thioflavin t has been researched along with Alzheimer Disease in 325 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (3.38) | 18.7374 |
| 1990's | 32 (9.85) | 18.2507 |
| 2000's | 129 (39.69) | 29.6817 |
| 2010's | 126 (38.77) | 24.3611 |
| 2020's | 27 (8.31) | 2.80 |
| Authors | Studies |
|---|---|
| Arano, Y; Haratake, M; Ishibashi, K; Mori, H; Nakayama, M; Ono, M; Yoshida, N | 1 |
| Haratake, M; Hori, M; Mori, H; Nakayama, M; Ono, M; Tomiyama, T | 1 |
| Haratake, M; Mori, H; Nakayama, M; Ono, M | 1 |
| Choi, SR; Kung, HF; Qu, W; Skovronsky, D; Zhang, W | 1 |
| Cui, MC; Duan, XH; Liu, BL; Qiao, JP; Yang, Y; Zhou, JN | 1 |
| An, GI; Chang, YT; Cheon, GJ; Choi, JY; Choi, TH; Hong, MC; Kim, DJ; Kim, HY; Kim, Y; Kim, YK; Lee, JS; Lee, KC; Rhee, H; Ryu, YH; Yang, SQ | 1 |
| Outeiro, TF; Paulo, A; Ribeiro Morais, G; Santos, I; Santos, IC; Vicente Miranda, H | 1 |
| Hur, MG; Kim, SW; Min, JJ; Park, JH; Park, SH; Park, YD; Yang, SD; Yoo, YJ; Yoon, YJ | 1 |
| Bulic, B; Mandelkow, E; Pickhardt, M | 1 |
| Busquets, MA; Espargaró, A; Estelrich, J; Ginex, T; Luque, FJ; Muñoz-Torrero, D; Sabate, R; Vadell, MD | 1 |
| Andrade, S; Loureiro, JA; Pereira, MC | 1 |
| Ahmadian, S; Alali, S; Ashrafi-Kooshk, MR; Hooshyari Ardakani, M; Hosseinkhani, B; Meknatkhah, S; Riazi, G | 1 |
| Ara, MHM; Jamali, M; Mohajer, S; Sheikhlary, S | 1 |
| Andozhskaya, VS; Kuznetsova, IM; Melnikova, NM; Mikhailova, EV; Rychkov, GN; Sulatskaya, AI; Sulatsky, MI; Turoverov, KK | 1 |
| Brännström, K; Gharibyan, AL; Golchin, SA; Hedberg, I; Islam, T; Olofsson, A; Olofsson, L; Pettersson, N; Virta, MM | 1 |
| Almeida, WP; Beppu, MM; Mahl, CRA; Rocha-Neto, JBM; Taketa, TB | 1 |
| Javagal, MR; Narasingappa, RB; Prasad, M; Ravi, SK; Vincent, B | 1 |
| Bhattacharjee, P; Bhattacharyya, D; Biswas, SC; Das, H; De, D; Kumar, KS | 1 |
| Carapeto, AP; Cordeiro, C; Cristóvão, JS; Gomes, CM; Landrieu, I; Moreira, GG; Rodrigues, MS; Torres, VM | 1 |
| Chakrabarti, P; Chatterjee, BK; Chatterjee, T; Das, G; Dhar, J; Ghosh, S | 1 |
| Candreva, J; Chau, E; Kim, JR; Rice, ME | 1 |
| Nair, AV; Ran, C; Ran, K; Yang, J; Zhu, B | 1 |
| Dong, X; Liu, W; Sun, Y; Wang, W | 1 |
| Harmer, JR; Kannaian, B; Kather, R; Pervushin, K; Phillips, M; Yang, JNT; Yuguang, M | 1 |
| Akke, M; Cukalevski, R; Knowles, TPJ; Leiding, T; Linse, S; Malmendal, A; Meisl, G; Törnquist, M; Weininger, U | 1 |
| Ding, B; Du, J; Fei, L; Huang, Z; LaCoste, JD; Wang, Q; Wang, XR; Wang, XZ; Xiao, NN; Zhang, Y | 1 |
| Luca, A; Paduraru, L; Stanciu, GD; Stefanescu, R; Tamba, BI | 1 |
| Genov, M; Hummel, T; Kasture, A; Krenn, L; Moloney, M; Pretsch, A; Pretsch, D; Rollinger, JM; Schmid, A; Wöhrer, T | 1 |
| Gamboa, JI; Knafo, S; Lalatsa, A; Sun, Y | 1 |
| Bonnet, H; Chierici, S; Piantanida, I; Šmidlehner, T | 1 |
| Hongo, K; Ishii, A; Kawata, Y; Mizobata, T; Ogawa, K; Shindo, A; Sogon, T | 1 |
| Banjade, S; Clemente, N; Coombs, SE; Gillilan, RE; Kriksunov, K; Oswald, RE; Wang, C; Zhao, J | 1 |
| Mikalauskaite, K; Smirnovas, V; Sneideris, T; Ziaunys, M | 1 |
| Kim, Y; Lee, H; Park, S; Shin, J | 1 |
| Fu, Z; Smith, SO; Van Nostrand, WE | 1 |
| Eom, K; Kwon, T; Wang, L | 1 |
| Bradfield, JC; Choi, EY; Han, BH; Mattock, DS; Miller, BR; Plassmeyer, SP; Windsor, PK | 1 |
| Kasho, K; Krasauskas, L; Morozova-Roche, LA; Smirnovas, V; Stojkovič, G; Wanrooij, S | 1 |
| Naiki, H | 1 |
| Ackermann, M; Denver, P; Kelly, P; Konerding, MA; Mitchell, CA; Satchell, SC | 1 |
| Contreras-García, J; Guallar, V; Pantaleone, S; Peccati, F; Riffet, V; Sodupe, M; Solans-Monfort, X | 1 |
| Taniguchi, A | 1 |
| Araki, M; Kamiya, N; Kawai, R; Okuno, Y; Ono, M; Saji, H; Yoshimura, M | 1 |
| Cui, M; Fu, H | 1 |
| Bennett, RE; Commins, C; Dujardin, S; Eftekharzadeh, B; Fan, Z; Hernandez-Vega, A; Hyman, AA; Hyman, BT; Kamath, T; Laskowski, PR; MacKenzie, D; Mandelkow, E; Molliex, AM; Muller, D; Roe, AD; Taylor, JP; Tepper, K; Vanderburg, C; Wegmann, S; Zoltowska, KM | 1 |
| Dong, X; Jiang, Z; Liu, Y; Sun, Y; Yan, X; Zhang, L | 1 |
| Gabr, MT; Pigge, FC | 1 |
| Alvarez, AR; Alvizú, I; Armijo, J; Bhuyan, H; Casanova-Morales, N; Chandía-Cristi, A; Estrada, LD; Favre, M; Gonzalez, RB; Guerrero, S; Guzman, F; Kogan, MJ; Maze, JR; Morales-Zavala, F; Oyarzún-Olave, M; Rebolledo, C; Rodriguez, E; Waselowski, V | 1 |
| Bode, DC; Gu, M; Viles, JH | 1 |
| Apetri, A; Crespo, R; Koudstaal, W | 1 |
| Anderson, A; Barton, SM; Gore, JC; Janve, VA; Matsubara, JA; McClure, R; Pham, W | 1 |
| Ahn, M; Chia, S; Dobson, CM; Habchi, J; Kumita, JR; Lee, BI; Park, CB; Vendruscolo, M | 1 |
| Anantharam, V; Hepker, M; Huang, X; Jin, H; Kanthasamy, A; Kanthasamy, AG; Kondru, N; Lewis, M; Manne, S | 1 |
| Di Somma, S; Ferraro, G; Florio, D; Iacobucci, I; Malfitano, AM; Marasco, D; Merlino, A; Monti, M; Morelli, G; Mügge, C; Weigand, W | 1 |
| Bogdanović, N; Gräslund, A; Järemo, P; Jarvet, J; Jelić, V; Rigler, R; Terenius, L; Tiiman, A; Vukojević, V | 1 |
| Orvig, C; Patrick, BO; Rodríguez-Rodríguez, C; Telpoukhovskaia, MA | 1 |
| Cinar, Y; Dornieden, S; Funke, SA; Jiang, N; Korth, C; Müller-Schiffmann, A; Sticht, H; Willbold, D; Wördehoff, M | 1 |
| Kapurniotu, A; Velkova, A; Yan, LM | 1 |
| Georgopoulos, S; Klinakis, A; Paouri, E; Sesele, K; Thanopoulou, K; Tsefou, E | 1 |
| Darreh-Shori, T; Hosseini, SM; Nordberg, A | 1 |
| Miličević, A; Raos, N | 1 |
| Chen, J; Cheng, XX; Shi, JQ; Xu, J; Zhang, QQ; Zhu, HQ | 1 |
| Fitzgerald, S; Lauer, SL; Levy, E; Lopez-Guzman, M; Nixon, RA; Schoen, C; Wilson, DA; Xu, W | 1 |
| Bartic, C; Benilova, I; Castillo Cano, V; De Strooper, B; Gallardo, R; Ramakers, M; Rousseau, F; Schymkowitz, J; Snellinx, A; Ungureanu, AA | 1 |
| Chen, L; Jia, L; Ren, J; Wang, C; Xie, J; Xu, L | 1 |
| Alí-Torres, J; Bailey, GA; Hidalgo, J; Manso, Y; Orvig, C; Rodríguez-Rodríguez, C; Rodríguez-Santiago, L; Sodupe, M; Telpoukhovskaia, MA | 1 |
| Airoldi, C; Cabrita, EJ; de Almeida, RF; Dias, C; Jesus, AR; Jiménez-Barbero, J; Macedo, MP; Marcelo, F; Martins, A; Matos, AM; Nicotra, F; Rauter, AP; Ribeiro, RT; Viana, AS | 1 |
| Curtis, MA; Dragunow, M; Faull, R; Lill, C; Narayan, PJ | 1 |
| Caine, JM; Macreadie, IG; Porzoor, A | 1 |
| Al-Soufi, W; Freire, S; Novo, M; Penedo, JC; Ríos Rodríguez, MC; Rodríguez-Prieto, F | 1 |
| Govindaraju, T; Manjithaya, R; Rajasekhar, K; Suresh, SN | 1 |
| Adlard, PA; Barnham, KJ; Curtain, CC; Doble, PA; Hare, DJ; Hinds, MG; Kirby, N; Li, QX; Lind, M; Masters, CL; McColl, G; Mertens, HD; Pham, CL; Roberts, AM; Roberts, BR; Ryan, TM | 1 |
| Viles, JH; Younan, ND | 1 |
| Di Carlo, MG; Foderà, V; Leone, M; Militello, V; Minicozzi, V; Morante, S; Vetri, V | 1 |
| Li, M; Qu, X; Ren, J; Zhao, C | 1 |
| Moir, RD; Moore, A; Ran, C; Ross, AW; Sun, H; Tanzi, RE; Tian, X; Tian, Y; Zhang, C; Zhang, X | 1 |
| Cantlon, A; Cao, KJ; Elbel, K; Guan, Y; Shah, JV; Theodorakis, EA; Walsh, DM; Yang, J | 1 |
| Ågren, H; Kuang, G; Murugan, NA; Nordberg, A; Tu, Y | 1 |
| Adachi, T; Hongo, K; Ichino, H; Kawata, Y; Kobayashi, S; Mizobata, T; Nakanishi, M; Nakashima, K; Uchino, K; Watanabe, Y; Yamakawa, MY | 1 |
| Liu, J; Liu, Z; Yin, F; Zhang, Y | 1 |
| Gao, X; Huang, HL; Shi, S; Wang, L; Wang, LL; Yao, JL; Yao, TM | 1 |
| Lahiri, DK; Paule, MG; Ray, B; Raymick, J; Sarkar, S; Schmued, L | 1 |
| Chojnacki, JE; Liu, K; Saathoff, JM; Zhang, S | 1 |
| Bilkova, Z; Hromadkova, L; Jankovicova, B; Kupcik, R; Ripova, D; Rousar, T | 1 |
| Fosso, MY; Garneau-Tsodikova, S; Head, E; LeVine, H; McCarty, K | 1 |
| Hu, YH; Ren, WM; Tang, XC; Xu, MM; Zhang, HY | 1 |
| Ågren, H; Govindaraju, T; Kuang, G; Murugan, NA; Narayanaswamy, N; Rajasekhar, K | 1 |
| Bednarikova, Z; Fedunova, D; Gazova, Z; Huy, PD; Li, MS; Mocanu, MM | 1 |
| Alberi, L; Alina Raio, N; Brai, E | 1 |
| Fan, HX; Feng, XL; Gao, H; He, RR; Kurihara, H; So, KF; Xiao, J; Yao, XS; Yu, Y; Zhou, ZQ | 1 |
| André, I; Faller, P; Gras, E; Hoarau, M; Hureau, C; Irague, R; Malbert, Y; Remaud-Siméon, M | 1 |
| Chemuru, S; Kar, K; Kodali, R; Misra, P; Wetzel, R | 1 |
| Andreasen, N; Andreasson, U; Blennow, K; Borén, J; Cukalevski, R; Linse, S; Molinuevo, JL; Padayachee, ER; Portelius, E; Zetterberg, H | 1 |
| Hinckley, SH; Kuret, J; Lin, L; Nanavaty, N | 1 |
| Ashe, KH; Borchelt, DR; Forster, CL; Hemmy, LS; Huang, ES; Kuskowski, MA; Liu, P; McNellis, BM; Rao, ER; Reichl, JH; Vassar, R; Zahs, KR | 1 |
| Beach, TG; Castaño, EM; Daugs, ID; Davis, J; Esh, CL; Kalback, WM; Kokjohn, TA; Lue, LF; Luehrs, DC; Patton, RL; Roher, AE; Van Nostrand, WE; Van Vickle, GD; Walker, DG | 1 |
| Hattori, M; In, Y; Ishida, T; Minoura, K; Sugino, E; Sumida, M; Taniguchi, T; Tomoo, K | 1 |
| Levine, H; Walker, LC | 1 |
| Kellaway, LA; Kotwal, GJ; Kulkarni, AP; Pillay, NS | 1 |
| Cardoso, I; Costa, R; Ferreira-da-Silva, F; Saraiva, MJ | 1 |
| Gokce, O; Jan, A; Lashuel, HA; Luthi-Carter, R | 1 |
| Kovacs, B; Lumayag, S; Mufson, EJ; Perez, SE; Xu, S | 1 |
| Byun, JH; Kim, DJ; Kim, H; Kim, Y; Lee, WK; Mook-Jung, I; Yoo, KH | 1 |
| Chávez-Macías, L; Harrington, CR; Luna-Muñoz, J; Mena, R; Peralta-Ramirez, J; Wischik, CM | 1 |
| Condron, MM; Ho, L; Ono, K; Pasinetti, GM; Teplow, DB; Wang, J; Zhao, W | 1 |
| Gupta, VB; Indi, SS; Rao, KS | 1 |
| Arai, H; Fujiwara, H; Gamoh, S; Hashimoto, M; Katakura, M; Miyazawa, T; Shahdat, HM; Shido, O; Shimada, T; Tanabe, Y; Yamashita, S | 1 |
| Carroll, VL; Dickson, TC; Halliday, GM; King, AE; Shepherd, CE; Sokolova, A; Vickers, JC; Woodhouse, A | 1 |
| Beal, MF; Chen, HL; Gibson, GE; Karuppagounder, SS; Pinto, JT; Xu, H | 1 |
