thiophenes has been researched along with Adjuvant Arthritis in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (29.17) | 18.2507 |
| 2000's | 7 (29.17) | 29.6817 |
| 2010's | 8 (33.33) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, Y; Guo, F; Liu, C; Liu, H; Qi, D; Sun, X; Tao, T; Xiao, J; Zhao, L; Zhou, C; Zhu, Y | 1 |
| Pu, X; Wang, Z; Yang, J; Yang, Y; Zhang, N; Zhao, J | 1 |
| Chen, L; Li, D; Wu, X; Zhong, J | 1 |
| Bray, PF; DeLa Cadena, RA; Garcia, AE; Kunapuli, SP; Liverani, E; Rico, MC | 1 |
| Hosny, NM; Sherif, YE | 1 |
| Guma, M; Liu-Bryan, R; Viollet, B; Wang, Y | 1 |
| Aquino, M; Bruno, I; Guerrero, MD; Payá, M; Riccio, R; Terencio, MC | 1 |
| Ban, JO; Han, SB; Hong, JT; Jeong, HS; Kim, DJ; Kim, TM; Oh, JH | 1 |
| Barrish, JC; Davis, PM; Dhar, TG; Launay, M; McIntyre, KW; McKinnon, M; Potin, D; Salter-Cid, L; Shuster, DJ; Skala, S; Stetsko, DK; Suchard, SJ; Susulic, V | 1 |
| Barbosa, J; Di Paolo, J; Liu, L; Reif, K; Rong, H; Wong, H | 1 |
| Bardin, L; Berrocoso, E; Depoortère, R; Ladure, P; Mico, JA; Newman-Tancredi, A; Vitton, O | 1 |
| Doschak, MR; Maksymowych, WP; Panahifar, A | 1 |
| Fujita, M; Ikeda, N; Seki, T | 1 |
| Hasegawa, M; Mitsukuchi, M; Noguchi, T; Tomisawa, K | 1 |
| Andre, N; Bellot, I; Bresson, Y; Deschamps, C; Pastoureau, P; Tordjman, C; Wierzbicki, M | 1 |
| Bolognese, BJ; Callahan, JF; Carlson, K; Davis, TG; Evans, C; Li, YH; Mellor, GW; Podolin, PL; Roshak, AK | 1 |
| Carlsten, H; Islander, U; Jochems, C; Kallkopf, A; Lagerquist, M; Ohlsson, C | 1 |
| Crimmin, MJ; DiMartino, MJ; Galloway, WA; High, W | 1 |
| Ansell, J; Argentieri, D; Barbone, A; Beers, SA; Kirchner, T; Malloy, EA; Ritchie, D; Singer, M; Steber, M; Wachter, M; Wu, W | 1 |
| Konishi, N; Matsuo, M; Nakamura, K; Ochi, T; Ogino, T; Seki, N; Tojo, T; Tsuji, K | 1 |
| Antoon, JS; Perry, MA; Walker, JS; Wilson, JL | 1 |
| Karagouni, EE; Kourounakis, L | 1 |
| Gavalas, A; Karagouni, EE; Kourounakis, L; Kourounakis, P; Litina, D | 1 |
| Bollinger, P; Cooper, PH; Del Pozo, E; Elford, P; Graeber, M; Gubler, HU; Leutwiler, A; Mackenzie, AR; Payne, T; Ruch, W | 1 |
24 other study(ies) available for thiophenes and Adjuvant Arthritis
| Article | Year |
|---|---|
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Bone Remodeling; Case-Control Studies; Cells, Cultured; Humans; Inflammation Mediators; Knee Joint; Male; Matrix Metalloproteinases; Mice, Inbred DBA; Nuclear Receptor Subfamily 1, Group D, Member 1; Pyrrolidines; Reactive Oxygen Species; Signal Transduction; Synovial Membrane; Synoviocytes; Synovitis; Thiophenes | 2020 |
Targeted and Combined TPCA-1-Gold Nanocage Therapy for In Vivo Treatment of Inflammatory Arthritis.
Topics: Amides; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Gold; Hyaluronic Acid; Male; Metal Nanoparticles; Mice; Thiophenes | 2020 |
L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels.
