thioflavin t has been researched along with Amyloid Deposits in 105 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (6.67) | 18.2507 |
| 2000's | 60 (57.14) | 29.6817 |
| 2010's | 35 (33.33) | 24.3611 |
| 2020's | 3 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Arano, Y; Haratake, M; Ishibashi, K; Mori, H; Nakayama, M; Ono, M; Yoshida, N | 1 |
| Haratake, M; Hori, M; Mori, H; Nakayama, M; Ono, M; Tomiyama, T | 1 |
| Haratake, M; Mori, H; Nakayama, M; Ono, M | 1 |
| Choi, SR; Kung, HF; Qu, W; Skovronsky, D; Zhang, W | 1 |
| An, GI; Chang, YT; Cheon, GJ; Choi, JY; Choi, TH; Hong, MC; Kim, DJ; Kim, HY; Kim, Y; Kim, YK; Lee, JS; Lee, KC; Rhee, H; Ryu, YH; Yang, SQ | 1 |
| Hur, MG; Kim, SW; Min, JJ; Park, JH; Park, SH; Park, YD; Yang, SD; Yoo, YJ; Yoon, YJ | 1 |
| Nair, AV; Ran, C; Ran, K; Yang, J; Zhu, B | 1 |
| Girigoswami, A; Girigoswami, K; Metkar, SK; Vijayashree, R | 1 |
| Fu, Z; Smith, SO; Van Nostrand, WE | 1 |
| Bednarikova, Z; Gazova, Z; Huy, PDQ; Li, MS; Linh, HQ; Phuc, LH; Thai, NQ | 1 |
| Ackermann, M; Denver, P; Kelly, P; Konerding, MA; Mitchell, CA; Satchell, SC | 1 |
| Belton, DJ; Kaplan, DL; Perry, CC; Plowright, R | 1 |
| Eriksen, JL; Georgiou, P; Gould, TD; Jarvela, TS; Lindberg, I; Womack, T | 1 |
| Sha, LZ; Shi, XZ; Wei, X; Xu, Q | 1 |
| Bode, DC; Gu, M; Viles, JH | 1 |
| Anderson, A; Barton, SM; Gore, JC; Janve, VA; Matsubara, JA; McClure, R; Pham, W | 1 |
| Bogdanović, N; Gräslund, A; Järemo, P; Jarvet, J; Jelić, V; Rigler, R; Terenius, L; Tiiman, A; Vukojević, V | 1 |
| Gao, Y; He, X; Liu, Q; Xu, F; Xu, L; Zheng, N | 1 |
| Fuchigami, T; Haratake, M; Mandai, M; Nakayama, M; Yoshida, S | 1 |
| Baumann, F; Bühler, A; Höflinger, P; Jeffrey, M; Jucker, M; McGovern, G; Nagarathinam, A; Schäfer, C; Staufenbiel, M | 1 |
| Miličević, A; Raos, N | 1 |
| Furuta, A; Imagawa, H; Matsunaga, Y; Ouma, S; Suenaga, M; Takahashi, H; Tsuboi, Y; Wagatsuma, M | 1 |
| Curtis, MA; Dragunow, M; Faull, R; Lill, C; Narayan, PJ | 1 |
| Lahiri, DK; Paule, MG; Ray, B; Raymick, J; Sarkar, S; Schmued, L | 1 |
| Choi, B; Crouzet, C; Lo, P; Vasilevko, V | 1 |
| Alberi, L; Alina Raio, N; Brai, E | 1 |
| Ashe, KH; Borchelt, DR; Forster, CL; Hemmy, LS; Huang, ES; Kuskowski, MA; Liu, P; McNellis, BM; Rao, ER; Reichl, JH; Vassar, R; Zahs, KR | 1 |
| Etienne, MA; Gordon, M; Hammer, RP; Li, Q; Morgan, D | 1 |
| Csernansky, JG; Deal, C; Dong, H; Mace, AG; Martin, MV; Yoo, HS; Yuede, CM | 1 |
| Beach, TG; Castaño, EM; Daugs, ID; Davis, J; Esh, CL; Kalback, WM; Kokjohn, TA; Lue, LF; Luehrs, DC; Patton, RL; Roher, AE; Van Nostrand, WE; Van Vickle, GD; Walker, DG | 1 |
| Levine, H; Walker, LC | 1 |
| Chávez-Macías, L; Harrington, CR; Luna-Muñoz, J; Mena, R; Peralta-Ramirez, J; Wischik, CM | 1 |
| Carroll, VL; Dickson, TC; Halliday, GM; King, AE; Shepherd, CE; Sokolova, A; Vickers, JC; Woodhouse, A | 1 |
| Beal, MF; Chen, HL; Gibson, GE; Karuppagounder, SS; Pinto, JT; Xu, H | 1 |
| Caccialanza, G; Carotti, A; Catto, M; Colombo, R; De Lorenzi, E; Lanni, C; Racchi, M; Verga, L | 1 |
| Bowles, N; Gaspar, RC; Hepler, RW; Joyce, JG; Shughrue, PJ; Villarreal, SA | 1 |
| Durany, N; Fernàndez-Busquets, X; Gella, A; Unzeta, M; Valente, T | 1 |
| Bu, G; Crick, SL; Frieden, C; Hu, X; Lee, JM; Pappu, RV | 1 |
| Haddix, T; Lee, VM; Nakashima-Yasuda, H; Robinson, J; Trojanowski, JQ; Uryu, K | 1 |
| Huang, W; Lei, H; Wang, X; Xu, W; Zhan, Y; Zhang, S | 1 |
| Bartic, C; Benilova, I; Braeken, D; Broersen, K; Callewaert, G; D'Hooge, R; De Strooper, B; Debulpaep, M; Jonckheere, W; Kuperstein, I; Martins, IC; Rousseau, F; Rozenski, J; Schymkowitz, J; Segers-Nolten, I; Subramaniam, V; Van Der Werf, K; Vandersteen, A | 1 |
| Appelt, DM; Balin, BJ; Hallock, LR; Hammond, CJ; Howanski, RJ; Little, CS | 1 |
| Borbon, IA; Erickson, RP | 1 |
| Ansciaux, E; Burtea, C; Larbanoix, L; Laurent, S; Mahieu, I; Muller, RN; Vander Elst, L | 1 |
| Georgopoulos, S; Katsouri, L | 1 |
| Chamberlain, R; Curran, GL; Garwood, M; Hultman, KL; Jack, CR; Marjańska, M; Poduslo, JF; Preboske, GM; Wengenack, TM | 1 |
| Cho, JY; Heo, J; Hong, S; Jung, G; Lee, SJ; Ryu, J | 1 |
| Ikeda, T; Ono, K; Takahashi, R; Yamada, M | 1 |
| Beker, S; Kellner, V; Kerti, L; Stern, EA | 1 |
| Aronow, BJ; Bales, KR; DeMattos, RB; Harmony, JA; Holtzman, DM; O'dell, MA; Parsadanian, M; Paul, SM; Taylor, JW | 1 |
| Bacskai, BJ; Games, D; Hyman, BT; Kajdasz, ST; McLellan, ME; Schenk, D; Seubert, P | 1 |
