thioguanine-anhydrous and Anemia--Hemolytic

Refractory dysmyelopoietic anemia (RDA) is a myeloproliferative disorder usually of elderly patients which often evolves into acute myelogenous leukemia (AML). AML in such patients is usually considered untreatable with standard aggressive chemotherapy in part because these patients are often elderly, but primarily because of the concern that the bone marrow of these patients no longer has a residual stem cell to repopulate the bone marrow following chemotherapy-induced aplasia. The authors treated three patients (ages 72, 69, and 62 years, respectively) with intensive chemotherapy after RDA evolved into AML. Each patient had been pancytopenic for 3 to 15 months prior to their transition to AML. At the onset of therapy for AML, all were severely pancytopenic with greater than 50% myeloblasts in the bone marrow. All patients had bone marrow aplasia by day 14 after chemotherapy with a complete bone marrow remission and normal peripheral counts by day 26. These data suggest that intensive chemotherapy of AML with prior RDA may result in complete bone marrow remission.

Topics: Age Factors; Aged; Anemia, Hemolytic; Bone Marrow; Cytarabine; Doxorubicin; Drug Therapy, Combination; Follow-Up Studies; Humans; Leukemia, Myeloid, Acute; Pancytopenia; Thioguanine

Topics: Alcoholism; Anemia, Hemolytic; Anemia, Hypochromic; Anticonvulsants; Azathioprine; Deoxyuridine; Epilepsy; Erythrocytes; Erythrocytes, Abnormal; Erythropoiesis; Evaluation Studies as Topic; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Mercaptopurine; Sulfamethoxazole; Thioguanine; Trimethoprim; Vitamin B 12 Deficiency

Topics: Anemia; Anemia, Hemolytic; Dermatitis, Atopic; Dermatitis, Contact; Eczema; Humans; Lupus Erythematosus, Systemic; Mercaptopurine; Scleroderma, Systemic; Thioguanine