Topics: Animals; Ankle Joint; Arthritis, Experimental; Arthritis, Rheumatoid; Celecoxib; Cell Differentiation; Cell Proliferation; Chemokine CCL2; Collagen Type II; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Female; Humans; Injections, Intraperitoneal; Interleukin-17; Mice; Mice, Inbred DBA; Receptors, Prostaglandin E, EP4 Subtype; Severity of Illness Index; Signal Transduction; T-Lymphocytes, Regulatory; Th17 Cells; Thiophenes; Triazoles | 2017 |
Erosive arthritis and hepatic granuloma formation induced by peptidoglycan polysaccharide in rats is aggravated by prasugrel treatment.
Topics: Animals; Arthritis, Experimental; Clopidogrel; Cytokines; Female; Granuloma; Inflammation; Joints; Liver; Peptidoglycan; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Rats; Rats, Inbred Lew; Thiophenes; Ticlopidine | 2013 |
Anti-rheumatic potential of ethyl 2-(2-cyano-3-mercapto-3-(phenylamino) acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate and its Co(II), Cu(II) and Zn(II) complexes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Experimental; Carboxylic Acids; Cobalt; Coordination Complexes; Copper; Rats; Rats, Sprague-Dawley; Rheumatic Fever; Temperature; Thiophenes; Zinc | 2014 |
AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis.
Topics: AMP-Activated Protein Kinases; Animals; Arthritis, Experimental; Biphenyl Compounds; Bone Marrow Cells; Enzyme Activation; Gene Expression Regulation; Interleukin-6; Joints; Macrophages; Mice; Mice, Inbred C57BL; Pyrones; Thiophenes | 2015 |
Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression.
Topics: 4-Butyrolactone; Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Behavior, Animal; Blood Platelets; Cattle; Chronic Disease; Gene Expression Regulation, Enzymologic; Humans; Hyperalgesia; Inflammation; Intramolecular Oxidoreductases; Leukotriene B4; Male; Mice; Neutrophils; Prostaglandin-E Synthases; Thiophenes; Thromboxane B2 | 2009 |
Anti-inflammatory and arthritic effects of thiacremonone, a novel sulfur compound isolated from garlic via inhibition of NF-kappaB.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Blotting, Western; Electrophoretic Mobility Shift Assay; Garlic; Humans; Inflammation; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Pyridines; Rats; Rats, Sprague-Dawley; Thiophenes; Transfection | 2009 |
An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cell Adhesion; Cell Proliferation; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Lymphocyte Culture Test, Mixed; Lymphocyte Function-Associated Antigen-1; Mice; Spiro Compounds; Thiophenes | 2010 |
Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/pharmacodynamic modeling: relationships between inhibition of BTK phosphorylation and efficacy.
Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Antirheumatic Agents; Arthritis, Experimental; Cattle; Female; Male; Mice; Mice, Inbred BALB C; Models, Chemical; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidinones; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Thiophenes; Treatment Outcome | 2011 |
Effects of milnacipran, duloxetine and indomethacin, in polyarthritic rats using the Randall-Selitto model.
Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Indomethacin; Male; Milnacipran; Rats; Rats, Wistar; Thiophenes | 2011 |
Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation.
Topics: Alendronate; Animals; Arthritis, Experimental; Bone Density Conservation Agents; Drug Evaluation, Preclinical; Electron Probe Microanalysis; Female; Organometallic Compounds; Osteoarthritis; Osteogenesis; Osteophyte; Rats; Rats, Sprague-Dawley; Thiophenes; Tibial Meniscus Injuries; X-Ray Microtomography | 2012 |
Synthesis and bioactivities of novel bicyclic thiophenes and 4,5,6,7-tetrahydrothieno[2,3-c]pyridines as inhibitors of tumor necrosis factor-alpha (TNF-alpha) production.
