thiophenes has been researched along with Acute Myelogenous Leukemia in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 9 (50.00) | 24.3611 |
| 2020's | 7 (38.89) | 2.80 |
| Authors | Studies |
|---|---|
| Bharate, JB; Frett, B; Kharbanda, A; Lakkaniga, NR; Leung, YK; Li, HY; Mcconnell, N; Shah, NP; Wang, X; Zhang, L | 1 |
| Augeri, S; Aydin, S; Bracci, C; D'Ardia, S; Ferrero, E; Funaro, A; Marchisio, S; Massaia, M; Ortolan, E; Yakymiv, Y | 1 |
| Gai, Y; Lin, H; Liu, F; Liu, S; Lv, J; Su, Y; Wang, G; Wang, Y; Zhao, Q | 1 |
| Dittmann, J; Ewald, L; Fulda, S; Vogler, M | 1 |
| Belhadj, M; Birsen, R; Bouscary, D; Cantero Aguilar, L; Chapuis, N; Fontenay, M; Grignano, E; Guillonneau, F; Haddaoui, L; Hormi, M; Hunault, M; Huynh, T; Kosmider, O; Mayeux, P; Tamburini, J | 1 |
| Bu, ZL; Cao, Y; Fang, ZX; Lei, H; Liu, M; Liu, W; Wang, WW; Wang, YY; Wu, YL; Wu, YZ; Xiao, XH; Xu, HZ; Yu, M; Zhang, XM; Zhang, Y; Zhang, ZL | 1 |
| Adamia, S; Bhatt, S; Bohl, SR; Garcia, JS; Halilovic, E; Kim, AS; Kuang, Y; Letai, A; Leutz, B; Louissaint, A; Mashaka, T; Mehta, AK; Mogili, A; Morris, E; Olesinski, EA; Paweletz, CP; Pioso, MS; Ryan, JA; Sanghavi, S; Wang, Y; Weinstock, DM; Yilma, B; Zhu, H | 1 |
| Bacher, U; Flückiger, L; Graber, C; Pabst, T; Seipel, K | 1 |
| Adamia, S; Anderson, KC; Bhatt, S; Buhrlage, SJ; Chauhan, D; Christie, A; Christodoulou, A; De Cesare, V; Dhe-Paganon, S; Doherty, L; Gokhale, PC; Gray, NS; Griffin, JD; Lamberto, I; Letai, A; Meng, C; Nonami, A; Ritorto, MS; Sattler, M; Schauer, NJ; Seo, HS; Stone, R; Tiv, H; Trost, M; Weinstock, DM; Weisberg, EL; Wright, R; Yang, J | 1 |
| Chanrion, M; Claperon, A; Colland, F; Geneste, O; Ghiurau, C; Halilovic, E; Huang, D; Ivey, A; Kraus-Berthier, L; Lan, P; Lessene, G; Macraild, S; Maragno, AL; Morris, E; Moujalled, DM; Pomilio, G; Rijal, S; Roberts, AW; Rocchetti, F; Salmon, J; Segal, D; Teh, TC; Tiong, IS; Wang, Y; Wei, AH; Zhang, L; Zichi, A | 1 |
| Altman, MD; Bachman, E; Bouthillette, M; Chan, G; Childers, KK; Haidle, AM; Marshall, CG; Mathur, A; Mo, JR; Rosenstein, C; Rush, T; Tempest, P; Xu, L; Young, JR; Zabierek, AA | 1 |
| Albrecht, H; Basnet, SK; Diab, S; Kumarasiri, M; Li, P; Teo, T; Wang, S; Yu, M | 1 |
| Albrecht, H; Basnet, SK; Lam, F; Sykes, MJ; Teo, T; Wang, S; Yang, Y; Yu, M | 1 |
| Borkin, D; Cierpicki, T; Grembecka, J; He, M; Kempinska, K; Li, X; Miao, H; Pollock, J; Purohit, T; Shukla, S; Sun, D; Wen, B; Zhao, T | 1 |
| Cavelier, C; Demur, C; Didier, C; Ducommun, B; Quaranta, M | 1 |
| Bai, S; Lu, J; Sheng, G; Wang, C; Wang, L; Wang, Y | 1 |
| Demur, C; Didier, C; Ducommun, B; Grimal, F; Jullien, D; Manenti, S | 1 |
| Kobayashi, H; Miyachi, H; Takemura, Y | 1 |
18 other study(ies) available for thiophenes and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Molecular Structure; Mutation; NIMA-Related Kinases; Protein Kinase Inhibitors; Pyridines; Structure-Activity Relationship; Thiophenes | 2021 |
CD157 signaling promotes survival of acute myeloid leukemia cells and modulates sensitivity to cytarabine through regulation of anti-apoptotic Mcl-1.
Topics: ADP-ribosyl Cyclase; Adult; Aged; Aged, 80 and over; Antigens, CD; Antimetabolites, Antineoplastic; Apoptosis; Cells, Cultured; Cytarabine; Drug Resistance, Neoplasm; Female; GPI-Linked Proteins; Humans; Leukemia, Myeloid, Acute; Male; MAP Kinase Signaling System; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Thiophenes; THP-1 Cells | 2021 |
Cotargeting of Bcl-2 and Mcl-1 shows promising antileukemic activity against AML cells including those with acquired cytarabine resistance.