| Capsoni, S; Cattaneo, A; Giannotta, S | 1 |
| Ashe, KH; Cruz, L; Duff, K; Hyman, BT; Irizarry, MC; Le, R; Sanders, J; Stanley, HE; Urbanc, B | 1 |
| Hou, C; Kung, HF; Kung, MP; Lee, VM; Skovronsky, D; Trojanowski, JQ; Zhang, B; Zhuang, ZP | 1 |
| Borowski, BJ; Curran, GL; Jack, CR; Macura, SI; Poduslo, JF; Sigurdsson, EM; Wengenack, TM; Wisniewski, T | 1 |
| Bacskai, BJ; D'Amore, JD; Hyman, BT; Kajdasz, ST; McLellan, ME; Stern, EA | 1 |
| Ban, T; Goto, Y; Hamada, D; Hasegawa, K; Naiki, H | 1 |
| Bacskai, BJ; Hyman, BT; Kajdasz, ST; McLellan, ME | 1 |
| Dickson, TC; Tan, A; Vickers, JC | 1 |
| Clarke, K; DiCarlo, G; Gordon, MN; Henderson, D; Jackson, J; Morgan, D; Ugen, KE; Wilcock, DM | 1 |
| Hou, C; Jin, LW; Kung, HF; Kung, MP; Zhuang, ZP | 1 |
| Akatsu, H; Kudo, Y; Okamura, N; Sawada, T; Shimadzu, H; Shiomitsu, T; Suemoto, T; Suzuki, M; Yamamoto, T | 1 |
| Czilli, DL; DeMattos, RB; Gitter, B; Holtzman, DM; Kowalewski, T; Legleiter, J | 1 |
| Fonseca, MI; Kawas, CH; Tenner, AJ; Troncoso, JC | 1 |
| Emadi, S; Goud, G; Liu, R; Lyubchenko, Y; McAllister, C; Schulz, P; Sierks, MR; Yuan, B; Zameer, A | 1 |
| Dudal, S; Gervais, F; Krzywkowski, P; Lacombe, D; Morissette, C; Paquette, J; Tremblay, P | 1 |
| Duff, K; Hashimoto, T; Iwatsubo, T; Kowa, H; Mann, DM; Matsuura, Y; Sakakura, T; Tsuji, S; Wakabayashi, T | 1 |
| Barbour, R; Bard, F; Bussière, T; Buttini, M; Games, D; Grajeda, H; Guido, T; Khan, K; Schenk, D; Seubert, P | 1 |
| Chang, L; De Felice, FG; Ferreira, ST; Figueroa-Villar, JD; Garcia-Abreu, J; Klein, WL; Liu, R; Saraiva, LM; Vieira, MN | 1 |
| Ambegaokar, SS; Begum, AN; Chen, PP; Cole, GM; Frautschy, SA; Glabe, CG; Kayed, R; Lim, GP; Simmons, MR; Ubeda, OJ; Yang, F | 1 |
| Arendt, T; Brückner, MK; Gärtner, U; Gebhardt, R; Gruschka, H; Seeger, G; Ueberham, E; Ueberham, U | 1 |
| Beard, J; Das, P; DeLucia, M; Dickson, DW; Dolios, G; Eckman, CB; Eriksen, J; Golde, T; Hardy, J; Hutton, M; Jansen, K; Kim, J; Lin, WL; McGowan, E; Murphy, MP; Onstead, L; Pickford, F; Skipper, L; Wang, R; Yu, C | 1 |
| Iwasa, K; Matsumoto, Y; Naiki, H; Noguchi, M; Ono, K; Yamada, M; Yanase, D | 1 |
| Adriany, G; Borowski, BJ; Curran, GL; Garwood, M; Holasek, SS; Jack, CR; Lin, J; Poduslo, JF; Preboske, GM; Reyes, DA; Wengenack, TM | 1 |
| Cai, L; Pike, VW; Wang, Y; Wei, J; Wu, C | 1 |
| Bourhim, M; Kruzel, M; Nicotera, T; Srikrishnan, T | 1 |
| Johne, R; Reimers, C; Schliebs, R; Seeger, J; Stahl, T | 1 |
| Christen, Y; Garneau, P; Longpré, F; Ramassamy, C | 1 |
| Ono, M | 1 |
| Bojsen-Møller, M; Braendgaard, H; Frangione, B; Ghiso, J; Holton, J; Lashley, T; Meyerson, J; Ng, D; Plant, G; Revesz, T; Rostagno, A | 1 |
| Akagi, T; Takashima, A; Yoshiike, Y | 1 |
| Beach, TG; Brune, D; Esh, CL; Fifield, FG; Fraser, PE; Kalback, WM; Kokjohn, TA; Lopez, J; Luehrs, DC; McLaurin, J; Newel, AJ; Patton, RL; Poston, M; Roher, AE; Van Vickle, GD; Westaway, D | 1 |
| Austin, CP; Honson, NS; Huang, W; Inglese, J; Johnson, RL; Kuret, J | 1 |
| Guillozet, AL; Mash, DC; Mesulam, MM; Smiley, JF | 1 |
| Crutcher, KA; Joshi, SN | 1 |
| Crutcher, KA; Scott, SA; Tolar, M | 1 |
| Alvarez, A; Bronfman, FC; Inestrosa, NC; Morgan, C | 1 |
| Geula, C; Mesulam, MM; Saroff, DM; Wu, CK | 1 |
| Dickson, DW; Lee, VM; Trojanowski, JQ; Wang, J | 1 |
| Boelens, WC; Bosman, GJ; de Jong, WW; Overkamp, PS; Reijnen-Aalbers, A; Renkawek, K; Stege, GJ; van Rijk, AF; Verschuure, P | 1 |
| Bales, KR; Fagan, AM; Holtzman, DM; Mackey, B; McKeel, D; Olney, J; Parsadanian, M; Paul, SM; Sartorius, LJ; Tenkova, T; Wozniak, D | 1 |
| Isobe, I; Michikawa, M; Yanagisawa, K | 1 |
| Chu, CC; Parvizi, J; Van Hoesen, GW | 1 |
| Dagø, L; Olesen, OF | 1 |
| Hamilton, RL; Klunk, WE; Styren, GC; Styren, SD | 1 |
| Bacskai, BJ; Christie, RH; Hyman, BT; Kajdasz, ST; Webb, WW; Williams, RM; Zipfel, WR | 1 |
| Azizeh, BY; Cotman, CW; Cribbs, DH; Head, E; Lott, IT; Tenner, AJ | 1 |
| Bales, KR; Cummins, DJ; DeLong, CA; Esterman, MA; Fishman, CE; Hanson, JC; Jordan, WH; Paul, SM; White, SL | 1 |
| Dickson, TC; Vickers, JC | 1 |
| Cruz, L; Duff, K; Hsiao-Ashe, K; Hyman, BT; Irizarry, MC; Knowles, RB; Le, R; Stanley, HE; Urbanc, B | 1 |
| Emson, PC; Iritani, S; Niizato, K | 1 |
| Borowska-Lehman, J; Gross, M; Izycka-Swieszewska, E; Rzepko, R; Zółtowska, A | 1 |
| Mallory, M; Mante, M; Masliaha, E; Rockenstein, E; Sisk, A | 1 |