| Alvarez-Larena, A; González-Duarte, P; Lloveras, V; Rimola, A; Rodríguez-Rodríguez, C; Sánchez de Groot, N; Sodupe, M; Vendrell, J; Ventura, S; Vidal-Gancedo, J | 1 |
| Bulic, B; Mandelkow, E; Mandelkow, EM; Pickhardt, M; Schmidt, B; Waldmann, H | 1 |
| Caccialanza, G; Carotti, A; Catto, M; Colombo, R; De Lorenzi, E; Lanni, C; Racchi, M; Verga, L | 1 |
| Cassell, MD; Ding, SL; Poremba, A; Van Hoesen, GW | 1 |
| Davis, TJ; Gonzalez-Velasquez, FJ; Kotarek, JA; Moss, MA; Sivakumar, K; Soto-Ortega, DD; Wang, Q; Wu, L | 1 |
| Chen, L; He, R; Wang, X; Wei, Y | 1 |
| Bero, AW; Csernansky, JG; Dong, H; Holtzman, DM; Kling, MJ; Timson, BF; Yuede, CM; Zimmerman, SD | 1 |
| Baine, M; Georgie, DS; Moffet, DA; Nguyen, TP; Nogaj, LA; Shiferraw, EZ | 1 |
| Hashimoto, M; Hossain, S; Katakura, M; Miwa, K; Shido, O; Shimada, T | 1 |
| Bowles, N; Gaspar, RC; Hepler, RW; Joyce, JG; Shughrue, PJ; Villarreal, SA | 1 |
| Baldwin, A; Collingwood, J; Exley, C; Goodwin, S; House, E; Mold, M | 1 |
| Durany, N; Fernàndez-Busquets, X; Gella, A; Unzeta, M; Valente, T | 1 |
| Hulleman, JD; Kelly, JW; Paulsson, JF; Powers, ET; Siegel, SJ; Usui, K | 1 |
| Bitan, G; Chen, CH; Murakami, K; Rahimi, F; Summers, JL | 1 |
| Bu, G; Crick, SL; Frieden, C; Hu, X; Lee, JM; Pappu, RV | 1 |
| Goto, Y; Hasegawa, K; Morinaga, A; Naiki, H; Nomura, R; Ookoshi, T; Ozawa, D; Yamada, M | 1 |
| Anan, M; Hara, H; Kataoka, S; Mutoh, T; Tabira, T; Ueda, A | 1 |
| Malar, EJ; Nagarajan, S; Rajadas, J | 1 |
| Allsop, D; Beeg, M; Canovi, M; Gobbi, M; Mann, DM; Mayes, J; Moore, S; Parkin, E; Taylor, M | 1 |
| Haddix, T; Lee, VM; Nakashima-Yasuda, H; Robinson, J; Trojanowski, JQ; Uryu, K | 1 |
| Hao, J; Lei, G; Li, Z; Liu, L; Liu, R; Miao, J; Su, C; Zhang, P; Zhang, W | 1 |
| Goto, Y; Kawakami, T; Kuboi, R; Kuyama, H; Naiki, H; Nishimura, O; Ozawa, D; Sakurai, K; Shimanouchi, T; Yagi, H | 1 |
| Chang, HP; Hsiao, IT; Hsu, WC; Jin, LW; Kung, MP; Lin, KJ; Lo, CW; Skovronsky, D; Wai, YY; Wey, SP; Yao, CH; Yen, TC | 1 |
| Bresjanac, M; Kovacs, GG; Mohorko, N; Popović, M; Repovs, G | 1 |
| Archimandritis, S; Georgoulias, P; Papatriantafyllou, J; Sifakis, N; Valotassiou, V | 1 |
| Baban, B; Crick, SL; Frieden, C; Garai, K; Mustafi, SM | 1 |
| Antošová, A; Bartoš, A; Cechová, L; Gažová, Z; Klaschka, J; Krištofiková, Z; Ríčný, J; Rípová, D | 1 |
| Huang, W; Lei, H; Wang, X; Xu, W; Zhan, Y; Zhang, S | 1 |
| Bartic, C; Benilova, I; Braeken, D; Broersen, K; Callewaert, G; D'Hooge, R; De Strooper, B; Debulpaep, M; Jonckheere, W; Kuperstein, I; Martins, IC; Rousseau, F; Rozenski, J; Schymkowitz, J; Segers-Nolten, I; Subramaniam, V; Van Der Werf, K; Vandersteen, A | 1 |
| Appelt, DM; Balin, BJ; Hallock, LR; Hammond, CJ; Howanski, RJ; Little, CS | 1 |
| Bandopadhyay, D; Mishra, PK; Subramanian, S | 1 |
| Borbon, IA; Erickson, RP | 1 |
| Cerf, E; Goormaghtigh, E; Gustot, A; Raussens, V; Ruysschaert, JM | 1 |
| Baldus, M; Giriens, V; Hickman, DT; Karastaneva, H; López-Deber, MP; Madani, R; Muhs, A; Nagel-Steger, L; Nand, D; Ndao, DM; Nicolau, C; Pfeifer, A; Pihlgren, M; Riesner, D; Silva, AB; St-Pierre, A; Willbold, D | 1 |
| Flashner, E; Friedler, A; Raviv, U | 1 |
| Finder, VH; Glockshuber, R; Nitsch, RM; Ovchinnikova, OY; Vodopivec, I | 1 |
| Ito, Y; Mino, H; Mito, F; Sadasue, H; Sakai, K; Shirahama, C; Utsumi, H; Yamada, K; Yamasaki, T; Yamato, M | 1 |
| Gestwicki, JE; Reinke, AA | 1 |
| Bechinger, B; Dufrêne, YF; Dupres, V; Itkin, A; Raussens, V; Ruysschaert, JM | 1 |
| Andrieux, K; Brambilla, D; Couvreur, P; Hashemi, SH; Le Droumaguet, B; Moghimi, SM; Nicolas, J; Wu, LP | 1 |
| Arendt, T; Brückner, MK; Hoyer, S; Osmanovic-Barilar, J; Riederer, P; Salkovic-Petrisic, M | 1 |
| Broersen, K; Jonckheere, W; Pastore, A; Pauwels, K; Rousseau, F; Rozenski, J; Schymkowitz, J; Vandersteen, A | 1 |
| Ansciaux, E; Burtea, C; Larbanoix, L; Laurent, S; Mahieu, I; Muller, RN; Vander Elst, L | 1 |
| Jiji, RD; Wang, M | 1 |
| Aiso, S; Chiba, T; Hayashi, K; Sasabe, J; Utsunomiya-Tate, N | 1 |
| Georgopoulos, S; Katsouri, L | 1 |
| Chamberlain, R; Curran, GL; Garwood, M; Hultman, KL; Jack, CR; Marjańska, M; Poduslo, JF; Preboske, GM; Wengenack, TM | 1 |
| Cisek, K; Honson, NS; Jensen, JR; Kuret, J | 1 |
| Cheng, M; Huang, Q; Li, J; Liu, YN; Peng, Y; Wei, CW; Zhang, L | 1 |
| Cardoso, I; Costa, R; Crowther, DC; Speretta, E | 1 |
| Borkowski, AH; Landreth, GE; Levy, E; Nixon, RA; Wesson, DW; Wilson, DA | 1 |
| Li, M; Qu, K; Qu, X; Ren, J; Yang, X | 1 |
| Ben-Romano, T; Cooper, I; Farfara, D; Frenkel, D; Gazit, E; Levin, A; Scherzer-Attali, R; Segal, D; Segev-Amzaleg, N; Shalev, DE; Shaltiel-Karyo, R; Trudler, D; Vientrov, M | 1 |
| Barré, P; Eliezer, D; Huster, D; Künze, G; Scheidt, HA; Thomas, L | 1 |
| Bartnik, D; Brener, O; Funke, SA; Liu, H; Nagel-Steger, L; Sehl, T; Wiesehan, K; Willbold, D | 1 |
| Jiang, T; Pan, LF; Zhang, YH; Zhi, XL; Zhou, P | 1 |
| Andrieux, K; Brambilla, D; Canovi, M; Couvreur, P; De Kimpe, L; Gobbi, M; Hashemi, SH; Kóňa, J; Le Droumaguet, B; Lettiero, B; Moghimi, SM; Nicolas, J; Nicolas, V; Scheper, W; Taverna, M; Tvaroška, I; Verpillot, R | 1 |
| More, SS; Vartak, AP; Vince, R | 1 |
| Hayashi, S; Ihara, M; Kimura, H; Matsumura, K; Mori, H; Okamoto, Y; Ono, M; Saji, H; Takahashi, R | 1 |
| Beker, S; Kellner, V; Kerti, L; Stern, EA | 1 |
| Li, M; Qu, X; Ren, J; Xu, C; Yang, X; Zhao, C | 1 |
| Chen, J; Hecht, MH; McKoy, AF; Schupbach, T | 1 |
| Benilova, I; Broersen, K; De Baets, G; De Strooper, B; Jonckheere, W; Marrink, SJ; Masman, MF; Rousseau, F; Rozenski, J; Schymkowitz, J; Subramaniam, V; van der Werf, K; Vandersteen, A | 1 |
| Amijee, H; Bate, C; Chawner, R; Doig, AJ; Eyers, CE; Jeggo, R; Mazzitelli, S; Scopes, DI; Spanswick, D; Treherne, JM; Virdee, J; Williams, A | 1 |
| Akiyama, T; Kohno, H; Komoriya, T; Shimizu, T; Ye, X; Yoshimune, K | 1 |
| Li, YN; Liu, RT; Su, YJ; Wang, SW; Yang, SG; Yu, XL; Zhang, H; Zhang, R; Zhao, M; Zhou, WW | 1 |
| Dzyuba, SV; Jameson, LP; Smith, NW | 1 |
| Gouwens, LK; Nichols, MR; Paranjape, GS; Ruck, BM; Terrill, SE | 1 |
| Cheng, XR; Hau, BY; Kerman, K; Kraatz, HB; Martic, S; Veloso, AJ | 1 |
| Kopito, RR; Melki, R; Quake, SR; Sourigues, Y; Streets, AM | 1 |
| Balducci, C; Biasini, E; Borsello, T; Colombo, L; Diomede, L; Fluharty, BR; Forloni, G; Gobbi, M; Harris, DA; La Vitola, P; Messa, M; Sclip, A; Stravalaci, M | 1 |
| Collin, F; Eury, H; Faller, P; Hureau, C; Sasaki, I | 1 |
| Aronow, BJ; Bales, KR; DeMattos, RB; Harmony, JA; Holtzman, DM; O'dell, MA; Parsadanian, M; Paul, SM; Taylor, JW | 1 |
| Aggarwal, A; Balakhaneh, D; Callaway, DJ; Hartley, DM; Lashuel, HA; Teichberg, S | 1 |
| Bacskai, BJ; Games, D; Hyman, BT; Kajdasz, ST; McLellan, ME; Schenk, D; Seubert, P | 1 |
| Capsoni, S; Cattaneo, A; Giannotta, S | 1 |
| Ashe, KH; Cruz, L; Duff, K; Hyman, BT; Irizarry, MC; Le, R; Sanders, J; Stanley, HE; Urbanc, B | 1 |
| Cottingham, MG; Hollinshead, MS; Vaux, DJ | 1 |
| Signor, L; Staab, D; Staufenbiel, M; Stoeckli, M; Wiederhold, KH | 1 |
| Hou, C; Kung, HF; Kung, MP; Lee, VM; Skovronsky, D; Trojanowski, JQ; Zhang, B; Zhuang, ZP | 1 |
| Borowski, BJ; Curran, GL; Jack, CR; Macura, SI; Poduslo, JF; Sigurdsson, EM; Wengenack, TM; Wisniewski, T | 1 |
| Harkany, T; Härtig, W; Kacza, J; Paulke, BR; Seeger, J; Varga, C | 1 |
| Bacskai, BJ; D'Amore, JD; Hyman, BT; Kajdasz, ST; McLellan, ME; Stern, EA | 1 |
| Bacskai, BJ; Hyman, BT; Kajdasz, ST; McLellan, ME | 1 |
| Dickson, TC; Tan, A; Vickers, JC | 1 |
| Akagi, T; Chui, DH; Takashima, A; Tanaka, N; Yoshiike, Y | 1 |
| Clarke, K; DiCarlo, G; Gordon, MN; Henderson, D; Jackson, J; Morgan, D; Ugen, KE; Wilcock, DM | 1 |
| Bellmann, C; Giasson, BI; Horiguchi, T; Ischiropoulos, H; Lee, VM; LightFoot, R; Richter-Landsberg, C; Trojanowski, JQ; Uryu, K | 1 |
| Hasegawa, K; Naiki, H; Ono, K; Takashima, A; Yamada, M; Yoshiike, Y | 2 |
| Hou, C; Jin, LW; Kung, HF; Kung, MP; Zhuang, ZP | 1 |
| Akatsu, H; Kudo, Y; Okamura, N; Sawada, T; Shimadzu, H; Shiomitsu, T; Suemoto, T; Suzuki, M; Yamamoto, T | 1 |
| Czilli, DL; DeMattos, RB; Gitter, B; Holtzman, DM; Kowalewski, T; Legleiter, J | 1 |
| Fonseca, MI; Kawas, CH; Tenner, AJ; Troncoso, JC | 1 |
| Chirita, CN; Kuret, J | 1 |
| Hasegawa, K; Naiki, H; Ono, K; Yamada, M | 1 |
| Brown, J; Crowley, J; Eckman, CB; Gottardi-Littell, N; Lee, JM; Magnuson, D; Rahman, MM; Reiss, AB; Sambamurti, K; Silberman, S; Theisler, C; Wolozin, B; Yager, D | 1 |
| Hasegawa, K; Hayashi, H; Kimura, N; Lemere, CA; Matsuzaki, K; Michikawa, M; Naiki, H; Selkoe, DJ; Shibata, M; Terao, K; Yamaguchi, H; Yamamoto, N; Yanagisawa, K; Yokoseki, T; Yoshikawa, Y | 1 |
| Emadi, S; Goud, G; Liu, R; Lyubchenko, Y; McAllister, C; Schulz, P; Sierks, MR; Yuan, B; Zameer, A | 1 |
| Mash, D; Mesulam, M; Shaw, P; Weintraub, S | 1 |
| Dudal, S; Gervais, F; Krzywkowski, P; Lacombe, D; Morissette, C; Paquette, J; Tremblay, P | 1 |
| Duff, K; Hashimoto, T; Iwatsubo, T; Kowa, H; Mann, DM; Matsuura, Y; Sakakura, T; Tsuji, S; Wakabayashi, T | 1 |
| Larry Sparks, D | 1 |
| Moss, MA; Nichols, MR; Reed, DK; Rosenberry, TL; Varvel, NH | 1 |
| Barbour, R; Bard, F; Bussière, T; Buttini, M; Games, D; Grajeda, H; Guido, T; Khan, K; Schenk, D; Seubert, P | 1 |
| Chang, L; De Felice, FG; Ferreira, ST; Figueroa-Villar, JD; Garcia-Abreu, J; Klein, WL; Liu, R; Saraiva, LM; Vieira, MN | 1 |
| Bales, KR; Costa, DA; Nilsson, LN; Paul, SM; Potter, H | 1 |
| Cratic-McDaniel, S; Hoh, JH; Moss, MA; Nichols, MR; Reed, DK; Rosenberry, TL | 1 |