Topics: Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cytarabine; Drug Resistance, Neoplasm; Drug Synergism; Humans; Leukemia, Myeloid, Acute; Molecular Targeted Therapy; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Sulfonamides; Thiophenes | 2022 |
Side-by-side comparison of BH3-mimetics identifies MCL-1 as a key therapeutic target in AML.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Bridged Bicyclo Compounds, Heterocyclic; Caspases; Cell Line, Tumor; Humans; Leukemia, Myeloid, Acute; Middle Aged; Molecular Targeted Therapy; Myeloid Cell Leukemia Sequence 1 Protein; Peptide Fragments; Proto-Oncogene Proteins; Pyrimidines; Sulfonamides; Thiophenes; Young Adult | 2019 |
Pairing MCL-1 inhibition with venetoclax improves therapeutic efficiency of BH3-mimetics in AML.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cells, Cultured; Coculture Techniques; Drug Resistance, Neoplasm; Drug Synergism; Humans; Leukemia, Myeloid, Acute; Mesenchymal Stem Cells; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Sulfonamides; Thiophenes | 2020 |
Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Benzimidazoles; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Piperidines; Proteasome Endopeptidase Complex; Proteolysis; Signal Transduction; Thiophenes; Ubiquitin Thiolesterase | 2021 |
Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia.
Topics: Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Drug Resistance, Neoplasm; Humans; Leukemia, Myeloid, Acute; Mice; Mitochondria; Peptide Fragments; Proto-Oncogene Proteins; Pyrimidines; Signal Transduction; Sulfonamides; Thiophenes | 2020 |
Rationale for a Combination Therapy with the STAT5 Inhibitor AC-4-130 and the MCL1 Inhibitor S63845 in the Treatment of FLT3-Mutated or TET2-Mutated Acute Myeloid Leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Dioxygenases; DNA-Binding Proteins; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Proto-Oncogene Proteins; Pyrimidines; STAT5 Transcription Factor; Thiophenes; Tumor Suppressor Proteins | 2021 |
Inhibition of USP10 induces degradation of oncogenic FLT3.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Molecular Structure; Mutation; Neoplasms, Experimental; Protein Kinase Inhibitors; Small Molecule Libraries; Structure-Activity Relationship; Thiophenes; Tumor Cells, Cultured; Ubiquitin; Ubiquitin Thiolesterase | 2017 |
Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia.
Topics: Animals; Antineoplastic Agents; Biomimetics; Bridged Bicyclo Compounds, Heterocyclic; Drug Therapy, Combination; Female; Humans; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred NOD; Mice, SCID; Myeloid Cell Leukemia Sequence 1 Protein; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Sulfonamides; Thiophenes; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
Thiophene carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative neoplasms.
Topics: Aminoimidazole Carboxamide; Animals; Antineoplastic Agents; Disease Models, Animal; Enzyme Activation; Humans; Janus Kinase 2; Leukemia, Myeloid, Acute; Microsomes; Models, Biological; Molecular Structure; Protein Kinase Inhibitors; Rats; Thiophenes | 2014 |
Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d]pyrimidine derivatives as potent Mnk inhibitors: synthesis, structure-activity relationship analysis and biological evaluation.
Topics: Adenosine Triphosphate; Apoptosis; Carboxylic Acids; Cell Cycle; Cell Proliferation; Drug Discovery; Eukaryotic Initiation Factor-4E; Humans; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid, Acute; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Structure-Activity Relationship; Thiophenes; Tumor Cells, Cultured | 2015 |
Pharmacologic Inhibition of MNKs in Acute Myeloid Leukemia.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid, Acute; Mutation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Thiophenes | 2015 |
Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).
Topics: Animals; Caco-2 Cells; Cell Proliferation; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Histone-Lysine N-Methyltransferase; Humans; Injections, Intraventricular; Leukemia, Myeloid, Acute; Mice; Mice, Inbred C57BL; Mice, SCID; Models, Molecular; Molecular Structure; Myeloid-Lymphoid Leukemia Protein; Protein Binding; Proto-Oncogene Proteins; Pyrimidines; Small Molecule Libraries; Structure-Activity Relationship; Thiophenes | 2016 |
Evaluation of Polo-like Kinase 1 inhibition on the G2/M checkpoint in Acute Myelocytic Leukaemia.
Topics: Antineoplastic Agents, Phytogenic; Benzimidazoles; Cell Cycle Proteins; Cell Division; Etoposide; G2 Phase; Humans; Leukemia, Myeloid, Acute; Mitosis; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Thiophenes; U937 Cells | 2008 |
Combined effects of FLT3 and NF-κB selective inhibitors on acute myeloid leukemia in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Cell Line, Tumor; Cyclin D1; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; Nuclear Receptor Co-Repressor 2; Proto-Oncogene Proteins c-bcl-2; Sesquiterpenes; Thiophenes; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
Evaluation of checkpoint kinase targeting therapy in acute myeloid leukemia with complex karyotype.
Topics: Aged; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Checkpoint Kinase 1; Humans; Karyotype; Leukemia, Myeloid, Acute; Middle Aged; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Kinases; Thiophenes; Urea | 2012 |
Raltitrexed, a novel folate-based thymidylate synthase inhibitor, for the treatment of acute leukemia: is this drug active against acute myelogenous leukemia?
Topics: Antimetabolites, Antineoplastic; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Leukemia, Myeloid, Acute; Molecular Structure; Quinazolines; Thiophenes; Thymidylate Synthase | 2000 |