Topics: Animals; Arthritis, Experimental; Bridged Bicyclo Compounds; Disease Models, Animal; Inhibitory Concentration 50; Lipopolysaccharides; Pyridines; Rats; Structure-Activity Relationship; Thiophenes; Tumor Necrosis Factor-alpha | 2002 |
Synthesis and structure-activity relationships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Inhibitory Concentration 50; Interleukin-1; Mice; Mice, Inbred C3H; Phenylpropionates; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Thymus Gland | 2003 |
General pharmacology of the butanamide derivative S 19812, a new dual inhibitor of cyclooxygenase and lipoxygenase pathways.
Topics: Acetic Acid; Air; Amides; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Gastric Mucosa; Hot Temperature; Hyperalgesia; Lipoxygenase Inhibitors; Male; Mice; Naloxone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Reaction Time; Stomach Diseases; Thiophenes | 2003 |
Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and
Topics: Adenosine Triphosphate; Amides; Animals; Anti-Asthmatic Agents; Arthritis, Experimental; Binding, Competitive; Cell Proliferation; Chemokines; Collagen; Cytokines; Disease Models, Animal; Humans; I-kappa B Kinase; Interleukin-6; Interleukin-8; Lipopolysaccharides; Male; Mice; Mice, Inbred DBA; Monocytes; NF-kappa B; Protein Serine-Threonine Kinases; T-Lymphocytes; Thiophenes; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2005 |
Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis.
Topics: Animals; Arthritis; Arthritis, Experimental; Bone Density; Cytokines; Female; Humans; Mice; Osteoporosis, Postmenopausal; Postmenopause; Pyrrolidines; Raloxifene Hydrochloride; RANK Ligand; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Selective Estrogen Receptor Modulators; Thiophenes; Treatment Outcome; Tumor Necrosis Factor-alpha | 2007 |
Preclinical antiarthritic activity of matrix metalloproteinase inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Indomethacin; Inflammation; Isomerism; Metalloendopeptidases; Phenylalanine; Radiography; Rats; Thiophenes; Time Factors | 1994 |
N-(5-substituted) thiophene-2-alkylsulfonamides as potent inhibitors of 5-lipoxygenase.
Topics: Administration, Oral; Alkylation; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Ethers; Humans; Leukemia, Basophilic, Acute; Leukocytes, Mononuclear; Lipoxygenase Inhibitors; Male; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfides; Sulfonamides; Thiophenes; Tumor Cells, Cultured | 1997 |
Studies on anti-inflammatory agents. VI. Synthesis and pharmacological properties of 2,3-diarylthiophenes.
Topics: Adjuvants, Immunologic; Adult; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Humans; Hypersensitivity, Delayed; Male; Mice; Mice, Inbred DBA; Rats; Structure-Activity Relationship; Thiophenes | 1998 |
Intercellular adhesion molecule-1 expression in adjuvant arthritis in rats: inhibition by kappa-opioid agonist but not by NSAID.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Female; Intercellular Adhesion Molecule-1; Naproxen; Narcotics; Pyrroles; Rats; Rats, Inbred Lew; Receptors, Opioid, kappa; Thiophenes | 1998 |
Anti-inflammatory and immunomodulating effects of the novel agent gamma-(2-aminoethylamino)-2-butyrothienone. 3rd communication: effect on suppressor cells and cytokines production in normal and adjuvant arthritic rats.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cells, Cultured; Chemical Phenomena; Chemistry, Physical; Cytokines; Female; Interleukin-1; Interleukin-2; Male; Mitogens; Rats; Rats, Inbred F344; Spleen; T-Lymphocytes; T-Lymphocytes, Regulatory; Thiophenes | 1991 |
Anti-inflammatory and immunomodulating effects of the novel agent gamma-(2-aminoethylamino)-2-butyrothienone. 2nd communication: inhibitory effect on rat adjuvant induced disease.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Antibody-Producing Cells; Arthritis, Experimental; B-Lymphocytes; Body Weight; Concanavalin A; Female; Foot; Liver Glycogen; Male; Mitogens; Mycobacterium; Rats; Rats, Inbred F344; T-Lymphocytes; Thiophenes | 1991 |
Pharmacological effects of a new antiarthritic agent, IX 207-887.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dose-Response Relationship, Drug; Immunosuppressive Agents; Interleukin-1; Macrophages; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Inbred Strains; Thiophenes | 1991 |