thiopental and Hepatitis--Alcoholic

The effects of three anesthetic techniques on liver function were compared in patients with mild alcoholic hepatitis who required surgery, both peripheral and superficial. Thirty patients were randomly assigned to receive one of three anesthetics: thiopental, nitrous oxide and oxygen, enflurane, plus muscle relaxant; thiopental, nitrous oxide and oxygen, narcotic, plus muscle relaxant; or spinal anesthesia with tetracaine. Measurements of hepatic function were made preoperatively (on the day of operation) and on the first and third postoperative days. Levels of serum bilirubin, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, and lactate dehydrogenase liver isoenzyme were similar in the three groups on both postoperative days. They were not significantly different from those obtained preoperatively, although mean values decreased by the first postoperative day and again on the third. The data suggest that the choice among the three anesthetic methods studied could be based on factors other than the presence of mild alcoholic hepatitis and that, when peripheral surgery is required, one may not anticipate a worsening of any biochemical disorder in the first three postoperative days.

Topics: Adult; Alanine Transaminase; Anesthesia; Anesthesia, General; Anesthesia, Spinal; Aspartate Aminotransferases; Bilirubin; Enflurane; Hepatitis, Alcoholic; Humans; Isoenzymes; L-Lactate Dehydrogenase; Liver; Middle Aged; Narcotics; Nitrous Oxide; Random Allocation; Tetracaine; Thiopental