thiophenes has been researched along with Astrocytoma, Grade IV in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 12 (70.59) | 24.3611 |
| 2020's | 4 (23.53) | 2.80 |
| Authors | Studies |
|---|---|
| Kapoor-Narula, U; Lenka, N | 1 |
| Ando, S; Ii, H; Kojima, N; Moyama, C; Nakata, S; Nambu, H; Ohta, K | 1 |
| Choi, SH; Kim, SS; Lee, YS; Park, JY; Ryu, S; Shin, I; Sim, K; Sim, T; Song, C | 1 |
| Campolo, M; Casili, G; Colarossi, C; Cuzzocrea, S; Esposito, E; Esposito, F; Giuffrida, D; Irene, P; Lanza, M; Scuderi, SA | 1 |
| Kolar, MJ; Panda, S; Plikus, MV; Puca, F; Rommel, A; Saghatelian, A; Sulli, G; Verma, IM; Wang, X | 1 |
| Lee, C; Robinson, M; Willerth, SM | 1 |
| Camphausen, K; Caplen, NJ; Gehlhaus, K; Halthore, A; Kil, WJ; Kramp, T; Shankavaram, U; Tandle, AT; Tofilon, PJ | 1 |
| Abbott, NJ; Bertone, P; Danovi, D; Elbatsh, AM; Ender, C; Engström, PG; Ferretti, P; Folarin, A; Gagrica, S; Georgian, A; Gogolok, S; Harvey, KJ; Paddison, PJ; Pollard, SM; Preston, JE; Smith, A; Stricker, SH; U, KP; Yu, D | 1 |
| Arcaro, A; Boller, D; Cwiek, P; Djonov, V; Dolski, S; Frei, K; Hagel, C; Höland, K; Leni, Z; Pardo, OE; Salm, F; Shepherd, PR; Styp-Rekowska, B; Treszl, A; von Bueren, AO | 1 |
| Alicke, B; Barck, K; Carano, RA; Nishimura, M; Olivero, AG; Pang, J; Phillips, HS; Quiason, C; Salphati, L; Shahidi-Latham, S | 1 |
| Becker, CM; Brinkmann, DH; Elmquist, WF; Largaespada, DA; McFarren, SJ; Muldoon, DM; Oberoi, RK; Ohlfest, JR; Pafundi, DH; Pokorny, JL; Sarkaria, JN | 1 |
| Mason, WP | 1 |
| Alix, S; Box, G; Chuckowree, I; Clarke, PA; De Haven Brandon, A; Di Stefano, F; Eccles, SA; Folkes, A; Gowan, S; Hayes, A; Henley, AT; Lensun, L; McDonald, E; Patel, S; Pergl-Wilson, G; Raynaud, FI; Robson, A; Saghir, N; Sheldrake, P; Shuttleworth, S; Valenti, M; Wan, NC; Workman, P; Zhyvoloup, A | 1 |
| Ai, J; Chen, Y; Gao, X; Geng, M; Wang, Y; Zhang, A; Zhao, A | 1 |
| Raynaud, FI; Workman, P | 1 |
| Bolt, HM; Golka, K | 1 |
| Alicke, B; Barck, K; Carano, RA; Cheong, J; Edgar, KA; Gould, SE; Greve, J; Heffron, TP; Kharbanda, S; Koeppen, H; Lau, S; Lee, LB; Nishimura, M; Olivero, AG; Pang, J; Phillips, HS; Plise, EG; Pokorny, JL; Reslan, HB; Salphati, L; Sarkaria, JN; Wallin, JJ; Zhang, X | 1 |
17 other study(ies) available for thiophenes and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Elucidating the Anti-Tumorigenic Efficacy of Oltipraz, a Dithiolethione, in Glioblastoma.
Topics: Animals; beta Catenin; Carcinogenesis; Caspase 3; Cell Line, Tumor; Glioblastoma; Glutathione; HEK293 Cells; Humans; Mice; Mice, SCID; Neoplastic Stem Cells; Nestin; Pyrazines; Reactive Oxygen Species; Thiones; Thiophenes; Vimentin | 2022 |
Thiophene Carboxamide Analogs with Long Alkyl Chains Comprising Ethylene Glycol Units Inhibit Glioblastoma Cell Proliferation by Activating AMPK.
Topics: AMP-Activated Protein Kinases; Cell Line, Tumor; Cell Proliferation; Ethylene Glycols; Glioblastoma; Humans; Thiophenes | 2023 |
Anti-glioma effects of 2-aminothiophene-3-carboxamide derivatives, ANO1 channel blockers.