| Bacskai, BJ; Debnath, ML; Frosch, MP; Holt, DP; Huang, GF; Hyman, BT; Kajdasz, ST; Klunk, WE; Mathis, CA; McLellan, ME; Wang, Y | 1 |
| Geula, C; Nagykery, N; Wu, CK | 1 |
1 review(s) available for thioflavin t and Amyloid Deposits
| Article | Year |
|---|---|
[Molecular imaging of beta-amyloid plaques in the brain].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Brain; Congo Red; Humans; Mice; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2007 |
104 other study(ies) available for thioflavin t and Amyloid Deposits
| Article | Year |
|---|---|
Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Binding Sites; Brain; Flavones; Humans; Iodine Radioisotopes; Isotope Labeling; Mice; Peptide Fragments; Plaque, Amyloid; Protein Binding; Radiopharmaceuticals; Solutions; Structure-Activity Relationship; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2005 |
Structure-activity relationship of chalcones and related derivatives as ligands for detecting of beta-amyloid plaques in the brain.
Topics: Alzheimer Disease; Animals; Binding, Competitive; Brain; Chalcones; Disease Models, Animal; Ligands; Mice; Plaque, Amyloid; Structure-Activity Relationship | 2007 |
Novel chalcones as probes for in vivo imaging of beta-amyloid plaques in Alzheimer's brains.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Chalcones; Iodine Radioisotopes; Mice; Mice, Transgenic; Molecular Probes; Plaque, Amyloid; Solutions | 2007 |
18F stilbenes and styrylpyridines for PET imaging of A beta plaques in Alzheimer's disease: a miniperspective.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Fluorine Radioisotopes; Humans; Plaque, Amyloid; Positron-Emission Tomography; Pyridines; Stilbenes; Styrenes; Tissue Distribution | 2010 |
Synthesis and evaluation of stilbene derivatives as a potential imaging agent of amyloid plaques.
Topics: Alzheimer Disease; Animals; Brain; Fluorescent Dyes; Mice; Plaque, Amyloid; Positron-Emission Tomography; Stilbenes; Tomography, Emission-Computed, Single-Photon | 2010 |
Fluorescent 2-styrylpyridazin-3(2H)-one derivatives as probes targeting amyloid-beta plaques in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Fluorescence; Fluorescent Dyes; Humans; Mice; Mice, Transgenic; Plaque, Amyloid; Pyridazines; Sensitivity and Specificity; Spectrometry, Fluorescence; Staining and Labeling | 2012 |
CRANAD-28: A Robust Fluorescent Compound for Visualization of Amyloid Beta Plaques.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Boron Compounds; Brain; Curcumin; Disease Models, Animal; Female; Fluorescent Dyes; Humans; Mice; Mice, Transgenic; Microglia; Microscopy, Confocal; Microtomy; Plaque, Amyloid; Staining and Labeling | 2020 |
Attenuation of subcutaneous insulin induced amyloid mass in vivo using Lumbrokinase and Serratiopeptidase.
Topics: Animals; Benzothiazoles; Congo Red; Disease Models, Animal; Endopeptidases; Injection Site Reaction; Injections, Subcutaneous; Insulin; Male; Microscopy, Fluorescence; Microscopy, Polarization; Peptide Hydrolases; Plaque, Amyloid; Protein Aggregation, Pathological; Rats; Rats, Wistar; Subcutaneous Tissue | 2020 |
Anti-Parallel β-Hairpin Structure in Soluble Aβ Oligomers of Aβ40-Dutch and Aβ40-Iowa.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Cerebral Amyloid Angiopathy; Circular Dichroism; Fluorescence; Microscopy, Atomic Force; Mutation; Plaque, Amyloid; Protein Conformation, beta-Strand; Spectroscopy, Fourier Transform Infrared | 2021 |
Bexarotene Does Not Clear Amyloid Beta Plaques but Delays Fibril Growth: Molecular Mechanisms.
Topics: Amyloid beta-Peptides; Benzothiazoles; Bexarotene; Dose-Response Relationship, Drug; Humans; Kinetics; Microscopy, Atomic Force; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Neuroprotective Agents; Plaque, Amyloid; Protein Multimerization; Protein Structure, Secondary; Tetrahydronaphthalenes; Thiazoles; Water | 2017 |
Microvascular ultrastructural changes precede cognitive impairment in the murine APPswe/PS1dE9 model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Capillaries; Cerebral Cortex; Cognitive Dysfunction; Disease Models, Animal; Exploratory Behavior; Intussusception; Kidney Glomerulus; Liver; Male; Memory, Short-Term; Mice, Transgenic; Microvessels; Plaque, Amyloid; Spleen; Thiazoles | 2017 |
A robust spectroscopic method for the determination of protein conformational composition - Application to the annealing of silk.
