thiopental and Down-Syndrome

The victim was a morbidly obese and bull-necked woman in her twenties. She had the disorders, due to Down's syndrome, including severe mental retardation, advanced hearing loss, congenital cataract surgery, and amblyopia at postoperative glaucoma. She was deeply sedated for rest with an intravenous drip infusion of 350 mg of thiopental (TP) for 5 minutes during an intraocular pressure examination with secondary glaucoma at a hospital. The examination was finished within 10 minutes after the TP injection, but her respiratory condition deteriorated rapidly when the doctor left the patient. Although immediate artificial respiration was carried out, she was declared dead about 20 hours after the examination. Medical malpractice was suspected for her death. At autopsy, no fatal disease or injury was observed in the victim. The serum TP level was 0.80 µg /ml. TP is an ultra-short-acting intravenous anesthetic, and usually only the smallest amount should be administered by frequent additions after pre-anesthesia administration while maintaining contact with patients. Although contact with patients with a disability can be difficult, it was diagnosed that the death was caused by both respiratory arrest due to a single dose of TP and delay in resuscitation due to the absence of a doctor.

Topics: Adult; Anesthetics, Intravenous; Autopsy; Deep Sedation; Diagnostic Techniques, Ophthalmological; Down Syndrome; Fatal Outcome; Female; Glaucoma; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Intraocular Pressure; Malpractice; Respiratory Insufficiency; Thiopental; Young Adult

Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anesthetics, General; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Atracurium; Atropine; Diclofenac; Down Syndrome; Drug Therapy, Combination; Face; Fentanyl; Hip; Humans; Hypotension; Intraoperative Complications; Legg-Calve-Perthes Disease; Male; Midazolam; Thiopental