory Behavior; Fear; Male; Maze Learning; Melatonin; Rats; Receptor, Serotonin, 5-HT2C; Receptors, Melatonin; Thiophenes; Vocalization, Animal

Topics: Adenoviridae; Animals; Brain-Derived Neurotrophic Factor; Diethylamines; Disease Models, Animal; Facial Nerve Injuries; Gene Transfer Techniques; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Male; Metallothionein 3; Motor Neuron Disease; Motor Neurons; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotective Agents; Peripheral Nerve Injuries; Peripheral Nerves; Rats; Thiophenes; Transforming Growth Factor beta

Topics: Animals; Antihypertensive Agents; Cell Count; Disease Models, Animal; Drug Combinations; Female; Glaucoma; Intraocular Pressure; Pilot Projects; Rats; Rats, Wistar; Retinal Ganglion Cells; Sulfonamides; Thiophenes; Time Factors; Timolol

Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; DNA; Enzyme Inhibitors; Humans; I-kappa B Kinase; Interleukin-1; Lipopolysaccharides; Lung Diseases; Matrix Metalloproteinase 9; Pancreatic Elastase; Rats; Thiophenes; Tumor Necrosis Factor-alpha

Topics: Adenocarcinoma; Animals; Cell Division; Cell Line, Tumor; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Phenylalanine; Protease Inhibitors; Protein Kinase Inhibitors; Quinazolines; Survival Rate; Thiophenes

Topics: AMP-Activated Protein Kinases; Animals; Biphenyl Compounds; Cell Line; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Fatty Acid Synthases; Glucose-6-Phosphatase; Hepatocytes; Humans; In Vitro Techniques; Metabolic Syndrome; Metformin; Mice; Mice, Obese; Molecular Weight; Multienzyme Complexes; Phosphoenolpyruvate Carboxykinase (GTP); Protein Serine-Threonine Kinases; Pyrones; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiophenes

Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Dopamine Agonists; Helplessness, Learned; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Tetrahydronaphthalenes; Thiophenes

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antineoplastic Agents; Autoradiography; Cocaine; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Interactions; Iodine Isotopes; Male; Mice; Mice, Inbred ICR; Mice, Knockout; NF-E2-Related Factor 2; Parkinsonian Disorders; Phenotype; Thiones; Thiophenes

Topics: Acetylcysteine; Animals; Blood Pressure; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Free Radical Scavengers; Glutathione; Lung; Macrophages, Alveolar; Male; Malondialdehyde; Neutrophils; Premedication; Random Allocation; Rats; Rats, Wistar; Respiratory Distress Syndrome; Shock, Hemorrhagic; Thioglycolates; Thiophenes

Topics: Amides; Animals; Anti-Inflammatory Agents; Biomarkers; Budesonide; Disease Models, Animal; Exhalation; Lipopolysaccharides; Nitric Oxide; Pneumonia; Rats; Rats, Wistar; Respiratory System; Thiophenes

Topics: Animals; Cell Division; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Nicotinic Acids; Piperidines; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Survival Rate; Tetrahydronaphthalenes; Thiophenes

Topics: Animals; Asthma; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Eosinophils; Immunoglobulin E; Inflammation; Interleukin-5; Isoquinolines; Lung; Mice; Mice, Knockout; Ovalbumin; Pneumonia; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Respiratory Hypersensitivity; Th2 Cells; Thiophenes

Topics: Amphetamines; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Benzodiazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Indoles; Male; Maze Learning; Mice; Serotonin Receptor Agonists; Thiophenes

Topics: Animals; Antiparasitic Agents; Disease Models, Animal; Guanidines; Leishmania; Mice; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium; Thiophenes; Trypanosoma