| Ambegaokar, SS; Begum, AN; Chen, PP; Cole, GM; Frautschy, SA; Glabe, CG; Kayed, R; Lim, GP; Simmons, MR; Ubeda, OJ; Yang, F | 1 |
| Brown, J; Gee, AD; Hong, G; Judd, DB; Lockhart, A; Lowe, PN; Merritt, AT; Morgenstern, JL; Ye, L | 1 |
| Santhoshkumar, P; Sharma, KK | 1 |
| Machulla, HJ; Reischl, G; Solbach, C; Uebele, M | 1 |
| Dahlqvist, C; Ito, A; Kakuyama, H; Näslund, J; Söderberg, L; Thyberg, J; Tjernberg, LO; Winblad, B | 1 |
| Brown, J; Gee, AD; Hong, G; Lockhart, A; Morgenstern, JL; Ye, L | 1 |
| Akasofu, S; Kimura, M; Ogura, H; Sawada, K | 1 |
| Barghorn, S; Biernat, J; Mandelkow, E | 1 |
| LeVine, H | 2 |
| Hecht, MH; Kim, W | 1 |
| Allsop, D; Cooper, LJ; El-Agnaf, OM; Fullwood, NJ; German, MJ; Hayashi, Y; Paleologou, KE; Tabner, BJ; Turnbull, S | 1 |
| Bales, KR; Hartman, RE; Holtzman, DM; Jiang, H; Parsadanian, M; Paul, SM; Wahrle, SE | 1 |
| Koldamova, R; Lefterov, I; Staufenbiel, M | 1 |
| Iwasa, K; Matsumoto, Y; Naiki, H; Noguchi, M; Ono, K; Yamada, M; Yanase, D | 1 |
| Biernat, J; Gazova, Z; Khlistunova, I; Mandelkow, E; Mandelkow, EM; Pickhardt, M; von Bergen, M; Wang, Y | 1 |
| Adriany, G; Borowski, BJ; Curran, GL; Garwood, M; Holasek, SS; Jack, CR; Lin, J; Poduslo, JF; Preboske, GM; Reyes, DA; Wengenack, TM | 1 |
| He, Y; Luo, Y; Tang, H; Zhou, H | 1 |
| Bryszewska, M; Cladera, J; Cortijo-Arellano, M; Klajnert, B | 1 |
| Akagi, T; Chui, DH; Fukuda, T; Hashikawa, T; Kimura, T; Kudo, T; Miyasaka, T; Murayama, M; Nakano, Y; Park, JM; Takashima, A; Takeda, M; Tanemura, K; Tatebayashi, Y | 1 |
| Arai, H; Fujiwara, H; Furukawa, K; Hara, M; He, M; Higuchi, M; Iwasaki, K; Kudo, Y; Maeda, S; Maruyama, M; Ohizumi, Y; Saido, TC; Seki, T; Takashima, A; Tomita, N | 1 |
| Arnold, SE; Chatterjee, A; Clark, CM; Coslett, HB; Farmer, J; Forman, MS; Grossman, M; Hurtig, HI; Johnson, JK; Karlawish, JH; Lee, VM; Miller, BL; Rosen, HJ; Trojanowski, JQ; Van Deerlin, V | 1 |
| Gong, Y; Hughes, JA; King, MA; Klein, RL; Meyer, EM; Meyers, CA | 1 |
| Cai, L; Pike, VW; Wang, Y; Wei, J; Wu, C | 1 |
| Avila, J; Hernández, F; Moreno, FJ; Pérez, M; Santa-María, I | 1 |
| Naiki, H; Noguchi-Shinohara, M; Ono, K; Yamada, M; Yoshita, M | 1 |
| Bourhim, M; Kruzel, M; Nicotera, T; Srikrishnan, T | 1 |
| Chen, K; Maley, J; Yu, PH | 1 |
| Baud, S; Keeley, FW; Miao, M; Pomès, R; Rauscher, S | 1 |
| Ono, M | 1 |
| Enokita, M; Hashimoto, T; Hori, Y; Iwatsubo, T; Kato, M; Kinoshita, H; Toyo'oka, T | 1 |
| Ikeda, K; Matsuzaki, K; Okada, T; Wakabayashi, M | 1 |
| Beach, TG; Brune, D; Esh, CL; Fifield, FG; Fraser, PE; Kalback, WM; Kokjohn, TA; Lopez, J; Luehrs, DC; McLaurin, J; Newel, AJ; Patton, RL; Poston, M; Roher, AE; Van Vickle, GD; Westaway, D | 1 |
| Austin, CP; Honson, NS; Huang, W; Inglese, J; Johnson, RL; Kuret, J | 1 |
| Faller, P; Gras, E; Leuma Yona, R; Mazères, S | 1 |
| Cheng, RH; Hong, HS; Jin, LW; Kung, HF; Kung, MP; Laferla, FM; Lam, KS; Liu, R; Maezawa, I; Oddo, S; Wu, CY | 1 |
| Gupta, VB; Rao, KS | 1 |
| Calissano, P; Cicconi, S; Ciotti, MT; Gentile, A; Parasassi, T; Serafino, A | 1 |
| Chierici, S; Dolphin, GT; Dumy, P; Garcia, J; Ouberai, M | 1 |
| Thangavel, R; Van Hoesen, GW; Zaheer, A | 1 |
| Arendt, T; Bigl, V; Brückner, MK; Marcova, L | 1 |
| Biernat, J; Mandelkow, E; Mandelkow, EM; Schweers, O | 1 |
| Buée, L; Buée-Scherrer, V; Delacourte, A; Marugg, RA; Morrison, JH; Riederer, BM; Vickers, JC | 1 |
| Aimi, Y; Kawamata, T; McGeer, EG; McGeer, PL; Yasuhara, O | 1 |
| Cotman, CW; Cummings, BJ; Su, JH | 1 |
| Gómez-Ramos, P; Morán, MA; Navarro, C; Probst, A | 1 |
| Alvarez, A; Casanueva, OI; Garrido, J; Inestrosa, NC; Linker, C; Moreno, RD; Pérez, CA; Soto, C; Vicente, M | 1 |
| Naiki, H; Nakakuki, K | 1 |
| Rogers, J; Webster, S | 1 |
| Bubb, MR; Caviston, TL; DeTure, MA; Erdos, GW; Purich, DL; Whittaker, SD; Zhang, EY | 1 |
| Beavis, RC; Frangione, B; Golabek, A; Lalowski, M; Lemere, CA; Selkoe, DJ; Wisniewski, HM; Wisniewski, T | 1 |
| Hansen, LA; Mallory, M; Masliah, E; Vincent, I; Wakabayashi, K | 1 |
| Cunningham, AM; Hipkiss, AR; Mayer, S; Michaelis, J; Müller, R; Münch, G; Neumann, A; Riederer, P; Schinzel, R | 1 |
| Morrison, JH; Sampson, VL; Vickers, JC | 1 |
| Johnson-Wood, K; Lin, C; Mallory, M; Masliah, E; McConlogue, L; Mucke, L; Wyss-Coray, T | 1 |
| Guillozet, AL; Mash, DC; Mesulam, MM; Smiley, JF | 1 |
| Crutcher, KA; Joshi, SN | 1 |
| Crutcher, KA; Scott, SA; Tolar, M | 1 |
| Beal, MF; Kowall, NW; McKee, AC; Schumacher, JS | 1 |
| Geula, C; Mesulam, MM; Saroff, DM; Wu, CK | 1 |
| Friedhoff, P; Mandelkow, E; Mandelkow, EM; Schneider, A | 1 |
| Beffert, U; Poirier, J | 1 |
| Dickson, DW; Lee, VM; Trojanowski, JQ; Wang, J | 1 |
| Boelens, WC; Bosman, GJ; de Jong, WW; Overkamp, PS; Reijnen-Aalbers, A; Renkawek, K; Stege, GJ; van Rijk, AF; Verschuure, P | 1 |
| Bales, KR; Fagan, AM; Holtzman, DM; Mackey, B; McKeel, D; Olney, J; Parsadanian, M; Paul, SM; Sartorius, LJ; Tenkova, T; Wozniak, D | 1 |
| Chu, CC; Parvizi, J; Van Hoesen, GW | 1 |
| Dagø, L; Olesen, OF | 1 |
| Hatters, DM; Howlett, GJ; Lawrence, LJ; MacPhee, CE; Sawyer, WH | 1 |
| Hamilton, RL; Klunk, WE; Styren, GC; Styren, SD | 1 |
| Liang, JJ | 1 |
| Bacskai, BJ; Christie, RH; Hyman, BT; Kajdasz, ST; Webb, WW; Williams, RM; Zipfel, WR | 1 |
| Colombo, L; Forloni, G; Girola, L; Salmona, M; Tagliavini, F | 1 |
| Azizeh, BY; Cotman, CW; Cribbs, DH; Head, E; Lott, IT; Tenner, AJ | 1 |
| Exley, C; Korchazhkina, OV | 2 |
| Hashioka, S; Imoto, T; Monji, A; Tashiro , K; Tashiro, N; Ueda, T; Utsumi, H; Yoshida, I | 1 |
| Duff, K; La Francois, J; Matsuoka, Y; Picciano, M | 1 |
| Gordon, DJ; Meredith, SC; Sciarretta, KL | 1 |
| Bales, KR; Cummins, DJ; DeLong, CA; Esterman, MA; Fishman, CE; Hanson, JC; Jordan, WH; Paul, SM; White, SL | 1 |
| Dickson, TC; Vickers, JC | 1 |
| Cruz, L; Duff, K; Hsiao-Ashe, K; Hyman, BT; Irizarry, MC; Knowles, RB; Le, R; Stanley, HE; Urbanc, B | 1 |
| Debnath, ML; Holt, DP; Huang, GF; Klunk, WE; Mathis, CA; Wang, Y | 1 |
| Emson, PC; Iritani, S; Niizato, K | 1 |
| Mallory, M; Mante, M; Masliaha, E; Rockenstein, E; Sisk, A | 1 |
| Bacskai, BJ; Debnath, ML; Frosch, MP; Holt, DP; Huang, GF; Hyman, BT; Kajdasz, ST; Klunk, WE; Mathis, CA; McLellan, ME; Wang, Y | 1 |
| Balaban, TS; Greferath, R; Hopkins, RJ; Lazarte, JE; Nicolau, C | 1 |
| Fukushima, K; Isobe, Y; Kiuchi, Y | 1 |
| Irie, K; Morimoto, A; Murakami, K; Nagao, M; Ohigashi, H; Shimizu, T; Shindo, M; Shirasawa, T | 1 |
| Bouras, C; Guntern, R; Hof, PR; Vallet, PG | 1 |
| Bouras, C; Delacourte, A; Golaz, J; Guntern, R; Hof, PR; Robakis, NK; Vallet, PG | 1 |
| Cerwinski, S; Chou, SJ; Emory, C; Fisher, GH; Frey, WH; Man, EH; Martin, T; Payan, IL | 1 |
| Van Hoesen, GW; Vogt, BA; Vogt, LJ | 1 |
| Davous, P; Fallet-Bianco, C; Lamour, Y; Roudier, M; Senut, MC | 2 |
| Benes, FM; Bird, ED; Farol, PA; Majocha, RE; Marotta, CA | 1 |
| Davous, P; Fallet-Bianco, C; Lamour, Y; Roudier, M | 1 |
| German, DC; Saper, CB | 1 |
| Defossez, A; Delacourte, A; Peers, MC; Persuy, P | 1 |
| Défossez, A; Delacourte, A | 1 |
| Brion, JP; Delaère, P; Duyckaerts, C; Hauw, JJ; Poulain, V | 1 |
| Behrouz, N; Defossez, A; Delacourte, A; Hublau, P; Mazzuca, M | 1 |
| Jungalwala, FB; Majocha, RE; Marotta, CA; Rodenrys, A | 1 |
| Défossez, A; Delacourte, A; Lenders, MB; Mazzuca, M; Peers, MC | 1 |
| KuKuruga, D; Palutke, M; Roher, A; Wolfe, D | 1 |
| Gilroy, J; LeWitt, P; Pomara, N; Reitz, D; Townsend, LE; Weintraub, J; Wolfe, DE | 1 |
| German, DC; Saper, CB; White, CL | 1 |
| Gur, TL; Hou, C; Kung, HF; Kung, MP; Lee, VM; Plössl, K; Skovronsky, DM; Trojanowski, JQ; Zhuang, ZP | 1 |
| Gupta, S; Kumar, S; Modi, G; Rai, H; Ran, C; Singh, SK; Yang, J | 1 |
11 review(s) available for thioflavin t and Alzheimer Disease
| Article | Year |
|---|---|
Progress and developments in tau aggregation inhibitors for Alzheimer disease.
Topics: Alzheimer Disease; Animals; Clinical Trials as Topic; Humans; Hydrogen Bonding; Models, Molecular; Protein Binding; Protein Conformation; Structure-Activity Relationship; tau Proteins | 2013 |
Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Biological Products; Catechin; Flavonoids; Fluorescent Dyes; Luteolin; Mice; Mice, Transgenic; Protein Aggregates; Silybin | 2020 |
[Amyloid-selective Photooxygenation toward Treatment for Amyloid Diseases].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Catalysis; Dinitrocresols; Drug Discovery; Humans; Oxidation-Reduction; Photochemical Processes; Protein Aggregation, Pathological; Protein Binding; Riboflavin; Thiazoles | 2018 |
Fluorescent Imaging of Amyloid-β Deposits in Brain: An Overview of Probe Development and a Highlight of the Applications for In Vivo Imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Congo Red; Curcumin; Fluorescent Dyes; Humans; Microscopy, Fluorescence, Multiphoton; Positron Emission Tomography Computed Tomography; Thiazoles | 2018 |
Advances in development of fluorescent probes for detecting amyloid-β aggregates.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Boron Compounds; Curcumin; Fluorescent Dyes; Humans; Optical Imaging; Stilbenes; Thiazoles; Thiophenes | 2016 |
Development of tau aggregation inhibitors for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Databases, Factual; Humans; tau Proteins; Tauopathies; Thiazoles | 2009 |
Insight into amyloid structure using chemical probes.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Coloring Agents; Congo Red; Humans; Molecular Sequence Data; Protein Conformation; Thiazoles | 2011 |
Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues.
