thioflavin t has been researched along with Idiopathic Parkinson Disease in 52 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (9.62) | 18.2507 |
| 2000's | 17 (32.69) | 29.6817 |
| 2010's | 22 (42.31) | 24.3611 |
| 2020's | 8 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Outeiro, TF; Paulo, A; Ribeiro Morais, G; Santos, I; Santos, IC; Vicente Miranda, H | 1 |
| Aguirre, C; Baba, K; Choong, CJ; Doi, J; Goto, Y; Hideshima, M; Ikenaka, K; Kakuda, K; Kimura, Y; Mochizuki, H; Nabekura, K; Nagai, Y; Nagano, S; Nakajima, K; Takeuchi, T; Yamaguchi, K | 1 |
| Candreva, J; Chau, E; Kim, JR; Rice, ME | 1 |
| Genov, M; Hummel, T; Kasture, A; Krenn, L; Moloney, M; Pretsch, A; Pretsch, D; Rollinger, JM; Schmid, A; Wöhrer, T | 1 |
| Mikalauskaite, K; Smirnovas, V; Sneideris, T; Ziaunys, M | 1 |
| Baum, J; Hoop, CL; Wang, B; Williams, JK; Yang, X | 1 |
| Jiang, L; Liu, F; Lu, F; Sang, J; Wang, F; Wang, W; Wang, X; Wang, Y | 1 |
| Alijanvand, SH; Burdukiewicz, M; Christensen, LFB; Dueholm, MS; Herbst, FA; Kjeldal, H; Otzen, DE | 1 |
| Abdelhameed, AS; Khan, RH; Masroor, A; Neelofar, K; Nusrat, S; Siddqi, MK; Zaidi, N; Zaman, M | 1 |
| Abeyawardhane, DL; Crozier, MK; Fernández, RD; Forney, AK; Heitger, DR; Lucas, HR; Murgas, CJ | 1 |
| Ahn, DR; Doohun Kim, T; Kim, KK; Kim, KR; Le, LTHL; Lee, JH; Ryu, BH; Toth, G; Wang, Y; Yoo, WK | 1 |
| Bhaskar, K; Chi, EY; Fanni, AM; Lin, CY; Monge, FA; Thapa, A; Whitten, DG | 1 |
| Andreasen, M; Barker, RA; Fazal, SV; Fragniere, AMC; Scott, K; Stott, SRW | 1 |
| Adame, A; Aguzzi, A; Boersema, PJ; Courtheoux, T; Enchev, RI; Gerez, JA; Herrmann, US; Masliah, E; Peter, M; Picotti, P; Prymaczok, NC; Riek, R; Rockenstein, E; Schwarz, P | 1 |
| Egoz-Matia, N; Frenkel-Pinter, M; Gazit, E; Levy-Sakin, M; Masliah, E; Patrick, C; Rockenstein, E; Schiller, A; Segal, D; Shaltiel-Karyo, R | 1 |
| Casadei, N; De Heer, R; Kahle, PJ; Klucken, J; Krüger, R; Lucas, JJ; Noldus, LP; Nuber, S; Pöhler, AM; Riess, O; Schwedhelm, I; Spruijt, B; Tomás-Zapico, C; Torres-Peraza, J; Witz, A; Zamolo, I | 1 |
| Cremades, N; Dalla Serra, M; Dear, AJ; Dobson, CM; Horrocks, MH; Klenerman, D; Knowles, TP; Tosatto, L | 1 |
| Beckwith, JS; Chen, SW; Cremades, N; Devine, MJ; Dobson, CM; Gandhi, S; Horrocks, MH; Iljina, M; Kjaergaard, M; Klenerman, D; Lee, SF; Magdalinou, NK; Tosatto, L; Wood, NW; Zetterberg, H | 1 |
| Decossas-Mendoza, M; Krisa, S; Lambert, O; Mérillon, JM; Richard, T; Temsamani, H | 1 |
| Bickle, L; Hopwood, JJ; Karageorgos, L | 1 |
| Fink, AL; Hong, DP; Uversky, VN | 1 |
| Chiappe, D; Grimminger, V; Hang, I; Lashuel, HA; Moniatte, M; Pignat, V; Schmid, AW | 1 |
| Hirohata, M; Ikeda, T; Morinaga, A; Ono, K; Yamada, M | 1 |
