thiopental and Deglutition-Disorders

The insertion of a laryngeal mask airway (LMA) may result in postoperative sore throat. The choice of induction drug on airway morbidity after LMA insertion may be important. We performed this study to compare the incidence of postoperative pharyngeal morbidity after the insertion of a LMA in 340 patients administered either 2 mg/kg propofol (group P) or thiopental 5 mg/kg (group T) for induction of anesthesia. Patients were maintained at 1-2 minimum alveolar anesthetic concentration sevoflurane in 50% oxygen/air. Spontaneous or assisted spontaneous ventilation was maintained. An investigator blinded to group allocation visited patients at 2, 12, and 24 h postoperatively. Adverse responses were noted (yes/no) at each time point including sore throat, sore mouth, sore jaw, hoarseness, dysphonia, and dysphagia. At 2 h postoperatively, the incidence of sore throat, dysphagia, and postoperative nausea and vomiting in group T was higher than in group P (24% vs 13% for sore throat, 15% vs 3% for dysphagia, 20% vs 11% for nausea, 14% vs 6% for vomiting, P < 0.05). The number-needed-to-treat to prevent sore throat and dysphagia was 10 and 8, respectively (95% confidence intervals, 5-43). We concluded that, when propofol, rather than thiopental, is used for the induction of anesthesia, it results in a lower incidence of early pharyngeal morbidity and postoperative nausea and vomiting after the insertion of a LMA.

Topics: Adult; Aged; Analgesics; Anesthetics, Intravenous; Deglutition Disorders; Double-Blind Method; Female; Humans; Incidence; Laryngeal Masks; Male; Middle Aged; Pain, Postoperative; Patient Satisfaction; Pharyngitis; Postoperative Nausea and Vomiting; Propofol; Prospective Studies; Thiopental; Time Factors; Treatment Outcome

Topics: Analgesics; Anesthetics, Intravenous; Deglutition Disorders; Humans; Laryngeal Masks; Pain, Postoperative; Pharyngitis; Postoperative Nausea and Vomiting; Pressure; Propofol; Thiopental; Time Factors

Topics: Ampicillin; Anti-Bacterial Agents; Atropine; Child; Child, Preschool; Deglutition Disorders; Dyspnea; Epiglottis; Female; Haemophilus Infections; Humans; Infant; Infant, Newborn; Intensive Care Units; Intubation, Intratracheal; Laryngitis; Length of Stay; Male; Methods; Pneumococcal Infections; Premedication; Staphylococcal Infections; Streptococcal Infections; Succinylcholine; Thiopental; Time Factors