thioguanine-anhydrous and Neuritis

A patient with relapse of acute granulocytic leukemia developed an Aspergillus infection along the subcutaneous tract of a silicone rubber indwelling central venous catheter. The infection invaded the brachial plexus resulting in paralysis of the right upper extremity and subsequently invaded a major artery of the arm resulting in the demise of the patient. Both an infectious brachial plexus neuritis and fatal hemorrhage secondary to a Hickman catheter are apparently rare.

Topics: Antineoplastic Agents; Aspergillosis; Brachial Plexus; Catheters, Indwelling; Cytarabine; Female; Hemorrhage; Humans; Leukemia, Myeloid, Acute; Middle Aged; Neuritis; Thioguanine