Topics: Amides; Animals; Benzothiazoles; Biocompatible Materials; Bombyx; Fibroins; Humans; Normal Distribution; Plaque, Amyloid; Protein Structure, Secondary; Reproducibility of Results; Spectrophotometry; Spectroscopy, Fourier Transform Infrared | 2018 |
7B2 chaperone knockout in APP model mice results in reduced plaque burden.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Clusterin; Disease Models, Animal; Female; Genotype; Heterozygote; Humans; Memory; Mice, Inbred C57BL; Mice, Knockout; Neuroendocrine Secretory Protein 7B2; Plaque, Amyloid; Solubility; Transgenes | 2018 |
Comparison of β-Amyloid Plaque Labeling Methods: Antibody Staining, Gallyas Silver Staining, and Thioflavin-S Staining.
Topics: Amyloid beta-Peptides; Animals; Antibodies; Benzothiazoles; Hippocampus; Male; Mice; Plaque, Amyloid; Presenilin-1; Silver Staining | 2018 |
Copper Redox Cycling Inhibits Aβ Fibre Formation and Promotes Fibre Fragmentation, while Generating a Dityrosine Aβ Dimer.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Copper; Humans; Hydrogen Peroxide; Microscopy, Electron, Transmission; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Plaque, Amyloid; Protein Multimerization; Tyrosine | 2018 |
Lipopolysaccharide Induced Opening of the Blood Brain Barrier on Aging 5XFAD Mouse Model.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Biological Availability; Blood-Brain Barrier; Ferric Compounds; Humans; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nanoparticles; Permeability; Plaque, Amyloid | 2019 |
Amyloidogenic Nanoplaques in Blood Serum of Patients with Alzheimer's Disease Revealed by Time-Resolved Thioflavin T Fluorescence Intensity Fluctuation Analysis.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Benzothiazoles; Biomarkers; Cohort Studies; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Plaque, Amyloid; Protein Aggregation, Pathological; Serum; Spectrometry, Fluorescence | 2019 |
Imaging and Spectral Characteristics of Amyloid Plaque Autofluorescence in Brain Slices from the APP/PS1 Mouse Model of Alzheimer's Disease.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; Disease Models, Animal; Fluorescence; Fluorescent Antibody Technique; Mice; Mice, Transgenic; Optical Imaging; Plaque, Amyloid; Presenilin-1; Silver Staining; Staining and Labeling; Ultraviolet Rays | 2019 |
Elevated amyloid-β plaque deposition in dietary selenium-deficient Tg2576 transgenic mice.
Topics: Animals; Benzothiazoles; Brain; Diet; Feeding Behavior; Female; Fluorescence; Image Processing, Computer-Assisted; Mice; Mice, Transgenic; Plaque, Amyloid; Selenium; Thiazoles; Tissue Distribution | 2013 |
Membrane-anchored Aβ accelerates amyloid formation and exacerbates amyloid-associated toxicity in mice.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Biotinylation; Blotting, Western; Cell Membrane; Endopeptidase K; Fluorescent Dyes; HEK293 Cells; Humans; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Phosphatidylinositols; Plaque, Amyloid; Thiazoles; Type C Phospholipases | 2013 |
Comparison of two methods for the estimation of stability of copper(II) bis-complexes with aromatic ligands relevant to Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Copper; Humans; Ligands; Organometallic Compounds; Plaque, Amyloid; Regression Analysis; Thiazoles | 2013 |
Different effect of vitamin D2 and vitamin D3 on amyloid-β40 aggregation in vitro.
Topics: Amyloid beta-Peptides; Benzothiazoles; Cholecalciferol; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Ergocalciferols; Humans; In Vitro Techniques; Microscopy, Electron; Models, Chemical; Molecular Docking Simulation; Peptide Fragments; Plaque, Amyloid; Protein Interaction Mapping; Quartz Crystal Microbalance Techniques; Thiazoles; Time Factors | 2014 |
Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain.
Topics: Aged; Alzheimer Disease; Amyloid; Benzothiazoles; Blotting, Western; Brain; Cell Line, Tumor; Female; Fluorescent Antibody Technique; Histones; Humans; Male; Neurofibrillary Tangles; Plaque, Amyloid; tau Proteins; Thiazoles; Tissue Array Analysis; Ubiquitin | 2015 |
Oral Administration of Thioflavin T Prevents Beta Amyloid Plaque Formation in Double Transgenic AD Mice.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Benzothiazoles; Brain; Disease Models, Animal; Female; Male; Mice, Transgenic; Microglia; Neuroprotective Agents; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2015 |
Visualization of microbleeds with optical histology in mouse model of cerebral amyloid angiopathy.
Topics: Animals; Benzothiazoles; Carbocyanines; Cerebral Amyloid Angiopathy; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; Fluorescent Dyes; Genetic Predisposition to Disease; Imaging, Three-Dimensional; Mice, Transgenic; Microcirculation; Microscopy, Confocal; Microvessels; Optical Imaging; Plaque, Amyloid; Staining and Labeling; Thiazoles | 2016 |
Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Benzothiazoles; Biomarkers; Blotting, Western; Cell Line, Tumor; Cerebral Cortex; Disease Models, Animal; Female; Hippocampus; Humans; Immunohistochemistry; Liver; Male; Mice; Middle Aged; Plaque, Amyloid; Receptor, Notch1; tau Proteins; Thiazoles | 2016 |
Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice.