Topics: Animals; Benzyl Compounds; Blood-Brain Barrier; Dexamethasone; Dimethyl Sulfoxide; Disease Models, Animal; Drug Combinations; Drug Evaluation, Preclinical; Encephalitis; Endothelial Cells; Enzyme Inhibitors; Genetic Variation; Heterocyclic Compounds, 1-Ring; Inflammation Mediators; Lipopolysaccharides; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Pentoxifylline; Phenylalanine; Rats; Rats, Inbred WKY; Solvents; Species Specificity; Succinates; Sulfones; Thiophenes

Topics: Anastomosis, Surgical; Angiopoietin-1; Animals; Bone Morphogenetic Protein Receptors; Brachiocephalic Trunk; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Isoxazoles; Pulmonary Artery; RNA, Messenger; Swine; Thiophenes

Topics: Administration, Oral; Animals; Anticoagulants; Blood Coagulation Tests; Disease Models, Animal; Dose-Response Relationship, Drug; Factor Xa Inhibitors; Fibrinolytic Agents; Fondaparinux; Hemorrhage; Humans; Infusions, Intravenous; Injections, Intravenous; Jugular Veins; Ligation; Morpholines; Nadroparin; Polysaccharides; Rabbits; Random Allocation; Rivaroxaban; Thiophenes; Thromboplastin; Venous Thrombosis

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Rats; Structure-Activity Relationship; Thiophenes

Topics: Acridines; Animals; Antioxidants; Colitis; Collagen; Colon; Disease Models, Animal; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Expectorants; Female; Free Radical Scavengers; Glutathione; Luminescence; Luminol; Malondialdehyde; Oxidative Stress; Peroxidase; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Thioglycolates; Thiophenes; Trinitrobenzenesulfonic Acid

Topics: Analgesics; Animals; Behavior, Animal; Cyclophosphamide; Cystitis; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Ketorolac; Male; Mice; Morphine; Pain; Pain Measurement; Thiophenes

Topics: Animals; Catalase; Chemoprevention; Cyclosporine; Disease Models, Animal; Expectorants; Fibrosis; Glutathione Peroxidase; Heart; Heart Diseases; Immunosuppressive Agents; Male; Malondialdehyde; Myocardium; Nitric Oxide; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar; Superoxide Dismutase; Thioglycolates; Thiophenes

Topics: Analgesics; Animals; Antidepressive Agents; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Formaldehyde; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Selective Serotonin Reuptake Inhibitors; Thiophenes; Time Factors

Topics: Animals; Antiviral Agents; Disease Models, Animal; Interferon-gamma; Matrix Metalloproteinase 12; Matrix Metalloproteinase 7; Matrix Metalloproteinase 8; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenylalanine; Reverse Transcriptase Polymerase Chain Reaction; Thiophenes; Tissue Inhibitor of Metalloproteinases; Tumor Necrosis Factor-alpha

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Administration, Intranasal; Allergens; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Histamine; Male; Nasal Mucosa; Nasal Obstruction; Nose; Ovalbumin; Pressure; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Rhinitis, Allergic, Perennial; Thiophenes; Time Factors

Topics: Animals; Blood Glucose; Disease Models, Animal; Dose-Response Relationship, Drug; Glucagon; Glucose; Glucose Tolerance Test; Glycogen Phosphorylase; Glycogen Synthase; Hepatocytes; Hyperglycemia; Inhibitory Concentration 50; Male; Obesity; Quinolones; Rats; Rats, Wistar; Rats, Zucker; Thiophenes

Topics: Animals; Bone Density Conservation Agents; Bone Resorption; Bony Callus; Disease Models, Animal; Fracture Healing; Male; Organometallic Compounds; Osteogenesis; Radiography; Rats; Rats, Wistar; Thiophenes; Tibia

Topics: Animals; Aquaporin 5; Disease Models, Animal; Female; Fluorescent Antibody Technique; Mice; Mice, Inbred ICR; Muscarinic Agonists; Quinuclidines; Radiation Dosage; Reverse Transcriptase Polymerase Chain Reaction; Saliva; Secretory Rate; Submandibular Gland; Submandibular Gland Diseases; Thiophenes; Time Factors; X-Rays; Xerostomia

