thiophenes and Angiogenesis, Pathologic

Topics: Adult; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Apoptosis; Bevacizumab; Cell Communication; Drug Evaluation, Preclinical; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Ephrins; Forecasting; Growth Substances; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Lymphokines; Metalloendopeptidases; Mice; Neoplasms; Neovascularization, Pathologic; Neovascularization, Physiologic; Phenylalanine; Randomized Controlled Trials as Topic; Receptors, Vascular Endothelial Growth Factor; Research; Signal Transduction; Thalidomide; Thiophenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Humans; Melanoma, Experimental; Metalloendopeptidases; Neovascularization, Pathologic; Phenylalanine; Protease Inhibitors; Thiophenes

Topics: Antineoplastic Agents; Clinical Trials as Topic; Cyclohexanes; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Hydroxamic Acids; Interferon-alpha; Interleukin-12; Neoplasms; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Phenylalanine; Platelet Factor 4; Polysaccharides, Bacterial; Sesquiterpenes; Thalidomide; Thiophenes; Triazines; Triazoles; Tumor Cells, Cultured

Topics: Antineoplastic Agents; Cell Division; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Down-Regulation; Drugs, Investigational; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Hydroxamic Acids; Metalloendopeptidases; Molecular Weight; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; Phenylalanine; Protease Inhibitors; Protein Kinase C; Proteins; Thiophenes; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinase-3; Tissue Inhibitor of Metalloproteinases

Topics: Angiostatins; Antibiotics, Antineoplastic; Antineoplastic Agents; Collagen; Cyclohexanes; Endostatins; Humans; Hydroxamic Acids; Interferons; Interleukin-12; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Peptide Fragments; Phenylalanine; Plasminogen; Sesquiterpenes; Thalidomide; Thiophenes

Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Breast Neoplasms; Cell Movement; Cell Proliferation; Female; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Phosphorylation; Thiophenes; Tumor Cells, Cultured; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

Topics: AMP-Activated Protein Kinase Kinases; Animals; Animals, Newborn; Biphenyl Compounds; Ductus Arteriosus; Electron Transport; Endothelial Cells; Enzyme Activation; Female; Hypertension, Pulmonary; Intracellular Signaling Peptides and Proteins; Jagged-1 Protein; Ligands; Lung; Membrane Proteins; Metformin; Mitochondria; Neovascularization, Pathologic; Persistent Fetal Circulation Syndrome; Phosphorylation; Pregnancy; Protein Kinases; Pyrones; Receptors, Notch; Sheep; Thiophenes; Threonine; Transfection

Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Chick Embryo; Chorioallantoic Membrane; Dogs; Humans; Mice; Monocarboxylic Acid Transporters; Neoplasm Proteins; Neoplasms, Experimental; Neovascularization, Pathologic; Oxygen Consumption; Pyrimidinones; Symporters; Thiophenes; Xenograft Model Antitumor Assays

Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Curcumin; Energy Metabolism; Female; Hexokinase; I-kappa B Kinase; L-Lactate Dehydrogenase; Malondialdehyde; Mice; Mice, Nude; Mitochondrial Proton-Translocating ATPases; Neoplasms; Neovascularization, Pathologic; Oxygen Consumption; Phosphofructokinases; Pyruvate Kinase; Reactive Oxygen Species; Thiophenes

Topics: Animals; Caco-2 Cells; Humans; Hypertension, Portal; Liver Circulation; Liver Cirrhosis; Male; Neovascularization, Pathologic; Oxazoles; PPAR alpha; PPAR gamma; Rats; Rats, Sprague-Dawley; Splanchnic Circulation; Thiophenes

Topics: Actins; Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Collagen; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Drug Combinations; Ferrous Compounds; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Laminin; Lung Neoplasms; Neovascularization, Pathologic; Polymerization; Proteoglycans; Pyrazoles; Tetrazolium Salts; Thiazoles; Thiophenes

Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Colonic Neoplasms; Cyclooxygenase 2 Inhibitors; HT29 Cells; Humans; Neovascularization, Pathologic; Phenylurea Compounds; Protein-Tyrosine Kinases; Quinolines; Thiophenes

Topics: Acrylates; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Delivery Systems; Enzyme-Linked Immunosorbent Assay; Humans; Imidazoles; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Atomic Force; Microvessels; Neovascularization, Pathologic; Polyethyleneimine; Thiophenes

Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Neovascularization, Pathologic; Protein Conformation; Quinolines; Structure-Activity Relationship; Thiophenes; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2

Topics: Benzyl Compounds; Cell Movement; Dinoprostone; Endothelial Cells; Epoprostenol; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Neovascularization, Pathologic; Neovascularization, Physiologic; Prostaglandins I; Real-Time Polymerase Chain Reaction; Receptors, Epoprostenol; Receptors, G-Protein-Coupled; Receptors, Prostaglandin E, EP4 Subtype; Thiophenes; Triazoles; Xanthones

Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chickens; Chorioallantoic Membrane; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; HT29 Cells; Humans; Indoles; Neovascularization, Pathologic; Niacinamide; Oligonucleotides; Protein Kinase Inhibitors; Thiophenes

Topics: Angiogenesis Inhibitors; Apoptosis; Blotting, Western; Breast; Breast Neoplasms; Cell Proliferation; Cells, Cultured; Female; Humans; MAP Kinase Signaling System; Neovascularization, Pathologic; Phenylurea Compounds; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Thiophenes; Urea

Topics: Antineoplastic Agents; Benzopyrans; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Gene Expression Regulation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MAP Kinase Signaling System; Microvessels; Neoplasm Invasiveness; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Prohibitins; Proto-Oncogene Proteins c-akt; Thiophenes; Vascular Endothelial Growth Factor A

Topics: Adenylate Kinase; Animals; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Mice; Neovascularization, Pathologic; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Stability; Pyrazines; Ribosomal Protein S6 Kinases, 70-kDa; Thiones; Thiophenes; Transcription, Genetic; Ubiquitin

Topics: Animals; Endothelium, Vascular; Humans; Neoplasms; Neovascularization, Pathologic; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Spleen; Stem Cells; T-Lymphocytes, Regulatory; Thiophenes

Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Humans; Immunohistochemistry; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Nude; Microscopy, Confocal; Multiprotein Complexes; Neoplasms, Experimental; Neovascularization, Pathologic; Proteins; Quinolines; Sirolimus; Thiophenes; TOR Serine-Threonine Kinases; Transcription Factors; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

Topics: Animals; Cell Proliferation; Chymases; Cromolyn Sodium; Disease Models, Animal; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Mast Cells; Monocrotaline; Muscle, Smooth, Vascular; Neovascularization, Pathologic; Rats; Rats, Wistar; Sulfonamides; Thiophenes

Topics: Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cobalt; HT29 Cells; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; MicroRNAs; Neoplasm Invasiveness; Neovascularization, Pathologic; Pyrazines; Pyridazines; Pyrroles; Thiones; Thiophenes

Topics: Animals; Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Renal Cell; Cell Hypoxia; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Neoplasms; Mice; Microtubules; Mitosis; Neovascularization, Pathologic; Polymerization; Sulfonamides; Thiophenes; Tumor Burden; Vascular Endothelial Growth Factor A; Von Hippel-Lindau Tumor Suppressor Protein; Xenograft Model Antitumor Assays

Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Dexamethasone; Drug Resistance, Neoplasm; Drug Therapy, Combination; Humans; Lenalidomide; Mice; Mice, SCID; Molecular Sequence Data; Multiple Myeloma; Neovascularization, Pathologic; Protease Inhibitors; Proto-Oncogene Proteins c-mdm2; Pyrazines; Random Allocation; Thalidomide; Thiophenes; Ubiquitin Thiolesterase; Ubiquitin-Specific Peptidase 7; Xenograft Model Antitumor Assays

Topics: Animals; Breast Neoplasms; Butadienes; Cell Line, Tumor; Cell Movement; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; GPI-Linked Proteins; Humans; Lymphatic Metastasis; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; MCF-7 Cells; Mesothelin; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Neovascularization, Pathologic; Nitriles; Phenylalanine; Protease Inhibitors; Thiophenes; Transplantation, Heterologous

Topics: Adenoviridae; Aprotinin; Cells, Cultured; Collagen; Culture Media; Defective Viruses; Drug Synergism; Endothelial Growth Factors; Endothelium, Vascular; Fibrin; Fibroblast Growth Factor 2; Genetic Vectors; Heart Diseases; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Neovascularization, Pathologic; Neovascularization, Physiologic; Phenylalanine; Protease Inhibitors; Thiophenes; Thrombosis; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-3; Transduction, Genetic; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Chi-Square Distribution; Disease Models, Animal; Drug Therapy, Combination; Endothelial Growth Factors; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Male; Matrix Metalloproteinases; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Pancreatic Neoplasms; Phenylalanine; Probability; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric; Thiophenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinoma, Islet Cell; Chronotherapy; Indoles; Matrix Metalloproteinase Inhibitors; Mice; Neovascularization, Pathologic; Pancreatic Neoplasms; Phenylalanine; Protease Inhibitors; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Thiophenes