Topics: Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cerebral Cortex; Disease Models, Animal; Female; Hippocampus; Humans; Male; Mice, Transgenic; Plaque, Amyloid; Species Specificity; Thiazoles | 2017 |
Contrasting in vivo effects of two peptide-based amyloid-beta protein aggregation inhibitors in a transgenic mouse model of amyloid deposition.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Transgenic; Microglia; Molecular Structure; Peptides; Plaque, Amyloid; Thiazoles | 2008 |
Corticosterone and related receptor expression are associated with increased beta-amyloid plaques in isolated Tg2576 mice.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Benzothiazoles; Corticosterone; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Transgenic; Mutation; Plaque, Amyloid; Receptors, Corticotropin-Releasing Hormone; Receptors, Glucocorticoid; Stress, Psychological; Thiazoles | 2008 |
Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apolipoproteins E; Benzothiazoles; Cerebral Amyloid Angiopathy; Dimerization; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Plaque, Amyloid; Protein Conformation; Thiazoles | 2008 |
Molecular polymorphism of Abeta in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Binding Sites; Binding, Competitive; Coloring Agents; Congo Red; Diagnostic Imaging; Disease Models, Animal; Humans; Ligands; Molecular Probes; Pathology, Molecular; Plaque, Amyloid; Predictive Value of Tests; Protein Isoforms; Thiazoles | 2010 |
Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Female; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Male; Microscopy, Confocal; Middle Aged; Neurofibrillary Tangles; Neurons; Organic Chemicals; Plaque, Amyloid; Postmortem Changes; Silver Staining; tau Proteins; Thiazoles | 2008 |
Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Autopsy; Benzothiazoles; Blotting, Western; Cohort Studies; Cytoskeleton; Humans; Immunohistochemistry; Middle Aged; Neurofibrillary Tangles; Phosphorylation; Plaque, Amyloid; Presenilin-1; Severity of Illness Index; tau Proteins; Thiazoles | 2009 |
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Antioxidants; Ascorbic Acid; Benzothiazoles; Blotting, Western; Brain; Cerebral Ventricles; Cysteine; Dietary Supplements; Female; Glutathione; Hippocampus; Humans; Immunohistochemistry; Male; Mice; Mice, Transgenic; Plaque, Amyloid; Resveratrol; Sirtuin 1; Sirtuins; Stilbenes; tau Proteins; Thiazoles; Transcription Factors; Tumor Suppressor Protein p53 | 2009 |
CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Cell Survival; Electrophoresis, Capillary; Humans; Isoquinolines; Microscopy, Electron, Transmission; Mitoxantrone; Neuroprotective Agents; Particle Size; Peptide Fragments; Plaque, Amyloid; Protein Multimerization; Spectrometry, Fluorescence; Suramin; Thiazoles | 2009 |
Oligomers of beta-amyloid are sequestered into and seed new plaques in the brains of an AD mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Biotin; Disease Models, Animal; Humans; Immunohistochemistry; Islet Amyloid Polypeptide; Ligands; Male; Mice; Mice, Transgenic; Microscopy, Atomic Force; Molecular Weight; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2010 |
Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Cell Count; Diabetes Mellitus; Female; Fluorescent Antibody Technique; Glycation End Products, Advanced; Humans; Immunohistochemistry; Male; Microglia; Middle Aged; Peptide Fragments; Plant Lectins; Plaque, Amyloid; Receptor for Advanced Glycation End Products; Receptors, Immunologic; tau Proteins; Thiazoles | 2010 |
Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Line, Tumor; Cytoplasmic Vesicles; Fluorescence; Humans; Immunoblotting; Mice; Microscopy, Confocal; Neurons; Plaque, Amyloid; Thiazoles | 2009 |
Burden of neurodegenerative diseases in a cohort of medical examiner subjects.
Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Atrophy; Benzothiazoles; Brain; Brain Edema; Cohort Studies; Coroners and Medical Examiners; Female; Forensic Pathology; Frontotemporal Lobar Degeneration; Humans; Hygiene; Ill-Housed Persons; Immunohistochemistry; Male; Malnutrition; Middle Aged; Neurofibrillary Tangles; Neuropil Threads; Plaque, Amyloid; Staining and Labeling; Tauopathies; Thiazoles; Young Adult | 2010 |
Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Benzothiazoles; CA1 Region, Hippocampal; Creatine; Disease Models, Animal; Down-Regulation; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Nerve Degeneration; Plaque, Amyloid; Presenilin-1; Pyramidal Cells; Thiazoles | 2010 |
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Benzothiazoles; Biophysics; Fluorescent Dyes; Humans; Kinetics; Mice; Microelectrodes; Microscopy, Electron, Transmission; Neurons; Patch-Clamp Techniques; Peptide Fragments; Plaque, Amyloid; Protein Binding; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2010 |
Immunohistological detection of Chlamydia pneumoniae in the Alzheimer's disease brain.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Brain Chemistry; Cerebral Cortex; Chlamydia Infections; Chlamydophila pneumoniae; Coloring Agents; Female; Humans; Immunohistochemistry; Male; Neurofibrillary Tangles; Plaque, Amyloid; Reproducibility of Results; Thiazoles; Tissue Banks | 2010 |
Interactions of Npc1 and amyloid accumulation/deposition in the APP/PS1 mouse model of Alzheimer's.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Peptide Fragments; Plaque, Amyloid; Proteins; Regression Analysis; Thiazoles | 2011 |
Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer's disease: Comparison with two cyclic heptapeptides derived from a randomized phage display library.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Biotinylation; Blood-Brain Barrier; Contrast Media; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Kinetics; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Models, Molecular; Molecular Sequence Data; Molecular Targeted Therapy; Mutagenesis, Site-Directed; Peptide Fragments; Peptide Library; Peptides, Cyclic; Plaque, Amyloid; Protein Binding; Sequence Analysis, DNA; Thiazoles | 2011 |
Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Apolipoproteins E; Astrocytes; Benzothiazoles; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Transgenic; Microglia; Neuroglia; Plaque, Amyloid; Protein Processing, Post-Translational; Receptors, LDL; Thiazoles | 2011 |
Targeting vascular amyloid in arterioles of Alzheimer disease transgenic mice with amyloid β protein antibody-coated nanoparticles.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Arterioles; Benzothiazoles; Disease Models, Animal; Ferric Compounds; Humans; Immunoglobulin G; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Nanoparticles; Peptide Fragments; Plaque, Amyloid; Platelet Endothelial Cell Adhesion Molecule-1; Thiazoles | 2011 |
Protein L-isoaspartyl O-methyltransferase inhibits amyloid beta fibrillogenesis in vitro.
Topics: Amyloid beta-Peptides; Benzothiazoles; Blotting, Western; Circular Dichroism; Escherichia coli; Fluorescent Dyes; Humans; Microscopy, Electron, Transmission; Molecular Weight; Plaque, Amyloid; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Structure, Secondary; Thiazoles | 2011 |
Cross-seeding effects of amyloid β-protein and α-synuclein.