Topics: Acridines; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biocompatible Materials; Biomarkers; Brain; Chromones; Drug Delivery Systems; Ferric Compounds; Gold; Humans; Magnetite Nanoparticles; Nanoparticles; Thiazoles | 2011 |
Dye-binding assays for evaluation of the effects of small molecule inhibitors on amyloid (aβ) self-assembly.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Coloring Agents; Congo Red; Drug Discovery; False Positive Reactions; Fluorescent Dyes; Humans; Reproducibility of Results; Thiazoles | 2012 |
[Molecular imaging of beta-amyloid plaques in the brain].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Brain; Congo Red; Humans; Mice; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2007 |
Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Fluorescent Dyes; Humans; Precision Medicine; tau Proteins | 2022 |
2 trial(s) available for thioflavin t and Alzheimer Disease
| Article | Year |
|---|---|
Pharmacodynamics of cholinesterase inhibitors suggests add-on therapy with a low-dose carbamylating inhibitor in patients on long-term treatment with rapidly reversible inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Blotting, Western; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Drug Therapy, Combination; Fluorescence; Follow-Up Studies; Humans; Indans; Physostigmine; Piperidines; Thiazoles; Time Factors | 2014 |
Whole-body biodistribution and brain PET imaging with [18F]AV-45, a novel amyloid imaging agent--a pilot study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Brain; Case-Control Studies; Ethylene Glycols; Female; Fluorescent Dyes; Fluorine Radioisotopes; Humans; Male; Middle Aged; Pilot Projects; Positron-Emission Tomography; Radiometry; Thiazoles | 2010 |
312 other study(ies) available for thioflavin t and Alzheimer Disease
| Article | Year |
|---|---|
Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Binding Sites; Brain; Flavones; Humans; Iodine Radioisotopes; Isotope Labeling; Mice; Peptide Fragments; Plaque, Amyloid; Protein Binding; Radiopharmaceuticals; Solutions; Structure-Activity Relationship; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2005 |
Structure-activity relationship of chalcones and related derivatives as ligands for detecting of beta-amyloid plaques in the brain.
Topics: Alzheimer Disease; Animals; Binding, Competitive; Brain; Chalcones; Disease Models, Animal; Ligands; Mice; Plaque, Amyloid; Structure-Activity Relationship | 2007 |
Novel chalcones as probes for in vivo imaging of beta-amyloid plaques in Alzheimer's brains.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Chalcones; Iodine Radioisotopes; Mice; Mice, Transgenic; Molecular Probes; Plaque, Amyloid; Solutions | 2007 |
18F stilbenes and styrylpyridines for PET imaging of A beta plaques in Alzheimer's disease: a miniperspective.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Fluorine Radioisotopes; Humans; Plaque, Amyloid; Positron-Emission Tomography; Pyridines; Stilbenes; Styrenes; Tissue Distribution | 2010 |
Novel anilinophthalimide derivatives as potential probes for beta-amyloid plaque in the brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Humans; Mice; Phthalimides; Tomography, Emission-Computed, Single-Photon | 2010 |
Synthesis and evaluation of stilbene derivatives as a potential imaging agent of amyloid plaques.
Topics: Alzheimer Disease; Animals; Brain; Fluorescent Dyes; Mice; Plaque, Amyloid; Positron-Emission Tomography; Stilbenes; Tomography, Emission-Computed, Single-Photon | 2010 |
Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Fluorescence; Fluorine Radioisotopes; Heterocyclic Compounds; Insulin; Isomerism; Models, Molecular; Parkinson Disease; Protein Binding; Spectrometry, Fluorescence | 2011 |
Fluorescent 2-styrylpyridazin-3(2H)-one derivatives as probes targeting amyloid-beta plaques in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Fluorescence; Fluorescent Dyes; Humans; Mice; Mice, Transgenic; Plaque, Amyloid; Pyridazines; Sensitivity and Specificity; Spectrometry, Fluorescence; Staining and Labeling | 2012 |
Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Apigenin; Benzaldehydes; Cinnamates; Depsides; Flavonoids; Humans; In Vitro Techniques; Molecular Structure; Peptide Fragments; Phenols; Quercetin; Rosmarinic Acid | 2017 |
Caffeic acid for the prevention and treatment of Alzheimer's disease: The effect of lipid membranes on the inhibition of aggregation and disruption of Aβ fibrils.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Caffeic Acids; Circular Dichroism; Fluorescence; Humans; Kinetics; Membrane Lipids; Protein Aggregates; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared | 2021 |
Cannabidiol Inhibits Tau Aggregation In Vitro.
Topics: Alzheimer Disease; Benzothiazoles; Brain; Cannabidiol; Humans; Kinetics; Microscopy, Atomic Force; Neurons; Protein Aggregation, Pathological; Protein Isoforms; tau Proteins | 2021 |
Z-scan optical method complements the Thioflavin T assay for investigation of anti-Alzheimer's impact of polyphenols.
Topics: Alzheimer Disease; Benzothiazoles; Humans; Metal Nanoparticles; Photochemotherapy; Polyphenols; Silver | 2022 |
New Evidence on a Distinction between Aβ40 and Aβ42 Amyloids: Thioflavin T Binding Modes, Clustering Tendency, Degradation Resistance, and Cross-Seeding.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Cluster Analysis; Humans; Peptide Fragments | 2022 |
Apolipoprotein E impairs amyloid-β fibril elongation and maturation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Benzothiazoles; Fluorescent Dyes; Humans; Particle Size; Surface Plasmon Resonance; Surface Properties | 2020 |
Copper Ion Uptake by Chitosan in the Presence of Amyloid-β and Histidine.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biopolymers; Chitosan; Copper; Fluorescence; Histidine; Humans | 2020 |
Cassia tora prevents Aβ
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzothiazoles; Cassia; Cell Death; Cell Line, Tumor; Humans; Neuroblastoma; Neurodegenerative Diseases; Oxidative Stress; Peptide Fragments; Plant Preparations; Protective Agents; Reactive Oxygen Species | 2019 |
Destabilization of β-amyloid aggregates by thrombin derived peptide: plausible role of thrombin in neuroprotection.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Neuroprotection; Peptide Hydrolases; Peptides; Protein Aggregation, Pathological; Thrombin | 2020 |
Zinc Binding to Tau Influences Aggregation Kinetics and Oligomer Distribution.
Topics: Alzheimer Disease; Amyloid; Benzothiazoles; Calcium; Circular Dichroism; Humans; Kinetics; Protein Aggregates; Protein Conformation; Spectroscopy, Fourier Transform Infrared; tau Proteins; Zinc | 2019 |
The role of isoaspartate in fibrillation and its prevention by Protein-L-isoaspartyl methyltransferase.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Anticonvulsants; Aspartic Acid; Benzothiazoles; Brain; Dioxolanes; Epilepsy; Humans; Isoaspartic Acid; Neurons; PC12 Cells; Peptides; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Rats; Structure-Activity Relationship; Valproic Acid | 2020 |
Interactions between Soluble Species of β-Amyloid and α-Synuclein Promote Oligomerization while Inhibiting Fibrillization.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Brain; Electrophoresis, Polyacrylamide Gel; Humans; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Neurodegenerative Diseases; Parkinson Disease; Peptide Fragments; Protein Aggregation, Pathological | 2020 |
CRANAD-28: A Robust Fluorescent Compound for Visualization of Amyloid Beta Plaques.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Boron Compounds; Brain; Curcumin; Disease Models, Animal; Female; Fluorescent Dyes; Humans; Mice; Mice, Transgenic; Microglia; Microscopy, Confocal; Microtomy; Plaque, Amyloid; Staining and Labeling | 2020 |
Near-Infrared Light-Powered Janus Nanomotor Significantly Facilitates Inhibition of Amyloid-β Fibrillogenesis.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Blood-Brain Barrier; Cell Line, Tumor; Cell Survival; Humans; Infrared Rays; Models, Biological; Multifunctional Nanoparticles | 2020 |
Amyloid β chaperone - lipocalin-type prostaglandin D synthase acts as a peroxidase in the presence of heme.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Electron Spin Resonance Spectroscopy; Ferric Compounds; Fluorescent Dyes; Heme; Humans; Hydrophobic and Hydrophilic Interactions; Intramolecular Oxidoreductases; Ligands; Lipocalins; Molecular Chaperones; Molecular Dynamics Simulation; Peroxidase; Protein Binding; Protein Conformation | 2020 |
Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Cryoelectron Microscopy; Humans; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Peptide Fragments; Time-Lapse Imaging | 2020 |
Driving force to detect Alzheimer's disease biomarkers: application of a thioflavine T@Er-MOF ratiometric fluorescent sensor for smart detection of presenilin 1, amyloid β-protein and acetylcholine.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Base Sequence; Benzothiazoles; Biomarkers; Erbium; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Limit of Detection; Metal-Organic Frameworks; Microscopy, Confocal; Presenilin-1 | 2020 |
Prolongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans.
Topics: Aging; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Benzothiazoles; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Clioquinol; Disease Models, Animal; Emodin; Gene Knockdown Techniques; Homeostasis; Metallothionein; Metals; Neuroprotective Agents; Parkinson Disease; Quercetin; Signal Transduction | 2020 |
Preformulation Studies of a Stable PTEN-PDZ Lipopeptide Able to Cross an In Vitro Blood-Brain-Barrier Model as a Potential Therapy for Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Blood-Brain Barrier; Cell Line; Cell Survival; Cognition Disorders; Endothelium, Vascular; Half-Life; Lipopeptides; Male; Mice; Myristic Acid; PTEN Phosphohydrolase; Sodium Dodecyl Sulfate; Synapses; Zonula Occludens-1 Protein | 2020 |
Fluorescently-labelled amyloid paired helical filaments (PHF) in monitoring its fibrillation kinetics.
Topics: Alzheimer Disease; Amino Acids; Amyloid beta-Peptides; Benzothiazoles; Carbocyanines; Fluorescence; Fluorescent Dyes; Humans; Kinetics; Molecular Structure | 2020 |
Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Cell Line; Cell Survival; Cinnamates; Dementia; Depsides; Humans; Mentha spicata; Plant Extracts; Polyphenols; Rosmarinic Acid | 2020 |
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Humans; In Vitro Techniques; Memantine; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Protein Conformation, beta-Strand; Spectrometry, Fluorescence | 2020 |
Effect of Ionic Strength on Thioflavin-T Affinity to Amyloid Fibrils and Its Fluorescence Intensity.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Binding Sites; Fluorescence; Humans; Insulin; Kinetics; Mice; Osmolar Concentration; Parkinson Disease; Prion Proteins; Protein Aggregates; Protein Aggregation, Pathological; Protein Binding | 2020 |
Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Female; Male; Mice; Mice, Transgenic; Phosphorylation; Piperazines; Protein Aggregates; Protein Conformation, beta-Strand; tau Proteins | 2021 |
Anti-Parallel β-Hairpin Structure in Soluble Aβ Oligomers of Aβ40-Dutch and Aβ40-Iowa.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Cerebral Amyloid Angiopathy; Circular Dichroism; Fluorescence; Microscopy, Atomic Force; Mutation; Plaque, Amyloid; Protein Conformation, beta-Strand; Spectroscopy, Fourier Transform Infrared | 2021 |
Different Aggregation Pathways and Structures for Aβ40 and Aβ42 Peptides.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Humans; Microscopy, Atomic Force; Microscopy, Fluorescence; Neurodegenerative Diseases; Peptide Fragments; Peptides; Protein Binding; Protein Conformation; Protein Isoforms | 2021 |
Biflavonoid-Induced Disruption of Hydrogen Bonds Leads to Amyloid-β Disaggregation.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Biflavonoids; Brain; Humans; Hydrogen Bonding; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Aggregation, Pathological | 2021 |
Human Polymerase δ-Interacting Protein 2 (PolDIP2) Inhibits the Formation of Human Tau Oligomers and Fibrils.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Brain; Humans; Nuclear Proteins; tau Proteins; Tauopathies | 2021 |
Thioflavin T: not an all-rounder, but a trustworthy friend for over 27 years.
Topics: Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Humans | 2017 |
Microvascular ultrastructural changes precede cognitive impairment in the murine APPswe/PS1dE9 model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Capillaries; Cerebral Cortex; Cognitive Dysfunction; Disease Models, Animal; Exploratory Behavior; Intussusception; Kidney Glomerulus; Liver; Male; Memory, Short-Term; Mice, Transgenic; Microvessels; Plaque, Amyloid; Spleen; Thiazoles | 2017 |
Binding of Thioflavin T and Related Probes to Polymorphic Models of Amyloid-β Fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Fluorescent Dyes; Humans; Models, Molecular; Peptide Fragments; Protein Binding; Protein Conformation, beta-Strand; Thermodynamics; Thiazoles | 2017 |
Core Binding Site of a Thioflavin-T-Derived Imaging Probe on Amyloid β Fibrils Predicted by Computational Methods.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Humans; Hydrophobic and Hydrophilic Interactions; Iodine Radioisotopes; Molecular Dynamics Simulation; Peptide Fragments | 2018 |
Tau protein liquid-liquid phase separation can initiate tau aggregation.
Topics: Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Animals; Benzothiazoles; Biophysical Phenomena; Brain; Cloning, Molecular; DNA-Binding Proteins; Escherichia coli; Female; HEK293 Cells; Heterogeneous Nuclear Ribonucleoprotein A1; Humans; Liquid-Liquid Extraction; Mice; Mice, Transgenic; Molecular Weight; Neuroblastoma; Neurodegenerative Diseases; Neurofibrillary Tangles; Neurons; Phosphorylation; Protein Aggregation, Pathological; Recombinant Proteins; Sequence Analysis, Protein; Sf9 Cells; tau Proteins | 2018 |
Nanogels of dual inhibitor-modified hyaluronic acid function as a potent inhibitor of amyloid β-protein aggregation and cytotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Catechin; Cell Line; Cell Proliferation; Cell Survival; Humans; Hyaluronic Acid; Hydrogels; Hydrophobic and Hydrophilic Interactions; Nanoparticles; Polyethylene Glycols; Protein Aggregates | 2018 |
Rhenium Complexes of Bis(benzothiazole)-Based Tetraarylethylenes as Selective Luminescent Probes for Amyloid Fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Chelating Agents; Humans; Ligands; Luminescence; Peptide Fragments; Rhenium; Thiazoles | 2018 |
Functionalization of stable fluorescent nanodiamonds towards reliable detection of biomarkers for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Biomarkers; Cell Line; Cell Survival; Cell-Penetrating Peptides; Fluorescent Dyes; Humans; Mice, Transgenic; Nanodiamonds; Protein Aggregates | 2018 |
Copper Redox Cycling Inhibits Aβ Fibre Formation and Promotes Fibre Fragmentation, while Generating a Dityrosine Aβ Dimer.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Copper; Humans; Hydrogen Peroxide; Microscopy, Electron, Transmission; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Plaque, Amyloid; Protein Multimerization; Tyrosine | 2018 |
In Vitro Assay for Studying the Aggregation of Tau Protein and Drug Screening.
Topics: Alzheimer Disease; Benzothiazoles; Drug Evaluation, Preclinical; Heparin; Humans; Protein Aggregates; Protein Binding; Protein Folding; Protein Isoforms; tau Proteins | 2018 |
Lipopolysaccharide Induced Opening of the Blood Brain Barrier on Aging 5XFAD Mouse Model.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Biological Availability; Blood-Brain Barrier; Ferric Compounds; Humans; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nanoparticles; Permeability; Plaque, Amyloid | 2019 |
Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Kinetics; Oxidation-Reduction; Protein Aggregates | 2019 |
Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders.
