Page last updated: 2024-08-18

thiophenes and Acute Liver Injury, Drug-Induced

thiophenes has been researched along with Acute Liver Injury, Drug-Induced in 65 studies

Research

Studies (65)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (16.92)	18.7374
1990's	1 (1.54)	18.2507
2000's	19 (29.23)	29.6817
2010's	29 (44.62)	24.3611
2020's	5 (7.69)	2.80

Authors

Authors	Studies
Fan, K; Jiang, R; Li, L; Liu, G; Shao, R; Shen, Y; Tang, L; Wu, X; Yang, Y; Zhang, L	1
Abdul-Aziz, AA; Elshehawy, AA; Koutb, F; Mehany, H; Shaban, NZ; Zaki, MM	1
Chai, Y; Heng, C; Huang, X; Jiang, Z; Liu, B; Miao, Y; Sun, L; Wang, X; Wu, Z; Yang, H; Yang, T; Yu, Q; Yuan, Z; Zhang, L; Zhou, Y	1
Hao, S; Ishfaq, M; Li, C; Li, R; Liu, F; Ma, B; Shi, C; Wang, J; Yuan, L; Zhang, R; Zhang, Y	1
Fan, Y; Fu, F; Li, M; Wang, T; Yang, Y; Yue, S; Zhou, L	1
Beauchamp, J; Billon, C; Boulinguiez, A; Burris, TP; Delhaye, S; Dombrowicz, D; Duez, HM; Duhem, C; Eeckhoute, J; Ferri, L; Haas, JT; Lancel, S; Mayeuf-Louchart, A; Pourcet, B; Sebti, Y; Sitaula, S; Staels, B; Thorel, Q; Vanhoutte, J; Zecchin, M	1
Gong, Y; Kumar, S; Rahman, MA	1
Li, X; Yang, S; Yang, W; Zhan, F; Zhang, F; Zhao, G; Zhou, S	1
Catalá-López, F; de la Fuente Honrubia, C; Macías Saint-Gerons, D; Montero Corominas, D	1
Can, MM; Dinicolantonio, JJ; Kuliczkowski, W; Pershukov, IV; Serebruany, VL	1
Hong, W; Huang, Q; Liu, Y; Sun, X; Wu, J; Wu, W	1
Budmiger, M; Hürlimann, S; Kullak-Ublick, GA; Niedrig, DF; Russmann, S; Schmidt, C; Stieger, B	1
Blin, P; Gulmez, SE; Moore, N	1
Andersson, LC; Bergare, J; Billger, M; Eakins, JA; Elebring, M; Elmore, CS; Foster, AJ; Kenna, JG; Stahl, SH; Thompson, RA	1
Barrett, P; Chalasani, N; Masuoka, H; Vuppalanchi, R	1
Choi, DH; Hwang, JH; Kim, KS; Kim, YH; Lee, CH; Noh, JR	1
Abramson, J; Allbaugh, RA; Alter, H; Amano, C; Amicarella, F; Ara, N; Armengou, L; Asano, N; Bai, SJ; Ben-Shlomo, G; Benoit, E; Bhatnagar, A; Bolli, R; Boulanger, F; Brohawn, P; Brouchkov, A; Buckner, JD; Bukh, J; Buysschaert, C; Carlson, M; Cesarini, C; Cheng, L; Chipinda, I; Cogle, CR; Cooke, JP; Costa, DB; Damotte, D; Das, S; Däster, S; De Chatterjee, A; De Leon, J; Delko, T; Devi, P; Dieu-Nosjean, MC; Droeser, RA; Duarte, T; Ebert, RF; Ecker, AH; Ellis, SG; Eppenberger-Castori, S; Farhoudi, A; Folch, E; Foster, DW; Frasson, D; Fujishima, F; Gangadharan, SP; Gao, W; Germain, C; Glanemann, M; Governa, V; Grant, MB; Hammond, SA; Han, CX; Haspel, RL; He, X; Heberer, M; Henry, TD; Hettick, J; Higgs, BW; Hirt, C; Huang, Y; Huberman, MS; Iezzi, G; Iijima, K; Imatani, A; Ishikawa, N; Izumi, H; Jeon, CO; Jessell, L; Joblin, C; Johnstone, BH; Jose-Cunilleras, E; Joseph, LJ; Jung, WY; Kanazawa, I; Kang, N; Kawaguchi, K; Kawai, K; Kent, MS; Kettelhack, C; Khurshid, SS; Kinney, KA; Kitajima, S; Knockaert, S; Koike, T; Kubo, M; Kuroda, E; Lai, D; Laschke, MW; Lassiter, T; Le, X; Lee, HJ; Lehmann, K; Li, D; Li, F; Li, J; Li, XX; Liu, J; Liu, Y; Liu, YY; Liu, Z; Ma, J; Maejima, R; Majid, A; Makielski, KM; Man, S; Mao, M; Margesin, R; Martincigh, BS; Maruyama, R; Mele, V; Mendez, TL; Menger, MD; Meuleman, P; Miyake, H; Morakinyo, MK; Morimoto, Y; Moussavian, MR; Moyé, L; Myojo, T; Nebiker, CA; Nejad, SA; Nestor, B; Noguchi, T; Oertli, D; Onaka, T; Orozco, A; Oyabu, T; Padovan, E; Pepine, CJ; Perin, EC; Pilleri, P; Prentoe, J; Qiu, P; Rangachari, D; Resende, M; Ríos, J; Robles-Martinez, L; Safarzadeh, MA; Sahraei, E; Salehi, MM; Sasaki, T; Sayre, SL; Schlachtenberger, G; Schutt, RC; Sconocchia, G; Sebastian, Y; Shimada, M; Shimosegawa, T; Siegel, JA; Siegel, PD; Simari, RD; Simoyi, RH; Song, YH; Soysal, SD; Spagnoli, GC; Strongin, R; Sugimoto, T; Tanaka, KI; Tang, XD; Tao, Y; Taylor, DA; Terracciano, L; Thiessen, CE; Tofflemire, KL; Tomonaga, T; Tornillo, L; Traverse, JH; Uno, K; Valge-Archer, V; Validire, P; VanderLaan, PA; Velázquez Moctezuma, R; Verhoye, L; Viu, J; von Heesen, M; von Holzen, U; Wagner, M; Wang, FY; Wang, R; Weixler, B; Whitley, RD; Willerson, JT; Windsor, LC; Wise, E; Wu, FZ; Wu, ZY; Yamamoto, K; Yano, S; Yao, Y; Yatera, K; Yin, Q; Yoshiura, Y; Zhang, DC; Zhang, L; Zhao, DX; Zhou, Y; Zhu, W; Zhu, X; Zierold, C; Zvolensky, MJ	1
