thiopental and Vocal-Cord-Paralysis

To compare the effect of chemical and mechanical stimulation on arytenoid cartilage motion during anaesthetic induction with alfaxalone, thiopentone or propofol.. Masked, randomized, crossover study.. A group of eight adult Beagle dogs.. Anaesthesia was induced with thiopentone (7.5 mg kg. The duration of examination time was shorter among treatments combined with chemical stimulation (p=0.001). Examination time during induction was longer for alfaxalone-chemical (8.9 minutes) and -mechanical (10.9 minutes) compared to both induction with thiopentone-chemical (3.8 minutes) and propofol-chemical (4.0 minutes). The median number of arytenoid motions for both thiopentone (67) and propofol (59) induction combined with chemical stimulation was significantly higher in comparison to that of alfaxalone (1), thiopentone (2) and propofol (2), when combined with mechanical stimulation at 3 minutes after induction.. Among the regimens for assessing laryngeal motion assessed in the present study, combinations of thiopentone or propofol with doxapram are the most effective means of stimulating arytenoid motion and could improve the accuracy of diagnosis of laryngeal paralysis in dogs.

Topics: Anesthesia; Anesthetics; Anesthetics, Intravenous; Animals; Cross-Over Studies; Dog Diseases; Dogs; Larynx; Pregnanediones; Propofol; Random Allocation; Thiopental; Vocal Cord Paralysis