thiopental and Headache

The purpose of this study was to determine the rate and quality of recovery when general anaesthesia was induced with a mixture of thiopentone and propofol, compared with thiopentone or propofol alone. Sixty ASA class I and II women scheduled for out-patient laparoscopic surgery underwent induction of anaesthesia with either (i) thiopentone, (ii) propofol, or (iii) a mixture of the two, in a randomized, double-blind fashion. Anaesthesia was then maintained using nitrous oxide, isoflurane and fentanyl. A psychometric test was administered before and after surgery, and the time taken to reach a series of recovery milestones was noted. Patients were discharged as soon as they were ambulant and had satisfactory control of pain and nausea with oral agents. They were telephoned at 24-48 hr later, and asked to rate their experience of a list of side effects on an ordinal scale. Patient groups were demographically comparable and underwent surgery of the same duration. Those receiving thiopentone were discharged after a mean time of 3 hr 25 +/- 58 min (SD). The corresponding figures for propofol and the thiopentone/propofol mixture were 2 hr 40 min (+/- 49) and 2 hr 48 min (+/- 68) respectively. The recovery time between thiopentone and the other two regimes was different (P < 0.05). All three groups experienced equally frequent and severe nausea, headache, tiredness and other side effects during the next 24 hr. It is concluded that induction with a mixture of thiopentone and propofol leads to a similar rate and quality of recovery to that of propofol above.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthesia, Intravenous; Double-Blind Method; Drug Combinations; Fatigue; Female; Follow-Up Studies; Headache; Humans; Laparoscopy; Locomotion; Middle Aged; Nausea; Pain, Postoperative; Patient Discharge; Patient Satisfaction; Propofol; Psychomotor Performance; Thiopental

Between 1996 and 2000, a 36-year-old woman was admitted four times for the presumed diagnosis of status epilepticus. Major skin allergy followed by collapsus occurred each time after intravenous phenytoin therapy. Video-EEG demonstrated non epileptic, psychogenic seizure leading to the diagnosis of Münchausen syndrome by idiosyncratic reaction to antiepileptic drugs.

Topics: Adult; Anticonvulsants; Diazepam; Electroencephalography; Epilepsy; Female; Headache; Humans; Munchausen Syndrome; Panic Disorder; Phenytoin; Thiopental

Topics: Adult; Aged; Anesthesia, General; Anesthesia, Intravenous; Anesthesia, Local; Blood Gas Analysis; Blood Pressure; Electrocardiography; Female; Halothane; Headache; Humans; Infusions, Parenteral; Intracranial Pressure; Lidocaine; Male; Middle Aged; Pneumoencephalography; Posture; Respiration; Thiopental

Topics: Adult; Aged; Anesthesia, General; Arrhythmias, Cardiac; Ataxia; Atropine; Blood Pressure; Diazepam; Electrocardiography; Electroconvulsive Therapy; Electromyography; Female; Headache; Heart; Humans; Injections, Intravenous; Male; Mental Disorders; Middle Aged; Pulse; Respiration; Succinylcholine; Thiopental

Topics: Adolescent; Adult; Aged; Anesthetics; Apnea; Electroconvulsive Therapy; Female; Headache; Humans; Male; Middle Aged; Phenylacetates; Psychological Tests; Thiopental