thioguanine-anhydrous and Carcinoma--Basal-Cell

thioguanine-anhydrous has been researched along with Carcinoma--Basal-Cell* in 1 studies

Other Studies

1 other study(ies) available for thioguanine-anhydrous and Carcinoma--Basal-Cell

Article	Year
Normal sensitivity to mutagens, spontaneous chromosome breakage, and mutation frequency in nevoid basal cell carcinoma syndrome. Archives of dermatological research, 1988, Volume: 280 Suppl Genetic instability in nevoid basal cell carcinoma syndrome (NBCCS) was investigated by measuring in lymphocytes obtained from four patients the level of UV-induced DNA repair synthesis, the DNA replication rate after treatment with different mutagens (UV light, mono- and bifunctional alkylating agents), the baseline mutation frequency, and the spontaneous chromosome breakage. All the parameters analyzed showed normal values; only the response to mitogens in NBCCS lymphocytes was delayed in comparison to that in normal donors. Our findings indicate that chromosomal instability and cellular UV hypersensitivity described in some NBCCS patients are not distinctive and constant features of NBCCS. Topics: Adolescent; Adult; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Chromosome Aberrations; Chromosomes, Human; DNA Repair; DNA Replication; DNA, Neoplasm; Drug Resistance; Female; Humans; Lymphocytes; Male; Middle Aged; Mutagens; Mutation; Thioguanine; Ultraviolet Rays	1988

Article

Year

Normal sensitivity to mutagens, spontaneous chromosome breakage, and mutation frequency in nevoid basal cell carcinoma syndrome.

Archives of dermatological research, 1988, Volume: 280 Suppl

Genetic instability in nevoid basal cell carcinoma syndrome (NBCCS) was investigated by measuring in lymphocytes obtained from four patients the level of UV-induced DNA repair synthesis, the DNA replication rate after treatment with different mutagens (UV light, mono- and bifunctional alkylating agents), the baseline mutation frequency, and the spontaneous chromosome breakage. All the parameters analyzed showed normal values; only the response to mitogens in NBCCS lymphocytes was delayed in comparison to that in normal donors. Our findings indicate that chromosomal instability and cellular UV hypersensitivity described in some NBCCS patients are not distinctive and constant features of NBCCS.

Topics: Adolescent; Adult; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Chromosome Aberrations; Chromosomes, Human; DNA Repair; DNA Replication; DNA, Neoplasm; Drug Resistance; Female; Humans; Lymphocytes; Male; Middle Aged; Mutagens; Mutation; Thioguanine; Ultraviolet Rays

1988