Topics: alpha-Synuclein; Amyloid beta-Peptides; Animals; Benzothiazoles; Chromatography, Gel; Humans; Microscopy, Electron, Scanning; Peptide Fragments; Plaque, Amyloid; Protein Binding; Thiazoles | 2012 |
Interaction between amyloid-β pathology and cortical functional columnar organization.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Benzothiazoles; Brain Mapping; Disease Models, Animal; Electron Transport Complex IV; Humans; Mice; Mice, Transgenic; Models, Neurological; Mutation; Neural Pathways; Plaque, Amyloid; Presenilin-1; Somatosensory Cortex; Thiazoles | 2012 |
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; Clusterin; Disease Models, Animal; Glycoproteins; Mice; Mice, Knockout; Molecular Chaperones; Neurites; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2002 |
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.
Topics: Administration, Topical; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antibodies; Benzothiazoles; Brain; Disease Models, Animal; Fluorescent Dyes; Humans; Immunoglobulin Fab Fragments; Immunoglobulin Fc Fragments; Immunotherapy; Mice; Mice, Transgenic; Microscopy, Fluorescence; Mutation; Phagocytosis; Plaque, Amyloid; Thiazoles | 2002 |
Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autoantibodies; Benzothiazoles; Brain; Cerebellum; Disease Models, Animal; Locus Coeruleus; Mice; Mice, Transgenic; Neostriatum; Nerve Growth Factor; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; Signal Transduction; Silver Staining; Thiazoles | 2002 |
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Disease Models, Animal; Female; Humans; Male; Membrane Proteins; Mice; Mice, Transgenic; Neurotoxins; Plaque, Amyloid; Presenilin-1; Thiazoles | 2002 |
IMPY: an improved thioflavin-T derivative for in vivo labeling of beta-amyloid plaques.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autopsy; Autoradiography; Benzothiazoles; Fluorescence; Humans; Mice; Mice, Transgenic; Molecular Probes; Plaque, Amyloid; Pyridines; Thiazoles | 2002 |
Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Binding, Competitive; Blood-Brain Barrier; Brain; Contrast Media; Disease Models, Animal; Gadolinium; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Membrane Proteins; Mice; Mice, Transgenic; Molecular Probe Techniques; Neurons; Peptide Fragments; Plaque, Amyloid; Predictive Value of Tests; Presenilin-1; Putrescine; Reproducibility of Results; Thiazoles | 2002 |
In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Axons; Benzothiazoles; Cerebral Cortex; Dendrites; Dextrans; Disease Models, Animal; Fluorescent Dyes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence, Multiphoton; Neurites; Neuropil; Plaque, Amyloid; Thiazoles | 2003 |
Direct observation of amyloid fibril growth monitored by thioflavin T fluorescence.
Topics: Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Plaque, Amyloid; Thiazoles | 2003 |
In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antioxidants; Benzothiazoles; Cerebral Cortex; Cyclic N-Oxides; Disease Models, Animal; Fluorescent Dyes; Free Radical Scavengers; Free Radicals; Infrared Rays; Lasers; Mice; Mice, Transgenic; Microscopy, Fluorescence, Multiphoton; Nitrogen Oxides; Oxidation-Reduction; Oxidative Stress; Plaque, Amyloid; Reactive Oxygen Species; Thiazoles | 2003 |
Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Fluorescent Antibody Technique; Humans; Inclusion Bodies; Microtubule-Associated Proteins; Neocortex; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; tau Proteins; Thiazoles | 2003 |
Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antibodies; Benzothiazoles; Drug Administration Routes; Frontal Lobe; Hippocampus; Histocompatibility Antigens Class II; Immunization, Passive; Immunohistochemistry; Leukocyte Common Antigens; Membrane Proteins; Mice; Mice, Transgenic; Microglia; Plaque, Amyloid; Presenilin-1; Thiazoles; Time Factors | 2003 |
Characterization of radioiodinated ligand binding to amyloid beta plaques.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding Sites; Binding, Competitive; Brain; Humans; Iodine Radioisotopes; Ligands; Male; Mice; Mice, Inbred ICR; Peptide Fragments; Plaque, Amyloid; Pyrazoles; Pyridines; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2003 |
In vivo labeling of amyloid with BF-108.
Topics: Acridines; Affinity Labels; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Brain; Female; Fluorescent Dyes; Humans; In Vitro Techniques; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Neurofibrillary Tangles; Plaque, Amyloid; Rats; Rats, Wistar; Thiazoles | 2004 |
Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antibodies; Benzothiazoles; Fluorescence; Microscopy, Atomic Force; Neurofibrillary Tangles; Peptide Fragments; Plaque, Amyloid; Protein Structure, Quaternary; Software; Thiazoles | 2004 |
Neuronal localization of C1q in preclinical Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biomarkers; Brain; Cerebral Cortex; Complement C1q; Disease Progression; Down Syndrome; Encephalitis; Female; Genetic Predisposition to Disease; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Humans; Immunohistochemistry; Middle Aged; Neurons; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2004 |
Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Humans; Immunoglobulin Variable Region; Microscopy, Atomic Force; Neuroblastoma; Neurons; Peptide Library; Plaque, Amyloid; Surface Plasmon Resonance; Thiazoles; Tumor Cells, Cultured | 2004 |
Inflammation occurs early during the Abeta deposition process in TgCRND8 mice.
Topics: Age Factors; Alzheimer Disease; Amygdala; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; CD11b Antigen; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neocortex; Plaque, Amyloid; Thiazoles | 2004 |
Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Benzothiazoles; Down Syndrome; Female; Fluorescent Antibody Technique, Indirect; Humans; Immunohistochemistry; Male; Membrane Proteins; Mice; Mice, Transgenic; Middle Aged; Neocortex; Neurons; Non-Fibrillar Collagens; Peptide Fragments; Plaque, Amyloid; Thiazoles; Tissue Distribution | 2004 |
Morphological characterization of Thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Abeta immunotherapy on their clearance.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Fluorescent Dyes; Heterozygote; Humans; Immunization, Passive; Immunotherapy; Metabolic Clearance Rate; Mice; Mice, Transgenic; Neurites; Neurofibrillary Tangles; Plaque, Amyloid; Thiazoles | 2004 |
Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Survival; Cells, Cultured; Hippocampus; Inhibitory Concentration 50; Neurons; Neuroprotective Agents; Plaque, Amyloid; Protein Structure, Quaternary; Rats; Solubility; Thiazoles | 2004 |
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Benzothiazoles; Biphenyl Compounds; Blood-Brain Barrier; Brain; Cell Line, Tumor; Congo Red; Curcumin; Diamines; Humans; Ibuprofen; Mice; Mice, Transgenic; Naproxen; Peptide Fragments; Plaque, Amyloid; Protein Binding; Protein Denaturation; Protein Structure, Quaternary; Pyridazines; Solubility; Thiazoles | 2005 |
Inducible neuronal expression of transgenic TGF-beta1 in vivo: dissection of short-term and long-term effects.
