thiophenes has been researched along with Colonic Neoplasms in 81 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 27 (33.33) | 18.2507 |
| 2000's | 38 (46.91) | 29.6817 |
| 2010's | 14 (17.28) | 24.3611 |
| 2020's | 2 (2.47) | 2.80 |
| Authors | Studies |
|---|---|
| Artru, P; Auclin, E; Basile, D; Coutzac, C; Dior, M; Dubreuil, O; Faroux, R; Gallois, C; Hafliger, E; Hautefeuille, V; Locher, C; Palmieri, LJ; Pellat, A; Pernot, S; Perret, A; Randrian, V; Taieb, J; Turpin, A | 1 |
| Gandhi, T; Kong, J; Koya, J; Patel, K; Patki, M; Reznik, S; Yoganathan, S | 1 |
| Chambers, C; Giani, J; Sawyer, MB | 1 |
| Huang, J; Liao, X; Lin, W; Long, Z; Ma, W; Xie, Y | 1 |
| Chowdhury, SR; Dhatchana Moorthy, N; Gunasekaran, K; Iqbal, S; Karunakaran, J; Majumder, HK; Mohanakrishnan, AK; Vellaichamy, E | 1 |
| Altun, A; Kaya, TT; Turgut, NH | 1 |
| Chen, Z; Dai, CY; Lv, W; Ma, ZJ; Xu, DG; Xu, GH; Zhu, FF | 1 |
| Bovet, C; Erzinger, MM; Sturla, SJ; Uzozie, A | 1 |
| Ahluwalia, D; Bhupathi, D; Hart, CP; Liu, Q; Matteucci, MD; Meng, F; Sun, JD; Wang, Y | 1 |
| Bedenne, L; Carrato, A; Collette, L; El-Serafi, M; Kerr, D; Labianca, R; Mini, E; Paillot, B; Popov, I; Praet, M; Raffaele Bianco, A; Sanches, E; Sobrero, A; Vincent, M; Welch, J; Wils, J | 1 |
| Waldman, AS; Wyatt, MD; Yang, Z | 1 |
| Demetter, P; Geurs, F; Knape, S; Ponette, J; Ponette, S; Vandewaeter, S | 1 |
| Begleiter, A; Bird, RP; Lefas, GM; Maksymiuk, AW; Sivananthan, K | 1 |
| Serebruany, VL | 1 |
| Ban, JO; Han, SB; Hong, JT; Hwang, BY; Jeong, HS; Lee, HS; Moon, DC; Song, S; Yoon, DY | 1 |
| Fang, H; Guan, P; Jiao, J; Wang, X; Xu, W; Yuan, Y | 1 |
| Botchkina, G; Formentini, A; Ju, J; Kornmann, M; Song, B; Titmus, MA; Wang, Y | 1 |
| El-Sherif, AA; Eldebss, TM | 1 |
| Borisova, O; Ilyinsky, N; Kaluzhny, D; Livshits, M; Shchekotikhin, A; Shchyolkina, A; Shtil, A; Sinkevich, Y; Tsvetkov, PO; Tsvetkov, V; Veselovsky, A | 1 |
| Aris, SM; Pommier, Y | 1 |
| Baba, K; Hirata, M; Hirata, Y; Kawaratani, Y; Nagaoka, Y; Ohmomo, Y; Shibano, M; Taniguchi, M; Uesato, S; Yasuda, M | 1 |
| Doroshow, JH; Gaur, S; Juhasz, A; Lu, J; Markel, S; Synold, TW; van Balgooy, J; Wu, X; Xi, B | 1 |
| Can, MM; Dinicolantonio, JJ; Goto, S; Serebruany, VL | 1 |
| Binetti, P; La Cesa, A; Massacesi, C; Picardi, A; Santini, D; Tonini, G; Vincenzi, B | 1 |
| Begleiter, A; Bird, RP; Curphey, TJ; Sivananthan, K | 1 |
| Levine, L | 1 |
| Cao, S; Durrani, FA; Rustum, YM | 1 |
| Bocci, G; Danesi, R; Di Paolo, A | 1 |
| Ebert, B; Lampen, A; Seidel, A | 1 |
| Fukushima, M; Hoogeland, MF; Peters, GJ; Temmink, OH | 1 |
| Chattopadhyay, S; Goldman, ID; Krupenko, N; Krupenko, SA; Zhao, R | 1 |
| Bramlett, KS; Burris, TP; Chandrasekhar, S; Chin, WW; Chintalacharuvu, SR; Iturria, SJ; Kato, S; Khalifa, B; Linebarger, JH; Lu, J; Ma, Y; Memezawa, A; Nagpal, S; Savkur, RS; Stayrook, KR; Yamamoto, Y; Yamaoka, K; Yee, YK; Yu, XP; Zeng, QQ | 1 |
| Cooper, RD; Daniel-Issakani, S; Goff, D; Goldstein, E; Gururaja, TL; Hitoshi, Y; Huang, J; Kinoshita, T; McLaughlin, J; Pali, E; Payan, DG; Singh, R; Yung, S | 1 |