Topics: Animals; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cholestasis, Intrahepatic; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Phenobarbital; Protective Agents; Pyrazines; Pyridines; RNA, Messenger; Symporters; Thiones; Thiophenes; Time Factors; Up-Regulation

Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Corneal Neovascularization; Corneal Stroma; Disease Models, Animal; Drug Implants; Fibroblast Growth Factor 2; Latanoprost; Prostaglandins F, Synthetic; Quinoxalines; Rats; Rats, Wistar; Sulfonamides; Thiophenes; Timolol

Topics: Alcohol Deterrents; Animals; Behavior, Addictive; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Ethanol; Male; Naltrexone; Pyrimidines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Saccharin; Self Administration; Sweetening Agents; Thiophenes

Topics: Acetyl-CoA C-Acetyltransferase; Actins; Animals; Apolipoproteins E; Apoptosis; Atherosclerosis; Caspase 3; Cells, Cultured; Disease Models, Animal; DNA Damage; Endothelial Cells; Enzyme Inhibitors; Foam Cells; Hydrogen Peroxide; Isoquinolines; Ketocholesterols; MAP Kinase Kinase 4; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Necrosis; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Thiophenes; Time Factors; Tumor Necrosis Factor-alpha

Topics: Allergens; Animals; Cytokines; Disease Models, Animal; Inflammation; Isoquinolines; Lung; Mice; Mice, Inbred C57BL; Mucus; Ovalbumin; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Respiratory Hypersensitivity; Th2 Cells; Thiophenes; Treatment Outcome

Topics: Animals; Anti-Bacterial Agents; Bronchial Hyperreactivity; Bronchitis; Cells, Cultured; Disease Models, Animal; Doxycycline; Furans; Gene Expression; I-kappa B Kinase; Lymphocytes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Smooth; Neutrophils; NF-kappa B; Respiratory Mucosa; RNA; Thiophenes; Transgenes

Topics: Animals; Carbonic Anhydrase Inhibitors; Disease Models, Animal; Fluorescein Angiography; Hypoxia; Injections, Intravenous; Ion-Selective Electrodes; Ischemia; Oxygen; Oxygen Consumption; Partial Pressure; Retina; Retinal Vein Occlusion; Sulfonamides; Swine; Thiophenes

Topics: Acylation; Aminopyridines; Animals; Anorexia; Antineoplastic Agents; Body Weight; Chalcones; Cisplatin; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Eating; Flavones; Gastric Mucosa; Gastrointestinal Agents; Ghrelin; Hesperidin; Indoles; Male; Oligopeptides; Piperazines; Protein Binding; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Receptors, Ghrelin; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Receptor Agonists; Stomach; Thiophenes; Vagotomy

Topics: Animals; Aspirin; Blood Platelets; Dipyridamole; Disease Models, Animal; Fibrinolytic Agents; Heparin; Lasers; Male; Mesenteric Arteries; Mesenteric Vascular Occlusion; Molsidomine; Oxazoles; Platelet Aggregation; Propionates; Pyrazoles; Pyrazolones; Rats; Rats, Inbred Strains; Sydnones; Thiophenes; Thrombosis; Ticlopidine

Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation; Epilepsy; Gerbillinae; Seizures; Thiophenes; Valproic Acid

Topics: Animals; Carbamazepine; Disease Models, Animal; Drug Evaluation; Epilepsy; Female; Ferrets; Male; Thiophenes

Topics: Animals; Aspirin; Disease Models, Animal; Disseminated Intravascular Coagulation; Endotoxins; Female; Fibrin Fibrinogen Degradation Products; Fibrinogen; Kidney Glomerulus; Partial Thromboplastin Time; Platelet Count; Prothrombin Time; Rats; Rats, Inbred Strains; Thiophenes; Ticlopidine