Topics: Animals; Anti-Bacterial Agents; Apolipoproteins E; Benzothiazoles; Brain; Doxycycline; Gene Expression Regulation; Gene Silencing; Mice; Mice, Transgenic; Molecular Biology; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Plaque, Amyloid; Propionates; Thiazoles; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transgenes | 2005 |
Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.
Topics: Age Factors; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Blood Vessels; Blotting, Northern; Blotting, Western; Brain; Cerebral Amyloid Angiopathy; Enzyme-Linked Immunosorbent Assay; Female; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Immunoprecipitation; In Situ Hybridization; Male; Mass Spectrometry; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Mutation; Peptide Fragments; Pia Mater; Plaque, Amyloid; Thiazoles | 2005 |
Cerebrospinal fluid of Alzheimer patients promotes beta-amyloid fibril formation in vitro.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Brain Chemistry; Cerebrospinal Fluid; Humans; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Middle Aged; Peptide Fragments; Plaque, Amyloid; Polymers; Thiazoles | 2005 |
In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice.
Topics: Age Factors; Alzheimer Disease; Animals; Benzothiazoles; Brain Mapping; Disease Models, Animal; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Plaque, Amyloid; Staining and Labeling; Thiazoles | 2005 |
Lipophilic analogs of thioflavin S as novel amyloid-imaging agents.
Topics: Affinity Labels; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding, Competitive; Carbon Radioisotopes; Diagnostic Imaging; Drug Evaluation, Preclinical; Fluorescent Dyes; Humans; Iodine Radioisotopes; Mice; Molecular Structure; Neurofibrillary Tangles; Plaque, Amyloid; Protein Binding; Radionuclide Imaging; Radiopharmaceuticals; Thiazoles | 2006 |
Linear quantitation of Abeta aggregation using Thioflavin T: reduction in fibril formation by colostrinin.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biological Assay; Biomarkers; Dose-Response Relationship, Drug; Down-Regulation; Fluorescence; Fluorescent Dyes; Humans; Intercellular Signaling Peptides and Proteins; Linear Models; Microscopy, Fluorescence; Molecular Weight; Neurochemistry; Neuroprotective Agents; Peptide Fragments; Peptides; Plaque, Amyloid; Solubility; Thiazoles | 2007 |
Viral-induced inflammation is accompanied by beta-amyloid plaque reduction in brains of amyloid precursor protein transgenic Tg2576 mice.
Topics: Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Benzothiazoles; Borna disease virus; Brain; Cytokines; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Gene Expression; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroglia; Nucleoproteins; Plaque, Amyloid; T-Lymphocytes; Thiazoles; Time Factors; Viral Proteins | 2006 |
Protection by EGb 761 against beta-amyloid-induced neurotoxicity: involvement of NF-kappaB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation.
Topics: Amyloid beta-Peptides; Benzothiazoles; Cell Survival; Flavonoids; Ginkgo biloba; Ginkgolides; Humans; Lactones; MAP Kinase Kinase 4; Microscopy, Electron; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Neuroprotective Agents; Neurotoxicity Syndromes; NF-kappa B; Plant Extracts; Plaque, Amyloid; Sirtuin 1; Sirtuins; Thiazoles; Tumor Cells, Cultured | 2006 |
Preferential association of serum amyloid P component with fibrillar deposits in familial British and Danish dementias: similarities with Alzheimer's disease.
Topics: Adaptor Proteins, Signal Transducing; Aged; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Biomarkers; Brain; Cerebral Amyloid Angiopathy, Familial; Dementia; Denmark; England; Humans; Immunohistochemistry; Membrane Glycoproteins; Membrane Proteins; Neurofibrils; Peptide Fragments; Plaque, Amyloid; Protein Subunits; Serum Amyloid P-Component; Thiazoles | 2007 |
Surface structure of amyloid-beta fibrils contributes to cytotoxicity.
Topics: Acetylation; Amyloid beta-Peptides; Animals; Benzothiazoles; Carrier Proteins; Cattle; Cell Survival; Cells, Cultured; Fluorescence; Humans; Kidney; Maltose-Binding Proteins; Microscopy, Electron, Transmission; Peptide Fragments; Plaque, Amyloid; Thiazoles; Tryptophan | 2007 |
TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Benzothiazoles; Brain; Chromatography, High Pressure Liquid; Immunotherapy; Mice; Mice, Transgenic; Molecular Sequence Data; Plaque, Amyloid; Protein Processing, Post-Translational; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles | 2007 |
Differentiating Alzheimer disease-associated aggregates with small molecules.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Mass Spectrometry; Neurofibrillary Tangles; Peptide Library; Plaque, Amyloid; tau Proteins; Thiazines; Thiazoles | 2007 |
Butyrylcholinesterase in the life cycle of amyloid plaques.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Butyrylcholinesterase; Case-Control Studies; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Plaque, Amyloid; Temporal Lobe; Thiazoles | 1997 |
Rat microglia exhibit increased density on Alzheimer's plaques in vitro.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Benzothiazoles; Brain; Carbocyanines; Cell Count; Cells, Cultured; Fluorescent Dyes; Humans; Lipoproteins, LDL; Microglia; Middle Aged; Plaque, Amyloid; Rats; Rats, Sprague-Dawley; Reference Values; Thiazoles | 1998 |
Sympathetic neurite outgrowth is greater on plaque-poor vs. plaque-rich regions of Alzheimer's disease cryostat sections.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amygdala; Animals; Benzothiazoles; Case-Control Studies; Chick Embryo; Cryopreservation; Fluorescent Dyes; Humans; Neurites; Plaque, Amyloid; Sympathetic Nervous System; Thiazoles | 1998 |
Laminin blocks the assembly of wild-type A beta and the Dutch variant peptide into Alzheimer's fibrils.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Amyloidosis; Benzothiazoles; Fluorescence; Kinetics; Laminin; Nephelometry and Turbidimetry; Peptide Fragments; Plaque, Amyloid; Protein Binding; Thiazoles | 1998 |
Relationship between plaques, tangles, and loss of cortical cholinergic fibers in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cerebral Cortex; Choline O-Acetyltransferase; Fluorescent Dyes; Humans; Nerve Fibers; Neurofibrillary Tangles; Organ Specificity; Plaque, Amyloid; Reference Values; Regression Analysis; Thiazoles | 1998 |
The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Antibodies, Monoclonal; Benzothiazoles; Brain; Brain Chemistry; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Peptide Fragments; Plaque, Amyloid; Reference Values; Solubility; Thiazoles | 1999 |
The molecular chaperone alphaB-crystallin enhances amyloid beta neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Apoptosis; Benzothiazoles; Cell Survival; Cells, Cultured; Cerebral Cortex; Crystallins; Dose-Response Relationship, Drug; Hippocampus; Molecular Chaperones; Neurons; Peptide Fragments; Plaque, Amyloid; Protein Binding; Protein Structure, Secondary; Rats; Thiazoles | 1999 |
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Apolipoproteins E; Benzothiazoles; Disease Models, Animal; Genetic Predisposition to Disease; Hippocampus; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Nerve Degeneration; Neurites; Plaque, Amyloid; Protein Isoforms; Thiazoles; Time Factors | 2000 |
A possible model of senile plaques using synthetic amyloid beta-protein and rat glial culture.