| Chen, XB; Cherukuri, DP; Goulet, AC; Han, Y; Heimark, RL; Meuillet, E; Nelson, MA; Regan, JW; Young, RN | 1 |
| Ban, JO; Chung, YB; Hong, JT; Hwang, BY; Jeong, HS; Kim, DJ; Kim, TM; Lee, US; Oh, KW; Woo, KS; Yuk, DY | 1 |
| Czaykowski, PM | 1 |
| Holt, PR; Liu, T; Mokuolu, AO; Rao, CV; Reddy, BS | 1 |
| Brown, PD | 1 |
| Brown, PD; Crimmin, MJ; Fu, X; Hoffman, RM; Wang, X | 1 |
| Chen, LB; Garlid, KD; Hu, J; Song, K; Sun, X; Wong, JR | 1 |
| Lehman, NL; Moran, RG; Smith, SG | 1 |
| Malmberg, M; Rustum, YM; Slocum, HK; Yin, MB; Zhang, ZG | 1 |
| Katiwalla, M; Kelloff, GJ; Rao, CV; Reddy, BS; Rivenson, A | 1 |
| Allegra, CJ; Drake, JC; Johnston, PG; Moran, RG | 1 |
| Arredondo, MA; Matsui, SI; Rustum, YM; Wrzosek, C | 1 |
| Horowitz, RW; Ladner, RD; Schwartz, EL; Wadler, S; Zhang, H | 1 |
| Bertino, JR; Chang, YM; Chou, TC; Gorlick, R; Izzo, J; Longo, GS; Tong, WP; Zielinski, Z | 1 |
| Reddy, BS | 1 |
| Aschele, C; Baldo, C; Bertino, JR; Bornmann, WG; Debernardis, D; Sobrero, AF | 1 |
| McCann, J | 1 |
| Bours, V; Fillet, G; Jerusalem, G | 1 |
| Clayton, M; Halbherr, T; Myers, CB; O'Dwyer, PJ; Yao, Ks | 1 |
| Aiba, K; Akazawa, S; Fukuoka, M; Furue, H; Furuse, K; Horikoshi, N; Kanamaru, R; Konishi, T; Kotake, T; Kudoh, S; Kurihara, M; Niitani, H; Ota, K; Sakata, Y; Taguchi, T; Tsukagoshi, S; Wakui, A; Yoshida, S | 1 |
| Aparicio, T; Dessirier, V; Kermorgant, S; Lehy, T; Lewin, MJ | 1 |
| Endo, W; Haridas, K; Hausheer, FH; Matsui, S; Rustum, YM; Seetharamulu, P; Wrzosek, C | 1 |
| Blaese, RM; Candotti, F; Wildner, O | 1 |
| Jansen, G; Peters, GJ; Pinedo, HM; Smid, K; Smitskamp-Wilms, E | 1 |
| Cunningham, D; Ford, HE | 1 |
| Ford, HE; Jackman, AL; Kimbell, R | 1 |
| Ebata, T; Kikkawa, N; Mitachi, Y; Nishiguchi, Y; Nishisho, I; Osanai, H; Sawai, K; Tsutsui, M; Ujiie, S; Wakasugi, H; Wakui, A; Yasutake, K | 1 |
| Backus, HH; Kuiper, CM; Peters, GJ; Pinedo, HM; van der Wilt, CL; van Triest, B | 1 |
| Kuiper, CM; Peters, GJ; van der Wilt, CL | 1 |
| Avallone, A; Casaretti, R; Catalano, G; Comella, G; Comella, P; De Lucia, L; De Vita, F; Orditura, M; Palmeri, S; Rivellini, F | 1 |
| Inoue, T; Itoh, Y; Koono, M; Nabeshima, K; Okada, Y; Seiki, M; Shimao, Y | 1 |
| Jackson, LE; Leach, MO; Maisey, NR; Ronen, SM; Smith, TA; Titley, JC | 1 |
| De Mey, J; Meysman, M; Neyns, B; Schallier, D | 1 |
| Baguley, BC; Chen, J; Deady, LW; Denny, WA; Desneves, J; Finlay, GJ; Kaye, AJ | 1 |
| Agrawal, S; Chu, E; Schmitz, JC; Yu, D | 1 |
| Akutsu, M; Furukawa, Y; Kano, Y; Suzuki, K; Tsunoda, S; Yazawa, Y | 2 |
| Backus, HH; Bunni, MA; Comijn, L; Jackman, AL; Jansen, G; Mitchell, F; Peters, GJ; Priest, DG; Smid, K; van der Wilt, CL; Veerman, G; Voorn, DA; Wouters, D | 1 |
| Andrei, G; Balzarini, J; De Clercq, E; Felder, TM; Snoeck, R; Sowell, JW; Stephens, CE | 1 |
| Backus, HH; Kuiper, CM; Peters, GJ; Pinedo, HM; van der Wilt, CL; van Groeningen, CJ; Wouters, D | 1 |
| Reutova, EV | 1 |
| Choi, WJ; Chun, MW; Jeong, LS; Kim, HO; Lee, SK; Moon, HR | 1 |