Topics: Administration, Oral; Animals; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Femoral Artery; Fibrinolytic Agents; Injections, Intravenous; Platelet Aggregation; Thiophenes; Thrombosis; Ticlopidine; Verapamil

Topics: Adenosine Triphosphate; Anemia, Aplastic; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Benzo(a)pyrene; Benzopyrenes; Bone Marrow; Bone Marrow Cells; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Dicumarol; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Leukemia, Experimental; Male; Methionine Sulfoximine; Mice; Mice, Inbred DBA; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Quinones; Stromal Cells; Superoxide Dismutase; Thiones; Thiophenes

Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Captopril; Disease Models, Animal; Kidney Failure, Chronic; Male; Naphthalenes; Nephrectomy; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Thiophenes

Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cardiomegaly; Catecholamines; Cells, Cultured; Creatine Kinase; Disease Models, Animal; Glycogen; Heart; Heart Rate; Infusion Pumps, Implantable; Infusions, Intravenous; L-Lactate Dehydrogenase; Microscopy, Electron; Myocardium; Rats; Rats, Sprague-Dawley; Rats, Wistar; Tetrazoles; Thiophenes

Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Biological Assay; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Indomethacin; Interleukin-1; Male; Mice; Peritonitis; Thiophenes; Zymosan

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Bromocriptine; Disease Models, Animal; Dominance, Cerebral; Dopamine Agents; Female; Injections, Intramuscular; Macaca nemestrina; Male; Oxazines; Oxidopamine; Parkinson Disease, Secondary; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Stereotyped Behavior; Substantia Nigra; Tetrahydronaphthalenes; Thiophenes

Topics: Aniline Compounds; Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Brain Ischemia; Cerebral Infarction; Crystallography, X-Ray; Disease Models, Animal; Gerbillinae; Hippocampus; Isomerism; Male; Mice; Molecular Structure; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Thiophenes

Topics: Adenocarcinoma, Mucinous; Animals; Colonic Neoplasms; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Humans; Male; Metalloendopeptidases; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Phenylalanine; Thiophenes; Transplantation, Heterologous

Topics: Adenocarcinoma; Adenosine Triphosphate; Aniline Compounds; Animals; Antineoplastic Agents; Chlorocebus aethiops; Colonic Neoplasms; Disease Models, Animal; Epithelium; Female; Humans; Hydrolysis; Male; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Nude; Mitochondria, Liver; Models, Biological; Neoplasm Transplantation; Ovarian Neoplasms; Oxygen Consumption; Thiophenes; Transplantation, Heterologous; Tumor Cells, Cultured; Urinary Bladder Neoplasms

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Chlorpheniramine; Disease Models, Animal; Guinea Pigs; Indomethacin; Male; Methacrylates; Ovalbumin; Propranolol; Prostaglandin Endoperoxides, Synthetic; SRS-A; Thiophenes; Thromboxane A2; Thromboxane-A Synthase; Vasoconstrictor Agents

Topics: Animals; Brain; Carrier Proteins; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Evaluation Studies as Topic; Fluorine Radioisotopes; Isotope Labeling; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Parkinson Disease; Piperidines; Radioligand Assay; Thiophenes; Tomography, Emission-Computed

Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eosinophils; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Pulmonary Eosinophilia; Thiophenes; Thromboxane-A Synthase

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Behavior, Animal; Callithrix; CHO Cells; Corpus Striatum; Cricetinae; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Fishes; Humans; Kinetics; Male; Mice; Parkinson Disease, Secondary; Prodrugs; Pyridines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Tetrahydronaphthalenes; Thiophenes

Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chlordiazepoxide; Disease Models, Animal; Indoles; Male; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Thiophenes; Urea

Topics: Administration, Oral; Animals; Bone Density; Disease Models, Animal; Dose-Response Relationship, Drug; Electron Probe Microanalysis; Female; Humans; Ilium; Macaca fascicularis; Male; Organometallic Compounds; Osteoporosis, Postmenopausal; Spectrometry, X-Ray Emission; Spectrum Analysis, Raman; Strontium; Thiophenes; Tissue Distribution; Uncoupling Agents; X-Ray Diffraction

