thioinosine and Trypanosomiasis--African

thioinosine has been researched along with Trypanosomiasis--African* in 2 studies

Other Studies

2 other study(ies) available for thioinosine and Trypanosomiasis--African

Article	Year
Efflux of 3H-thymidine by erythrocytes from mice infected with Trypanosoma brucei brucei. Annals of tropical medicine and parasitology, 1986, Volume: 80, Issue:6 Erythrocytes from mice infected with Trypanosoma brucei brucei showed a higher rate of efflux of labelled thymidine than did control erythrocytes from uninfected mice (0.56 +/- 0.10 and 0.38 +/- 0.06 mumole min-1 ml-1 packed cells respectively). Efflux of the nucleoside from erythrocytes of normal and infected mice were inhibited to the same extent by a specific nucleoside transport inhibitor, nitrobenzylthioinosine. Enumeration of nitrobenzylthioinosine binding sites on the erythrocytes showed that both have similar numbers of sites (6.2-6.6 X 10(3) sites/erythrocyte). It is concluded that the membrane permeability of the erythrocytes from infected mice was affected by the trypanosome in such a way as to enhance the purine nucleoside transport capacity. This may result in an increased supply of vital purine bases and nucleosides to trypanosomes which depend on their hosts for these nutrients. Topics: Animals; Binding Sites; Erythrocytes; Mice; Purines; Thioinosine; Thymidine; Tritium; Trypanosoma brucei brucei; Trypanosomiasis, African	1986
Effect of nitrobenzylthioinosinate on the toxicity of tubercidin and ethidium against Trypanosoma gambiense. Acta tropica, 1982, Volume: 39, Issue:3 The coadministration of tubercidin and ethidium to mice infected with Trypanosoma gambiense gave a better parasite clearance than either of the single drugs. The combination was also more toxic to the mice but the inclusion of nitrobenzylthioinosinate in the therapy significantly alleviated the toxicity of the drug combination. Nitrobenzylthioinosinate per se had no trypanocidal activity and did not affect the trypanocidal action of the drugs. The biochemical basis for the nitrobenzylthioinosinate action appears to be due to the reduction of access of the drugs to tissues or organs sensitive to the toxic drugs. The potential for the use of this compound with nucleoside analogue compounds in the therapy of African trypanosomiasis is suggested. Topics: Animals; Drug Synergism; Drug Therapy, Combination; Ethidium; Inosine; Male; Mice; Ribonucleosides; Thioinosine; Thionucleotides; Trypanosoma brucei gambiense; Trypanosomiasis, African; Tubercidin	1982

Article

Year

Efflux of 3H-thymidine by erythrocytes from mice infected with Trypanosoma brucei brucei.

Annals of tropical medicine and parasitology, 1986, Volume: 80, Issue:6

Erythrocytes from mice infected with Trypanosoma brucei brucei showed a higher rate of efflux of labelled thymidine than did control erythrocytes from uninfected mice (0.56 +/- 0.10 and 0.38 +/- 0.06 mumole min-1 ml-1 packed cells respectively). Efflux of the nucleoside from erythrocytes of normal and infected mice were inhibited to the same extent by a specific nucleoside transport inhibitor, nitrobenzylthioinosine. Enumeration of nitrobenzylthioinosine binding sites on the erythrocytes showed that both have similar numbers of sites (6.2-6.6 X 10(3) sites/erythrocyte). It is concluded that the membrane permeability of the erythrocytes from infected mice was affected by the trypanosome in such a way as to enhance the purine nucleoside transport capacity. This may result in an increased supply of vital purine bases and nucleosides to trypanosomes which depend on their hosts for these nutrients.

Topics: Animals; Binding Sites; Erythrocytes; Mice; Purines; Thioinosine; Thymidine; Tritium; Trypanosoma brucei brucei; Trypanosomiasis, African

1986

Effect of nitrobenzylthioinosinate on the toxicity of tubercidin and ethidium against Trypanosoma gambiense.

Acta tropica, 1982, Volume: 39, Issue:3

The coadministration of tubercidin and ethidium to mice infected with Trypanosoma gambiense gave a better parasite clearance than either of the single drugs. The combination was also more toxic to the mice but the inclusion of nitrobenzylthioinosinate in the therapy significantly alleviated the toxicity of the drug combination. Nitrobenzylthioinosinate per se had no trypanocidal activity and did not affect the trypanocidal action of the drugs. The biochemical basis for the nitrobenzylthioinosinate action appears to be due to the reduction of access of the drugs to tissues or organs sensitive to the toxic drugs. The potential for the use of this compound with nucleoside analogue compounds in the therapy of African trypanosomiasis is suggested.

Topics: Animals; Drug Synergism; Drug Therapy, Combination; Ethidium; Inosine; Male; Mice; Ribonucleosides; Thioinosine; Thionucleotides; Trypanosoma brucei gambiense; Trypanosomiasis, African; Tubercidin

1982