| Boyer, CR; Karjian, PL; Neuteboom, ST; Pegram, M; Wahl, GM | 1 |
| Bardiau, C; Guillouzo, A; Lagadic-Gossmann, D; Le Ferrec, E; Le Vee, M; Maheo, K; Massiere, F; Morel, F; Rauch, C | 1 |
| Aherne, GW; Brunton, L; Jackman, AL; Kimbell, R; Melin, CJ; Theti, DS; Walton, M | 1 |
| Lam, LK; Zhang, J | 1 |
| Nayini, J; Rao, CV; Reddy, BS | 1 |
5 review(s) available for thiophenes and Colonic Neoplasms
| Article | Year |
|---|---|
Aggressive chronic platelet inhibition with prasugrel and increased cancer risks: revising oral antiplatelet regimens?
Topics: Animals; Aspirin; Clopidogrel; Colonic Neoplasms; Gastrointestinal Hemorrhage; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Thiophenes; Ticlopidine | 2009 |
Chemoprevention of colon cancer by dietary administration of naturally-occurring and related synthetic agents.
Topics: Allyl Compounds; Anethole Trithione; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Arachidonic Acids; Aspirin; Colon; Colonic Neoplasms; Dinoprostone; Disulfides; Eflornithine; Food, Fortified; Ibuprofen; Intestinal Mucosa; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Piroxicam; Pyrazines; Thiones; Thiophenes | 1997 |
[Drug clinics. How I treat. II. Therapeutic approaches to metastatic colorectal cancer].
Topics: Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Enzyme Inhibitors; Fluorouracil; Hospitalization; Humans; Irinotecan; Leucovorin; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Quality of Life; Quinazolines; Rectal Neoplasms; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors | 1998 |
Combination of raltitrexed with other cytotoxic agents: rationale and preclinical observations.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Quinazolines; Thiophenes; Tumor Cells, Cultured | 1999 |
A rationale for the clinical development of the thymidylate synthase inhibitor ZD9331 in ovarian and other solid tumours.
Topics: Antineoplastic Agents; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Folic Acid Antagonists; Gene Expression; Humans; Ovarian Neoplasms; Peptide Synthases; Quinazolines; RNA, Messenger; RNA, Neoplasm; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
4 trial(s) available for thiophenes and Colonic Neoplasms
| Article | Year |
|---|---|
Raltitrexed (Tomudex) versus standard leucovorin-modulated bolus 5-fluorouracil: Results from the randomised phase III Pan-European Trial in Adjuvant Colon Cancer 01 (PETACC-1).
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Quinazolines; Survival Analysis; Thiophenes; Treatment Outcome; Young Adult | 2008 |
[Phase I study of raltitrexed (ZD-1694)].
Topics: Adult; Aged; Alanine Transaminase; Anorexia; Antimetabolites, Antineoplastic; Aspartate Aminotransferases; Colonic Neoplasms; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Nausea; Neoplasms; Quinazolines; Thiophenes; Thymidylate Synthase | 1998 |
[A late phase II study of raltitrexed (ZD 1694) in chemotherapy-naive patients with advanced colorectal cancer].