Akküçük, S; Karaboğa, I; Motor, S; Nacar, A; Nacar, E; Okuyan, HM; Ozkan, OV; Sefil, NK	1
Acharya, N; Heinloth, AN; Kuritzky, L; Regev, A; Robinson, M; Strombom, I; Wernicke, JF; Wohlreich, MM	1
Acharya, N; D'Souza, DN; DiPietro, N; Gahimer, JL; Strombom, I; Uetrecht, JP; Wernicke, J	1
Acharya, N; D'Souza, DN; Seeger, J; Strombom, I; Wernicke, JF	1
D'Souza, DN; Henck, JW; Knadler, MP; Murray, I; Pangallo, B; Uetrecht, JP; Wang, F; Wernicke, J	1
Aaron, L; Autret-Leca, E; Crickx, B; Hartingh, I; Jonville-Béra, AP	1
Ağackiran, Y; Naziroğlu, M; Ozden, A; Sirmali, R; Uz, E; Vural, H; Yesildağ, A; Yesildağ, M; Yilmaz, HR; Yilmaz, N	1
Golpon, H; Hoeper, MM; Olsson, KM; Schneider, A	1
Antoine, DJ; Benson, CA; Foster, J; Graham, EE; Hirst, CM; Kenna, JG; Mercer, AE; Park, BK; Regan, SL; Williams, DP	1
Chamoto, K; Fukuda, Y; Goto, M; Hayashi, Y; Inoue, H; Kadoshima-Yamaoka, K; Kanki, S; Miura, K; Murafuji, H; Murakawa, M; Nagahira, A; Nagahira, K; Nakatsuka, T; Nishimura, T; Ogata, A; Tanaka, Y	1
Hoeper, MM	1
Gaine, SP; Kelleher, B; Lavelle, A; Lawler, G; Mulligan, N; Murphy, DM; Sugrue, R	1
Fernandez-Fernandez, FJ; Fuente-Aguado, Jde L; Montero-Tinnirello, J; Rodriguez-Pecci, MS	1
Corris, PA; Langleben, D	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Bonkovsky, H; Chalasani, N; Fontana, RJ; Hayashi, PH; Hoofnagle, JH; Kleiner, D; Saxena, R; Vuppalanchi, R	1
Chernysheva, GA; Ivanov, IS; Kandalintseva, NV; Plotnikov, MB; Prosenko, AE; Smol'iakova, VI	2
Bayrak, R; Delibasi, T; Ekiz, F; Erarslan, E; Koca, C; Turkcu, UO; Uz, B	1
Galiè, N; Gibbs, JS; Hoeper, MM; Simonneau, G	1
Fisher, AJ; Johnson, MK; Kirkham, N; Lee, WT; Lordan, JL; Peacock, AJ	1
Berkowitz, SD; Desai, M; Horsmans, Y; Larrey, D; Maddrey, W; Peters, G; Watkins, PB	1
Adamski, H; Chevrant-Breton, J; Colin, F; Dinulescu, M; Grimaud, H; Le Gall, F; Le Merlouette, M	1
Galiè, N; Gibbs, R; Hoeper, MM; Simon, J; Simonneau, G	1
Seeger, JD; Strombom, I; Turnbull, B; Xue, F; Zhu, S	1
Bortolatto, CF; Chagas, PM; Nogueira, CW; Wilhelm, EA	1
He, F; He, Y; Huang, W; Li, Y; Qing, Y; Tong, QY; Wang, ZL; Wei, YQ; Wu, X; Wu, Y; Yang, L	1
Baltaci, D; Colakoglu, S; Kandis, H; Kara, IH; Karakus, A; Kaya, H; Memisogullari, R; Saritas, A; Yildirim, U	1
Binetti, P; La Cesa, A; Massacesi, C; Picardi, A; Santini, D; Tonini, G; Vincenzi, B	1
Bonsignori, M; Delprete, S; La Cesa, A; Marcucci, F; Massacesi, C; Rocchi, MB; Santini, D; Tonini, G; Vincenzi, B	1
MEHES, J; MOLNAR, Z; VARGA, F	1
Fadillioglu, E; Idiz, N; Ilhan, A; Iraz, M; Sahin, S; Terzi, A	1
Ammar, H; Malani, AK	1
Farombi, EO; Surh, YJ	1
Bas, O; Karaman, O; Mollaoglu, H; Nacar, A; Sahin, O; Songur, A; Yagmurca, M	1
Chordia, MD; Li, F; Macdonald, TL; Woodling, KA	1
Graham, EE; Harding, JR; Hirst, CM; Kenna, JG; Maggs, JL; Martin, S; Park, BK; Peter, RM; Walsh, RJ; Wild, MJ; Williams, DP; Wilson, ID	1
Eugene, C; Gury, B; Lefebvre, JF; Quevauvilliers, J	1
Casaretti, L; Magliocca, R	1
Arpurt, JP; Bianchi, D; Chichmanian, R; Delmont, J; Hastier, P; Kuhdorf, H; Saint-Paul, MC	1
Mitchell, JR; Potter, WZ	1
McMurtry, RJ; Mitchell, JR	1
Dybing, E; McMurtry, RJ; Mitchell, JR; Nelson, SD; Thorgeirsson, SS	1
Hirayama, Y; Kobayashi, M; Taguchi, K; Takahashi, T; Tsuchida, S; Uchida, T; Yamaki, T; Yano, M	1
Ishikawa, T; Motoi, Y; Nagasawa, S; Takizawa, T; Yamanaka, H	1
Charmot, G; Coulaud, JP; Marche, C; Penalba, C; Saimot, AG	1
Fuchs, H; Schutz, E	1
Chabrier, G; Cherfan, J; Imler, M; Simon, C	1

