thiophenes has been researched along with Acute Post-operative Pain in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 9 (42.86) | 24.3611 |
| 2020's | 8 (38.10) | 2.80 |
| Authors | Studies |
|---|---|
| Bergese, SD; Gan, TJ; Gupta, A; Jin, Z; Page, C; Zhu, M | 1 |
| Azzam, AAH; Lambert, DG | 1 |
| Demitrack, MA; Fossler, MJ; Simpson, KN; Wandstrat, TL; Wase, L | 1 |
| Viscusi, ER | 1 |
| Ayad, S; Burt, DA; Demitrack, MA; Fossler, MJ; Khanna, AK; Michalsky, C; Wase, L | 1 |
| Bergese, S; Berkowitz, R; Cochrane, K; Demitrack, MA; Griffith, S; Habib, AS; Ladouceur, M; Rider, P; Segura Vasi, A; Wase, L | 1 |
| Hu, Q; Liu, Y; Yang, J | 1 |
| Habib, AS; Tan, HS | 1 |
| Burt, DA; Farrell, C; Fossler, MJ; Pitsiu, M; Sadler, BM; Skobieranda, F; Soergel, DG | 2 |
| Clark, JD; Irvine, KA; Li, WW; Liang, DY; Nwaneshiudu, C | 1 |
| Burt, DA; Demitrack, MA; Salamea, M; Singla, NK; Skobieranda, F; Soergel, DG; Viscusi, ER | 1 |
| Bhatnagar, A; Billeter, AT; Hellmann, JL; Polk, HC | 1 |
| Dong, YL; Hu, W; Li, HS; Lu, GJ; Sun, YH; Wu, SX; Yang, J; Zhao, GL; Zhu, C | 1 |
| Russell, G; Strichartz, GR; Wang, CF; Wang, GK | 1 |
| Chia, SL; Ho, KY; Liu, H; Lo, NN; Tay, W; Yeo, MC; Yeo, SJ | 1 |
| Limper, U; Lynch, J | 1 |
| Baker, S; Brioni, JD; Chang, R; EI-Kouhen, O; Gauvin, DM; Hernandez, G; Hollingsworth, PR; Honore, P; Lehto, SG; Moreland, RB; Stewart, AO; Zheng, G; Zhu, CZ | 1 |
| La Coste, JJ; Milroy, E; Ormiston, MC; Thornton, EJ; Vaughton, KC | 1 |
| Bornfleth, GH; Löschner, R | 1 |
| Goutaine, DJ | 1 |
4 review(s) available for thiophenes and Acute Post-operative Pain
| Article | Year |
|---|---|
Evaluating oliceridine as a treatment option for moderate to severe acute post-operative pain in adults.
Topics: Acute Pain; Adult; Analgesics, Opioid; Humans; Morphine; Pain, Postoperative; Postoperative Nausea and Vomiting; Spiro Compounds; Thiophenes | 2022 |
A critical review of oliceridine injection as an IV opioid analgesic for the management of severe acute pain.
Topics: Acute Pain; Adult; Analgesics, Opioid; Humans; Pain, Postoperative; Randomized Controlled Trials as Topic; Spiro Compounds; Thiophenes | 2022 |
Safety evaluation of oliceridine for the management of postoperative moderate-to-severe acute pain.
Topics: Analgesics, Opioid; Animals; Humans; Pain, Postoperative; Severity of Illness Index; Signal Transduction; Spiro Compounds; Thiophenes | 2021 |
Transient receptor potential ion channels: powerful regulators of cell function.
Topics: Analgesics; Anti-Inflammatory Agents; Biomarkers; Calcium Channels; Capsaicin; Chronic Pain; Duloxetine Hydrochloride; Humans; Inflammation; Macrophages; Melanoma; Monocytes; Nerve Tissue Proteins; Pain, Postoperative; Respiratory Tract Diseases; Surgical Wound Infection; Thiophenes; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2014 |
5 trial(s) available for thiophenes and Acute Post-operative Pain
| Article | Year |
|---|---|
Oliceridine (TRV130), a Novel G Protein-Biased Ligand at the μ-Opioid Receptor, Demonstrates a Predictable Relationship Between Plasma Concentrations and Pain Relief. I: Development of a Pharmacokinetic/Pharmacodynamic Model.
Topics: Adult; Aged; Cytochrome P-450 CYP2D6; Double-Blind Method; Female; Hallux Valgus; Humans; Male; Middle Aged; Models, Biological; Pain; Pain Measurement; Pain, Postoperative; Spiro Compounds; Thiophenes; Treatment Outcome; Young Adult | 2018 |
APOLLO-2: A Randomized, Placebo and Active-Controlled Phase III Study Investigating Oliceridine (TRV130), a G Protein-Biased Ligand at the μ-Opioid Receptor, for Management of Moderate to Severe Acute Pain Following Abdominoplasty.
