thiopental and Edema

Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Arteriovenous Malformations; Edema; Femoral Vein; Humans; Male; Methyl Ethers; Neuromuscular Nondepolarizing Agents; Paraplegia; Piperidines; Radial Artery; Remifentanil; Sevoflurane; Thiopental; Thorax; Upper Extremity; Vecuronium Bromide; Young Adult

Starting from isothiazolopyridine-1,1-dioxide (1), corresponding derivatives of 3-aryl-4-hydroxypyrido[3,2-e]-1,2-thiazine-1,1-dioxide (6) possessing the 3-[4-(substituted-phenyl)piperazinyl]propyl or 3-(4-substituted-piperidinyl)propyl side chain by the nitrogen atom of the thiazine ring were prepared. Under pharmacological central nervous system (CNS) screening in animal models (mice), all of the six pyridothiazines 6 tested exhibited analgesic action as the predominant profile of their activity ('writhing' test 12.5-50 mg/kg). Moreover, the radical scavenging activity against peroxyl radicals of the representative pyridothiazines 6 was evaluated in vitro in water environment and some of them proved to be moderate antioxidants.

Topics: Analgesics; Animals; Antioxidants; Central Nervous System; Drug Synergism; Edema; Mice; Motor Activity; Oxides; Pain Measurement; Peroxides; Rats; Rats, Wistar; Structure-Activity Relationship; Thiazines; Thiopental

In chloralose-anesthetized cats, a hind-limb was perfused at constant flow and the vascular endothelium was made permeable for protein by intravascular injection of polidocanol and thiopental. Besides parameters of circulation and the transcapillary fluid exchange the contents of plasma protein and water were measured in skin and muscle tissue of the edematous hind-limb as well as in the contralateral untreated hind-limb. Benzarone, 2.5 mg/kg i.v., inhibited the development of the protein edemas when injected before the application of the edema producing substances. In polidocanol and thiopental-induced edemas--except for the thiopental-induced skin edema that was less marked even in the controls--benzarone had a significant effect.

Topics: Animals; Benzofurans; Blood Proteins; Cats; Edema; Muscles; Polyethylene Glycols; Skin; Thiopental

Two cases of adverse sequelae associated with the use of 2.5% thiopentone are reported: one involved extensive local venous thrombosis at the site of the injection causing great distress to the patient; the other involved a histaminoid reaction in a patient who, like others who have been reported with this type of reaction, had a history of allergy.

Topics: Adult; Anesthesia, Intravenous; Child; Drug Hypersensitivity; Edema; Female; Humans; Thiopental; Thrombophlebitis

Three patients with sensitivity to an intravenous anaesthetic-thiopentone, propanidid, and Althesin (alphadolone and alphaxalone)-are described. In the cases of thiopentone and Althesin the reaction was characterized by cardiovascular collapse, while bronchospasm also occurred with thiopentone. The reaction to propanidid was a direct skin sensitivity. All patients had a personal or family history of asthma and all had been previously exposed to the offending drug. A leucocyte challenge test showed an allergic response to thiopentone and Althesin in two patients but gave a negative result in the patient with the skin reaction. Allergic reactions can occur to all types of intravenous anaesthetics in a few patients.

Topics: Adult; Aminophylline; Anesthesia, Intravenous; Asthma; Bronchial Spasm; Carbon Dioxide; Cardiovascular System; Child; Drug Combinations; Drug Eruptions; Drug Hypersensitivity; Edema; Humans; Hydroxysteroids; Immunoglobulin E; Lactates; Leukocytes; Male; Oxygen; Pregnanediones; Propanidid; Skin Tests; Thiopental

Topics: Aged; Autonomic Nerve Block; Cyanosis; Edema; Hand; Hibernation; Humans; Hypothermia, Induced; Injections; Injections, Intra-Arterial; Injections, Intravenous; Pharmacology; Procaine; Spasm; Stellate Ganglion; Thiopental; Thrombophlebitis; Toxicology