Topics: Age Factors; Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Animals; Benzothiazoles; Biomarkers; Brain Chemistry; Case-Control Studies; Computer Systems; Fluorescent Dyes; Fluorometry; High-Throughput Screening Assays; Humans; Lewy Body Disease; Mice; Microglia; Middle Aged; Neuroglia; Parkinsonian Disorders; Protein Aggregates; Recombinant Proteins; Reproducibility of Results; Sensitivity and Specificity; Single-Blind Method; Synucleinopathies | 2019 |
Platinum(II)
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Benzothiazoles; Cell Line; Cinnamates; Circular Dichroism; Coordination Complexes; Humans; Ligands; Nuclear Proteins; Nucleophosmin; Peptide Termination Factors; Platinum; Protein Aggregation, Pathological; Saccharomyces cerevisiae Proteins | 2019 |
Amyloidogenic Nanoplaques in Blood Serum of Patients with Alzheimer's Disease Revealed by Time-Resolved Thioflavin T Fluorescence Intensity Fluctuation Analysis.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Benzothiazoles; Biomarkers; Cohort Studies; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Plaque, Amyloid; Protein Aggregation, Pathological; Serum; Spectrometry, Fluorescence | 2019 |
Exploring the multifunctionality of thioflavin- and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzothiazoles; Binding, Competitive; Blood-Brain Barrier; Catalytic Domain; Cell Survival; Cholinesterase Inhibitors; Deferiprone; Humans; Kinetics; Ligands; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Permeability; Prodrugs; Protein Binding; Pyridones; Thiazoles | 2013 |
Characterization of a single-chain variable fragment recognizing a linear epitope of aβ: a biotechnical tool for studies on Alzheimer's disease?
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Enzyme-Linked Immunosorbent Assay; Epitopes; Humans; Immunoglobulin G; Immunohistochemistry; Ligands; Mice; Mice, Transgenic; Models, Molecular; Molecular Sequence Data; Neurodegenerative Diseases; Permeability; Plasmids; Protein Binding; Sequence Alignment; Single-Chain Antibodies; Thiazoles | 2013 |
Molecular characterization of the hetero-assembly of β-amyloid peptide with islet amyloid polypeptide.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Amyloidosis; Animals; Benzothiazoles; Cell Survival; Circular Dichroism; Diabetes Mellitus, Type 2; Islet Amyloid Polypeptide; Kinetics; Microscopy, Electron, Transmission; Molecular Sequence Data; PC12 Cells; Peptide Fragments; Protein Binding; Protein Folding; Protein Multimerization; Rats; Spectrometry, Fluorescence; Thiazoles | 2014 |
Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Benzothiazoles; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Gliosis; Humans; Integrases; Membrane Glycoproteins; Mice; Mice, Transgenic; Nerve Degeneration; Neurons; Phenotype; Presenilin-1; Thiazoles | 2013 |
Comparison of two methods for the estimation of stability of copper(II) bis-complexes with aromatic ligands relevant to Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Copper; Humans; Ligands; Organometallic Compounds; Plaque, Amyloid; Regression Analysis; Thiazoles | 2013 |
[Application of thioflavin T staining in detection of β-amyloid].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Cerebral Amyloid Angiopathy; Fluorescent Dyes; Humans; Mice; Peptide Fragments; Staining and Labeling; Thiazoles | 2013 |
Spared piriform cortical single-unit odor processing and odor discrimination in the Tg2576 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Benzothiazoles; Disease Models, Animal; Entorhinal Cortex; Female; Habituation, Psychophysiologic; Hippocampus; Male; Memory; Mice, Transgenic; Odorants; Olfactory Bulb; Olfactory Pathways; Piriform Cortex; Thiazoles | 2014 |
The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Benzothiazoles; Brain; Cell Culture Techniques; Cell Line; Cricetinae; Disease Models, Animal; Humans; Kinetics; Mice; Mice, Inbred C57BL; Mutagenesis; Mutation; Neurons; Peptide Fragments; Solubility; Thermodynamics; Thiazoles | 2014 |
Detection of Aβ-interacting proteins via a novel Aβ-adsorbents that use immobilized regular comb polymer.
Topics: Adsorption; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain Chemistry; Fluorescent Dyes; Immobilized Proteins; Mice; Nerve Tissue Proteins; Polymers; Sepharose; Thiazoles | 2014 |
Thioflavin-based molecular probes for application in Alzheimer's disease: from in silico to in vitro models.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Brain; Brain Chemistry; Cell Line; Cell Survival; Humans; Mice; Models, Biological; Molecular Docking Simulation; Molecular Probes; Phenols; Thiazoles | 2015 |
Exploiting the therapeutic potential of 8-β-d-glucopyranosylgenistein: synthesis, antidiabetic activity, and molecular interaction with islet amyloid polypeptide and amyloid β-peptide (1-42).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Diabetes Mellitus, Experimental; Drug Design; Epitopes; Genista; Genistein; Glucosides; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Islet Amyloid Polypeptide; Magnetic Resonance Spectroscopy; Microscopy, Atomic Force; Microscopy, Fluorescence; Oxygen; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Rats; Rats, Wistar; Streptozocin; Thiazoles | 2014 |
Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain.
Topics: Aged; Alzheimer Disease; Amyloid; Benzothiazoles; Blotting, Western; Brain; Cell Line, Tumor; Female; Fluorescent Antibody Technique; Histones; Humans; Male; Neurofibrillary Tangles; Plaque, Amyloid; tau Proteins; Thiazoles; Tissue Array Analysis; Ubiquitin | 2015 |
Pretreatment of chemically-synthesized Aβ42 affects its biological activity in yeast.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Benzothiazoles; Candida glabrata; Flow Cytometry; Microscopy, Confocal; Microscopy, Electron, Transmission; Neurons; Peptide Fragments; Peptides; Propanols; Protein Binding; Protein Conformation; Saccharomyces cerevisiae; Thiazoles | 2014 |
Towards ratiometric sensing of amyloid fibrils in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding Sites; Cattle; Electrochemistry; Fluorescence; Fluorescent Dyes; Humans; Imidazoles; Protein Binding; Pyridines; Serum Albumin, Bovine; Thiazoles | 2015 |
Rationally designed peptidomimetic modulators of aβ toxicity in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Autophagy; Benzothiazoles; Biological Assay; Circular Dichroism; Drug Design; Green Fluorescent Proteins; Humans; Kinetics; Microscopy, Fluorescence; Models, Biological; Peptide Fragments; Peptidomimetics; Protein Aggregates; Proteolysis; Saccharomyces cerevisiae; Thiazoles | 2015 |
Stabilization of nontoxic Aβ-oligomers: insights into the mechanism of action of hydroxyquinolines in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Biophysics; Caenorhabditis elegans; Cells, Cultured; Cerebral Cortex; Chromatography, Gel; Clioquinol; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxyquinolines; Mice; Microscopy, Electron; Neurons; Peptide Fragments; Protein Binding; Scattering, Small Angle; Thiazoles | 2015 |
A Comparison of Three Fluorophores for the Detection of Amyloid Fibers and Prefibrillar Oligomeric Assemblies. ThT (Thioflavin T); ANS (1-Anilinonaphthalene-8-sulfonic Acid); and bisANS (4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid).
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Anilino Naphthalenesulfonates; Benzothiazoles; Diabetes Mellitus, Type 2; Fluorescent Dyes; Humans; Islet Amyloid Polypeptide; Molecular Sequence Data; Spectrometry, Fluorescence; Thiazoles | 2015 |
Thioflavin T templates amyloid β(1-40) conformation and aggregation pathway.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Fluorescence Recovery After Photobleaching; Fluorescent Dyes; Humans; Molecular Dynamics Simulation; Molecular Sequence Data; Peptide Fragments; Protein Aggregates; Protein Aggregation, Pathological; Protein Conformation; Protein Multimerization; Protein Stability; Protein Structure, Secondary; Thiazoles | 2015 |
Chiral Metallo-Supramolecular Complex Directed Enantioselective Self-Assembly of β-Sheet Breaker Peptide for Amyloid Inhibition.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Humans; Kinetics; Metal Nanoparticles; Metals; Nanotechnology; PC12 Cells; Protein Structure, Secondary; Rats; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Temperature; Thiazoles | 2015 |
Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Carbon-13 Magnetic Resonance Spectroscopy; Disease Models, Animal; Drug Monitoring; Fluorescent Dyes; Humans; Mice, Transgenic; Molecular Imaging; Photons; Presenilin-1; Proton Magnetic Resonance Spectroscopy; Spectrometry, Fluorescence; Spectroscopy, Near-Infrared; Thiazoles; Tissue Extracts; Titrimetry | 2015 |
Real-Time Monitoring of Alzheimer's-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy.
Topics: Acrylamides; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Kinetics; Molecular Structure; Naphthalenes; Peptide Fragments; Protein Aggregates; Solubility; Spectrometry, Fluorescence; Thiazoles | 2015 |
Investigation of the Binding Profiles of AZD2184 and Thioflavin T with Amyloid-β(1-42) Fibril by Molecular Docking and Molecular Dynamics Methods.
Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Benzothiazoles; Drug Design; Elasticity; Fluorescent Dyes; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Peptide Fragments; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Static Electricity; Thiazoles | 2015 |
Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in in vitro and in vivo models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Anthocyanins; Benzothiazoles; Brain; Cell Line, Tumor; Cognition; Cognition Disorders; Female; Humans; Male; Mice; Microscopy, Atomic Force; Peptide Fragments; Plant Extracts; Polyphenols; Thiazoles; Vaccinium myrtillus | 2016 |
A novel antagonistic role of natural compound icariin on neurotoxicity of amyloid β peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzothiazoles; Cell Line; Cell Survival; Flavonoids; Humans; Hydrogen Peroxide; Microscopy, Electron, Transmission; Neurons; Peptide Fragments; Protein Aggregation, Pathological; Thiazoles | 2015 |
Molecular "light switch" [Ru(phen)2dppzidzo](2+) monitoring the aggregation of tau.
Topics: Alzheimer Disease; Benzothiazoles; Fluorescent Dyes; Humans; Light; Luminescent Agents; Luminescent Measurements; Models, Molecular; Organometallic Compounds; Protein Aggregates; Protein Aggregation, Pathological; tau Proteins; Thiazoles | 2015 |
Oral Administration of Thioflavin T Prevents Beta Amyloid Plaque Formation in Double Transgenic AD Mice.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Benzothiazoles; Brain; Disease Models, Animal; Female; Male; Mice, Transgenic; Microglia; Neuroprotective Agents; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2015 |
Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Cell Survival; Curcumin; Diosgenin; Drug Design; Humans; Ligands; Neuroprotective Agents; Reactive Oxygen Species; Thiazoles | 2015 |
Difficulties associated with the structural analysis of proteins susceptible to form aggregates: The case of Tau protein as a biomarker of Alzheimer's disease.
Topics: Adhesiveness; Adsorption; Alzheimer Disease; Amino Acid Motifs; Antibodies, Monoclonal; Benzothiazoles; Biomarkers; Chymotrypsin; Epitopes; Humans; Magnetics; Mass Spectrometry; Proteolysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; tau Proteins; Thiazoles; Trypsin | 2016 |
Differential Effects of Structural Modifications on the Competition of Chalcones for the PIB Amyloid Imaging Ligand-Binding Site in Alzheimer's Disease Brain and Synthetic Aβ Fibrils.
Topics: Aged; Alkenes; Alzheimer Disease; Amyloid beta-Peptides; Amyloidogenic Proteins; Aniline Compounds; Benzoates; Benzothiazoles; Binding Sites; Brain; Chalcones; Female; Fluorescent Dyes; Humans; Ligands; Peptide Fragments; Positron-Emission Tomography; Thiazoles; Tritium | 2016 |
A High Affinity Red Fluorescence and Colorimetric Probe for Amyloid β Aggregates.
Topics: Absorption, Radiation; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Colorimetry; Fluorescent Dyes; Fluorometry; Humans; Molecular Docking Simulation; Molecular Structure; Peptide Fragments; Protein Aggregation, Pathological; Thiazoles | 2016 |
Fullerenol C60(OH)16 prevents amyloid fibrillization of Aβ40-in vitro and in silico approach.
Topics: Alzheimer Disease; Amyloid; Amyloidogenic Proteins; Benzothiazoles; Computer Simulation; Fullerenes; Thiazoles | 2016 |
Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Benzothiazoles; Biomarkers; Blotting, Western; Cell Line, Tumor; Cerebral Cortex; Disease Models, Animal; Female; Hippocampus; Humans; Immunohistochemistry; Liver; Male; Mice; Middle Aged; Plaque, Amyloid; Receptor, Notch1; tau Proteins; Thiazoles | 2016 |
Polyphenols from wolfberry and their bioactivities.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzothiazoles; Biphenyl Compounds; Chlorogenic Acid; Cholinesterase Inhibitors; Flavonoids; Food Analysis; Free Radical Scavengers; Free Radicals; Lignans; Lycium; Molecular Structure; Oxygen; Picrates; Plant Extracts; Polyphenols; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thiazoles | 2017 |
A Robust and Efficient Production and Purification Procedure of Recombinant Alzheimers Disease Methionine-Modified Amyloid-β Peptides.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Humans; Inclusion Bodies; Methionine; Peptide Fragments; Recombinant Proteins; Spectrophotometry, Ultraviolet; Staining and Labeling; Thiazoles | 2016 |
Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Fluorescent Dyes; Humans; Peptide Fragments; Peptides; Protein Aggregation, Pathological; Protein Engineering; Protein Multimerization; Protein Structure, Secondary; Spectrum Analysis; Thiazoles; Time Factors | 2016 |
Cerebrospinal fluid-induced retardation of amyloid β aggregation correlates with Alzheimer's disease and the APOE ε4 allele.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Benzothiazoles; Case-Control Studies; Cerebrospinal Fluid; Cholesterol, HDL; Chromatography, Gel; Female; Heterozygote; Humans; Immunoblotting; Kinetics; Male; Middle Aged; Peptide Fragments; Prospective Studies; Protein Multimerization; Thiazoles | 2016 |
Detection and Quantification Methods for Fibrillar Products of In Vitro Tau Aggregation Assays.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Biological Assay; Humans; Microscopy, Electron; Protein Aggregation, Pathological; tau Proteins; Thiazoles | 2017 |
Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice.
Topics: Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cerebral Cortex; Disease Models, Animal; Female; Hippocampus; Humans; Male; Mice, Transgenic; Plaque, Amyloid; Species Specificity; Thiazoles | 2017 |
Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apolipoproteins E; Benzothiazoles; Cerebral Amyloid Angiopathy; Dimerization; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Plaque, Amyloid; Protein Conformation; Thiazoles | 2008 |
Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain.
Topics: Alzheimer Disease; Anthocyanins; Benzothiazoles; Cells, Cultured; Fluorescence; Fluorescent Dyes; Heparin; Humans; Methylene Blue; Microtubules; Protein Structure, Tertiary; tau Proteins; Thiazoles | 2008 |
Molecular polymorphism of Abeta in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Binding Sites; Binding, Competitive; Coloring Agents; Congo Red; Diagnostic Imaging; Disease Models, Animal; Humans; Ligands; Molecular Probes; Pathology, Molecular; Plaque, Amyloid; Predictive Value of Tests; Protein Isoforms; Thiazoles | 2010 |
Intracranial administration of vaccinia virus complement control protein in Mo/Hu APPswe PS1dE9 transgenic mice at an early age shows enhanced performance at a later age using a cheese board maze test.