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Leukopenia; Male; Middle Aged; Quinazolines; Rectal Neoplasms; Thiophenes; Thymidylate Synthase | 2000 |
Oxaliplatin and raltitrexed combined with leucovorin-modulated 5-fluorouracil i.v. bolus every two weeks: a dose finding study in advanced previously treated colorectal carcinoma. Southern Italy Cooperative Oncology Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Rectal Neoplasms; Thiophenes; Treatment Outcome | 2000 |
72 other study(ies) available for thiophenes and Colonic Neoplasms
| Article | Year |
|---|---|
First-line chemotherapy with raltitrexed in metastatic colorectal cancer: an Association des Gastro-entérologues Oncologues (AGEO) multicentre study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colonic Neoplasms; Colorectal Neoplasms; Humans; Quinazolines; Rectal Neoplasms; Retrospective Studies; Thiophenes | 2022 |
Development of an Arginine Anchored Nanoglobule with Retrograde Trafficking Inhibitor (Retro-2) for the Treatment of an Enterohemorrhagic
Topics: Animals; Arginine; Benzamides; Biological Transport; Caco-2 Cells; Cells, Cultured; Colonic Neoplasms; Disease Outbreaks; Drug Delivery Systems; Enterohemorrhagic Escherichia coli; Escherichia coli Infections; Humans; Macrophages; Mice; Nanoparticles; Thiophenes | 2019 |
Tolerability of pemetrexed and oxaliplatin in the treatment of stage III colon cancer during raltitrexed shortage.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Canada; Colonic Neoplasms; Female; Humans; Kidney Diseases; Middle Aged; Oxaliplatin; Pemetrexed; Quinazolines; Thiophenes; Tomography, X-Ray Computed; Treatment Outcome | 2021 |
APTM, a Thiophene Heterocyclic Compound, Inhibits Human Colon Cancer HCT116 Cell Proliferation Through p53-Dependent Induction of Apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Colonic Neoplasms; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Inhibitory Concentration 50; Thiophenes; Tumor Suppressor Protein p53 | 2018 |
Divergent Synthesis and Evaluation of the in vitro Cytotoxicity Profiles of 3,4-Ethylenedioxythiophenyl-2-propen-1-one Analogues.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Checkpoint Kinase 2; Colonic Neoplasms; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Thiophenes | 2019 |
Anticancer effect of COX-2 inhibitor DuP-697 alone and in combination with tyrosine kinase inhibitor (E7080) on colon cancer cell lines.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Colonic Neoplasms; Cyclooxygenase 2 Inhibitors; HT29 Cells; Humans; Neovascularization, Pathologic; Phenylurea Compounds; Protein-Tyrosine Kinases; Quinolines; Thiophenes | 2014 |
2-(Pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene induces apoptosis through reactive oxygen species-mediated JNK activation in human colon cancer SW620 cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Echinops Plant; Enzyme Activation; Humans; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Plant Extracts; Plant Roots; Reactive Oxygen Species; Thiophenes | 2015 |
Induction of complementary function reductase enzymes in colon cancer cells by dithiole-3-thione versus sodium selenite.
Topics: Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Enzyme Induction; Gene Expression Regulation, Neoplastic; Humans; NAD(P)H Dehydrogenase (Quinone); Neoplasm Proteins; NF-E2-Related Factor 2; Sodium Selenite; Thiones; Thiophenes; Thioredoxin Reductase 1; Trace Elements | 2015 |
Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition.
Topics: Animals; Antineoplastic Agents; Apoptosis; CDC2 Protein Kinase; Cell Cycle Checkpoints; Cell Survival; Checkpoint Kinase 1; Colonic Neoplasms; DNA Damage; Female; Histones; HT29 Cells; Humans; Mice; Mice, Nude; Mutation; Nitroimidazoles; Phosphoproteins; Phosphoramide Mustards; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Rad51 Recombinase; Signal Transduction; Thiophenes; Tumor Suppressor Protein p53; Urea | 2015 |
DNA damage and homologous recombination signaling induced by thymidylate deprivation.
Topics: Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Flow Cytometry; Folic Acid; Folic Acid Antagonists; HeLa Cells; Humans; Nucleotides; Phosphorylation; Quinazolines; Rad51 Recombinase; Recombination, Genetic; Replication Protein A; Thiophenes; Thymidine Monophosphate; Thymidylate Synthase | 2008 |
Successful and well-tolerated second line therapy with cetuximab, irinotecan, and raltitrexed in progressive liver disease due to metastatic colon cancer.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colonic Neoplasms; Humans; Irinotecan; Liver Diseases; Liver Neoplasms; Male; Quinazolines; Thiophenes | 2008 |
Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Enzyme Induction; Glucuronosyltransferase; Glutathione Transferase; Intestinal Mucosa; Male; NAD(P)H Dehydrogenase (Quinone); Neoplasms, Experimental; Precancerous Conditions; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes; Time Factors | 2009 |
Thiacremonone augments chemotherapeutic agent-induced growth inhibition in human colon cancer cells through inactivation of nuclear factor-{kappa}B.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Docetaxel; Drug Administration Schedule; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Taxoids; Thiophenes; Xenograft Model Antitumor Assays | 2009 |
Design, synthesis and preliminary biological evaluation of N-hydroxy-4-(3-phenylpropanamido)benzamide (HPPB) derivatives as novel histone deacetylase inhibitors.
