thiopental and Spasm

Topics: Anesthesia, Intravenous; Child; Creatine Kinase; Humans; Male; Malignant Hyperthermia; Masseter Muscle; Neuromuscular Depolarizing Agents; Spasm; Succinylcholine; Thiopental

Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Female; Humans; Middle Aged; Muscle Rigidity; Muscle Tonus; Reflex, Stretch; Spasm; Succinylcholine; Thiopental; Time Factors

Superoxide dismutase (SOD), barbiturates, and hypothermic crystalloid were evaluated for their effectiveness in minimizing ischemic damage to the spinal cord at 40 minutes of aortic occlusion. Forty-two dogs underwent proximal and distal thoracic aortic occlusion for 40 minutes with infusion of test agents into the occluded segment. The dogs were divided into six groups. Group 1 (n = 6) served as control. Group 2 (n = 6) received hypothermic crystalloid. Group 3 (n = 6) animals received thiopental. Group 4 (n = 7) received SOD. Group 5 (n = 9) received hypothermic crystalloid and thiopental. Group 6 (n = 8) received hypothermic crystalloid, thiopental and SOD. The animals were observed for neurologic deficit for 72 hours. In group 1, six of six dogs showed complete paralysis. Five of six dogs from group 2, five of six dogs from group 3, and five of seven dogs from group 4 showed complete paraplegia. The remaining dogs in these groups showed varying degrees of recovery. Four of nine dogs in group 5 had complete paraplegia, three dogs showed varying degrees of recovery, and two dogs had no neurologic deficit. In group 6, one dog had complete paraplegia, three had partial recovery, and four had no neurologic deficit. Group 6 was the only group that showed significantly less late neurologic impairment than the control group. We concluded that although cold perfusion, barbiturates, and SOD are not protective when used alone, they are effective when all are used in combination. The combination of cold perfusion, barbiturates, and SOD significantly decreases neurologic deficit after 40 minutes of aortic occlusion.

Topics: Animals; Aorta, Thoracic; Constriction; Dogs; Hypothermia, Induced; Ischemia; Paraplegia; Perfusion; Spasm; Spinal Cord; Superoxide Dismutase; Thiopental; Thoracotomy; Time Factors

Following major intracranial surgery in a 35-year-old man, sodium pentothal was intravenously infused to minimize cerebral ischaemia. Intense vasospasm with threatened gangrene arose in the arm used for the infusion. Since the cranial condition precluded use of more usual methods, lidocaine was given intra-arterially, with careful cardiovascular monitoring, to counteract the vasospasm. The treatment was rapidly successful.

Topics: Adult; Angiography; Arteries; Humans; Injections, Intra-Arterial; Lidocaine; Male; Muscle, Smooth, Vascular; Spasm; Thiopental

A case of probable crisis of malignant hyperthermia triggered by halothane is reported. The diagnosis was rapidly suspected; it evolved rapidly after the start of the specific treatment of malignant hyperthermia and the injection of calcium and thiopentone. The diagnosis and the role of calcium and thiopentone are discussed.

Topics: Anesthesia, Inhalation; Child, Preschool; Diagnosis, Differential; Halothane; Humans; Male; Malignant Hyperthermia; Spasm; Tetany; Thiopental

Topics: Acepromazine; Anesthesia, Intravenous; Anesthetics; Animals; Cyclopropanes; Drug Combinations; Hindlimb; Horse Diseases; Horses; Injections, Intravenous; Leg Injuries; Morphinans; Muscle Relaxants, Central; Narcotic Antagonists; Spasm; Thiopental; Time Factors

Topics: Acepromazine; Action Potentials; Anesthesia, Inhalation; Anesthesia, Spinal; Animals; Dog Diseases; Dogs; Electric Stimulation; Electromyography; Female; Hip Dislocation, Congenital; Male; Methoxyflurane; Muscle Contraction; Muscle Denervation; Muscles; Radiography; Reflex, Stretch; Spasm; Thiopental

Topics: Anesthesia, Intravenous; Animals; Arteries; Blood Vessels; Ear, External; Gangrene; Necrosis; Rabbits; Radiography; Spasm; Thiopental; Thrombophlebitis; Thrombosis; Veins; Venous Insufficiency

Topics: Anesthetics; Animals; Castor Oil; Electroshock; Eugenol; Hot Temperature; Hyperesthesia; Methohexital; Mice; Propanidid; Quinones; Spasm; Thiopental

Topics: Adult; Anesthesia, General; Apnea; Bicarbonates; Decamethonium Compounds; Fever; Heart Massage; Humans; Isoproterenol; Male; Metaraminol; Methamphetamine; Pulmonary Atelectasis; Pulmonary Edema; Spasm; Succinylcholine; Thiopental

Topics: Aged; Autonomic Nerve Block; Cyanosis; Edema; Hand; Hibernation; Humans; Hypothermia, Induced; Injections; Injections, Intra-Arterial; Injections, Intravenous; Pharmacology; Procaine; Spasm; Stellate Ganglion; Thiopental; Thrombophlebitis; Toxicology

Topics: Humans; Injections, Intra-Arterial; Spasm; Thiopental; Vascular Diseases

Topics: Barbiturates; Humans; Laryngeal Diseases; Laryngismus; Larynx; Spasm; Thiopental