thiopental and Nerve-Degeneration

thiopental has been researched along with Nerve-Degeneration* in 2 studies

Other Studies

2 other study(ies) available for thiopental and Nerve-Degeneration

Article	Year
Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex. Brain research, 2001, Sep-21, Volume: 913, Issue:2 N-Methyl-D-aspartate (NMDA) antagonists act by an anti-excitotoxic action to provide neuroprotection against acute brain injury, but these agents can also cause toxic effects. In low doses they induce reversible neuronal injury, but in higher doses they cause irreversible degeneration of cerebrocortical neurons. GABAmimetic drugs protect against the reversible neurotoxic changes in rat brain. Here we show that two GABAmimetic anesthetic agents--propofol and sodium thiopental--protect against the irreversible neurodegenerative reaction induced by the powerful NMDA antagonist, MK-801. Topics: Anesthetics, Intravenous; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Female; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Necrosis; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Thiopental	2001
Malignant hyperthermia during anaesthesia. A neurophysiological and neuropathological follow-up study of a patient and his family. Acta anaesthesiologica Scandinavica, 1971, Volume: 15, Issue:4 Topics: Action Potentials; Adolescent; Adult; Anesthesia, General; Apnea; Biopsy; Central Nervous System; Child; Creatine Kinase; Electromyography; Female; Fever; Follow-Up Studies; Heart Rate; Humans; Male; Middle Aged; Muscles; Nerve Degeneration; Reflex, Abnormal; Succinylcholine; Thiopental	1971

Article

Year

Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex.

Brain research, 2001, Sep-21, Volume: 913, Issue:2

N-Methyl-D-aspartate (NMDA) antagonists act by an anti-excitotoxic action to provide neuroprotection against acute brain injury, but these agents can also cause toxic effects. In low doses they induce reversible neuronal injury, but in higher doses they cause irreversible degeneration of cerebrocortical neurons. GABAmimetic drugs protect against the reversible neurotoxic changes in rat brain. Here we show that two GABAmimetic anesthetic agents--propofol and sodium thiopental--protect against the irreversible neurodegenerative reaction induced by the powerful NMDA antagonist, MK-801.

Topics: Anesthetics, Intravenous; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Female; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Necrosis; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Thiopental

2001

Malignant hyperthermia during anaesthesia. A neurophysiological and neuropathological follow-up study of a patient and his family.

Acta anaesthesiologica Scandinavica, 1971, Volume: 15, Issue:4

Topics: Action Potentials; Adolescent; Adult; Anesthesia, General; Apnea; Biopsy; Central Nervous System; Child; Creatine Kinase; Electromyography; Female; Fever; Follow-Up Studies; Heart Rate; Humans; Male; Middle Aged; Muscles; Nerve Degeneration; Reflex, Abnormal; Succinylcholine; Thiopental

1971