Reviews

8 review(s) available for thiophenes and Acute Liver Injury, Drug-Induced

Article	Year
[Hepatotoxicity in patients treated with endothelin receptor antagonists: systematic review and meta-analysis of randomized clinical trials]. Medicina clinica, 2014, Apr-22, Volume: 142, Issue:8 Topics: Antihypertensive Agents; Biomarkers; Bosentan; Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Humans; Hypertension; Isoxazoles; Phenylpropionates; Pyridazines; Randomized Controlled Trials as Topic; Safety-Based Drug Withdrawals; Sulfonamides; Thiophenes; Transaminases	2014
Raltitrexed-based chemotherapy for advanced colorectal cancer. Clinics and research in hepatology and gastroenterology, 2014, Volume: 38, Issue:2 Topics: Alopecia; Anemia; Antineoplastic Combined Chemotherapy Protocols; Asthenia; Chemical and Drug Induced Liver Injury; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Mucositis; Nausea; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Randomized Controlled Trials as Topic; Stomatitis; Thiophenes; Vomiting	2014
Answers to the most common questions about the hepatic safety profile of duloxetine. Postgraduate medicine, 2008, Volume: 120, Issue:2 Topics: Antidepressive Agents; Chemical and Drug Induced Liver Injury; Depressive Disorder; Drug Approval; Drug Labeling; Duloxetine Hydrochloride; Humans; Liver Diseases; Risk Assessment; Thiophenes; United States	2008
Hepatic effects of duloxetine-II: spontaneous reports and epidemiology of hepatic events. Current drug safety, 2008, Volume: 3, Issue:2 Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Adverse Drug Reaction Reporting Systems; Age Distribution; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Child; Consumer Product Safety; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Female; Humans; Liver; Liver Diseases; Male; Middle Aged; Risk Assessment; Selective Serotonin Reuptake Inhibitors; Sex Distribution; Thiophenes; Young Adult	2008
Hepatic effects of duloxetine-I: non-clinical and clinical trial data. Current drug safety, 2008, Volume: 3, Issue:2 Topics: Adrenergic Uptake Inhibitors; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Consumer Product Safety; Drug Evaluation, Preclinical; Duloxetine Hydrochloride; Humans; Liver; Liver Diseases; Risk Assessment; Risk Factors; Selective Serotonin Reuptake Inhibitors; Species Specificity; Thiophenes	2008
Heme oxygenase-1 as a potential therapeutic target for hepatoprotection. Journal of biochemistry and molecular biology, 2006, Sep-30, Volume: 39, Issue:5 Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Enzyme Induction; Garlic; Heme Oxygenase-1; Humans; Liver; Liver Diseases; Metals, Heavy; Pyrazines; Signal Transduction; Thiones; Thiophenes	2006
Drug metabolism in the production of liver injury. The Medical clinics of North America, 1975, Volume: 59, Issue:4 Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Drug Hypersensitivity; Ethers; Furosemide; Glutathione; Halothane; Humans; Inactivation, Metabolic; Isoniazid; Liver; Liver Neoplasms; Necrosis; Pharmaceutical Preparations; Phenacetin; Protein Binding; Thiophenes	1975
Metabolic activation: biochemical basis for many drug-induced liver injuries. Progress in liver diseases, 1976, Volume: 5 Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Furosemide; Humans; Hydrazines; Isoniazid; Liver; Methyldopa; Necrosis; Pharmaceutical Preparations; Phenacetin; Thiophenes	1976