Topics: Antineoplastic Agents; Benzamides; Carcinoma; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Screening Assays, Antitumor; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Structure-Activity Relationship; Thiophenes | 2009 |
Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Male; Methotrexate; MicroRNAs; Middle Aged; Nuclear Proteins; Osteosarcoma; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Transfection; Ubiquitin-Protein Ligases | 2010 |
Synthesis, spectral characterization, solution equilibria, in vitro antibacterial and cytotoxic activities of Cu(II), Ni(II), Mn(II), Co(II) and Zn(II) complexes with Schiff base derived from 5-bromosalicylaldehyde and 2-aminomethylthiophene.
Topics: Aldehydes; Anti-Bacterial Agents; Antineoplastic Agents; Bacteria; Cell Proliferation; Cell Survival; Colonic Neoplasms; Copper; Electron Spin Resonance Spectroscopy; Humans; Laryngeal Neoplasms; Magnetic Resonance Spectroscopy; Magnetics; Manganese; Mass Spectrometry; Metals; Microbial Sensitivity Tests; Molecular Structure; Nickel; Organometallic Compounds; Schiff Bases; Spectrophotometry, Infrared; Thermogravimetry; Thiophenes; Tumor Cells, Cultured; Zinc | 2011 |
Disordering of human telomeric G-quadruplex with novel antiproliferative anthrathiophenedione.
Topics: Anthraquinones; Cell Proliferation; Circular Dichroism; Colonic Neoplasms; G-Quadruplexes; Humans; Leukemia; Models, Molecular; Molecular Dynamics Simulation; Nucleic Acid Conformation; Oligonucleotides; Potassium; Sodium; Telomere; Thiophenes; Tumor Cells, Cultured | 2011 |
Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762.
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzodioxoles; Checkpoint Kinase 1; Checkpoint Kinase 2; Colonic Neoplasms; DNA Replication; Drug Synergism; HT29 Cells; Humans; Isoquinolines; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Thiophenes; Topoisomerase I Inhibitors; Urea | 2012 |
Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain.
Topics: Animals; Antineoplastic Agents; Benzamides; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Histone Deacetylase Inhibitors; Histone Deacetylases; Mice; Mice, Nude; Thiophenes; Xenograft Model Antitumor Assays | 2012 |
Effects of iodonium-class flavin dehydrogenase inhibitors on growth, reactive oxygen production, cell cycle progression, NADPH oxidase 1 levels, and gene expression in human colon cancer cells and xenografts.
Topics: Animals; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclins; Flavoproteins; G1 Phase Cell Cycle Checkpoints; Gene Expression; Humans; Hydrogen Peroxide; Male; Mice; NADPH Oxidase 1; NADPH Oxidases; Neoplasm Transplantation; Onium Compounds; Prostatic Neoplasms; Reactive Oxygen Species; RNA, Messenger; Thiophenes; Transplantation, Heterologous | 2013 |
Unclassified pleomorphic and spindle cell pulmonary neoplasm with brain metastases after prasugrel.
Topics: Aged; Aspirin; Brain Neoplasms; Carcinoma; Clinical Trials, Phase III as Topic; Clopidogrel; Colonic Neoplasms; Coronary Stenosis; Diabetes Mellitus, Type 1; Diabetic Cardiomyopathies; Drug Therapy, Combination; Drug-Eluting Stents; Fatal Outcome; Female; Humans; Lung Neoplasms; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Factors; Thiophenes; Ticlopidine; Time Factors | 2013 |
Severe liver dysfunction after raltitrexed administration in an HCV-positive colorectal cancer patient.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Chemical and Drug Induced Liver Injury; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Enzyme Inhibitors; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver Function Tests; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes; Viremia | 2003 |
Induction of NAD(P)H quinone: oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Colon; Colonic Neoplasms; Dimethyl Fumarate; Disease Models, Animal; Enzyme Induction; Fumarates; Glucuronosyltransferase; Glutathione Transferase; Inactivation, Metabolic; Intestinal Mucosa; Liver; Male; NAD(P)H Dehydrogenase (Quinone); NADP; Pyrazines; Radiation-Sensitizing Agents; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes | 2003 |
Tamoxifen and the Rafoxifene analog LY117018: their effects on arachidonic acid release from cells in culture and on prostaglandin I2 production by rat liver cells.