Topics: Animals; Anoctamin-1; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Drug Synergism; Glioblastoma; HEK293 Cells; Humans; Mice; Molecular Structure; Neoplasm Proteins; Structure-Activity Relationship; Temozolomide; Thiophenes | 2020 |
TBK1 Inhibitor Exerts Antiproliferative Effect on Glioblastoma Multiforme Cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Brain Neoplasms; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cell Survival; Glioblastoma; Humans; I-kappa B Kinase; Inflammation; NF-kappa B; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Signal Transduction; Thiophenes | 2021 |
Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence.
Topics: Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Circadian Clocks; Female; Glioblastoma; GTP Phosphohydrolases; Humans; Lipogenesis; Male; Membrane Proteins; Mice, Inbred C57BL; Neoplasms; Nevus; Nuclear Receptor Subfamily 1, Group D, Member 1; Oncogenes; Pyrrolidines; Signal Transduction; Thiophenes | 2018 |
Direct Reprogramming of Glioblastoma Cells into Neurons Using Small Molecules.
Topics: Basic Helix-Loop-Helix Transcription Factors; Brain Neoplasms; Cell Line, Tumor; Cellular Reprogramming; Cellular Reprogramming Techniques; Colforsin; Diamines; Glioblastoma; Heterocyclic Compounds, 4 or More Rings; Homeodomain Proteins; Humans; Isoxazoles; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurons; POU Domain Factors; Pyridines; Pyrimidines; Thiazoles; Thiophenes; Up-Regulation | 2018 |
Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation.
Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Glioblastoma; Humans; Mice; Mice, Nude; Mitosis; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; RNA Interference; Thiophenes; Xenograft Model Antitumor Assays | 2013 |
A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Blotting, Western; Brain Neoplasms; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Cells, Cultured; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Indans; Mice; Mice, Knockout; Neoplastic Stem Cells; Neural Stem Cells; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; Small Molecule Libraries; Swine; Thiophenes; Tumor Suppressor Protein p53 | 2013 |
Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Adhesion; Cell Division; Cell Line, Tumor; Cell Movement; Cell Survival; Chick Embryo; Class Ia Phosphatidylinositol 3-Kinase; Drug Screening Assays, Antitumor; Enzyme Induction; Glioblastoma; Humans; Hydrazones; Morpholines; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Substrate Specificity; Sulfonamides; Thiophenes; Tumor Cells, Cultured | 2014 |
Distribution of the phosphatidylinositol 3-kinase inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 intracranial glioblastoma models-assessment by matrix-assisted laser desorption ionization imaging.
Topics: Animals; Brain Neoplasms; Enzyme Inhibitors; Female; Glioblastoma; Humans; Indazoles; Mice; Mice, Nude; Phosphoinositide-3 Kinase Inhibitors; Pyrimidines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfonamides; Thiophenes; Tissue Distribution | 2014 |
Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Brain Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Drug Delivery Systems; Glioblastoma; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphoinositide-3 Kinase Inhibitors; Pyrimidines; Thiophenes; TOR Serine-Threonine Kinases | 2015 |
Blood-brain barrier-associated efflux transporters: a significant but underappreciated obstacle to drug development in glioblastoma.
Topics: Animals; Antineoplastic Agents; ATP-Binding Cassette Transporters; Brain Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Glioblastoma; Phosphoinositide-3 Kinase Inhibitors; Pyrimidines; Thiophenes; TOR Serine-Threonine Kinases | 2015 |
Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941.
Topics: Administration, Oral; Animals; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Female; Furans; Glioblastoma; Humans; Indazoles; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; Pyridines; Pyrimidines; Sulfonamides; Thiophenes; TOR Serine-Threonine Kinases; Umbilical Veins; Xenograft Model Antitumor Assays | 2009 |
Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d]pyrimidine or furo[2,3-d]pyrimidine scaffold.
Topics: Animals; Cell Line, Tumor; Drug Evaluation, Preclinical; Glioblastoma; Humans; Mice; Mice, Nude; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrimidines; Structure-Activity Relationship; Thiophenes; Transplantation, Heterologous | 2011 |
Discovering and developing PI3 kinase inhibitors for cancer: rapid progress through academic-biotech-pharma interactions.
Topics: Animals; Enzyme Inhibitors; Female; Furans; Glioblastoma; Humans; Indazoles; Ovarian Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Pyrimidines; Sulfonamides; Thiophenes | 2011 |
1,3-Propane sultone as an extremely potent human carcinogen: description of an exposed cohort in Germany.
Topics: Adult; Aged; Aged, 80 and over; Brain Neoplasms; Carcinogens; Chemical Industry; Cohort Studies; Germany; Glioblastoma; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms; Occupational Diseases; Occupational Exposure; Thiophenes | 2012 |
Targeting the PI3K pathway in the brain--efficacy of a PI3K inhibitor optimized to cross the blood-brain barrier.
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Cell Line; Cell Membrane Permeability; Dogs; Female; Glioblastoma; Humans; Mice; Molecular Targeted Therapy; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Thiophenes; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |