thioguanine-anhydrous has been researched along with Blindness* in 2 studies
2 other study(ies) available for thioguanine-anhydrous and Blindness
| Article | Year |
|---|---|
Ocular hemorrhage secondary to thioguanine-associated veno-occlusive disease in a child with acute lymphoblastic leukemia in delayed intensification.
Hepatic VOD is a potentially fatal complication during stem cell transplantation and is rarely seen in the non-transplant setting. We report the case of a five-year-old boy who presented with visual complaints during delayed intensification phase of treatment for ALL. He was found to have bilateral retinal hemorrhages associated with profound thrombocytopenia due to chemotherapy. VOD was diagnosed based on EBMT criteria and was managed with supportive care. Despite resolution of VOD, his vision progressively deteriorated and resulted in blindness. This case highlights the significance of close monitoring of ALL patients in delayed intensification when they are at risk for developing VOD, the importance of refractory thrombocytopenia as a diagnostic feature and the potential for VOD to manifest with intraocular bleeding. Topics: Antimetabolites, Antineoplastic; Blindness; Child, Preschool; Hepatic Veno-Occlusive Disease; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retinal Hemorrhage; Thioguanine; Thrombocytopenia | 2020 |
A case of acute loss of vision as the presenting symptom of Crohn's disease.
An adolescent boy aged 17 years presented with sudden onset of visual impairment, which was rapidly diagnosed as bilateral anterior uveitis by an ophthalmologist. A systemic review noted episodes of nonbloody diarrhea, weight loss of 3 kg and a diminished appetite during the previous 10 months. The patient's family history revealed an older brother with Crohn's disease.. Visual acuity test, slit-lamp examination, ophthalmologic fundoscopy and endoscopic evaluation of the upper and lower gastrointestinal tract with biopsy.. Multifocal Crohn's disease, involving the terminal ileum and cecum, in addition to the stomach and duodenum.. Treatment with topical corticosteroids, in the form of ophthalmic drops and oral budesonide ileal-release capsules. Once remission was achieved, it was maintained with mercaptopurine. Topics: Acute Disease; Adolescent; Blindness; Colonoscopy; Crohn Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Follow-Up Studies; Glucocorticoids; Humans; Male; Ophthalmic Solutions; Thioguanine | 2007 |