Topics: Animals; Antineoplastic Agents, Hormonal; Arachidonic Acid; Breast Neoplasms; Colonic Neoplasms; Cyclooxygenase 2; Epoprostenol; Estrogen Antagonists; Humans; Isoenzymes; Liver; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrrolidines; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Tumor Cells, Cultured | 2004 |
Synergistic antitumor activity of capecitabine in combination with irinotecan.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluorouracil; Irinotecan; Maximum Tolerated Dose; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thiophenes | 2005 |
Importance of preclinical investigations of the integration of capecitabine into polychemotherapy regimens.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluorouracil; Irinotecan; Maximum Tolerated Dose; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thiophenes | 2005 |
Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists.
Topics: Adenocarcinoma; Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzo(a)pyrene; Biological Transport; Cell Line, Tumor; Colonic Neoplasms; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Neoplasm Proteins; Polychlorinated Dibenzodioxins; Pyrazines; Receptors, Aryl Hydrocarbon; Reserpine; RNA, Messenger; Thiones; Thiophenes | 2005 |
Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells.
Topics: Antimetabolites; Colonic Neoplasms; DNA Damage; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homeostasis; Humans; Indoles; Isoindoles; Quinazolines; Thiophenes; Trifluridine; Tumor Cells, Cultured | 2006 |
The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.
Topics: Amino Acid Substitution; Antineoplastic Agents; Arginine; Carrier Proteins; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Glutamates; Glycine; Guanine; Humans; Leucovorin; Methotrexate; Mutation; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Purines; Pyrimidines; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase | 2006 |
Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators.
Topics: Acetates; Animals; Arylsulfonates; Caco-2 Cells; Calcitriol; Cell Proliferation; Cells, Cultured; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Humans; Hypercalcemia; Intestines; Keratinocytes; Ligands; Mice; Mice, Hairless; Mice, Inbred C57BL; Mice, Inbred Strains; Models, Biological; Osteoblasts; Psoriasis; Rats; Receptors, Calcitriol; Signal Transduction; Species Specificity; Thiophenes; Transcription, Genetic; Tumor Cells, Cultured; Vitamin D | 2006 |
R-253 disrupts microtubule networks in multiple tumor cell lines.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Flow Cytometry; HeLa Cells; Humans; Lung Neoplasms; Microtubules; Molecular Weight; Osteosarcoma; Pyrimidines; Thiophenes; Thiourea | 2006 |
The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclic AMP Response Element-Binding Protein; Dinoprostone; Early Growth Response Protein 1; Extracellular Signal-Regulated MAP Kinases; Humans; Promoter Regions, Genetic; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Thiophenes; Transcription, Genetic; Triazoles | 2007 |
Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfurcompound isolated from garlic in human colon cancer cells.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA, Neoplasm; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Garlic; Gene Expression Regulation; Humans; NF-kappa B; Tetradecanoylphorbol Acetate; Thiophenes; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2007 |
Therapy of colon carcinoma: an oncology perspective. Interview with Piotr M. Czaykowski by Paul C. Adams.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Carcinoembryonic Antigen; Carcinoma; Colonic Neoplasms; Combined Modality Therapy; Fluorouracil; Humans; Irinotecan; Quinazolines; Rectal Neoplasms; Thiophenes | 2007 |
Regional chemoprevention of carcinogen-induced tumors in rat colon.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Eflornithine; Ellagic Acid; Male; Piroxicam; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1995 |
Matrix metalloproteinase inhibitors: a novel class of anticancer agents.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Female; Humans; Melanoma, Experimental; Metalloendopeptidases; Mice; Mice, Inbred Strains; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Phenylalanine; Protease Inhibitors; Thiophenes | 1995 |
Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.
Topics: Adenocarcinoma, Mucinous; Animals; Colonic Neoplasms; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Humans; Male; Metalloendopeptidases; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Phenylalanine; Thiophenes; Transplantation, Heterologous | 1994 |
AA1, a newly synthesized monovalent lipophilic cation, expresses potent in vivo antitumor activity.
Topics: Adenocarcinoma; Adenosine Triphosphate; Aniline Compounds; Animals; Antineoplastic Agents; Chlorocebus aethiops; Colonic Neoplasms; Disease Models, Animal; Epithelium; Female; Humans; Hydrolysis; Male; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Nude; Mitochondria, Liver; Models, Biological; Neoplasm Transplantation; Ovarian Neoplasms; Oxygen Consumption; Thiophenes; Transplantation, Heterologous; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1994 |
Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells.
Topics: Acyltransferases; Antineoplastic Agents; Cell Division; Cell Survival; Colonic Neoplasms; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; Hypoxanthine; Hypoxanthines; Methotrexate; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
Isolation and characterization of a human ileocecal carcinoma cell line (HCT-8) subclone resistant to fluorodeoxyuridine.