Topics: Animals; Autoimmune Diseases; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Disease Models, Animal; Disease Progression; Estradiol Congeners; Estrogen Antagonists; Ethinyl Estradiol; Female; Kidney; Lupus Erythematosus, Systemic; Lymph Nodes; Mice; Mice, Inbred MRL lpr; Molecular Structure; Pyrrolidines; Receptors, Estrogen; Thiophenes; Thymus Gland

Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Carbonic Anhydrase Inhibitors; Chymotrypsin; Circadian Rhythm; Disease Models, Animal; Epinephrine; Female; Glaucoma; Intraocular Pressure; Ophthalmic Solutions; Rabbits; Sulfonamides; Telemetry; Thiophenes; Timolol

Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease Models, Animal; Enzyme Inhibitors; Insulin; Lipids; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymers; Rats; Regional Blood Flow; Sciatic Nerve; Sucrose; Tetrazoles; Thiophenes

Topics: Administration, Oral; Alkylation; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Ethers; Humans; Leukemia, Basophilic, Acute; Leukocytes, Mononuclear; Lipoxygenase Inhibitors; Male; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfides; Sulfonamides; Thiophenes; Tumor Cells, Cultured

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benzazepines; Disease Models, Animal; Dopamine Agonists; Drug Evaluation, Preclinical; Drug Interactions; Female; Macaca nemestrina; Parkinson Disease, Secondary; Receptors, Dopamine D1; Receptors, Dopamine D2; Tetrahydronaphthalenes; Thiophenes

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase Inhibitors; Disease Models, Animal; Dogs; Evaluation Studies as Topic; Female; Inflammation; Leukotriene B4; Lipoxygenase Inhibitors; Male; Sulfonamides; Thiophenes

Topics: Animals; Antigens, CD19; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; B-Lymphocytes; Cell Lineage; Combined Modality Therapy; Disease Models, Animal; Enzyme Inhibitors; Humans; Immunotoxins; Mice; Mice, SCID; N-Glycosyl Hydrolases; Plant Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Ribosome Inactivating Proteins, Type 1; Survival Analysis; Thiophenes; Thymidylate Synthase

Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bifidobacterium; Disease Models, Animal; Drug Therapy, Combination; Gram-Negative Bacteria; Gram-Positive Rods; Ileal Diseases; Injections, Subcutaneous; Lactobacillus acidophilus; Lipid Peroxidation; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Thiophenes; Ulcer

Topics: Acrylates; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Cardiomegaly; Disease Models, Animal; Dose-Response Relationship, Drug; Enalapril; Heart Failure; Hemodynamics; Imidazoles; Kidney; Male; Rats; Rats, Wistar; Renal Circulation; Sodium; Thiophenes

Topics: Animals; Antibodies, Monoclonal; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Male; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar; Thiophenes

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adamantane; Animals; Benzopyrans; Callithrix; Disease Models, Animal; Dopamine Agents; Dopamine Agonists; Dyskinesia, Drug-Induced; Female; Levodopa; Locomotion; Male; Quinolones; Receptors, Dopamine D1; Thiophenes

Topics: Animals; Anticoagulants; Binding Sites; Crystallography, X-Ray; Disease Models, Animal; Humans; Models, Molecular; Rats; Structure-Activity Relationship; Thiophenes; Thrombin; Thrombosis

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Interactions; Indomethacin; Inflammation; Isoenzymes; Leukocytes; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Rats; Rats, Wistar; Thiophenes

Topics: Animals; Animals, Newborn; Collagenases; Disease Models, Animal; Gelatinases; Injections, Intraperitoneal; Ischemia; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Mice; Mice, Inbred C57BL; Phenylalanine; Protease Inhibitors; Retina; Retinal Neovascularization; Retinal Vessels; Thiophenes; Urokinase-Type Plasminogen Activator

Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thiophenes; Thymidine; Transplantation, Heterologous; Tumor Cells, Cultured

Topics: Administration, Oral; Animals; Cell Count; Cells, Cultured; Central Nervous System Stimulants; Choline O-Acetyltransferase; Cyclic AMP; Diethylamines; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Forelimb; Hand Strength; L-Lactate Dehydrogenase; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Motor Neuron Disease; Muscle, Skeletal; Organ Size; Spinal Cord; Thiophenes

Topics: Adenosine Diphosphate; Administration, Oral; Animals; Arteriovenous Shunt, Surgical; Binding, Competitive; Bleeding Time; Blood Platelets; Clopidogrel; Collagen; Cyclic AMP; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Thionucleotides; Thiophenes; Thrombin; Thrombosis; Ticlopidine; Time Factors; Tritium

Topics: Animals; Cardiomegaly; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Hypertrophy; Hypoxia; Isoxazoles; Male; Monocrotaline; Oxygen; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Thiophenes; Vasoconstriction; Weight Gain

Topics: Animals; Animals, Newborn; Brain; Cell Membrane; Cells, Cultured; Chemokine CX3CL1; Chemokines, CX3C; Chemotaxis; Culture Media, Conditioned; Disease Models, Animal; Encephalitis; Endothelium, Vascular; Glutamic Acid; Infarction, Middle Cerebral Artery; Interleukin-1; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Membrane Proteins; Microglia; Monocytes; Neurons; Phenylalanine; Protease Inhibitors; Rats; RNA, Messenger; Thiophenes; Transfection; Tumor Necrosis Factor-alpha

Topics: Animals; Brain Ischemia; Disease Models, Animal; Dogs; Drug Design; Enzyme Inhibitors; Humans; Isoquinolines; Kinetics; Macaca fascicularis; Male; Mice; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Stroke; Tetrahydroisoquinolines; Thiophenes

Topics: Adenylyl Cyclases; Administration, Oral; Animals; Binding, Competitive; Brain; Cognition; Disease Models, Animal; Electric Stimulation; HeLa Cells; Humans; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Recombinant Proteins; Seizures; Serotonin Antagonists; Sulfonamides; Thiophenes; Transfection

Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Disease Models, Animal; Drug Administration Schedule; Drug Synergism; Female; Interleukin-12; Mammary Neoplasms, Experimental; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Phenylalanine; Protease Inhibitors; Thiophenes

Topics: Animals; Cerebral Hemorrhage; Disease Models, Animal; Fibrinolytic Agents; Humans; Intracranial Embolism; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Rabbits; Stroke; Thiophenes; Thromboembolism; Tissue Plasminogen Activator

Topics: Animals; Antipyrine; Autoradiography; Brain Ischemia; Carbon Radioisotopes; Cerebral Infarction; Cerebrovascular Circulation; Disease Models, Animal; Estrogen Antagonists; Estrogen Replacement Therapy; Female; Humans; Ovariectomy; Piperidines; Rats; Rats, Wistar; Receptors, Estrogen; Thiophenes

Topics: Animals; Disease Models, Animal; Kidney; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Phenylalanine; Polycystic Kidney, Autosomal Dominant; Protease Inhibitors; Rats; Rats, Inbred Strains; RNA, Messenger; Thiophenes; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta; Transforming Growth Factor beta2

Topics: Administration, Oral; Animals; Bronchitis; Bronchoalveolar Lavage Fluid; Chronic Disease; Disease Models, Animal; Expectorants; Hypochlorous Acid; Inflammation; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred BALB C; Reactive Oxygen Species; Thioglycolates; Thiophenes; Tumor Necrosis Factor-alpha

Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cell Nucleus; Disease Models, Animal; Disease Susceptibility; DNA-Binding Proteins; Epoxide Hydrolases; Female; FMN Reductase; Gene Expression; Genotype; Glucuronosyltransferase; Glutathione Transferase; Mice; Mice, Inbred ICR; Mice, Knockout; NADH, NADPH Oxidoreductases; NF-E2-Related Factor 2; Pyrazines; Stomach Neoplasms; Thiones; Thiophenes; Trans-Activators

Topics: Analysis of Variance; Animals; Antineoplastic Agents; Carcinoma, Large Cell; Cisplatin; Disease Models, Animal; Doxorubicin; Humans; Lung Neoplasms; Male; Mitomycin; Neoplasm Invasiveness; Neoplasm Transplantation; Phenylalanine; Rats; Rats, Nude; Survival Rate; Thiophenes; Treatment Outcome; Xenograft Model Antitumor Assays

Topics: Animals; Chronic Disease; Colitis, Ulcerative; Disease Models, Animal; Hematoxylin; Intestinal Mucosa; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Peroxidase; Phenylalanine; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Thiophenes; Trinitrobenzenesulfonic Acid

Topics: Animals; Binding Sites; Carbamates; Cell Adhesion; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Guanidine; Osteoporosis; Parathyroidectomy; Platelet Glycoprotein GPIIb-IIIa Complex; Rats; Receptors, Vitronectin; Sensitivity and Specificity; Sulfonamides; Thiophenes; Thyroidectomy

Topics: Angiography; Animals; Blood Flow Velocity; Capillaries; Disease Models, Animal; Endothelial Growth Factors; Enzyme Activation; Femoral Artery; Fibroblast Growth Factor 2; Hindlimb; Interleukin-10; Ischemia; Laser-Doppler Flowmetry; Lymphokines; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Phenylalanine; Platelet Endothelial Cell Adhesion Molecule-1; Protease Inhibitors; Thiophenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Animals; Carcinoma, Adenoid Cystic; Disease Models, Animal; Female; Lung Neoplasms; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Phenylalanine; Protease Inhibitors; Salivary Gland Diseases; Thiophenes

Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Edema; Leukotriene Antagonists; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Pleurisy; Pyrazoles; Pyridines; Rabbits; Rats; Receptors, Leukotriene; Structure-Activity Relationship; Thiophenes; Thromboxane-A Synthase

Topics: Animals; Brain Ischemia; Calcium; Cell Death; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Circulation; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Rats; Rats, Inbred SHR; Sodium; Sodium-Hydrogen Exchangers; Thiophenes; Treatment Outcome

Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Disease Models, Animal; Humans; Male; Matrix Metalloproteinase Inhibitors; Neoplasm Metastasis; Phenylalanine; Prostatic Neoplasms; Thiophenes

Topics: Animals; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Bone Remodeling; Bone Transplantation; Calcium; Disease Models, Animal; Fetal Tissue Transplantation; Humans; Immunohistochemistry; In Situ Hybridization; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, SCID; Neoplasm Metastasis; Oligonucleotide Probes; Osteoclasts; Phenylalanine; Prostatic Neoplasms; RNA, Messenger; Thiophenes; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

Topics: Animals; Depression, Chemical; Disease Models, Animal; Guanidines; Interleukin-8; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Peroxidase; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Thiophenes

Topics: Animals; Carotid Arteries; Carotid Artery Injuries; Catheterization; Cell Count; Cell Division; Cell Movement; Cyclophosphamide; Disease Models, Animal; Male; Metalloendopeptidases; Muscle, Smooth, Vascular; Phenylalanine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thiophenes; Tunica Intima

Topics: Animals; Blood Flow Velocity; Brain; Brain Ischemia; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; Enzyme Inhibitors; Intracranial Embolism; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Phenylalanine; Rats; Rats, Inbred SHR; Sodium, Dietary; Survival Rate; Thiophenes; Thrombolytic Therapy; Tissue Plasminogen Activator

