thioguanine-anhydrous and Vascular-Diseases

Lesions of hepatic veno-occlusive disease were found in the needle biopsy specimen of one patient suffering from chronic granulocytic leukaemia and in the liver at necropsy of a second patient suffering from acute myeloid leukaemia. The treatment included administration of 6-thioguanine which was the only relevant compound used in the first patient and which was combined with cytosine arabinoside in the second patient.

Topics: Adult; Chemical and Drug Induced Liver Injury; Constriction, Pathologic; Female; Hepatic Veins; Humans; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Liver; Liver Diseases; Male; Thioguanine; Vascular Diseases

Clinically reversible veno-occlusive disease of the liver developed in a 23-year-old man with acute lymphocytic leukemia after 10 months of maintenance therapy with 6-thioguanine. Serial liver biopsies showed the development and resolution of intense sinusoidal engorgement. Although this disease was clinically reversible, some subintimal fibrosis about the terminal hepatic veins persisted. This case presented a unique opportunity to observe the histologic features of clinically reversible hepatic veno-occlusive disease over time, and may be the first case of veno-occlusive related solely to 6-thioguanine.

Topics: Adult; Hepatic Veins; Humans; Leukemia, Lymphoid; Liver; Male; Thioguanine; Vascular Diseases

Topics: Antineoplastic Agents; Autoimmune Diseases; Dermatitis; Dermatitis, Atopic; Dermatomyositis; Drug Therapy; Genetics, Medical; Humans; Lupus Erythematosus, Systemic; Neurodermatitis; Psoriasis; Scleroderma, Systemic; Thioguanine; Vascular Diseases