Topics: Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorouracil; Humans; Methotrexate; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidine Kinase; Thymidine Phosphorylase; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Azoxymethane; Colonic Neoplasms; Drug Administration Schedule; Drug Screening Assays, Antitumor; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1993 |
Resistance to tomudex (ZD1694): multifactorial in human breast and colon carcinoma cell lines.
Topics: Blotting, Northern; Blotting, Western; Breast Neoplasms; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Folic Acid Antagonists; Humans; Quinazolines; Thiophenes; Time Factors; Tumor Cells, Cultured | 1996 |
DNA damage and p53 induction do not cause ZD1694-induced cell cycle arrest in human colon carcinoma cells.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Cell Cycle; Cell Division; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; DNA Replication; DNA, Neoplasm; G1 Phase; G2 Phase; Humans; Neoplasm Proteins; Quinazolines; S Phase; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1996 |
Measurement of deoxyuridine triphosphate and thymidine triphosphate in the extracts of thymidylate synthase-inhibited cells using a modified DNA polymerase assay.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Colonic Neoplasms; Deoxyuracil Nucleotides; DNA-Directed DNA Polymerase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Kinetics; Pyrophosphatases; Quinazolines; Templates, Genetic; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1997 |
Pretreatment of colon carcinoma cells with Tomudex enhances 5-fluorouracil cytotoxicity.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Fluorouracil; Humans; Nucleotides; Phosphoribosyl Pyrophosphate; Quinazolines; RNA, Neoplasm; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1998 |
Schedule-dependent synergism between raltitrexed and irinotecan in human colon cancer cells in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Humans; Irinotecan; Quinazolines; Thiophenes; Tumor Cells, Cultured | 1998 |
Colon cancer: new drug options improve on 5-FU.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Folic Acid Antagonists; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Survival Analysis; Tegafur; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome | 1998 |
Cellular kinetics of induction by oltipraz and its keto derivative of detoxication enzymes in human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Anticarcinogenic Agents; Cell Cycle; Cell Survival; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Glutathione Transferase; Humans; Inactivation, Metabolic; Kinetics; NAD(P)H Dehydrogenase (Quinone); Pyrazines; RNA, Messenger; Thiones; Thiophenes; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
Matrix metalloproteinase inhibition prevents colon cancer peritoneal carcinomatosis development and prolongs survival in rats.
Topics: Animals; Antineoplastic Agents; Carcinoma; Collagenases; Colonic Neoplasms; Female; Gelatinases; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Neoplasm Invasiveness; Neoplasm Proteins; Peritoneal Neoplasms; Phenylalanine; Rats; Thiophenes; Tumor Cells, Cultured | 1999 |
Drug-company decision to end cancer trial.
Topics: Advisory Committees; Antidotes; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Colonic Neoplasms; Control Groups; Drug Industry; Europe; Fluorouracil; Humans; Leucovorin; Multicenter Studies as Topic; Quinazolines; Research Subjects; Thiophenes | 1999 |
Characterisation of a synergistic interaction between a thymidylate synthase inhibitor, ZD1694, and a novel lipophilic topoisomerase I inhibitor karenitecin, BNP1100: mechanisms and clinical implications.
Topics: Antimetabolites, Antineoplastic; Camptothecin; Cell Division; Cell Survival; Colonic Neoplasms; DNA Damage; Drug Synergism; Enzyme Inhibitors; Humans; Quinazolines; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 1999 |
Enzyme prodrug gene therapy: synergistic use of the herpes simplex virus-cellular thymidine kinase/ganciclovir system and thymidylate synthase inhibitors for the treatment of colon cancer.
Topics: Antiviral Agents; Bromodeoxyuridine; Colonic Neoplasms; Combined Modality Therapy; Enzyme Inhibitors; Fluorouracil; Ganciclovir; Genetic Therapy; Humans; Quinazolines; Simplexvirus; Thiophenes; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1999 |
Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
Topics: Blotting, Western; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Immunohistochemistry; Indoles; Inhibitory Concentration 50; Isoindoles; Methotrexate; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Safety of raltitrexed.
Topics: Antimetabolites, Antineoplastic; Clinical Trials as Topic; Colonic Neoplasms; Humans; Quinazolines; Thiophenes | 1999 |
Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Colonic Neoplasms; Enzyme Inhibitors; Flow Cytometry; Fluorouracil; Genes, bcl-2; Genes, p53; Humans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2000 |
Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Colonic Neoplasms; DNA Damage; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Front-cell-specific expression of membrane-type 1 matrix metalloproteinase and gelatinase A during cohort migration of colon carcinoma cells induced by hepatocyte growth factor/scatter factor.