Trials

2 trial(s) available for thiophenes and Acute Liver Injury, Drug-Induced

Article	Year
Evaluation of drug-induced serious hepatotoxicity (eDISH): application of this data organization approach to phase III clinical trials of rivaroxaban after total hip or knee replacement surgery. Drug safety, 2011, Mar-01, Volume: 34, Issue:3 Topics: Adverse Drug Reaction Reporting Systems; Aged; Alanine Transaminase; Alkaline Phosphatase; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Bilirubin; Chemical and Drug Induced Liver Injury; Double-Blind Method; Enoxaparin; Female; Fibrinolytic Agents; Humans; Liver Function Tests; Male; Middle Aged; Morpholines; Rivaroxaban; Severity of Illness Index; Thiophenes	2011
Raltitrexed-induced hepatotoxicity: multivariate analysis of predictive factors. Anti-cancer drugs, 2003, Volume: 14, Issue:7 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Folic Acid Antagonists; Humans; Logistic Models; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Predictive Value of Tests; Quinazolines; Thiophenes; Transaminases	2003

Article

Year

Evaluation of drug-induced serious hepatotoxicity (eDISH): application of this data organization approach to phase III clinical trials of rivaroxaban after total hip or knee replacement surgery.

Drug safety, 2011, Mar-01, Volume: 34, Issue:3

Topics: Adverse Drug Reaction Reporting Systems; Aged; Alanine Transaminase; Alkaline Phosphatase; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Bilirubin; Chemical and Drug Induced Liver Injury; Double-Blind Method; Enoxaparin; Female; Fibrinolytic Agents; Humans; Liver Function Tests; Male; Middle Aged; Morpholines; Rivaroxaban; Severity of Illness Index; Thiophenes

2011

Raltitrexed-induced hepatotoxicity: multivariate analysis of predictive factors.

Anti-cancer drugs, 2003, Volume: 14, Issue:7

Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Folic Acid Antagonists; Humans; Logistic Models; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Predictive Value of Tests; Quinazolines; Thiophenes; Transaminases

2003

Other Studies

55 other study(ies) available for thiophenes and Acute Liver Injury, Drug-Induced