Topics: Age Factors; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Association Learning; Behavior, Animal; Benzothiazoles; Complement System Proteins; Conditioning, Psychological; Disease Models, Animal; Genotype; Injections; Maze Learning; Mice; Mice, Transgenic; Reversal Learning; Space Perception; Thiazoles; Viral Proteins | 2008 |
Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aprotinin; Benzothiazoles; Humans; Microscopy, Electron; Prealbumin; Recombinant Proteins; Thiazoles | 2008 |
The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Line; Humans; Microscopy, Electron, Transmission; Models, Biological; Neurons; Peptide Fragments; Peptides; Polymers; Protein Binding; Rats; Thiazoles; Time Factors | 2008 |
Beta-amyloid deposition and functional impairment in the retina of the APPswe/PS1DeltaE9 transgenic mouse model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antigens, Differentiation; Benzothiazoles; Choline O-Acetyltransferase; Disease Models, Animal; Electroretinography; Female; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Gliosis; Male; Mice; Mice, Transgenic; Microscopy, Confocal; Presenilin-1; Retina; Retinal Diseases; Syntaxin 1; Thiazoles | 2009 |
Aminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzofurans; Benzothiazoles; Benzoxazoles; Chemistry, Pharmaceutical; Curcumin; Drug Design; Electrons; Humans; Inhibitory Concentration 50; Models, Chemical; Peptide Fragments; Structure-Activity Relationship; Styrenes; Thiazoles | 2008 |
Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Female; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Male; Microscopy, Confocal; Middle Aged; Neurofibrillary Tangles; Neurons; Organic Chemicals; Plaque, Amyloid; Postmortem Changes; Silver Staining; tau Proteins; Thiazoles | 2008 |
Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Flavonoids; Humans; Kinetics; L-Lactate Dehydrogenase; Microscopy, Electron; Models, Chemical; Molecular Conformation; Peptide Fragments; Peptides; Phenols; Polyphenols; Protein Conformation; Protein Isoforms; Protein Structure, Secondary; Thiazoles | 2008 |
Garlic extract exhibits antiamyloidogenic activity on amyloid-beta fibrillogenesis: relevance to Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Garlic; Humans; Microscopy, Electron, Transmission; Plant Extracts; Thiazoles | 2009 |
Docosahexaenoic acid disrupts in vitro amyloid beta(1-40) fibrillation and concomitantly inhibits amyloid levels in cerebral cortex of Alzheimer's disease model rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies; Benzothiazoles; Cerebral Cortex; Cholesterol; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Hippocampus; Microscopy, Electron, Transmission; Neurofibrillary Tangles; Peptide Fragments; Rats; Rats, Wistar; Thiazoles | 2008 |
Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Autopsy; Benzothiazoles; Blotting, Western; Cohort Studies; Cytoskeleton; Humans; Immunohistochemistry; Middle Aged; Neurofibrillary Tangles; Phosphorylation; Plaque, Amyloid; Presenilin-1; Severity of Illness Index; tau Proteins; Thiazoles | 2009 |
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Antioxidants; Ascorbic Acid; Benzothiazoles; Blotting, Western; Brain; Cerebral Ventricles; Cysteine; Dietary Supplements; Female; Glutathione; Hippocampus; Humans; Immunohistochemistry; Male; Mice; Mice, Transgenic; Plaque, Amyloid; Resveratrol; Sirtuin 1; Sirtuins; Stilbenes; tau Proteins; Thiazoles; Transcription Factors; Tumor Suppressor Protein p53 | 2009 |
Design, selection, and characterization of thioflavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Chelating Agents; Copper; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Iodine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Peptide Fragments; Thiazoles; Zinc | 2009 |
CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Cell Survival; Electrophoresis, Capillary; Humans; Isoquinolines; Microscopy, Electron, Transmission; Mitoxantrone; Neuroprotective Agents; Particle Size; Peptide Fragments; Plaque, Amyloid; Protein Multimerization; Spectrometry, Fluorescence; Suramin; Thiazoles | 2009 |
Parcellation of human temporal polar cortex: a combined analysis of multiple cytoarchitectonic, chemoarchitectonic, and pathological markers.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Antigens, Nuclear; Benzothiazoles; Female; Histocytochemistry; Humans; Immunohistochemistry; Male; Nerve Tissue Proteins; Plant Lectins; Pyramidal Cells; Receptors, N-Acetylglucosamine; Tauopathies; Temporal Lobe; Thiazoles | 2009 |
Comparative study of inhibition at multiple stages of amyloid-beta self-assembly provides mechanistic insight.
Topics: Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Inhibitory Concentration 50; Light; Molecular Structure; Peptide Fragments; Protein Binding; Protein Conformation; Quinolizines; Scattering, Radiation; Solubility; Spectrometry, Fluorescence; Structure-Activity Relationship; Thiazoles | 2009 |
D-Ribosylated Tau forms globular aggregates with high cytotoxicity.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Cell Line; Fluorescent Dyes; Glycosylation; Humans; Microscopy, Atomic Force; Molecular Sequence Data; Neurofibrillary Tangles; Protein Conformation; Ribose; tau Proteins; Thiazoles | 2009 |
Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cerebral Cortex; Disease Models, Animal; Hippocampus; Humans; Memory; Memory Disorders; Mice; Mice, Transgenic; Organ Size; Peptide Fragments; Physical Conditioning, Animal; Protease Nexins; Random Allocation; Receptors, Cell Surface; Recognition, Psychology; Thiazoles; Time Factors | 2009 |
Inhibition of Abeta42 aggregation using peptides selected from combinatorial libraries.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Drug Evaluation, Preclinical; Molecular Sequence Data; Peptide Library; Peptides; Thiazoles | 2009 |
Mechanism of docosahexaenoic acid-induced inhibition of in vitro Abeta1-42 fibrillation and Abeta1-42-induced toxicity in SH-S5Y5 cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; In Vitro Techniques; Microscopy, Confocal; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Neurofibrillary Tangles; Peptide Fragments; Spectrum Analysis; Thiazoles | 2009 |
Oligomers of beta-amyloid are sequestered into and seed new plaques in the brains of an AD mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Biotin; Disease Models, Animal; Humans; Immunohistochemistry; Islet Amyloid Polypeptide; Ligands; Male; Mice; Mice, Transgenic; Microscopy, Atomic Force; Molecular Weight; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2010 |
Copper abolishes the beta-sheet secondary structure of preformed amyloid fibrils of amyloid-beta(42).
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Birefringence; Congo Red; Copper; Fluorescent Dyes; Humans; Microscopy, Electron, Transmission; Peptide Fragments; Peptides; Protein Structure, Secondary; Thiazoles | 2009 |
Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Cell Count; Diabetes Mellitus; Female; Fluorescent Antibody Technique; Glycation End Products, Advanced; Humans; Immunohistochemistry; Male; Microglia; Middle Aged; Peptide Fragments; Plant Lectins; Plaque, Amyloid; Receptor for Advanced Glycation End Products; Receptors, Immunologic; tau Proteins; Thiazoles | 2010 |
Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Cells, Cultured; Cholesterol; Fluorescence; Kinetics; Light; Microscopy, Immunoelectron; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurons; Oxidation-Reduction; Peptides; Protein Structure, Quaternary; Rats; Scattering, Radiation; Thiazoles | 2009 |
RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aptamers, Nucleotide; Benzothiazoles; Densitometry; Dimerization; DNA, Single-Stranded; Humans; Ligands; Peptide Fragments; Protein Binding; Protein Folding; Protein Structure, Secondary; Thiazoles | 2009 |
Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Line, Tumor; Cytoplasmic Vesicles; Fluorescence; Humans; Immunoblotting; Mice; Microscopy, Confocal; Neurons; Plaque, Amyloid; Thiazoles | 2009 |
Critical role of interfaces and agitation on the nucleation of Abeta amyloid fibrils at low concentrations of Abeta monomers.
Topics: Air; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Brain Chemistry; Fluorescent Dyes; Humans; In Vitro Techniques; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Neurodegenerative Diseases; Peptide Fragments; Protein Binding; Protein Conformation; Protein Multimerization; Solutions; Spectrometry, Fluorescence; Thiazoles; Water | 2010 |
The therapeutic effects of the herbal medicine, Juzen-taiho-to, on amyloid-beta burden in a mouse model of Alzheimer's disease.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antigens, CD; Antipsychotic Agents; Benzothiazoles; Bone Marrow Cells; Calcium-Binding Proteins; Cell Culture Techniques; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Drugs, Chinese Herbal; Flow Cytometry; Gene Expression Regulation; Humans; Ki-67 Antigen; Macrophages; Mice; Mice, Transgenic; Microfilament Proteins; Mutation; Thiazoles | 2010 |
Density functional theory analysis and spectral studies on amyloid peptide Abeta(28-35) and its mutants A30G and A30I.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Peptide Fragments; Protein Conformation; Protein Stability; Protein Structure, Secondary; Spectrometry, Fluorescence; Static Electricity; Thermodynamics; Thiazoles | 2010 |
Development of a proteolytically stable retro-inverso peptide inhibitor of beta-amyloid oligomerization as a potential novel treatment for Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Aggregation; Cell Line; Cell Survival; Humans; Immunoassay; Molecular Sequence Data; Peptide Fragments; Peptides; Surface Plasmon Resonance; Thiazoles | 2010 |
Burden of neurodegenerative diseases in a cohort of medical examiner subjects.
Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Atrophy; Benzothiazoles; Brain; Brain Edema; Cohort Studies; Coroners and Medical Examiners; Female; Forensic Pathology; Frontotemporal Lobar Degeneration; Humans; Hygiene; Ill-Housed Persons; Immunohistochemistry; Male; Malnutrition; Middle Aged; Neurofibrillary Tangles; Neuropil Threads; Plaque, Amyloid; Staining and Labeling; Tauopathies; Thiazoles; Young Adult | 2010 |
Abeta20-29 peptide blocking apoE/Abeta interaction reduces full-length Abeta42/40 fibril formation and cytotoxicity in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Benzothiazoles; Cell Survival; Cells, Cultured; Fluorescent Dyes; Humans; Microscopy, Electron; Neurofibrils; Peptide Fragments; Spectrometry, Fluorescence; Tetrazolium Salts; Thiazoles | 2010 |
Laser-induced propagation and destruction of amyloid beta fibrils.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; beta 2-Microglobulin; Humans; Kinetics; Lasers; Models, Biological; Peptide Fragments; Peptides; Photochemotherapy; Protein Folding; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles; Ultracentrifugation | 2010 |
Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples.
Topics: Alzheimer Disease; Benzothiazoles; Brain Diseases; Curcumin; Humans; Neurofibrillary Tangles; Neurons; Pick Disease of the Brain; Silver Staining; Supranuclear Palsy, Progressive; tau Proteins; Tauopathies; Thiazoles | 2010 |
Alzheimer's disease: spect and pet tracers for beta-amyloid imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain Mapping; Cerebral Cortex; Congo Red; Fluorodeoxyglucose F18; Humans; Neurofibrillary Tangles; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2010 |
Substoichiometric inhibition of Abeta(1-40) aggregation by a tandem Abeta(40-1-Gly8-1-40) peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Fluorescent Dyes; Humans; Microscopy, Atomic Force; Peptide Fragments; Peptides; Thiazoles | 2010 |
Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Benzothiazoles; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Fluorescence; Humans; Magnetite Nanoparticles; Male; Nanomedicine; Protein Structure, Quaternary; Thiazoles | 2010 |
Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Benzothiazoles; CA1 Region, Hippocampal; Creatine; Disease Models, Animal; Down-Regulation; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Nerve Degeneration; Plaque, Amyloid; Presenilin-1; Pyramidal Cells; Thiazoles | 2010 |
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Benzothiazoles; Biophysics; Fluorescent Dyes; Humans; Kinetics; Mice; Microelectrodes; Microscopy, Electron, Transmission; Neurons; Patch-Clamp Techniques; Peptide Fragments; Plaque, Amyloid; Protein Binding; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2010 |
Immunohistological detection of Chlamydia pneumoniae in the Alzheimer's disease brain.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Brain Chemistry; Cerebral Cortex; Chlamydia Infections; Chlamydophila pneumoniae; Coloring Agents; Female; Humans; Immunohistochemistry; Male; Neurofibrillary Tangles; Plaque, Amyloid; Reproducibility of Results; Thiazoles; Tissue Banks | 2010 |
I32E and V36K double mutation in beta2-sheet abrogates amyloid beta peptide toxicity.
Topics: Alzheimer Disease; Alzheimer Vaccines; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Antibody Specificity; Benzothiazoles; Cell Shape; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Humans; Molecular Sequence Data; Mutation; Protein Binding; Rabbits; Thiazoles | 2010 |
Interactions of Npc1 and amyloid accumulation/deposition in the APP/PS1 mouse model of Alzheimer's.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Peptide Fragments; Plaque, Amyloid; Proteins; Regression Analysis; Thiazoles | 2011 |
High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E3; Apolipoprotein E4; Benzothiazoles; Blotting, Western; Electrophoresis; Humans; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2011 |
Sequence-independent control of peptide conformation in liposomal vaccines for targeting protein misfolding diseases.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Circular Dichroism; Female; Humans; Immunoglobulin G; Liposomes; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Peptides; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Proteostasis Deficiencies; Thiazoles; Vaccines | 2011 |
The effect of tachykinin neuropeptides on amyloid β aggregation.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Fluorescence; Fluorescent Dyes; Humans; Peptide Fragments; Protein Structure, Secondary; Tachykinins; Thiazoles | 2011 |
The Osaka FAD mutation E22Δ leads to the formation of a previously unknown type of amyloid β fibrils and modulates Aβ neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cells, Cultured; Humans; Mutation; Neurons; Neurotoxins; Rats; Thiazoles | 2011 |
Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Electron Spin Resonance Spectroscopy; Fluorescent Dyes; Humans; Nitrogen Oxides; Oxidation-Reduction; Spectrometry, Fluorescence; Spin Labels; Thiazoles | 2011 |
Calcium ions promote formation of amyloid β-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Blotting, Western; Calcium; Fluorescence; Humans; Ions; Models, Biological; Mutant Proteins; Neurons; Protein Structure, Quaternary; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2011 |
Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer's disease: a long-term follow up study.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibiotics, Antineoplastic; Benzothiazoles; Cerebral Amyloid Angiopathy; Disease Models, Animal; Disease Progression; Longitudinal Studies; Male; Peptide Fragments; Rats; Rats, Wistar; Staining and Labeling; Streptozocin; Thiazoles | 2011 |
A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biomedical Research; Cell Line, Tumor; Cytological Techniques; Humans; Indicators and Reagents; Kinetics; Microscopy, Electron, Transmission; Nuclear Magnetic Resonance, Biomolecular; Reproducibility of Results; Solubility; Spectrometry, Fluorescence; Thiazoles | 2011 |
Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer's disease: Comparison with two cyclic heptapeptides derived from a randomized phage display library.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Biotinylation; Blood-Brain Barrier; Contrast Media; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Kinetics; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Models, Molecular; Molecular Sequence Data; Molecular Targeted Therapy; Mutagenesis, Site-Directed; Peptide Fragments; Peptide Library; Peptides, Cyclic; Plaque, Amyloid; Protein Binding; Sequence Analysis, DNA; Thiazoles | 2011 |
Resolution of localized small molecule-Aβ interactions by deep-ultraviolet resonance Raman spectroscopy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Flavonoids; Humans; Peptide Fragments; Protein Binding; Protein Structure, Secondary; Spectrum Analysis, Raman; Thiazoles | 2011 |
D-Ser-containing humanin shows promotion of fibril formation.