Topics: Amyloid beta-Peptides; Animals; Astrocytes; Benzothiazoles; Cells, Cultured; Coloring Agents; Congo Red; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Histocompatibility Antigens Class II; Image Processing, Computer-Assisted; Interleukin-1; Microglia; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptide Fragments; Plaque, Amyloid; Rats; Rats, Sprague-Dawley; Staining and Labeling; Thiazoles | 2000 |
Orbitofrontal cortex pathology in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Fluorescent Dyes; Frontal Lobe; Humans; Middle Aged; Neurofibrillary Tangles; Organ Size; Plaque, Amyloid; Thiazoles | 2000 |
High density lipoprotein inhibits assembly of amyloid beta-peptides into fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Fluorometry; Humans; Lipoproteins, HDL; Nerve Tissue Proteins; Particle Size; Peptide Fragments; Plaque, Amyloid; Protein Binding; Solubility; Thiazoles | 2000 |
X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology.
Topics: Aged; Aged, 80 and over; Alkenes; Alzheimer Disease; Amyloid; Amyloidosis; Benzoates; Benzothiazoles; Coloring Agents; Congo Red; Female; Fluorescent Dyes; Histocytochemistry; Humans; Male; Middle Aged; Neurofibrillary Tangles; Plaque, Amyloid; Protein Structure, Secondary; Silver; Thiazoles | 2000 |
Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Disease Models, Animal; Disease Progression; Feedback; Fluorescent Dyes; Image Processing, Computer-Assisted; Male; Mice; Mice, Transgenic; Microscopy; Plaque, Amyloid; Thiazoles | 2001 |
Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Complement C1q; Down Syndrome; Encephalitis; Female; Humans; Immunohistochemistry; Male; Microglia; Middle Aged; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; Thiazoles | 2001 |
Statistical aspects of quantitative image analysis of beta-amyloid in the APP(V717F) transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cell Count; Data Interpretation, Statistical; Disease Models, Animal; Hippocampus; Image Processing, Computer-Assisted; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Plaque, Amyloid; Reproducibility of Results; Statistical Distributions; Thiazoles | 2001 |
The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cerebral Cortex; Fluorescent Dyes; Humans; Immunohistochemistry; Microscopy, Confocal; Nerve Degeneration; Neurites; Neurofilament Proteins; Phenotype; Plaque, Amyloid; tau Proteins; Thiazoles | 2001 |
Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption.
Topics: Action Potentials; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Dendrites; In Vitro Techniques; Mice; Mice, Transgenic; Microscopy, Confocal; Models, Neurological; Neurites; Plaque, Amyloid; Reaction Time; Thiazoles | 2001 |
Relationship of calbindin D28K-immunoreactive cells and neuropathological changes in the hippocampal formation of Alzheimer's disease.
Topics: Age of Onset; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Benzothiazoles; Calbindin 1; Calbindins; Female; Fluorescent Dyes; Hippocampus; Humans; Immunohistochemistry; Male; Middle Aged; Neurofibrillary Tangles; Plaque, Amyloid; Pyramidal Cells; S100 Calcium Binding Protein G; Thiazoles | 2001 |
Vasculopathy and amyloid beta reactivity in brains of patients with acquired immune deficiency (AIDS).
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; AIDS-Related Opportunistic Infections; Amyloid beta-Peptides; Axons; Benzothiazoles; Brain; Brain Chemistry; Brain Neoplasms; Cerebral Arteries; Cerebral Veins; Cerebrovascular Circulation; Coloring Agents; Congo Red; Female; Humans; Leukoencephalopathy, Progressive Multifocal; Lymphoma, AIDS-Related; Lymphoma, B-Cell; Male; Meningitis, Cryptococcal; Middle Aged; Plaque, Amyloid; Thiazoles; Toxoplasmosis, Cerebral; Ubiquitin; Vasculitis | 2000 |
Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; Congo Red; Disease Models, Animal; Gene Expression Regulation, Developmental; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Microscopy, Electron; Mutagenesis, Insertional; Mutation; Neurites; Neurons; Peptide Fragments; Plaque, Amyloid; Presynaptic Terminals; Promoter Regions, Genetic; Thiazoles | 2001 |
A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.
Topics: Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Binding, Competitive; Brain; Chemical Phenomena; Chemistry, Physical; Mice; Mice, Transgenic; Microscopy; Plaque, Amyloid; Radiopharmaceuticals; Structure-Activity Relationship; Thiazoles; Tomography, Emission-Computed | 2002 |
Amyloid-beta deposits in the cerebral cortex of the aged common marmoset (Callithrix jacchus): incidence and chemical composition.
Topics: Aging; alpha 1-Antichymotrypsin; Amyloid beta-Peptides; Animals; Apolipoproteins E; Benzothiazoles; Brain Diseases; Callithrix; Cerebral Cortex; Cholinesterases; Disease Models, Animal; Female; Incidence; Male; Neurites; Peptide Fragments; Plaque, Amyloid; Survival Analysis; Thiazoles | 2002 |