Article	Year
REV-ERBα Agonist GSK4112 attenuates Fas-induced Acute Hepatic Damage in Mice. International journal of medical sciences, 2021, Volume: 18, Issue:16 Topics: Acute Disease; Animals; Antibodies; Apoptosis; Chemical and Drug Induced Liver Injury; Circadian Rhythm; fas Receptor; Glycine; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group D, Member 1; Thiophenes	2021
Protective and therapeutic role of mango pulp and eprosartan drug and their anti-synergistic effects against thioacetamide-induced hepatotoxicity in male rats. Environmental science and pollution research international, 2022, Volume: 29, Issue:34 Topics: Acrylates; Animals; Antioxidants; Becaplermin; Chemical and Drug Induced Liver Injury; Fibrosis; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Imidazoles; Inflammation; Liver; Male; Mangifera; Oxidative Stress; Quercetin; Rats; Rats, Wistar; Superoxide Dismutase; Thioacetamide; Thiophenes; Tumor Necrosis Factor-alpha	2022
SEW2871 attenuates ANIT-induced hepatotoxicity by protecting liver barrier function via sphingosine 1-phosphate receptor-1-mediated AMPK signaling pathway. Cell biology and toxicology, 2021, Volume: 37, Issue:4 Topics: 1-Naphthylisothiocyanate; AMP-Activated Protein Kinases; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Liver; Mice; Oxadiazoles; Signal Transduction; Sphingosine-1-Phosphate Receptors; Tandem Mass Spectrometry; Thiophenes	2021
Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway. Journal of applied toxicology : JAT, 2021, Volume: 41, Issue:12 Topics: Chemical and Drug Induced Liver Injury; Glutathione Transferase; Hep G2 Cells; Hepatocyte Nuclear Factor 1-alpha; Humans; MAP Kinase Signaling System; Pyrazines; Sphingosine; Thiones; Thiophenes	2021
Lipopolysaccharide/D-galactosamine-induced acute liver injury could be attenuated by dopamine receptor agonist rotigotine via regulating NF-κB signaling pathway. International immunopharmacology, 2021, Volume: 96 Topics: Animals; Chemical and Drug Induced Liver Injury; Dopamine Agonists; Galactosamine; Lipopolysaccharides; Liver; Male; Mice, Inbred BALB C; Microspheres; NF-kappa B; Signal Transduction; Tetrahydronaphthalenes; Thiophenes; Tumor Necrosis Factor-alpha	2021
Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice. Gastroenterology, 2018, Volume: 154, Issue:5 Topics: Animals; Caspase 1; Cells, Cultured; Chemical and Drug Induced Liver Injury; Circadian Rhythm; Cytokines; Disease Models, Animal; Galactosamine; Genetic Predisposition to Disease; Inflammasomes; Lipopolysaccharides; Liver; Liver Failure, Acute; Macrophage Activation; Macrophages, Peritoneal; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein; Nuclear Receptor Subfamily 1, Group D, Member 1; Peritonitis; Phenotype; Pyrrolidines; RNA Interference; Severity of Illness Index; Signal Transduction; Thiophenes; Time Factors; Transfection	2018
In vitro evaluation of structural analogs of diallyl sulfide as novel CYP2E1 inhibitors for their protective effect against xenobiotic-induced toxicity and HIV replication. Toxicology letters, 2018, Volume: 292 Topics: Acetaminophen; Allyl Compounds; Anti-HIV Agents; Cell Survival; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytoprotection; Dose-Response Relationship, Drug; Ethanol; Hepatocytes; HIV-1; Humans; Molecular Structure; Structure-Activity Relationship; Sulfides; Thiophenes; U937 Cells; Virus Replication	2018
Inositol-requiring enzyme 1 alpha endoribonuclease specific inhibitor STF-083010 protects the liver from thioacetamide-induced oxidative stress, inflammation and injury by triggering hepatocyte autophagy. International immunopharmacology, 2019, Volume: 73 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Autophagy; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytokines; Endoribonucleases; Hepatocytes; Male; Mice, Inbred C57BL; Oxidative Stress; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Sulfonamides; Thioacetamide; Thiophenes	2019
Gastrointestinal adverse events after dual antiplatelet therapy: clopidogrel is safer than ticagrelor, but prasugrel data are lacking or inconclusive. Cardiology, 2013, Volume: 126, Issue:1 Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Chemical and Drug Induced Liver Injury; Clinical Trials, Phase III as Topic; Clopidogrel; Double-Blind Method; Female; Gastrointestinal Hemorrhage; Gastrointestinal Neoplasms; Humans; Kaplan-Meier Estimate; Male; Multicenter Studies as Topic; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine	2013
Rivaroxaban postmarketing risk of liver injury. Journal of hepatology, 2014, Volume: 61, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Factor Xa Inhibitors; Female; Humans; Male; Middle Aged; Morpholines; Product Surveillance, Postmarketing; Risk; Rivaroxaban; Thiophenes	2014
New oral anticoagulants (NOAC) and liver injury. Journal of hepatology, 2014, Volume: 61, Issue:2 Topics: Chemical and Drug Induced Liver Injury; Factor Xa Inhibitors; Female; Humans; Male; Morpholines; Rivaroxaban; Thiophenes	2014
Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists. The Journal of pharmacology and experimental therapeutics, 2015, Volume: 352, Issue:2 Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Bosentan; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Epithelial Cells; Hepatocytes; Humans; Isoxazoles; Mitochondria; Molecular Structure; Oxygen Consumption; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes	2015