Topics: Adenocarcinoma; Cell Movement; Colonic Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
Treatment of SW620 cells with Tomudex and oxaliplatin induces changes in 2-deoxy-D-glucose incorporation associated with modifications in glucose transport.
Topics: Antineoplastic Agents; Biological Transport; Cell Cycle; Colonic Neoplasms; Deoxyglucose; Enzyme Inhibitors; Flow Cytometry; Glucose; Humans; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes; Thymidylate Synthase; Time Factors; Tritium; Tumor Cells, Cultured | 2000 |
Raltitrexed-related pulmonary toxicity.
Topics: Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; Dyspnea; Female; Humans; Lung Diseases; Quinazolines; Radiography, Thoracic; Thiophenes | 2000 |
Synthesis of substituted indeno[1,2-b]quinoline-6-carboxamides, [1]benzothieno[3,2-b]quinoline-4-carboxamides and 10H-quindoline-4-carboxamides: evaluation of structure-activity relationships for cytotoxicity.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Indenes; Indoles; Mice; Molecular Structure; Neoplasm Transplantation; Quinolines; Structure-Activity Relationship; Thiophenes; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 2000 |
Effect of 2'-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells.
Topics: Colonic Neoplasms; Enzyme Inhibitors; Growth Inhibitors; Humans; Oligoribonucleotides, Antisense; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2001 |
Schedule-dependent synergism and antagonism between raltitrexed ("Tomudex") and methotrexate in human colon cancer cell lines in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Methotrexate; Quinazolines; Thiophenes; Tumor Cells, Cultured | 2001 |
Schedule-dependent interaction between raltitrexed and 5-fluorouracil in human colon cancer cell lines in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluorouracil; Humans; Quinazolines; Thiophenes; Tumor Cells, Cultured | 2000 |
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pemetrexed; Quinazolines; Thiophenes; Thymidine; Thymidine Kinase; Thymidylate Synthase | 2001 |
Synthesis and antiviral/antitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones.
Topics: Anti-HIV Agents; Antineoplastic Agents; Antiviral Agents; Arylsulfonic Acids; Breast Neoplasms; Cells, Cultured; Colonic Neoplasms; Cytomegalovirus; HIV-1; HIV-2; Humans; Inhibitory Concentration 50; Leukemia; Simplexvirus; Thiophenes | 2001 |
Thymidylate synthase inhibition induces p53 dependent and independent cell death.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Caspase 3; Caspases; Colonic Neoplasms; DNA Damage; Enzyme Inhibitors; Fas Ligand Protein; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Humans; Membrane Glycoproteins; Pemetrexed; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
[Irinotecan and tomudex in the treatment of patients with advanced cancer of the large intestine].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Female; Humans; Irinotecan; Male; Middle Aged; Quinazolines; Rectal Neoplasms; Thiophenes; Time Factors | 2001 |
Synthesis and biological evaluation of novel thioapio dideoxynucleosides.
Topics: Anti-HIV Agents; Antineoplastic Agents; Colonic Neoplasms; Dideoxynucleosides; Dose-Response Relationship, Drug; HIV-1; Humans; Structure-Activity Relationship; Thionucleosides; Thiophenes; Tumor Cells, Cultured | 2002 |
Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Bromodeoxyuridine; Carrier Proteins; Cell Survival; Colonic Neoplasms; Dipyridamole; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Humans; Membrane Proteins; Nucleoside Transport Proteins; Quinazolines; Thioinosine; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.
Topics: Animals; Anticarcinogenic Agents; Base Sequence; Caco-2 Cells; Colonic Neoplasms; Cytochrome P-450 CYP1A1; DNA Primers; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Male; Molecular Sequence Data; Promoter Regions, Genetic; Pyrazines; Rats; Rats, Wistar; Receptors, Aryl Hydrocarbon; RNA, Messenger; Thiones; Thiophenes; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Reduction of aberrant crypt formation in the colon of CF1 mice by potential chemopreventive agents.
Topics: 1,2-Dimethylhydrazine; Animals; Butylated Hydroxyanisole; Cecum; Colonic Neoplasms; Colorectal Neoplasms; Dimethylhydrazines; Female; Methylene Blue; Mice; Mice, Inbred Strains; Precancerous Conditions; Thiophenes | 1991 |
Effect of oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] on azoxymethane-induced biochemical changes related to early colon carcinogenesis in male F344 rats.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Body Weight; Colon; Colonic Neoplasms; Cytosol; DNA; Glutathione Transferase; Intestinal Mucosa; Liver; Male; Methylation; Ornithine Decarboxylase; Protein-Tyrosine Kinases; Pyrazines; Rats; Rats, Inbred F344; Reference Values; Thiones; Thiophenes | 1991 |