thioinosine and Malaria

The transport of adenosine into blood from beta-thalassaemia subjects was measured to provide a background to the relationship between resistance of malaria infection and beta-thalassaemia. Adenosine transport was significantly reduced in the abnormal cells in the blood samples. As adenosine is one of the major purines salvaged by P. falciparum malaria, we suggest that the resistance to malaria in beta-thalassaemia subjects may be due to a nutrient deficiency in the abnormal red cells.

Topics: Adenosine; Adult; beta-Thalassemia; Biological Transport; Child; Erythrocytes; Humans; Malaria; Thioinosine

Topics: Adenosine; Animals; Babesia bovis; Babesiosis; Biological Transport; Cattle; Cattle Diseases; Dilazep; Drug Therapy, Combination; Erythrocyte Membrane; Erythrocytes; Malaria; Malaria, Falciparum; Mice; Plasmodium falciparum; Pyrimidine Nucleosides; Thioinosine; Thionucleotides; Tubercidin

In normal mouse erythrocytes, nucleoside permeation was almost completely blocked in the presence of binding site-saturating concentrations of nitrobenzylthioinosine, whereas permeation in erythrocytes infected with the malarial parasite, Plasmodium yoelii, was substantial under these conditions, suggesting the presence of a permeation mechanism of low sensitivity to nitrobenzylthioinosine in the infected cells. Binding sites for nitrobenzylthioinosine were more numerous on infected erythrocytes than on uninfected cells. When mice infected with P. yoelii were treated with combinations of tubercidin and nitrobenzylthioinosine 5'-monophosphate, progression of parasitemia was delayed and survival times were increased.

Topics: Adenosine; Affinity Labels; Animals; Biological Transport; Erythrocytes; Female; Inosine; Kinetics; Malaria; Mice; Mice, Inbred Strains; Plasmodium; Ribonucleosides; Thioinosine; Tritium; Tubercidin