Severe drug-induced skin and liver injury from rivaroxaban. Digestive diseases and sciences, 2015, Volume: 60, Issue:6 Topics: Aged; Biopsy; Chemical and Drug Induced Liver Injury; Drug Eruptions; Factor Xa Inhibitors; Humans; Male; Morpholines; Rivaroxaban; Thiophenes	2015
Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury. Molecules and cells, 2015, Volume: 38, Issue:10 Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; Biphenyl Compounds; Cells, Cultured; Chemical and Drug Induced Liver Injury; Drug Overdose; Glycolysis; Hepatocytes; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Necrosis; Phosphorylation; Primary Cell Culture; Pyrones; Thiophenes	2015
Journal of social and clinical psychology, 2015, Volume: 34, Issue:9 Topics: Acid-Base Imbalance; Acidosis, Renal Tubular; Aged; Air Pollution, Indoor; Amino Acid Substitution; Animals; Animals, Newborn; Anti-Bacterial Agents; Antibodies, Neutralizing; Apoptosis; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Bone Marrow Transplantation; Carbonic Anhydrase Inhibitors; Castleman Disease; Cat Diseases; Cats; Cell Proliferation; Cell- and Tissue-Based Therapy; Chemical and Drug Induced Liver Injury; Chemotaxis, Leukocyte; Clinical Trials as Topic; Coated Materials, Biocompatible; Diagnosis, Differential; Disease Models, Animal; Environmental Monitoring; Female; Gas Chromatography-Mass Spectrometry; Genotype; Granuloma, Foreign-Body; Heart Failure; Hepacivirus; Hepatitis C; Horse Diseases; Horses; Housing; Humans; Hypercalcemia; Hypokalemia; Immunophenotyping; In Vitro Techniques; Liver; Liver Function Tests; Lymphocytes; Macrophages; Male; Medicine, Chinese Traditional; Metabolomics; Mice; Mice, Inbred C57BL; Middle Aged; Models, Animal; Mutation; Myocardial Ischemia; Neovascularization, Physiologic; Neutrophil Infiltration; Ocular Hypertension; Ophthalmic Solutions; Parathyroid Hormone; Particulate Matter; Polyethylene Terephthalates; Prednisolone; Prospective Studies; Prosthesis Design; Prosthesis-Related Infections; Rats; Rats, Wistar; Reactive Oxygen Species; Rifampin; Saponins; Sepsis; Skin; Stem Cells; Stroke Volume; Sulfonamides; Texas; Thiophenes; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left; Viral Hepatitis Vaccines; Viral Nonstructural Proteins; Viral Proteins; Vitamin D; Wound Healing	2015
Investigation of the protective effect of erdosteine against cyclosporine-induced injury in rat liver with histological and biochemical methods. Turkish journal of medical sciences, 2015, Volume: 45, Issue:6 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cyclosporine; Expectorants; Glutathione Peroxidase; Immunosuppressive Agents; Liver; Male; Malondialdehyde; Microscopy; Random Allocation; Rats, Wistar; Superoxide Dismutase; Thioglycolates; Thiophenes	2015
Hepatic effects of duloxetine-III: analysis of hepatic events using external data sources. Current drug safety, 2008, Volume: 3, Issue:2 Topics: Adrenergic Uptake Inhibitors; Adverse Drug Reaction Reporting Systems; Chemical and Drug Induced Liver Injury; Consumer Product Safety; Cyclohexanols; Databases as Topic; Duloxetine Hydrochloride; Humans; Liver; Risk Assessment; Selective Serotonin Reuptake Inhibitors; Thiophenes; United States; United States Food and Drug Administration; Venlafaxine Hydrochloride	2008
Strontium ranelate-induced DRESS syndrome: first two case reports. Allergy, 2009, Volume: 64, Issue:4 Topics: Aged; Anti-Inflammatory Agents; Bone Density Conservation Agents; Chemical and Drug Induced Liver Injury; Dexamethasone; Drug Eruptions; Eosinophilia; Fatal Outcome; Female; Humans; Organometallic Compounds; Osteoporosis; Thiophenes	2009
Erdosteine modulates radiocontrast-induced hepatotoxicity in rat. Cell biochemistry and function, 2009, Volume: 27, Issue:3 Topics: Animals; Catalase; Chemical and Drug Induced Liver Injury; Contrast Media; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Liver; Liver Diseases; Male; Radiopharmaceuticals; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Thioglycolates; Thiophenes	2009
Severe hepatitis associated with sitaxentan and response to glucocorticoid therapy. The European respiratory journal, 2009, Volume: 33, Issue:6 Topics: Chemical and Drug Induced Liver Injury; Eisenmenger Complex; Endothelin Receptor Antagonists; Female; Glucocorticoids; Humans; Isoxazoles; Liver Function Tests; Thiophenes; Young Adult	2009
Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis. Toxicology and applied pharmacology, 2009, Sep-15, Volume: 239, Issue:3 Topics: Animals; Apoptosis; Blotting, Western; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Glutamate-Cysteine Ligase; Glutathione; Heme Oxygenase-1; Hepatocytes; Liver; Male; Methapyrilene; Necrosis; Oxidation-Reduction; Rats; Rats, Wistar; Thiophenes	2009
Inhibition of phosphodiesterase 7A ameliorates Concanavalin A-induced hepatitis in mice. International immunopharmacology, 2009, Volume: 9, Issue:11 Topics: Alanine Transaminase; Animals; Cell Count; Chemical and Drug Induced Liver Injury; Concanavalin A; Cyclic Nucleotide Phosphodiesterases, Type 7; Fas Ligand Protein; Female; Galactosylceramides; Interleukin-4; Liver; Mice; Mice, Inbred C57BL; Natural Killer T-Cells; Pyrazoles; Spleen; Thiophenes; Tumor Necrosis Factor-alpha	2009
Liver toxicity: the Achilles' heel of endothelin receptor antagonist therapy? The European respiratory journal, 2009, Volume: 34, Issue:3 Topics: Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Humans; Isoxazoles; Thiophenes	2009
Sitaxentan-induced hepatic failure in two patients with pulmonary arterial hypertension. The European respiratory journal, 2009, Volume: 34, Issue:3 Topics: Aged; Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Thiophenes	2009