| Ahmad, A | 1 |
| Giehm, L; Otzen, DE | 1 |
| Björklund, A; Brundin, P; Englund, E; Li, JY; Lindvall, O; Rehncrona, S; Widner, H | 1 |
| Bae, SY; Hwang, H; Kim, HK; Kim, JH; Kim, S; Kim, TD; Lee, S; Yoon, HC | 1 |
| Chang, JY; Hong, DP; Jiang, C; Xiong, W | 1 |
| Bannach, O; Birkmann, E; Funke, SA; Hübinger, S; Willbold, D | 1 |
| Dikiy, I; Eliezer, D; Fares, MB; Fauvet, B; Lashuel, HA; Samuel, F; Tandon, A | 1 |
| Kopito, RR; Melki, R; Quake, SR; Sourigues, Y; Streets, AM | 1 |
| Brucale, M; Bubacco, L; Codolo, G; de Bernard, M; Plotegher, N; Pozzobon, T; Tessari, I | 1 |
| Fernández, CO; Griesinger, C; Hoyer, W; Jares-Erijman, EA; Jovin, TM; Subramaniam, V; Zweckstetter, M | 1 |
| Ali, FE; Barnham, KJ; Bottomley, SP; Cappai, R; Cherny, RA; Culvenor, JG; Curtain, CC; Galatis, D; Hill, AF; Leck, SL; Masters, CL; Sharples, RA; Smith, DP; Tew, DJ; Williamson, NA | 1 |
| Minichiello, L; Unsicker, K; von Bohlen und Halbach, O | 1 |
| Hongo, K; Kawata, Y; Kusaka, E; Mizobata, T; Yagi, H | 1 |
| Bodner, N; Edridge, S; Fink, AL; Hong, DP; Kaylor, J; Yamin, G | 1 |
| Alfonso, A; Burnam, L; Hoener, M; Liu, L; Perier, C; Przedborski, S; Rodrigues, CM; Saha, S; Sluder, A; Steer, C; Ved, R; Westlund, B; Wolozin, B | 1 |
| Lev, N; Melamed, E; Offen, D | 1 |
| Ono, K; Yamada, M | 1 |
| Calissano, P; Cicconi, S; Ciotti, MT; Gentile, A; Parasassi, T; Serafino, A | 1 |
| Danzer, KM; Duan, W; Finger, S; Garidel, P; Giese, A; Glabe, CG; Habeck, M; Heinzelmann, U; Högen, T; Kostka, M; Kretzschmar, H; Levin, J; Ross, CA; Wagner, R; Wirth, A | 1 |
| Arendt, T; Bigl, V; Brückner, MK; Marcova, L | 1 |
| Hansen, LA; Mallory, M; Masliah, E; Vincent, I; Wakabayashi, K | 1 |
| Hashimoto, M; Hsu, LJ; Masliah, E; Sisk, A; Sundsmo, M; Takeda, A; Xia, Y | 1 |
| Curran, MD; El-Agnaf, OM; Jakes, R; Wallace, A | 1 |
| Bianchi, E; Curran, MD; El-Agnaf, OM; Ingenito, R; Jakes, R; Middleton, D; Neill, D; Pessi, A; Wallace, A | 1 |
| Conway, KA; Ding, TT; Lansbury, PT; Lee, SJ; Rochet, JC; Williamson, RE | 1 |
| Conway, KA; Harper, JD; Lansbury, PT | 1 |
| Farer, M; Hardy, J; Lee, JM; Ostrerova-Golts, N; Petrucelli, L; Wolozin, B | 1 |
| Duda, JE; Giasson, BI; Golbe, LI; Lee, VM; Mabon, ME; Miller, DC; Trojanowski, JQ | 1 |
| Bian, J; Chu, Y; He, J; Lin, X; Liu, YQ; Qiu, CY; Shen, Y; Wang, J; Ye, DY; Yu, WB; Zhu, ZY | 1 |
52 other study(ies) available for thioflavin t and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Fluorescence; Fluorine Radioisotopes; Heterocyclic Compounds; Insulin; Isomerism; Models, Molecular; Parkinson Disease; Protein Binding; Spectrometry, Fluorescence | 2011 |
Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson's disease.