Topics: Alzheimer Disease; Amino Acid Sequence; Benzothiazoles; Circular Dichroism; Congo Red; Humans; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Neuroprotective Agents; Protein Structure, Secondary; Solutions; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2012 |
Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Apolipoproteins E; Astrocytes; Benzothiazoles; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Transgenic; Microglia; Neuroglia; Plaque, Amyloid; Protein Processing, Post-Translational; Receptors, LDL; Thiazoles | 2011 |
Targeting vascular amyloid in arterioles of Alzheimer disease transgenic mice with amyloid β protein antibody-coated nanoparticles.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Arterioles; Benzothiazoles; Disease Models, Animal; Ferric Compounds; Humans; Immunoglobulin G; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Nanoparticles; Peptide Fragments; Plaque, Amyloid; Platelet Endothelial Cell Adhesion Molecule-1; Thiazoles | 2011 |
Ligand polarizability contributes to tau fibril binding affinity.
Topics: Alzheimer Disease; Benzothiazoles; Binding Sites; Humans; Indoles; Ligands; Oxindoles; Phenothiazines; Protein Binding; tau Proteins; Thiazoles | 2011 |
Synthesis and evaluation of ferrocenoyl pentapeptide (Fc-KLVFF) as an inhibitor of Alzheimer's Aβ₁-₄₂ fibril formation in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Drug Design; Drug Evaluation, Preclinical; Electrochemical Techniques; Ferric Compounds; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Molecular Targeted Therapy; Nootropic Agents; Oligopeptides; Oxidation-Reduction; Peptide Fragments; Peptides; Solubility; Thiazoles | 2011 |
Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Anti-Bacterial Agents; Benzothiazoles; Caspase 3; Cell Line, Tumor; Disease Models, Animal; Doxycycline; Drosophila melanogaster; Fluorescent Dyes; Humans; Longevity; Thiazoles | 2011 |
Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's β-amyloidosis mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Behavioral Symptoms; Benzoates; Benzothiazoles; Benzylamines; Brain Waves; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Enzyme-Linked Immunosorbent Assay; Fourier Analysis; Habituation, Psychophysiologic; Humans; Mice; Mice, Transgenic; Odorants; Olfactory Pathways; Sensation Disorders; Smell; Thiazoles | 2011 |
Using graphene oxide high near-infrared absorbance for photothermal treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Cell Survival; Graphite; Humans; Hyperthermia, Induced; Mice; Nanostructures; Oxides; PC12 Cells; Phototherapy; Rats; Thiazoles | 2012 |
Naphthoquinone-tyrptophan reduces neurotoxic Aβ*56 levels and improves cognition in Alzheimer's disease animal model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Benzothiazoles; Blood-Brain Barrier; Brain Chemistry; Cognition; Drosophila; Fluorescent Dyes; Humans; Longevity; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Models, Molecular; Motor Activity; Naphthalenes; Neurofibrils; Neuroprotective Agents; Psychomotor Performance; Recognition, Psychology; Thiazoles; Tryptophan | 2012 |
Binding of the three-repeat domain of tau to phospholipid membranes induces an aggregated-like state of the protein.
Topics: Alzheimer Disease; Amino Acid Sequence; Benzothiazoles; Biophysics; Circular Dichroism; Humans; Lipid Bilayers; Lipids; Liposomes; Lysine; Magnetic Resonance Spectroscopy; Methylation; Molecular Sequence Data; Phosphatidylcholines; Phosphatidylserines; Phospholipids; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Static Electricity; tau Proteins; Thiazoles; Unilamellar Liposomes | 2012 |
Identification and characterization of an aβ oligomer precipitating peptide that may be useful to explore gene therapeutic approaches to Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Line, Tumor; Centrifugation, Density Gradient; Disease Models, Animal; Genetic Therapy; Humans; Mice; Nephelometry and Turbidimetry; Neurons; Peptides; Sequence Analysis, DNA; Thiazoles | 2012 |
Inhibitory effect of curcumin on the Al(III)-induced Aβ₄₂ aggregation and neurotoxicity in vitro.
Topics: Aluminum; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Circular Dichroism; Curcumin; Microscopy, Atomic Force; Neurotoxicity Syndromes; PC12 Cells; Peptide Fragments; Rats; Thiazoles | 2012 |
PEGylated nanoparticles bind to and alter amyloid-beta peptide conformation: toward engineering of functional nanomedicines for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Bioengineering; Complement Activation; Electrophoresis, Capillary; Humans; In Vitro Techniques; Models, Molecular; Molecular Dynamics Simulation; Nanomedicine; Nanoparticles; Nanotechnology; Peptide Fragments; Polyethylene Glycols; Protein Binding; Protein Conformation; Surface Plasmon Resonance; Thiazoles | 2012 |
The butter flavorant, diacetyl, exacerbates β-amyloid cytotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Blood-Brain Barrier; Butter; Cell Line; Cell Survival; Circular Dichroism; Diacetyl; Dogs; Flavoring Agents; Fluorescent Dyes; Humans; Lactoylglutathione Lyase; Madin Darby Canine Kidney Cells; Peptide Fragments; Permeability; Protein Conformation; Thiazoles | 2012 |
Rhodanine and thiohydantoin derivatives for detecting tau pathology in Alzheimer's brains.
Topics: Alzheimer Disease; Animals; Autoradiography; Benzothiazoles; Brain; Humans; Iodine Radioisotopes; Mice; Neurofibrillary Tangles; Positron-Emission Tomography; Radiopharmaceuticals; Recombinant Proteins; Rhodanine; Tauopathies; Thiazoles; Thiohydantoins; Tissue Distribution | 2011 |
Interaction between amyloid-β pathology and cortical functional columnar organization.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Benzothiazoles; Brain Mapping; Disease Models, Animal; Electron Transport Complex IV; Humans; Mice; Mice, Transgenic; Models, Neurological; Mutation; Neural Pathways; Plaque, Amyloid; Presenilin-1; Somatosensory Cortex; Thiazoles | 2012 |
In situ monitoring Alzheimer's disease β-amyloid aggregation and screening of Aβ inhibitors using a perylene probe.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cations; DNA, Single-Stranded; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Humans; Kinetics; Microscopy, Atomic Force; Models, Chemical; Peptide Fragments; Perylene; Protein Binding; Spectrophotometry, Ultraviolet; Surface Plasmon Resonance; Thiazoles | 2013 |
A novel inhibitor of amyloid β (Aβ) peptide aggregation: from high throughput screening to efficacy in an animal model of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Benzothiazoles; Chemistry, Pharmaceutical; Drosophila melanogaster; Drug Design; Drug Evaluation, Preclinical; Green Fluorescent Proteins; Humans; Indoles; Models, Chemical; Peptide Fragments; Peptides; Reactive Oxygen Species; Thiazoles | 2012 |
Molecular plasticity regulates oligomerization and cytotoxicity of the multipeptide-length amyloid-β peptide pool.
Topics: Alzheimer Disease; Amino Acid Motifs; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Cell Line; Cell Survival; Fluorescent Dyes; Humans; Kinetics; Microscopy, Atomic Force; Peptide Fragments; Protein Multimerization; Protein Structure, Quaternary; Thiazoles | 2012 |
The N-methylated peptide SEN304 powerfully inhibits Aβ(1-42) toxicity by perturbing oligomer formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Survival; Circular Dichroism; Humans; Long-Term Potentiation; Male; Mice; Neurons; Oligopeptides; Peptide Fragments; Protein Multimerization; Protein Structure, Quaternary; Rats; Surface Plasmon Resonance; Thiazoles; Tumor Cells, Cultured | 2012 |
Monoclonal antibodies against large oval aggregates of Aβ1-42.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Antibody Specificity; Benzothiazoles; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Epitope Mapping; Humans; Mice; Microscopy, Atomic Force; Peptide Fragments; Protein Structure, Secondary; Thiazoles | 2013 |
A peptide binding to the β-site of APP improves spatial memory and attenuates Aβ burden in Alzheimer's disease transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Benzothiazoles; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Humans; Maze Learning; Memory; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Peptide Library; Peptides; Protein Binding; Protein Structure, Tertiary; Sequence Analysis, DNA; Spatial Behavior; Tetrazolium Salts; Thiazoles | 2012 |
Amyloid-β(1-42) protofibrils formed in modified artificial cerebrospinal fluid bind and activate microglia.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Cerebrospinal Fluid; Chromatography, Gel; Culture Media; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Macrophage Activation; Mice; Microglia; Microscopy, Electron; Peptide Fragments; Quinolines; Thiazoles; Tumor Necrosis Factor-alpha | 2013 |
Surface plasmon resonance imaging of amyloid-β aggregation kinetics in the presence of epigallocatechin gallate and metals.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Catechin; Copper; Ferric Compounds; Humans; Ions; Kinetics; Metals; Microscopy, Electron, Transmission; Peptide Fragments; Surface Plasmon Resonance; Thiazoles; Zinc | 2013 |
Simultaneous measurement of amyloid fibril formation by dynamic light scattering and fluorescence reveals complex aggregation kinetics.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Fluorescence; Humans; Huntington Disease; Kinetics; Light; Parkinson Disease; Particle Size; Protein Structure, Secondary; Thiazoles | 2013 |
An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidogenic Proteins; Animals; Benzothiazoles; Caenorhabditis elegans; Hippocampus; Mice; Mice, Inbred C57BL; Models, Biological; Neurodegenerative Diseases; Neurons; Peptides; Prions; Protein Binding; Protein Structure, Tertiary; Surface Plasmon Resonance; Synapses; Thiazoles | 2013 |
Pt(II) compounds interplay with Cu(II) and Zn(II) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Coordination Complexes; Copper; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Platinum; Spectrometry, Fluorescence; Thiazoles; Zinc | 2013 |
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; Clusterin; Disease Models, Animal; Glycoproteins; Mice; Mice, Knockout; Molecular Chaperones; Neurites; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2002 |
New class of inhibitors of amyloid-beta fibril formation. Implications for the mechanism of pathogenesis in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apomorphine; Benzothiazoles; Fluorescent Dyes; Humans; Hydroxylation; Kinetics; Microscopy, Electron; Models, Biological; Protein Structure, Quaternary; Thiazoles | 2002 |
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.
Topics: Administration, Topical; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antibodies; Benzothiazoles; Brain; Disease Models, Animal; Fluorescent Dyes; Humans; Immunoglobulin Fab Fragments; Immunoglobulin Fc Fragments; Immunotherapy; Mice; Mice, Transgenic; Microscopy, Fluorescence; Mutation; Phagocytosis; Plaque, Amyloid; Thiazoles | 2002 |
Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autoantibodies; Benzothiazoles; Brain; Cerebellum; Disease Models, Animal; Locus Coeruleus; Mice; Mice, Transgenic; Neostriatum; Nerve Growth Factor; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; Signal Transduction; Silver Staining; Thiazoles | 2002 |
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Disease Models, Animal; Female; Humans; Male; Membrane Proteins; Mice; Mice, Transgenic; Neurotoxins; Plaque, Amyloid; Presenilin-1; Thiazoles | 2002 |
Amyloid fibril formation by a synthetic peptide from a region of human acetylcholinesterase that is homologous to the Alzheimer's amyloid-beta peptide.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Biotinylation; Cell Division; Circular Dichroism; Coloring Agents; Congo Red; Fluorescent Dyes; Humans; Microscopy, Electron; Neurofibrillary Tangles; PC12 Cells; Peptide Fragments; Protein Binding; Rats; Thiazoles | 2002 |
Molecular imaging of amyloid beta peptides in mouse brain sections using mass spectrometry.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Neuropathies, Familial; Animals; Benzothiazoles; Blotting, Western; Brain; Brain Chemistry; Frozen Sections; Humans; Image Processing, Computer-Assisted; Mice; Mice, Transgenic; Molecular Sequence Data; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles; Tissue Distribution | 2002 |
IMPY: an improved thioflavin-T derivative for in vivo labeling of beta-amyloid plaques.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autopsy; Autoradiography; Benzothiazoles; Fluorescence; Humans; Mice; Mice, Transgenic; Molecular Probes; Plaque, Amyloid; Pyridines; Thiazoles | 2002 |
Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Binding, Competitive; Blood-Brain Barrier; Brain; Contrast Media; Disease Models, Animal; Gadolinium; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Membrane Proteins; Mice; Mice, Transgenic; Molecular Probe Techniques; Neurons; Peptide Fragments; Plaque, Amyloid; Predictive Value of Tests; Presenilin-1; Putrescine; Reproducibility of Results; Thiazoles | 2002 |
Electron microscopic analysis of nanoparticles delivering thioflavin-T after intrahippocampal injection in mouse: implications for targeting beta-amyloid in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Drug Carriers; Drug Delivery Systems; Enbucrilate; Female; Fluorescent Dyes; Hippocampus; Injections; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Nanotechnology; Particle Size; Polymers; Polystyrenes; Thiazoles | 2003 |
In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Axons; Benzothiazoles; Cerebral Cortex; Dendrites; Dextrans; Disease Models, Animal; Fluorescent Dyes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence, Multiphoton; Neurites; Neuropil; Plaque, Amyloid; Thiazoles | 2003 |
In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antioxidants; Benzothiazoles; Cerebral Cortex; Cyclic N-Oxides; Disease Models, Animal; Fluorescent Dyes; Free Radical Scavengers; Free Radicals; Infrared Rays; Lasers; Mice; Mice, Transgenic; Microscopy, Fluorescence, Multiphoton; Nitrogen Oxides; Oxidation-Reduction; Oxidative Stress; Plaque, Amyloid; Reactive Oxygen Species; Thiazoles | 2003 |
Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Fluorescent Antibody Technique; Humans; Inclusion Bodies; Microtubule-Associated Proteins; Neocortex; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; tau Proteins; Thiazoles | 2003 |
Specific compositions of amyloid-beta peptides as the determinant of toxic beta-aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line; Dimerization; Genetic Variation; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Peptide Fragments; Static Electricity; Thiazoles | 2003 |
Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antibodies; Benzothiazoles; Drug Administration Routes; Frontal Lobe; Hippocampus; Histocompatibility Antigens Class II; Immunization, Passive; Immunohistochemistry; Leukocyte Common Antigens; Membrane Proteins; Mice; Mice, Transgenic; Microglia; Plaque, Amyloid; Presenilin-1; Thiazoles; Time Factors | 2003 |
Nitration of tau protein is linked to neurodegeneration in tauopathies.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Basal Ganglia; Benzothiazoles; Cell Line; Cerebral Cortex; Down Syndrome; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Nerve Degeneration; Neurodegenerative Diseases; Neurofibrillary Tangles; Nitrates; Pick Disease of the Brain; tau Proteins; Tauopathies; Thiazoles; Tissue Distribution | 2003 |
Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Flavonoids; Humans; Kidney; Kinetics; Microscopy, Electron; Peptide Fragments; Phenols; Polymers; Quercetin; Spectrometry, Fluorescence; Tetrazolium Salts; Thiazoles | 2003 |
Characterization of radioiodinated ligand binding to amyloid beta plaques.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding Sites; Binding, Competitive; Brain; Humans; Iodine Radioisotopes; Ligands; Male; Mice; Mice, Inbred ICR; Peptide Fragments; Plaque, Amyloid; Pyrazoles; Pyridines; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2003 |
In vivo labeling of amyloid with BF-108.
Topics: Acridines; Affinity Labels; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Brain; Female; Fluorescent Dyes; Humans; In Vitro Techniques; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Neurofibrillary Tangles; Plaque, Amyloid; Rats; Rats, Wistar; Thiazoles | 2004 |
Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antibodies; Benzothiazoles; Fluorescence; Microscopy, Atomic Force; Neurofibrillary Tangles; Peptide Fragments; Plaque, Amyloid; Protein Structure, Quaternary; Software; Thiazoles | 2004 |
Neuronal localization of C1q in preclinical Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biomarkers; Brain; Cerebral Cortex; Complement C1q; Disease Progression; Down Syndrome; Encephalitis; Female; Genetic Predisposition to Disease; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Humans; Immunohistochemistry; Middle Aged; Neurons; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2004 |
Evidence for an intermediate in tau filament formation.
