thiopental and Shock

Topics: Acute Disease; Anesthesia; Animals; Blood Circulation; Chronic Disease; Endorphins; Halothane; Humans; Ketamine; Naloxone; Pain; Receptors, Opioid; Shock; Sleep; Thiopental

Topics: Abdomen; Anesthesia, Conduction; Anesthetics; Animals; Blood Flow Velocity; Blood Glucose; Carbon Dioxide; Chloroform; Cyclopropanes; Ethyl Ethers; Halothane; Humans; Hypotension, Controlled; Hypoxia; Insulin; Liver Circulation; Neuroleptanalgesia; Nitrous Oxide; Oxygen; Pentobarbital; Preanesthetic Medication; Regional Blood Flow; Shock; Sympathomimetics; Thiopental

Topics: Aged; Anesthetics, Intravenous; Blood Pressure; Cause of Death; Decision Making; Drug Administration Schedule; Etomidate; Heart; Humans; Middle Aged; New South Wales; Propofol; Risk Factors; Shock; Thiopental

The cardiopulmonary effects of thiopental sodium were studied in hypovolemic dogs from completion of until 1 hour after administration of the drug. Hypovolemia was induced by withdrawal of blood from dogs until mean arterial pressure of 60 mm of Hg was achieved. After stabilization at this pressure for 1 hour, 8 mg of thiopental/kg of body weight was administered IV to 7 dogs, and cardiopulmonary effects were measured. After blood withdrawal and prior to thiopental administration, heart rate and oxygen utilization ratio increased, whereas mean arterial pressure, mean pulmonary arterial pressure, central venous pressure, pulmonary wedge pressure, cardiac index, oxygen delivery, mixed venous oxygen tension, and mixed venous oxygen content decreased from baseline. Three minutes after thiopental administration, heart rate, mean arterial pressure, mean pulmonary arterial pressure, pulmonary vascular resistance, and mixed venous oxygen tension increased, whereas oxygen utilization ratio and arterial and mixed venous pH decreased from values measured prior to thiopental administration. Fifteen minutes after thiopental administration, heart rate was still increased; however by 60 minutes after thiopental administration, all measurements had returned to values similar to those obtained prior to thiopental administration.

Topics: Anesthesia; Animals; Blood Pressure; Cardiac Output; Central Venous Pressure; Dog Diseases; Dogs; Female; Heart Rate; Hemodynamics; Hydrogen-Ion Concentration; Male; Oxygen; Oxygen Consumption; Pulmonary Wedge Pressure; Respiration; Shock; Thiopental; Vascular Resistance

Topics: Animals; Blood Flow Velocity; Blood Pressure; Diazepam; Dogs; Female; Hemodynamics; Ketamine; Kidney; Male; Renal Circulation; Shock; Thiopental; Vascular Resistance

It has been shown experimentally that irreversible brain injury and death may follow after 5-7 min of cerebral ischemia and that even brief periods, 2 min or less, can produce focal damage to the nervous system. All published studies demonstrating a protective effect of barbiturates have been performed in animals. A patient is presented who recovered full neurological function after 13 min of hypovolemic hypotension. This remarkable outcome may have been due to the rapid institution of high-dose barbiturate therapy. The extent to which such therapy affected his outcome is unclear, but does add to the growing body of evidence suggesting a favorable effect from this type of barbiturate therapy.

Topics: Brain Damage, Chronic; Coronary Artery Bypass; Heart-Lung Machine; Humans; Intraoperative Complications; Ischemic Attack, Transient; Male; Middle Aged; Shock; Thiopental

Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Bradycardia; Diazepam; Dogs; Femoral Artery; Hypotension; Injections, Intra-Arterial; Muscular Diseases; Shock; Thiopental; Vascular Diseases

Topics: Adult; Anesthesia, Endotracheal; Anesthesia, Obstetrical; Cesarean Section; Female; Humans; Hypotension, Orthostatic; Obstetric Labor Complications; Posture; Pregnancy; Pregnancy Complications, Cardiovascular; Shock; Thiopental

Topics: Anesthesia, Local; Bronchial Neoplasms; Carcinoma, Adenoid Cystic; Child; Child, Preschool; Drainage; Echinococcosis, Pulmonary; Female; Heart Arrest; Hemangioma; Humans; Male; Mepivacaine; Middle Aged; Oxygen Inhalation Therapy; Postoperative Complications; Shock; Thiopental; Thoracic Neoplasms

Topics: Aged; Dilatation; Electrocardiography; Heart; Humans; Hypoxia; Lidocaine; Phonocardiography; Shock; Shock, Hemorrhagic; Thiopental

Topics: Blood Circulation; Emergencies; Heart; Hyperbaric Oxygenation; Hypoxia, Brain; Oximetry; Oxygen; Physiology; Respiration; Seizures; Shock; Thiopental; Toxicology

Topics: Animals; Barbiturates; Cyclopropanes; Ether; Rats; Shock; Thiopental

Topics: Barbital; Barbiturates; Convulsive Therapy; Curare; Electroconvulsive Therapy; Shock; Sodium; Therapeutics; Thiopental

Topics: Anesthesia; Barbital; Barbiturates; Coma; Insulin; Psychotherapy; Shock; Sodium; Thiopental