Topics: Abdominoplasty; Acute Pain; Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Double-Blind Method; Female; Humans; Male; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Receptors, Opioid, mu; Spiro Compounds; Thiophenes | 2019 |
Duloxetine reduces morphine requirements after knee replacement surgery.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Double-Blind Method; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; Follow-Up Studies; Humans; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Postoperative Care; Selective Serotonin Reuptake Inhibitors; Thiophenes; Young Adult | 2010 |
The comparative effectiveness of tiaprofenic acid and aspirin in the treatment of post-prostatectomy pain.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Male; Middle Aged; Pain, Postoperative; Propionates; Prostatectomy; Thiophenes; Wound Healing | 1981 |
[Treatment of postoperative edema and pain with the antiphlogistic Surgam].
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Edema; Female; Humans; Male; Middle Aged; Pain, Postoperative; Propionates; Thiophenes | 1981 |
12 other study(ies) available for thiophenes and Acute Post-operative Pain
| Article | Year |
|---|---|
Preclinical discovery and development of oliceridine (Olinvyk®) for the treatment of post-operative pain.
Topics: Analgesics, Opioid; Humans; Morphine; Pain, Postoperative; Spiro Compounds; Thiophenes | 2022 |
Budget impact and pharmacy costs with targeted use of oliceridine for postsurgical pain in patients at high risk of opioid-related adverse events.
Topics: Aged; Analgesics, Opioid; Humans; Morphine; Pain, Postoperative; Pharmacy; Spiro Compounds; Thiophenes | 2022 |
Evaluating the Incidence of Opioid-Induced Respiratory Depression Associated with Oliceridine and Morphine as Measured by the Frequency and Average Cumulative Duration of Dosing Interruption in Patients Treated for Acute Postoperative Pain.
Topics: Acute Pain; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Female; Humans; Incidence; Male; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Respiratory Insufficiency; Spiro Compounds; Thiophenes | 2020 |
Low Incidence of Postoperative Respiratory Depression with Oliceridine Compared to Morphine: A Retrospective Chart Analysis.
Topics: Acute Pain; Adolescent; Adult; Analgesics, Opioid; Clinical Trials, Phase III as Topic; Female; Humans; Incidence; Male; Middle Aged; Morphine; Pain Management; Pain, Postoperative; Respiratory Insufficiency; Retrospective Studies; Spiro Compounds; Thiophenes; Young Adult | 2020 |
Oliceridine for the Management of Acute Postoperative Pain.
Topics: Acute Pain; Analgesics, Opioid; Humans; Morphine; Pain, Postoperative; Spiro Compounds; Thiophenes | 2021 |
Oliceridine, a Novel G Protein-Biased Ligand at the μ-Opioid Receptor, Demonstrates a Predictable Relationship Between Plasma Concentrations and Pain Relief. II: Simulation of Potential Phase 3 Study Designs Using a Pharmacokinetic/Pharmacodynamic Model.
Topics: Analgesics; Clinical Protocols; Clinical Trials as Topic; Computer Simulation; Cytochrome P-450 CYP2D6; Humans; Ligands; Models, Biological; Pain; Pain Measurement; Pain, Postoperative; Spiro Compounds; Thiophenes | 2018 |
Pharmacological Characters of Oliceridine, a μ-Opioid Receptor G-Protein-Biased Ligand in Mice.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Ligands; Male; Mice; Mice, Inbred C57BL; Morphine; Pain, Postoperative; Receptors, Opioid, mu; Spiro Compounds; Thiophenes; Tibial Fractures; Toll-Like Receptor 4 | 2019 |
The analgesia effect of duloxetine on post-operative pain via intrathecal or intraperitoneal administration.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Duloxetine Hydrochloride; Hyperalgesia; Idazoxan; Injections, Intraperitoneal; Injections, Spinal; Ketanserin; Male; Microdialysis; Norepinephrine; Pain, Postoperative; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Spinal Cord; Thiophenes | 2014 |
The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model.
Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Animals; Bupivacaine; Cells, Cultured; Dermatologic Surgical Procedures; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Hyperalgesia; Injections, Intraperitoneal; Male; Pain Measurement; Pain, Postoperative; Pituitary Gland; Rats, Sprague-Dawley; Sciatic Nerve; Sodium Channel Blockers; Sodium Channels; Thiophenes; Time Factors | 2015 |
[Removal of epidural catheter under dual antiplatelet therapy following acute coronary syndrome : scenario without special consideration to the current guidelines on epidural regional anesthesia].
Topics: Acute Coronary Syndrome; Analgesia, Epidural; Aspirin; Catheterization; Clopidogrel; Digestive System Surgical Procedures; Drug Interactions; Hemorrhage; Humans; Male; Middle Aged; Pain, Postoperative; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Risk; Thiophenes; Ticlopidine | 2012 |
Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats.
Topics: Analgesics, Non-Narcotic; Animals; Calcium; Cell Membrane; Cerebellum; Dimethylamines; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Fluorometry; Glycine; Heterocyclic Compounds, 3-Ring; Hindlimb; Male; Molecular Structure; Morphine; Pain, Postoperative; Pyridines; Pyrimidinones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Rotarod Performance Test; Thiophenes; Tritium | 2008 |
[Valve of the use of an analgesic and antispasmodic medication in surgery].
Topics: Adolescent; Adult; Aged; Aminopyrine; Analgesics; Dipyrone; Drug Evaluation; Female; Humans; Male; Middle Aged; Morpholines; Pain, Postoperative; Parasympatholytics; Thiophenes | 1975 |