thioinosine has been researched along with Lesch-Nyhan-Syndrome* in 2 studies
1 review(s) available for thioinosine and Lesch-Nyhan-Syndrome
Article | Year |
---|---|
High-performance liquid chromatography of nucleotides, nucleosides and bases.
Topics: Animals; Breast Neoplasms; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Deficiency Diseases; Female; Fluorouracil; Guanine; Humans; Inosine Monophosphate; Lesch-Nyhan Syndrome; Leukemia; Nucleosides; Nucleotides; Sarcoma 180; Skin; Thioinosine | 1981 |
1 other study(ies) available for thioinosine and Lesch-Nyhan-Syndrome
Article | Year |
---|---|
Adenosine transport in peripheral blood lymphocytes from Lesch-Nyhan patients.
We postulated that adenosine function could be related to some of the neurological features of Lesch-Nyhan syndrome and therefore characterized adenosine transport in PBLs (peripheral blood lymphocytes) obtained from Lesch-Nyhan patients (PBL(LN)) and from controls (PBL(C)). Adenosine transport was significantly lower in PBL(LN) when compared with that in PBL(C) and a significantly lower number of high affinity sites for [(3)H]nitrobenzylthioinosine binding were quantified per cell ( B (max)) in PBL(LN) when compared with that in PBL(C). After incubation with 25 microM hypoxanthine, adenosine transport was significantly decreased in PBL(LN) with respect to PBL(C). Hypoxanthine incubation lowers [(3)H]nitrobenzylthioinosine binding in PBL(C), with respect to basal conditions, but does not affect it in PBL(LN). This indicates that hypoxanthine affects adenosine transport in control and hypoxanthine-guanine phosphoribosyltransferase-deficient cells by different mechanisms. Topics: Adenosine; Biological Transport; Cells, Cultured; Cyclic AMP; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Lymphocytes; Thioinosine | 2004 |