[Mirtazapine-associated hepatotoxicity]. Medicina clinica, 2010, Nov-06, Volume: 135, Issue:13 Topics: Antidepressive Agents; Chemical and Drug Induced Liver Injury; Cholestasis; Depressive Disorder; Drug Interactions; Duloxetine Hydrochloride; Humans; Kidney Failure, Chronic; Male; Mianserin; Middle Aged; Mirtazapine; Nephrosclerosis; Thiophenes	2010
The Achilles heel of endothelin receptor therapy for pulmonary arterial hypertension. The European respiratory journal, 2010, Volume: 35, Issue:2 Topics: Bosentan; Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Liver; Phenotype; Receptors, Endothelin; Sulfonamides; Thiophenes	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Duloxetine hepatotoxicity: a case-series from the drug-induced liver injury network. Alimentary pharmacology & therapeutics, 2010, Volume: 32, Issue:9 Topics: Adult; Antidepressive Agents; Biopsy; Chemical and Drug Induced Liver Injury; Duloxetine Hydrochloride; Female; Humans; Liver; Male; Middle Aged; Prospective Studies; Thiophenes	2010
[Hemorheological effects of thiophane on tetrachloromethane induced hepatic damage]. Eksperimental'naia i klinicheskaia farmakologiia, 2010, Volume: 73, Issue:8 Topics: Animals; Blood Viscosity; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Erythrocyte Aggregation; Erythrocyte Deformability; Male; Rats; Rats, Wistar; Thiophenes	2010
Effects of erdosteine on cyclosporine-A-induced hepatotoxicity in rats. Drug and chemical toxicology, 2011, Volume: 34, Issue:1 Topics: Animals; Antioxidants; Catalase; Chemical and Drug Induced Liver Injury; Cyclosporine; Glutathione Peroxidase; Immunosuppressive Agents; Liver; Liver Function Tests; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Thioglycolates; Thiophenes	2011
Liver toxicity of sitaxentan in pulmonary arterial hypertension. The European respiratory journal, 2011, Volume: 37, Issue:2 Topics: Chemical and Drug Induced Liver Injury; Contraindications; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Isoxazoles; Liver Failure; Practice Guidelines as Topic; Thiophenes	2011
Sitaxentan-related acute liver failure in a patient with pulmonary arterial hypertension. The European respiratory journal, 2011, Volume: 37, Issue:2 Topics: Chemical and Drug Induced Liver Injury; Contraindications; Endothelin A Receptor Antagonists; Familial Primary Pulmonary Hypertension; Fatal Outcome; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Jaundice; Liver Failure, Acute; Piperazines; Purines; Sildenafil Citrate; Sulfones; Thiophenes; Vasodilator Agents; Young Adult	2011
[Strontium ranelate-induced DRESS syndrome]. Annales de dermatologie et de venereologie, 2011, Volume: 138, Issue:2 Topics: Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bacteremia; Biopsy; Bone Density Conservation Agents; Chemical and Drug Induced Liver Injury; Drug Eruptions; Eosinophilia; Female; Fluorescent Antibody Technique, Direct; Humans; Immunoglobulin A; Methicillin-Resistant Staphylococcus aureus; Organometallic Compounds; Osteoporosis, Postmenopausal; Prednisone; Skin; Skin Diseases, Vesiculobullous; Staphylococcal Infections; Syndrome; Thiophenes; Vancomycin	2011
Liver toxicity of sitaxentan in pulmonary arterial hypertension. European heart journal, 2011, Volume: 32, Issue:4 Topics: Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Early Termination of Clinical Trials; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Isoxazoles; Safety-Based Drug Withdrawals; Thiophenes	2011
Duloxetine for depression and the incidence of hepatic events in adults. Journal of clinical psychopharmacology, 2011, Volume: 31, Issue:4 Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Cohort Studies; Depression; Duloxetine Hydrochloride; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Retrospective Studies; Thiophenes; Young Adult	2011
High doses of 2,2'-dithienyl diselenide cause systemic toxicity in rats: an in vitro and in vivo study. Journal of applied toxicology : JAT, 2013, Volume: 33, Issue:6 Topics: Animals; Antioxidants; Ascorbic Acid; Brain; Catalase; Chemical and Drug Induced Liver Injury; Chlorides; Drinking; Eating; Enzyme Inhibitors; Female; Glutathione; Kidney Diseases; Lipid Peroxidation; Male; Organoselenium Compounds; Oxidoreductases Acting on Sulfur Group Donors; Porphobilinogen Synthase; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Superoxide Dismutase; Thiophenes; Weight Gain; Zinc Compounds	2013
[Hepatoprotective effect of thiophane in rats with experimental carbon tetrachloride-induced hepatitis]. Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:8 Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Carbohydrate Metabolism; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatitis, Animal; Inactivation, Metabolic; Lipid Metabolism; Liver; Male; Protective Agents; Rats; Rats, Wistar; Silymarin; Thiophenes; Triglycerides	2011
TP-58, a novel thienopyridine derivative, protects mice from concanavalinA-induced hepatitis by suppressing inflammation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012, Volume: 29, Issue:1-2 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cell Line; Chemical and Drug Induced Liver Injury; Concanavalin A; Cytokines; Disease Models, Animal; Female; I-kappa B Proteins; Inflammation; Interleukin-6; Lipopolysaccharides; Liver; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Thiophenes; Tumor Necrosis Factor-alpha	2012