Topics: Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Dipeptides; Doxycycline; Enzyme Activation; Humans; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Membrane Microdomains; Membrane Proteins; Neovascularization, Pathologic; Phenylalanine; Protein Binding; Protein Transport; Receptors, LDL; Recombinant Fusion Proteins; Thiophenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Aorta; Breast Neoplasms; Cell Line, Tumor; Disease Progression; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Humans; Inhibitory Concentration 50; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Microscopy, Fluorescence; Models, Chemical; Neoplasm Invasiveness; Neoplasm Transplantation; Neovascularization, Pathologic; Phenylalanine; Piperazines; Protease Inhibitors; Pyrimidines; Rats; Thiophenes; Time Factors; Up-Regulation

Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Lewis Lung; Cell Division; Cells, Cultured; Coculture Techniques; Collagen; Drug Combinations; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Laminin; Mice; Mice, Inbred C57BL; Muscle, Smooth; Neoplasm Transplantation; Neovascularization, Pathologic; Neutralization Tests; Oxadiazoles; Propylene Glycols; Proteoglycans; Receptors, CXCR4; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Transcriptional Activation; Transplantation, Isogeneic; Umbilical Veins; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

Topics: Angiogenesis Inhibitors; Animals; Cell Proliferation; Diethylstilbestrol; Drug Screening Assays, Antitumor; Drug Therapy, Combination; Estrogens; Image Processing, Computer-Assisted; Male; Metalloendopeptidases; Neovascularization, Pathologic; Organ Size; Phenylalanine; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactinoma; Proliferating Cell Nuclear Antigen; Protease Inhibitors; Rats; Rats, Inbred F344; Thiophenes

Topics: Autocrine Communication; Cell Transformation, Viral; Cells, Cultured; Collagenases; Endothelial Cells; Gene Expression Regulation, Enzymologic; Herpesvirus 8, Human; Humans; Neoplasm Invasiveness; Neovascularization, Pathologic; Paracrine Communication; Phenylalanine; Protease Inhibitors; Response Elements; RNA, Messenger; RNA, Neoplasm; Sarcoma, Kaposi; Thiophenes; Transcription Factor AP-1; Umbilical Veins; Up-Regulation

Topics: Animals; Dose-Response Relationship, Drug; Female; Hemangioendothelioma; Metalloendopeptidases; Mice; Neoplasm Invasiveness; Neovascularization, Pathologic; Phenylalanine; Thiophenes; Time Factors

Topics: Animals; Aorta; Doxycycline; Gelatinases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Minocycline; Neoplasm Proteins; Neovascularization, Pathologic; Phenylalanine; Rats; Rats, Inbred F344; Thiophenes

Topics: Amidines; Amiloride; Animals; Antineoplastic Agents; Cell Division; Diuretics; Enzyme Inhibitors; Female; Fibrinolysis; Fibronectins; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Neoplasm Metastasis; Neovascularization, Pathologic; Thiophenes; Triamterene; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator

Topics: Angiostatins; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Carcinoma, Islet Cell; Collagen; Cyclohexanes; Disease Progression; Drug Evaluation, Preclinical; Endostatins; Female; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Staging; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Pancreatic Neoplasms; Peptide Fragments; Phenylalanine; Plasminogen; Sesquiterpenes; Thiophenes

Topics: Animals; Antineoplastic Agents; Cell Division; Cyclohexanes; Liver Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Phenylalanine; Sesquiterpenes; Suramin; Thiophenes; Triazoles

Topics: Animals; Cell Movement; Cell Survival; Injections, Intraperitoneal; Injections, Intravenous; Liver Neoplasms; Melanoma, Experimental; Mesenteric Veins; Mice; Microscopy, Video; Neovascularization, Pathologic; Phenylalanine; Thiophenes; Tumor Cells, Cultured

Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Disease Models, Animal; Drug Administration Schedule; Drug Synergism; Female; Interleukin-12; Mammary Neoplasms, Experimental; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Phenylalanine; Protease Inhibitors; Thiophenes

Topics: Angiography; Animals; Blood Flow Velocity; Capillaries; Disease Models, Animal; Endothelial Growth Factors; Enzyme Activation; Femoral Artery; Fibroblast Growth Factor 2; Hindlimb; Interleukin-10; Ischemia; Laser-Doppler Flowmetry; Lymphokines; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Phenylalanine; Platelet Endothelial Cell Adhesion Molecule-1; Protease Inhibitors; Thiophenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Angiogenesis Inhibitors; Animals; Anticarcinogenic Agents; Cell Division; Dose-Response Relationship, Drug; Endothelium, Vascular; Hemangiosarcoma; Humans; Insulin-Like Growth Factor I; Liver; Male; Mice; Mice, Nude; Neovascularization, Pathologic; Oligonucleotide Array Sequence Analysis; Pyrazines; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 4; Receptors, Fibroblast Growth Factor; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Ribonuclease, Pancreatic; Thiones; Thiophenes; Transplantation, Heterologous; Tumor Cells, Cultured