Topics: alpha-Synuclein; Animals; Animals, Genetically Modified; Antiparkinson Agents; Benzothiazoles; Biological Assay; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Models, Animal; Drug Repositioning; HeLa Cells; High-Throughput Screening Assays; Humans; Mice, Inbred C57BL; Neurons; Parkinson Disease; Protein Aggregates; Protein Aggregation, Pathological; Spectrometry, Fluorescence; Tannins | 2022 |
Interactions between Soluble Species of β-Amyloid and α-Synuclein Promote Oligomerization while Inhibiting Fibrillization.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Brain; Electrophoresis, Polyacrylamide Gel; Humans; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Neurodegenerative Diseases; Parkinson Disease; Peptide Fragments; Protein Aggregation, Pathological | 2020 |
Prolongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans.
Topics: Aging; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Benzothiazoles; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Clioquinol; Disease Models, Animal; Emodin; Gene Knockdown Techniques; Homeostasis; Metallothionein; Metals; Neuroprotective Agents; Parkinson Disease; Quercetin; Signal Transduction | 2020 |
Effect of Ionic Strength on Thioflavin-T Affinity to Amyloid Fibrils and Its Fluorescence Intensity.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Binding Sites; Fluorescence; Humans; Insulin; Kinetics; Mice; Osmolar Concentration; Parkinson Disease; Prion Proteins; Protein Aggregates; Protein Aggregation, Pathological; Protein Binding | 2020 |
NMR unveils an N-terminal interaction interface on acetylated-α-synuclein monomers for recruitment to fibrils.
Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Binding Sites; Humans; Intrinsically Disordered Proteins; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nuclear Magnetic Resonance, Biomolecular; Parkinson Disease | 2021 |
The food additive fast green FCF inhibits α-synuclein aggregation, disassembles mature fibrils and protects against amyloid-induced neurotoxicity.
Topics: alpha-Synuclein; Amyloid; Animals; Benzothiazoles; Cell Survival; Food Additives; Hydrogen Bonding; Lissamine Green Dyes; Molecular Dynamics Simulation; Neurons; Neurotoxicity Syndromes; Parkinson Disease; PC12 Cells; Protective Agents; Protein Aggregates; Rats; Static Electricity | 2021 |
Identification of amyloidogenic proteins in the microbiomes of a rat Parkinson's disease model and wild-type rats.
Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid; Amyloidogenic Proteins; Animals; Bacterial Proteins; Benzothiazoles; Biofilms; Disease Models, Animal; Endopeptidase K; Feces; Female; Formates; Gastrointestinal Microbiome; Humans; Hydrogen-Ion Concentration; Microbial Consortia; Parkinson Disease; Protein Aggregates; Rats; Rats, Transgenic; Urea | 2021 |
Deciphering the enhanced inhibitory, disaggregating and cytoprotective potential of promethazine towards amyloid fibrillation.
Topics: Amyloid; Amyloidogenic Proteins; Amyloidosis; Anilino Naphthalenesulfonates; Benzothiazoles; Circular Dichroism; Dynamic Light Scattering; Fluorescence; Humans; Insulin; Muramidase; Parkinson Disease; Promethazine; Protein Aggregates; Protein Aggregation, Pathological; Thiazoles | 2018 |
Iron Redox Chemistry Promotes Antiparallel Oligomerization of α-Synuclein.
Topics: alpha-Synuclein; Benzothiazoles; Ferrous Compounds; Fluorescent Dyes; Humans; Oxidation-Reduction; Parkinson Disease; Thiazoles | 2018 |
Modulating α-synuclein fibril formation using DNA tetrahedron nanostructures.
Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Chromatography, Gel; DNA; Humans; Light; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Nanostructures; Nucleic Acid Conformation; Parkinson Disease; Scattering, Radiation | 2019 |
High Selectivity and Sensitivity of Oligomeric p-Phenylene Ethynylenes for Detecting Fibrillar and Prefibrillar Amyloid Protein Aggregates.