N-Acetyl cysteine and erdosteine treatment in acetaminophen-induced liver damage. Toxicology and industrial health, 2014, Volume: 30, Issue:7 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Antipyretics; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; International Normalized Ratio; Oxidants; Prothrombin Time; Rats; Rats, Wistar; Thioglycolates; Thiophenes	2014
Severe liver dysfunction after raltitrexed administration in an HCV-positive colorectal cancer patient. Cancer investigation, 2003, Volume: 21, Issue:1 Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Chemical and Drug Induced Liver Injury; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Enzyme Inhibitors; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver Function Tests; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes; Viremia	2003
[THE LIVER PROTECTIVE EFFECT OF CYSTEINE, HOMOCYSTEINE THIOLACTONE AND N-ACETYLHOMOCYSTEINE THIOLACTONE IN EXPERIMENTAL LIVER DAMAGE]. Arzneimittel-Forschung, 1963, Volume: 13 Topics: Alcohols; Aspartate Aminotransferases; Benzene; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cysteine; Hepatitis; Homocysteine; Lactones; Liver Function Tests; Rats; Research; Sulfobromophthalein; Thiophenes; Toxicology	1963
Protective effects of erdosteine on rotenone-induced oxidant injury in liver tissue. Toxicology and industrial health, 2004, Volume: 20, Issue:6-10 Topics: Animals; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Insecticides; Lipid Peroxidation; Liver; Male; Oxidative Stress; Rats; Rats, Wistar; Rotenone; Thioglycolates; Thiophenes	2004
Medical management of depression. The New England journal of medicine, 2006, Feb-09, Volume: 354, Issue:6 Topics: Chemical and Drug Induced Liver Injury; Depressive Disorder; Duloxetine Hydrochloride; Humans; Liver Function Tests; Piperazines; Selective Serotonin Reuptake Inhibitors; Thiophenes; Triazoles	2006
Protective effects of erdosteine on doxorubicin-induced hepatotoxicity in rats. Archives of medical research, 2007, Volume: 38, Issue:4 Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Chemical and Drug Induced Liver Injury; Doxorubicin; Lipid Peroxidation; Liver; Liver Diseases; Male; Rats; Rats, Sprague-Dawley; Thioglycolates; Thiophenes	2007
Irreversible alkylation of human serum albumin by zileuton metabolite 2-acetylbenzothiophene-S-oxide: a potential model for hepatotoxicity. Chemical research in toxicology, 2007, Volume: 20, Issue:12 Topics: Alkylation; Anti-Asthmatic Agents; Binding, Competitive; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Half-Life; Humans; Hydroxyurea; Ibuprofen; Models, Biological; Serum Albumin; Tandem Mass Spectrometry; Thiophenes; Warfarin	2007
Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 326, Issue:2 Topics: Animals; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Glutathione; Hepatocytes; Histamine H1 Antagonists; Humans; Male; Methapyrilene; Mice; Mice, Inbred Strains; Microsomes, Liver; Molecular Structure; Rats; Rats, Wistar; Thiophenes	2008
[Cholestatic hepatitis. Presumptive role of ticlopidine]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Nov-17, Volume: 59, Issue:42 Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Thiophenes; Ticlopidine	1983
[Mechanism of hepatocyte-protective action of prostenoglycine]. La Clinica terapeutica, 1981, Dec-31, Volume: 99, Issue:6 Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Glycine; Liver; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Sulfides; Thiophenes	1981
[Thiophene-induced hepatitis: a new case]. Gastroenterologie clinique et biologique, 1993, Volume: 17, Issue:8-9 Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Respiratory Tract Diseases; Thiophenes	1993
Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridine. Toxicology and applied pharmacology, 1977, Volume: 42, Issue:2 Topics: Animals; Cephaloridine; Chemical and Drug Induced Liver Injury; Furans; Furosemide; In Vitro Techniques; Kidney; Kidney Diseases; Liver; Liver Diseases; Male; Mice; Microsomes; Necrosis; Thiophenes	1977
[Preventive effect of KZ-1026 on acute liver injury induced by CCl4 in rats: histochemical, enzyme-histochemical and ultrastructural studies]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1989, Volume: 93, Issue:1 Topics: Acute Disease; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Glucose-6-Phosphatase; Histocytochemistry; Ketones; Liver; Liver Glycogen; Male; Microscopy, Electron; Rats; Rats, Inbred Strains; RNA; Thiophenes	1989
Effect of isoprothiolane on hepatic lesions of heifer caused by carbon tetrachloride. Nihon juigaku zasshi. The Japanese journal of veterinary science, 1989, Volume: 51, Issue:2 Topics: Animals; Blood Cell Count; Carbon Tetrachloride Poisoning; Cattle; Chemical and Drug Induced Liver Injury; Fatty Acids; Female; Lipids; Microsomes, Liver; Thiophenes	1989
[Eosinophilic granulomatous hepatitis. Apropos of 3 cases]. Bulletin de la Societe de pathologie exotique et de ses filiales, 1987, Volume: 80, Issue:1 Topics: Adult; Chemical and Drug Induced Liver Injury; Eosinophilic Granuloma; Humans; Male; Pyrazines; Schistosomiasis haematobia; Schistosomicides; Thiones; Thiophenes	1987
[Hepatic tolerance to ultracaine. Effect on porphyria]. L' Information dentaire, 1986, Mar-20, Volume: 68, Issue:12 Topics: Anesthesia, Dental; Animals; Carticaine; Chemical and Drug Induced Liver Injury; Dogs; Drug Tolerance; Female; Liver; Male; Porphyrias; Porphyrins; Rabbits; Rats; Thiophenes	1986
[Hepatitis caused by thiophene]. Gastroenterologie clinique et biologique, 1987, Volume: 11, Issue:2 Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Thiophenes	1987