thioguanine-anhydrous and Cerebral-Infarction

Numerous children have been treated successfully for cancer and are surviving into adulthood. As this population has aged, an increasing number of secondary malignancies has emerged. Renal cell carcinoma (RCC) is a rare tumor in childhood and has not been documented previously to occur after treatment of acute promyelocytic leukemia (APL). This report describes the clinical course of APL treated in a child in whom RCC subsequently developed during adolescence approximately 5 years after therapy.

Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cerebral Infarction; Child; Chromosomes, Human, Pair 17; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Daunorubicin; Dexamethasone; Etoposide; Humans; Hypertension; Kidney Failure, Chronic; Leukemia, Promyelocytic, Acute; Male; Neoplasms, Second Primary; Obesity; Remission Induction; Thioguanine