Topics: alpha-Synuclein; Amyloid beta-Peptides; Amyloidogenic Proteins; Benzothiazoles; Fluorescent Dyes; Humans; Parkinson Disease; Protein Aggregates | 2019 |
Hyperosmotic stress induces cell-dependent aggregation of α-synuclein.
Topics: alpha-Synuclein; Animals; Benzothiazoles; Blotting, Western; Cell Death; Cell Line; Cell Survival; Electrophoresis, Polyacrylamide Gel; HEK293 Cells; Hot Temperature; Humans; Hydrogen Peroxide; L-Lactate Dehydrogenase; Mice; Osmolar Concentration; Parkinson Disease; Sodium Chloride; Sodium Dodecyl Sulfate; Urea | 2019 |
A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology.
Topics: alpha-Synuclein; Animals; Benzothiazoles; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Humans; Lewy Bodies; Mice; Neuroblastoma; Neurons; Parkinson Disease; Proteome; S-Phase Kinase-Associated Proteins; Ubiquitin; Ubiquitin-Protein Ligases | 2019 |
A blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD).
Topics: alpha-Synuclein; Amyloid; Animals; Antiparkinson Agents; Benzothiazoles; Blood-Brain Barrier; Drosophila; Female; Fluorescent Dyes; Hippocampus; HSP70 Heat-Shock Proteins; Humans; Locomotion; Male; Mannitol; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Microscopy, Electron, Transmission; Neocortex; Parkinson Disease; Protein Multimerization; Protein Structure, Secondary; Thiazoles | 2013 |
Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.
Topics: Aging; alpha-Synuclein; Animals; Autophagy; Benzothiazoles; Brain; Carrier Proteins; Gene Expression; Humans; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Parkinson Disease; Protein Folding; Solubility; Thiazoles; Ubiquitin | 2014 |
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants.
Topics: alpha-Synuclein; Amino Acid Sequence; Benzothiazoles; Biological Assay; Fluorescence Resonance Energy Transfer; Humans; Kinetics; Molecular Sequence Data; Mutant Proteins; Mutation, Missense; Parkinson Disease; Protein Multimerization; Thiazoles | 2015 |
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.
Topics: Aged; Aged, 80 and over; Amyloidogenic Proteins; Benzothiazoles; Circular Dichroism; Diagnostic Imaging; Female; Humans; Male; Microscopy, Atomic Force; Microscopy, Fluorescence; Middle Aged; Parkinson Disease; Thiazoles | 2016 |
Piceatannol and Other Wine Stilbenes: A Pool of Inhibitors against α-Synuclein Aggregation and Cytotoxicity.
Topics: alpha-Synuclein; Animals; Benzothiazoles; Cell Survival; Electrophoresis, Polyacrylamide Gel; Flavonoids; Microscopy, Electron, Transmission; Parkinson Disease; PC12 Cells; Phenols; Rats; Stilbenes; Thiazoles; Wine | 2016 |
Analysis of sheep α-synuclein provides a molecular strategy for the reduction of fibrillation.
Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Humans; Hydrogen-Ion Concentration; Kinetics; Lewy Bodies; Mutation; Parkinson Disease; Protein Aggregation, Pathological; Sequence Alignment; Sheep; Solubility; Thiazoles | 2017 |
Smoking and Parkinson's disease: does nicotine affect alpha-synuclein fibrillation?
Topics: alpha-Synuclein; Amino Acid Sequence; Anabasine; Benzothiazoles; Chromatography, Gel; Cotinine; Humans; Hydroquinones; Microscopy, Atomic Force; Molecular Sequence Data; Mutation; Nicotine; Parkinson Disease; Protein Binding; Protein Multimerization; Smoking; Thiazoles | 2009 |
Dissecting the mechanisms of tissue transglutaminase-induced cross-linking of alpha-synuclein: implications for the pathogenesis of Parkinson disease.
Topics: alpha-Synuclein; Benzothiazoles; Circular Dichroism; Cross-Linking Reagents; Dimerization; Glutamine; Humans; Immunoblotting; Mutagenesis, Site-Directed; Mutation; Parkinson Disease; Protein Conformation; Spectrometry, Mass, Electrospray Ionization; Thiazoles; Transglutaminases | 2009 |
Anti-aggregation and fibril-destabilizing effects of sex hormones on alpha-synuclein fibrils in vitro.
