thiophenes has been researched along with Acute Pain in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 10 (71.43) | 2.80 |
| Authors | Studies |
|---|---|
| Bergese, SD; Gan, TJ; Gupta, A; Jin, Z; Page, C; Zhu, M | 1 |
| Viscusi, ER | 1 |
| Arscott, KA; Burt, DA; Cochrane, K; Fossler, MJ; Nafziger, AN; Skobieranda, F | 1 |
| Gan, TJ; Wase, L | 1 |
| Ayad, S; Burt, DA; Demitrack, MA; Fossler, MJ; Khanna, AK; Michalsky, C; Wase, L | 1 |
| Markham, A | 1 |
| Bergese, S; Berkowitz, R; Cochrane, K; Demitrack, MA; Griffith, S; Habib, AS; Ladouceur, M; Rider, P; Segura Vasi, A; Wase, L | 1 |
| Hu, Q; Liu, Y; Yang, J | 1 |
| Eleswarpu, SS; Habib, AS | 1 |
| Demitrack, MA; Fossler, MJ; Simpson, KN; Wase, L | 1 |
| Burt, DA; Demitrack, MA; Salamea, M; Singla, NK; Skobieranda, F; Soergel, DG; Viscusi, ER | 1 |
| Chen, XT; Cowan, CL; Crombie, AL; Dewire, SM; Gotchev, D; Koblish, M; Liu, G; Pitis, P; Rominger, DH; Violin, JD; Yamashita, DS; Yuan, C | 1 |
| Bolognese, JA; Cook, E; Daniels, S; Kuss, M; Skobieranda, F; Soergel, DG; Subach, RA; Viscusi, ER; Webster, L; Zuckerman, S | 1 |
| Bannon, AW; Decker, MW; Gauvin, D; Hsieh, GC; Joshi, SK; Lee, CH; Lewis, LG; Mikusa, J; Mills, CD; Rueter, LE; Zhong, C; Zhu, CZ | 1 |
4 review(s) available for thiophenes and Acute Pain
| Article | Year |
|---|---|
Evaluating oliceridine as a treatment option for moderate to severe acute post-operative pain in adults.
Topics: Acute Pain; Adult; Analgesics, Opioid; Humans; Morphine; Pain, Postoperative; Postoperative Nausea and Vomiting; Spiro Compounds; Thiophenes | 2022 |
A critical review of oliceridine injection as an IV opioid analgesic for the management of severe acute pain.
Topics: Acute Pain; Adult; Analgesics, Opioid; Humans; Pain, Postoperative; Randomized Controlled Trials as Topic; Spiro Compounds; Thiophenes | 2022 |
Oliceridine: First Approval.
Topics: Acute Pain; Administration, Intravenous; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Drug Approval; Humans; Pain Measurement; Receptors, Opioid, mu; Severity of Illness Index; Spiro Compounds; Thiophenes | 2020 |
Oliceridine in the treatment of moderate to severe acute pain.
Topics: Acute Pain; Analgesics, Opioid; Humans; Morphine; Receptors, Opioid, mu; Spiro Compounds; Thiophenes | 2021 |
3 trial(s) available for thiophenes and Acute Pain
| Article | Year |
|---|---|
The Influence of Renal or Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Oliceridine.
Topics: Acute Pain; Administration, Intravenous; Adult; Case-Control Studies; Female; Half-Life; Healthy Volunteers; Humans; Kidney Failure, Chronic; Ligands; Liver Diseases; Male; Middle Aged; Receptors, Opioid, mu; Safety; Severity of Illness Index; Spiro Compounds; Thiophenes | 2020 |
APOLLO-2: A Randomized, Placebo and Active-Controlled Phase III Study Investigating Oliceridine (TRV130), a G Protein-Biased Ligand at the μ-Opioid Receptor, for Management of Moderate to Severe Acute Pain Following Abdominoplasty.
Topics: Abdominoplasty; Acute Pain; Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Double-Blind Method; Female; Humans; Male; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Receptors, Opioid, mu; Spiro Compounds; Thiophenes | 2019 |
A randomized, phase 2 study investigating TRV130, a biased ligand of the μ-opioid receptor, for the intravenous treatment of acute pain.
Topics: Acute Pain; Adolescent; Adult; Aged; Analgesics, Opioid; Double-Blind Method; Female; Hallux Valgus; Humans; Male; Middle Aged; Morphine; Orthopedic Procedures; Receptors, Opioid, mu; Spiro Compounds; Thiophenes; Treatment Outcome; Young Adult | 2016 |
7 other study(ies) available for thiophenes and Acute Pain
| Article | Year |
|---|---|
Oliceridine, a G protein-selective ligand at the μ-opioid receptor, for the management of moderate to severe acute pain.
Topics: Acute Pain; Analgesics, Opioid; GTP-Binding Proteins; Humans; Morphine; Randomized Controlled Trials as Topic; Receptors, Opioid, mu; Spiro Compounds; Thiophenes | 2020 |
Evaluating the Incidence of Opioid-Induced Respiratory Depression Associated with Oliceridine and Morphine as Measured by the Frequency and Average Cumulative Duration of Dosing Interruption in Patients Treated for Acute Postoperative Pain.
Topics: Acute Pain; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Female; Humans; Incidence; Male; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Respiratory Insufficiency; Spiro Compounds; Thiophenes | 2020 |
Low Incidence of Postoperative Respiratory Depression with Oliceridine Compared to Morphine: A Retrospective Chart Analysis.
Topics: Acute Pain; Adolescent; Adult; Analgesics, Opioid; Clinical Trials, Phase III as Topic; Female; Humans; Incidence; Male; Middle Aged; Morphine; Pain Management; Pain, Postoperative; Respiratory Insufficiency; Retrospective Studies; Spiro Compounds; Thiophenes; Young Adult | 2020 |
Oliceridine for the Management of Acute Postoperative Pain.
Topics: Acute Pain; Analgesics, Opioid; Humans; Morphine; Pain, Postoperative; Spiro Compounds; Thiophenes | 2021 |
Cost-effectiveness and cost-benefit analysis of oliceridine in the treatment of acute pain.
Topics: Acute Pain; Cost-Benefit Analysis; Humans; Spiro Compounds; Thiophenes | 2021 |
Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain.
Topics: Acute Pain; Analgesics; Animals; Disease Models, Animal; Drug Discovery; GTP-Binding Proteins; HEK293 Cells; Humans; Mice; Models, Chemical; Molecular Structure; Rats; Receptors, Opioid, mu; Severity of Illness Index; Spiro Compounds; Structure-Activity Relationship; Thiophenes | 2013 |
Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain.
Topics: Acute Pain; Adrenergic Uptake Inhibitors; Amines; Amphetamine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Central Nervous System Stimulants; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Ibuprofen; Lameness, Animal; Male; Morphine; Motor Activity; Neuritis; Rats; Rats, Sprague-Dawley; Thiophenes | 2012 |