thioguanine-anhydrous has been researched along with Head-and-Neck-Neoplasms* in 2 studies
1 trial(s) available for thioguanine-anhydrous and Head-and-Neck-Neoplasms
| Article | Year |
|---|---|
Phase II trial of 5 day continuous intravenous infusion of 6-thioguanine in patients with recurrent and metastatic squamous cell carcinoma of the head and neck.
Fifteen patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck received a 5 day continuous I.V. infusion of 6-thioguanine repeated every five weeks. Dose limiting toxicity was primarily hematological with grade III/IV leucopenia and thrombocytopenia seen in seven patients. Nausea and vomiting was moderate and well controlled with antiemetics. No complete or partial responses were observed, with a median time to progression of 58 days and a median survival of 227+ days for the entire group. Based on these results we do not recommend I.V. 6-thioguanine for the treatment of this disease. Topics: Adult; Aged; Carcinoma, Squamous Cell; Drug Administration Schedule; Drug Evaluation; Female; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; Thioguanine; Treatment Outcome | 1992 |
1 other study(ies) available for thioguanine-anhydrous and Head-and-Neck-Neoplasms
| Article | Year |
|---|---|
Clinical and pharmacologic effects of combinations of 6-thioguanine and duazomycin A in patients with neoplastic disease.
Topics: Adult; Aged; Antimetabolites; Azo Compounds; Carcinoma, Squamous Cell; Drug Synergism; Female; Head and Neck Neoplasms; Humans; Laryngeal Neoplasms; Lung Neoplasms; Male; Maxillary Neoplasms; Middle Aged; Mouth Neoplasms; Nasopharyngeal Neoplasms; Pancreatic Neoplasms; Pharyngeal Neoplasms; Sulfur Isotopes; Thioguanine; Tongue Neoplasms; Tonsillar Neoplasms | 1965 |