Topics: alpha-Synuclein; Benzothiazoles; Estradiol; Estriol; Gonadal Steroid Hormones; Humans; In Vitro Techniques; Lewy Bodies; Lewy Body Disease; Microscopy, Electron; Molecular Structure; Neurofibrils; Neuroprotective Agents; Parkinson Disease; Spectrometry, Fluorescence; Testosterone; Thiazoles | 2009 |
DnaK/DnaJ/GrpE of Hsp70 system have differing effects on alpha-synuclein fibrillation involved in Parkinson's disease.
Topics: alpha-Synuclein; Amino Acid Sequence; Benzothiazoles; Chromatography, Gel; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Molecular Sequence Data; Parkinson Disease; Protein Structure, Quaternary; Thiazoles; Time Factors | 2010 |
Strategies to increase the reproducibility of protein fibrillization in plate reader assays.
Topics: alpha-Synuclein; Benzothiazoles; Fluorescent Dyes; Humans; Kinetics; Parkinson Disease; Recombinant Proteins; Reproducibility of Results; Sodium Dodecyl Sulfate; Thiazoles | 2010 |
Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease.
Topics: alpha-Synuclein; Benzothiazoles; Fetal Tissue Transplantation; Humans; Lewy Bodies; Longitudinal Studies; Male; Mesencephalon; Microscopy, Electron, Transmission; Middle Aged; Neurons; Parkinson Disease; Postmortem Changes; Thiazoles; Time Factors | 2010 |
Amyloid formation and disaggregation of α-synuclein and its tandem repeat (α-TR).
Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Catechin; Flavanones; Humans; Imidazoles; Imides; Ionic Liquids; Microscopy, Electron, Transmission; Parkinson Disease; Sulfonamides; Tandem Repeat Sequences; Thiazoles | 2010 |
The role of the C-terminus of human α-synuclein: intra-disulfide bonds between the C-terminus and other regions stabilize non-fibrillar monomeric isomers.
Topics: alpha-Synuclein; Benzothiazoles; Circular Dichroism; Cysteine; Cystine; Fluorescent Dyes; Humans; Isomerism; Kinetics; Mutagenesis, Site-Directed; Mutant Proteins; Oxidation-Reduction; Parkinson Disease; Protein Denaturation; Protein Folding; Protein Stability; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 2011 |
Detection of α-synuclein aggregates by fluorescence microscopy.
Topics: alpha-Synuclein; Benzothiazoles; Biomarkers; Circular Dichroism; Dopaminergic Neurons; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Models, Biological; Neurodegenerative Diseases; Parkinson Disease; Recombinant Proteins; Surface Properties; Temperature; Thiazoles | 2012 |
Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein.
Topics: Acetylation; alpha-Synuclein; Animals; Benzothiazoles; Escherichia coli; HEK293 Cells; HeLa Cells; Humans; Mice; Mice, Knockout; Multiprotein Complexes; Parkinson Disease; Protein Binding; Protein Structure, Secondary; Saccharomyces cerevisiae; Thiazoles | 2012 |
Simultaneous measurement of amyloid fibril formation by dynamic light scattering and fluorescence reveals complex aggregation kinetics.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Fluorescence; Humans; Huntington Disease; Kinetics; Light; Parkinson Disease; Particle Size; Protein Structure, Secondary; Thiazoles | 2013 |
Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies.
Topics: alpha-Synuclein; Analysis of Variance; Benzothiazoles; Blotting, Western; Carrier Proteins; Chromatography, Reverse-Phase; DNA Primers; Humans; Inflammasomes; Inflammation; Interleukin-1beta; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Confocal; Microscopy, Electron, Transmission; Neurons; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; Phagocytosis; Real-Time Polymerase Chain Reaction; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thiazoles; Toll-Like Receptor 2 | 2013 |
NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation.
Topics: alpha-Synuclein; Amino Acid Sequence; Benzothiazoles; Binding Sites; Fluorescent Dyes; Humans; Molecular Sequence Data; Molecular Structure; Nerve Tissue Proteins; Nuclear Magnetic Resonance, Biomolecular; Parkinson Disease; Polyamines; Protein Structure, Secondary; Synucleins; Thiazoles | 2004 |
Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway.
Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Circular Dichroism; Dopamine; Ferric Compounds; Humans; Parkinson Disease; Protein Folding; Protein Structure, Secondary; Sodium Dodecyl Sulfate; Thiazoles | 2005 |
Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra.
Topics: Aging; Alkaloids; alpha-Synuclein; Animals; Axons; Benzothiazoles; Brain-Derived Neurotrophic Factor; Crosses, Genetic; Densitometry; Dopamine; Fluorescent Dyes; Heterozygote; Immunohistochemistry; Indoles; Ligands; Male; Mice; Mutation; Neurons; Parkinson Disease; Phenotype; Quinolines; Receptor, trkB; Receptor, trkC; Signal Transduction; Substantia Nigra; Thiazoles; Tyrosine 3-Monooxygenase | 2005 |
Amyloid fibril formation of alpha-synuclein is accelerated by preformed amyloid seeds of other proteins: implications for the mechanism of transmissible conformational diseases.
Topics: alpha-Synuclein; Amyloid; Animals; Benzothiazoles; Biochemistry; Cattle; Chaperonin 10; Chickens; Circular Dichroism; Escherichia coli; Humans; Insulin; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Models, Biological; Molecular Chaperones; Muramidase; Parkinson Disease; Peptides; Protein Binding; Protein Conformation; Scattering, Radiation; Thiazoles; X-Rays | 2005 |
Characterization of oligomeric intermediates in alpha-synuclein fibrillation: FRET studies of Y125W/Y133F/Y136F alpha-synuclein.
Topics: alpha-Synuclein; Anilino Naphthalenesulfonates; Benzothiazoles; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Parkinson Disease; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Synucleins; Thiazoles; Tryptophan; Tyrosine | 2005 |
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
Topics: 3-Hydroxybutyric Acid; alpha-Synuclein; Amino Acid Sequence; Animals; Animals, Genetically Modified; Antioxidants; Apoptosis; Benzoates; Benzothiazoles; Bile Acids and Salts; Caenorhabditis elegans; Cholagogues and Choleretics; Copper; Disease Models, Animal; Electron Transport Complex I; Gene Deletion; Gene Expression Regulation; Gene Library; Genetic Techniques; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Ions; Iron; Mitochondria; Molecular Sequence Data; Mutagenesis; Mutation; Neurons; Oncogene Proteins; Oxygen Consumption; Paraquat; Parkinson Disease; Polyenes; Probucol; Protein Deglycase DJ-1; Pyrazoles; Pyridazines; RNA, Small Interfering; Rotenone; Sequence Homology, Amino Acid; Sodium Azide; Taurochenodeoxycholic Acid; Thiazoles; Time Factors; Transgenes; Ubiquitin-Protein Ligases | 2005 |
Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage.
Topics: alpha-Synuclein; Benzothiazoles; Cell Differentiation; Cell Line, Tumor; Cytoplasm; Ferrous Compounds; Humans; Immunohistochemistry; Molsidomine; Mutation; Neuroblastoma; Oxidative Stress; Parkinson Disease; Proteasome Inhibitors; Reactive Oxygen Species; Rotenone; Thiazoles; Ubiquitin | 2006 |
Vitamin A potently destabilizes preformed alpha-synuclein fibrils in vitro: implications for Lewy body diseases.
Topics: alpha-Synuclein; Antioxidants; Benzothiazoles; beta Carotene; Coenzymes; Humans; Lewy Body Disease; Microscopy, Atomic Force; Microscopy, Electron; Microscopy, Fluorescence; Neurofibrils; Neuroprotective Agents; Parkinson Disease; Thiazoles; Ubiquinone; Vitamin A; Vitamins | 2007 |
Apoptotic death induces Abeta production and fibril formation to a much larger extent than necrotic-like death in CGNs.
Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Apoptosis; Benzothiazoles; Cerebellum; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Humans; Huntington Disease; Membrane Proteins; Microfilament Proteins; Microscopy, Electron, Transmission; Necrosis; Parkinson Disease; Reticulin; Thiazoles | 2007 |
Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers.
Topics: alpha-Synuclein; Benzothiazoles; Electrophysiology; Flavanones; Fluorescent Dyes; Gene Expression Regulation; Humans; Iron; Lipid Bilayers; Microscopy, Atomic Force; Microscopy, Confocal; Models, Biological; Parkinson Disease; Protein Binding; Solvents; Thiazoles | 2008 |
Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer's disease. II. Ageing, Korsakoff's disease, Parkinson's disease, and Alzheimer's disease.
Topics: Adult; Aged; Aging; Alcohol Amnestic Disorder; Alzheimer Disease; Benzothiazoles; Cell Count; Dendrites; Female; Fluorescent Dyes; Histocytochemistry; Humans; Male; Middle Aged; Nerve Degeneration; Neuronal Plasticity; Parkinson Disease; Prosencephalon; Staining and Labeling; Thiazoles | 1995 |
Neurofibrillary tangles in the dentate granule cells of patients with Alzheimer's disease, Lewy body disease and progressive supranuclear palsy.
Topics: Alzheimer Disease; Antibodies, Monoclonal; Benzothiazoles; Dentate Gyrus; Fluorescent Dyes; Humans; Immunohistochemistry; Microscopy, Immunoelectron; Neurofibrillary Tangles; Parkinson Disease; Supranuclear Palsy, Progressive; Thiazoles | 1997 |
Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease.
Topics: Benzothiazoles; Humans; Hydrogen-Ion Concentration; Nerve Tissue Proteins; Osmolar Concentration; Parkinson Disease; Recombinant Proteins; Synucleins; Temperature; Thiazoles; Time Factors | 1998 |
Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease.
Topics: alpha-Synuclein; Amino Acid Substitution; Amyloid; Benzothiazoles; Biopolymers; Circular Dichroism; Dimerization; Humans; Hydrogen-Ion Concentration; Lewy Bodies; Microscopy, Electron; Mutation; Nerve Tissue Proteins; Parkinson Disease; Protein Structure, Secondary; Recombinant Proteins; Synucleins; Thiazoles | 1998 |
Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments.
Topics: alpha-Synuclein; Amyloid; Apoptosis; Benzothiazoles; Biopolymers; Cell Nucleus; Cell Survival; Circular Dichroism; Humans; Microscopy, Electron; Mutation; Nerve Tissue Proteins; Neuroblastoma; Neurodegenerative Diseases; Neurons; Parkinson Disease; Peptides; Protein Structure, Secondary; Synucleins; Thiazoles; Tumor Cells, Cultured | 1998 |
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy.
Topics: Age of Onset; alpha-Synuclein; Amino Acid Substitution; Amyloid; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Fluorescence; Humans; Microscopy, Atomic Force; Mutation; Nerve Tissue Proteins; Parkinson Disease; Protein Conformation; Synucleins; Thiazoles; Ultracentrifugation | 2000 |
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid.
Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; Binding Sites; Brain; Circular Dichroism; Congo Red; Endopeptidases; Humans; Hydrolysis; Immunohistochemistry; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Polarization; Molecular Sequence Data; Mutation, Missense; Nerve Tissue Proteins; Parkinson Disease; Postmortem Changes; Proline; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins; Thiazoles; Threonine | 2000 |
The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.
Topics: alpha-Synuclein; Benzothiazoles; Cell Survival; Free Radicals; Humans; Inclusion Bodies; Iron; Lewy Bodies; Mutation; Nerve Tissue Proteins; Neuroblastoma; Neurons; Oxidative Stress; Parkinson Disease; Synucleins; Thiazoles; Tumor Cells, Cultured; Ubiquitins | 2000 |
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.
Topics: Adult; alpha-Synuclein; Archives; Benzothiazoles; Brain; Fluorescent Antibody Technique; Fluorescent Dyes; Humans; Male; Microscopy, Immunoelectron; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Parkinson Disease; Synucleins; tau Proteins; Thiazoles | 2002 |
Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands.
Topics: alpha-Synuclein; Aniline Compounds; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Discovery; Humans; Ligands; Male; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Molecular Structure; Parkinson Disease; Protein Aggregates; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2021 |