Topics: Angioplasty, Balloon; Animals; Arteries; Cell Movement; Constriction, Pathologic; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Hydroxamic Acids; Hyperplasia; Male; Matrix Metalloproteinase Inhibitors; Muscle, Smooth, Vascular; Oligopeptides; Phenylalanine; Rats; Receptors, Vitronectin; Thiophenes; Tunica Intima

Topics: Animals; Carbachol; Disease Models, Animal; Duodenal Ulcer; Gastric Mucosa; Histamine H1 Antagonists; Pentagastrin; Pyrrolidines; Rats; Thiophenes

Topics: Adrenergic beta-Antagonists; Animals; Carotid Arteries; Disease Models, Animal; Hemodynamics; Injections, Intravenous; Migraine Disorders; Pindolol; Propanolamines; Propranolol; Receptors, Serotonin; Swine; Thiophenes

Topics: Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cells, Cultured; Disease Models, Animal; Erythrocytes; Furans; Glutathione; Guinea Pigs; Humans; Ocular Hypertension; Rabbits; Structure-Activity Relationship; Sulfonamides; Thiophenes

Topics: Animals; Anticonvulsants; Disease Models, Animal; Male; Morphine; Narcotics; Pain; Peripheral Nerves; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes

Topics: Alzheimer Disease; Animals; Avoidance Learning; Binding, Competitive; Cognition Disorders; Copper; Disease Models, Animal; Male; Memory; Mice; Motor Activity; Parasympathomimetics; Pilocarpine; Quinuclidines; Quinuclidinyl Benzilate; Receptors, Muscarinic; Thiophenes

Topics: Administration, Oral; Airway Resistance; Aminophylline; Anaphylaxis; Animals; Asthma; Bronchodilator Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Epinephrine; Female; Guinea Pigs; Injections, Intravenous; Lung Compliance; Male; Molecular Structure; Thiophenes

Topics: Alzheimer Disease; Animals; Aziridines; Behavior, Animal; Choline; Cognition Disorders; Disease Models, Animal; Drug Design; Male; Molecular Structure; Parasympathomimetics; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Thiophenes

Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy; Hippocampus; Kindling, Neurologic; Microcephaly; Rats; Thiophenes

Topics: Animals; Blood Pressure; Coronary Circulation; Disease Models, Animal; Embolism; Female; Heart Failure; Heart Rate; Male; Platelet Aggregation; Swine; Thiophenes; Ticlopidine

Topics: Adrenergic beta-Antagonists; Amino Alcohols; Animals; Anti-Arrhythmia Agents; Anura; Arrhythmias, Cardiac; Benzopyrans; Disease Models, Animal; Dogs; Epinephrine; Guinea Pigs; Ligation; Ouabain; Propanolamines; Propranolol; Propylamines; Sciatic Nerve; Sulfides; Thiophenes

Topics: Animals; Carbenicillin; Carboxylic Acids; Disease Models, Animal; Penicillins; Pseudomonas aeruginosa; Pyelonephritis; Rats; Thiophenes

Topics: Animals; Anti-Bacterial Agents; Carbenicillin; Carboxylic Acids; Disease Models, Animal; Drug Synergism; Female; Gentamicins; Immunosuppressive Agents; Penicillins; Pseudomonas Infections; Rats; Thiophenes

Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Disease Models, Animal; DNA, Neoplasm; Ependymoma; Glycosides; Injections; Injections, Subcutaneous; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Podophyllotoxin; Thiophenes; Thymidine; Tritium

Topics: Angiography; Animals; Benzyl Compounds; Body Weight; Carboxylic Acids; Dipyridamole; Disease Models, Animal; Electrocardiography; Glycols; Hydrocortisone; Indomethacin; Isoproterenol; Male; Microradiography; Microscopy, Electron; Myocardial Infarction; Myocardium; Organ Size; Phenoxybenzamine; Phenylbutazone; Propranolol; Pyridines; Rats; Rats, Inbred Strains; Thiophenes