Topics: Alzheimer Disease; Anions; Arachidonic Acid; Benzothiazoles; Humans; Hydrophobic and Hydrophilic Interactions; Intermediate Filament Proteins; Micelles; Microspheres; Neurofibrillary Tangles; Neurofilament Proteins; Recombinant Proteins; Spectrometry, Fluorescence; Static Electricity; Surface Properties; Surface-Active Agents; tau Proteins; Thiazoles | 2004 |
Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Cinnamates; Curcumin; Depsides; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Lipoxygenase Inhibitors; Masoprocol; Microscopy, Electron; Microscopy, Polarization; Neurofibrillary Tangles; Peptide Fragments; Platelet Aggregation Inhibitors; Rosmarinic Acid; Spectrometry, Fluorescence; Thiazoles; Time Factors | 2004 |
Differential expression of cholesterol hydroxylases in Alzheimer's disease.
Topics: Adenoviridae; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocytes; Benzothiazoles; Brain; Cells, Cultured; Cerebral Cortex; Cholestanetriol 26-Monooxygenase; Cholesterol 24-Hydroxylase; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxycholesterols; Immunoblotting; Immunohistochemistry; Inhibitory Concentration 50; Liver X Receptors; Neurons; Oligodendroglia; Orphan Nuclear Receptors; Polymorphism, Genetic; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Signal Transduction; Steroid Hydroxylases; Thiazoles; Time Factors | 2004 |
A seed for Alzheimer amyloid in the brain.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Antibody Specificity; Benzothiazoles; Brain; Brain Chemistry; Cell Survival; Cells, Cultured; G(M1) Ganglioside; Humans; Liposomes; Macaca fascicularis; Macromolecular Substances; Microscopy, Immunoelectron; Middle Aged; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors | 2004 |
Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Humans; Immunoglobulin Variable Region; Microscopy, Atomic Force; Neuroblastoma; Neurons; Peptide Library; Plaque, Amyloid; Surface Plasmon Resonance; Thiazoles; Tumor Cells, Cultured | 2004 |
Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum.
Topics: Acetylcholine; Acetyltransferases; Aged; Aged, 80 and over; Alzheimer Disease; Basal Nucleus of Meynert; Benzothiazoles; Case-Control Studies; Cognition Disorders; Cohort Studies; Female; Histological Techniques; Humans; Immunohistochemistry; Longitudinal Studies; Male; Neurofibrillary Tangles; Neuropsychological Tests; Postmortem Changes; tau Proteins; Thiazoles | 2004 |
Inflammation occurs early during the Abeta deposition process in TgCRND8 mice.
Topics: Age Factors; Alzheimer Disease; Amygdala; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; CD11b Antigen; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neocortex; Plaque, Amyloid; Thiazoles | 2004 |
Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Benzothiazoles; Down Syndrome; Female; Fluorescent Antibody Technique, Indirect; Humans; Immunohistochemistry; Male; Membrane Proteins; Mice; Mice, Transgenic; Middle Aged; Neocortex; Neurons; Non-Fibrillar Collagens; Peptide Fragments; Plaque, Amyloid; Thiazoles; Tissue Distribution | 2004 |
Cholesterol, copper, and accumulation of thioflavine S-reactive Alzheimer's-like amyloid beta in rabbit brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Blood Vessels; Brain; Cholesterol; Copper; Disease Models, Animal; Drug Synergism; Food, Formulated; Immunohistochemistry; Male; Metabolic Clearance Rate; Neurons; Rabbits; Thiazoles; Up-Regulation | 2004 |
Nordihydroguaiaretic acid does not disaggregate beta-amyloid(1-40) protofibrils but does inhibit growth arising from direct protofibril association.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzothiazoles; Fluorescence; Humans; Masoprocol; Peptide Fragments; Thiazoles | 2004 |
Morphological characterization of Thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Abeta immunotherapy on their clearance.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Fluorescent Dyes; Heterozygote; Humans; Immunization, Passive; Immunotherapy; Metabolic Clearance Rate; Mice; Mice, Transgenic; Neurites; Neurofibrillary Tangles; Plaque, Amyloid; Thiazoles | 2004 |
Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Survival; Cells, Cultured; Hippocampus; Inhibitory Concentration 50; Neurons; Neuroprotective Agents; Plaque, Amyloid; Protein Structure, Quaternary; Rats; Solubility; Thiazoles | 2004 |
Vitamin A exhibits potent antiamyloidogenic and fibril-destabilizing effects in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzothiazoles; beta Carotene; Cell Line; Dose-Response Relationship, Drug; Humans; Kinetics; Microscopy, Electron; Molecular Structure; Neurofibrils; Retinaldehyde; Thiazoles; Tretinoin; Vitamin A; Vitamins | 2004 |
Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Apolipoproteins E; Benzothiazoles; Cerebral Cortex; Disease Models, Animal; Intermediate Filament Proteins; Mice; Mice, Transgenic; Thiazoles | 2004 |
Amyloid-beta protofibrils differ from amyloid-beta aggregates induced in dilute hexafluoroisopropanol in stability and morphology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biochemistry; Chromatography; Circular Dichroism; Humans; Ions; Kinetics; Light; Microscopy, Atomic Force; Microscopy, Electron; Peptide Fragments; Propanols; Protein Conformation; Scattering, Radiation; Thiazoles; Time Factors | 2005 |
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Benzothiazoles; Biphenyl Compounds; Blood-Brain Barrier; Brain; Cell Line, Tumor; Congo Red; Curcumin; Diamines; Humans; Ibuprofen; Mice; Mice, Transgenic; Naproxen; Peptide Fragments; Plaque, Amyloid; Protein Binding; Protein Denaturation; Protein Structure, Quaternary; Pyridazines; Solubility; Thiazoles | 2005 |
Evidence for the presence of three distinct binding sites for the thioflavin T class of Alzheimer's disease PET imaging agents on beta-amyloid peptide fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Binding, Competitive; Centrifugation, Density Gradient; Dose-Response Relationship, Drug; Fluorescence Resonance Energy Transfer; Humans; Kinetics; Ligands; Models, Biological; Models, Chemical; Peptide Fragments; Peptides; Positron-Emission Tomography; Protein Binding; Spectrometry, Fluorescence; Thiazoles | 2005 |
Inhibition of amyloid fibrillogenesis and toxicity by a peptide chaperone.
Topics: alpha-Crystallins; Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Asparagine; Benzothiazoles; Cell Survival; Fluorescent Dyes; Humans; Molecular Chaperones; Molecular Sequence Data; PC12 Cells; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Thiazoles; Toxicity Tests | 2004 |
Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for beta-amyloid imaging in Alzheimer's Disease with PET.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Carbon Radioisotopes; Humans; Isotope Labeling; Mesylates; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2005 |
Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Nerve Tissue Proteins; Non-Fibrillar Collagens; Peptide Fragments; Thiazoles | 2005 |
Delineation of positron emission tomography imaging agent binding sites on beta-amyloid peptide fibrils.
Topics: 1-Naphthylamine; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Congo Red; Contrast Media; Fluorescence; Humans; Positron-Emission Tomography; Radioligand Assay; Thiazoles | 2005 |
Protective effect of donepezil against Abeta(1-40) neurotoxicity in rat septal neurons.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cells, Cultured; Cholinergic Fibers; Cholinesterase Inhibitors; Donepezil; Down-Regulation; Fluorescent Dyes; Immunohistochemistry; Indans; L-Lactate Dehydrogenase; Membrane Transport Proteins; Molecular Structure; Neurons; Neuroprotective Agents; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Septal Nuclei; Thiazoles; Vesicular Acetylcholine Transport Proteins | 2005 |
Purification of recombinant tau protein and preparation of Alzheimer-paired helical filaments in vitro.
Topics: Alzheimer Disease; Amyloid; Benzothiazoles; Cloning, Molecular; Humans; Microscopy, Electron; Protein Isoforms; Spectrometry, Fluorescence; tau Proteins; Thiazoles | 2005 |
Multiple ligand binding sites on A beta(1-40) fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Congo Red; Fluorescent Dyes; Humans; Ibuprofen; Ligands; Models, Chemical; Molecular Structure; Naproxen; Peptide Fragments; Protein Binding; Thiazoles | 2005 |
Sequence determinants of enhanced amyloidogenicity of Alzheimer A{beta}42 peptide relative to A{beta}40.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Biophysical Phenomena; Biophysics; Chromatography, High Pressure Liquid; DNA Primers; Green Fluorescent Proteins; Humans; Kinetics; Microscopy, Fluorescence; Models, Chemical; Mutation; Peptide Fragments; Peptide Library; Peptides; Phenotype; Protein Structure, Secondary; Recombinant Fusion Proteins; Sequence Analysis, Protein; Temperature; Thiazoles; Time Factors | 2005 |
Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Dementia; Electron Spin Resonance Spectroscopy; Enzyme-Linked Immunosorbent Assay; Family Health; Humans; Hydrogen Peroxide; Microscopy, Atomic Force; Models, Statistical; Neurodegenerative Diseases; Oxidative Stress; Oxygen; Peptide Fragments; Peptides; Spin Trapping; Thiazoles; Time Factors; United Kingdom | 2005 |
Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Apolipoproteins E; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Benzothiazoles; Blotting, Western; Brain; Enzyme-Linked Immunosorbent Assay; Gene Deletion; Heterozygote; Hippocampus; Mice; Mice, Transgenic; Models, Genetic; Protein Structure, Tertiary; Thiazoles; Time Factors | 2005 |
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Apolipoproteins E; Atherosclerosis; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Benzothiazoles; Blotting, Western; Brain; Cerebral Amyloid Angiopathy; Humans; Immunohistochemistry; Lipid Metabolism; Lipoproteins, HDL; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mice, Transgenic; Mutation; Protein Isoforms; Thiazoles; Time Factors | 2005 |
Cerebrospinal fluid of Alzheimer patients promotes beta-amyloid fibril formation in vitro.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Brain Chemistry; Cerebrospinal Fluid; Humans; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Middle Aged; Peptide Fragments; Plaque, Amyloid; Polymers; Thiazoles | 2005 |
Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs.
Topics: Alzheimer Disease; Amino Acid Motifs; Benzothiazoles; Brain; Cell Line; Cell Line, Tumor; Centrifugation, Density Gradient; Chromatography; DNA Fragmentation; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Gene Deletion; Humans; Mass Spectrometry; Microscopy, Electron; Microscopy, Fluorescence; Models, Biological; Models, Chemical; Mutation; Neurons; Peptide Hydrolases; Phosphorylation; Plasmids; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; tau Proteins; Tauopathies; Thiazoles; Thrombin; Time Factors | 2006 |
In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice.
Topics: Age Factors; Alzheimer Disease; Animals; Benzothiazoles; Brain Mapping; Disease Models, Animal; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Plaque, Amyloid; Staining and Labeling; Thiazoles | 2005 |
Deficiency of disulfide bonds facilitating fibrillogenesis of endostatin.
Topics: Alanine; Alzheimer Disease; Animals; Benzothiazoles; Cell Survival; Circular Dichroism; Disulfides; Endostatins; Escherichia coli; Fibril-Associated Collagens; Fluorescent Dyes; Glutathione; Hydrogen-Ion Concentration; Light; Microscopy, Atomic Force; Neovascularization, Pathologic; PC12 Cells; Protein Conformation; Protein Structure, Tertiary; Rats; Scattering, Radiation; Spectroscopy, Fourier Transform Infrared; Temperature; Tetrazolium Salts; Thiazoles; Time Factors; Tryptophan; Ultraviolet Rays | 2006 |
Influence of heparin and dendrimers on the aggregation of two amyloid peptides related to Alzheimer's and prion diseases.
Topics: Alzheimer Disease; Amyloid; Benzothiazoles; Dendrimers; Heparin; Kinetics; Molecular Structure; Peptide Fragments; Prion Diseases; Spectrometry, Fluorescence; Thiazoles | 2006 |
Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Benzothiazoles; Blotting, Western; Brain; Congo Red; Endopeptidases; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heterozygote; Hippocampus; Immunohistochemistry; Membrane Proteins; Mice; Mice, Transgenic; Microscopy, Electron; Mutation; Mutation, Missense; Neurons; Peptide Fragments; Phosphorylation; Presenilin-1; Protein Conformation; Sodium Dodecyl Sulfate; tau Proteins; Thiazoles | 2006 |
Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fluorescent Dyes; Microscopy, Atomic Force; Thiazoles; Uncaria | 2006 |
Frontotemporal dementia: clinicopathological correlations.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Brain; Dementia; Diagnosis, Differential; Female; Humans; Immunohistochemistry; Inclusion Bodies; Male; Middle Aged; Neurodegenerative Diseases; Neuropsychological Tests; Tauopathies; Thiazoles; Ubiquitin | 2006 |
Memory-related deficits following selective hippocampal expression of Swedish mutation amyloid precursor protein in the rat.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Benzothiazoles; Disease Models, Animal; Fluoresceins; Gene Expression; Genetic Vectors; Hippocampus; Humans; Immunohistochemistry; Male; Maze Learning; Memory Disorders; Mutation; Organic Chemicals; Peptide Fragments; Rats; Rats, Sprague-Dawley; Thiazoles | 2006 |
Lipophilic analogs of thioflavin S as novel amyloid-imaging agents.
Topics: Affinity Labels; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding, Competitive; Carbon Radioisotopes; Diagnostic Imaging; Drug Evaluation, Preclinical; Fluorescent Dyes; Humans; Iodine Radioisotopes; Mice; Molecular Structure; Neurofibrillary Tangles; Plaque, Amyloid; Protein Binding; Radionuclide Imaging; Radiopharmaceuticals; Thiazoles | 2006 |
Characteristics of the binding of thioflavin S to tau paired helical filaments.
Topics: Alzheimer Disease; Antibodies, Blocking; Benzothiazoles; Fluorescent Antibody Technique; Heparin Lyase; Humans; Microscopy, Electron; Microscopy, Fluorescence; Neurofilament Proteins; Protein Binding; Quinones; tau Proteins; Thiazoles | 2006 |
Cerebrospinal fluid of Alzheimer's disease and dementia with Lewy bodies patients enhances alpha-synuclein fibril formation in vitro.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Benzothiazoles; Female; Humans; Immunoglobulin G; Lewy Body Disease; Male; Microscopy, Electron; Middle Aged; Psychiatric Status Rating Scales; Spectrometry, Fluorescence; tau Proteins; Thiazoles | 2007 |
Linear quantitation of Abeta aggregation using Thioflavin T: reduction in fibril formation by colostrinin.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biological Assay; Biomarkers; Dose-Response Relationship, Drug; Down-Regulation; Fluorescence; Fluorescent Dyes; Humans; Intercellular Signaling Peptides and Proteins; Linear Models; Microscopy, Fluorescence; Molecular Weight; Neurochemistry; Neuroprotective Agents; Peptide Fragments; Peptides; Plaque, Amyloid; Solubility; Thiazoles | 2007 |
Potential inplications of endogenous aldehydes in beta-amyloid misfolding, oligomerization and fibrillogenesis.
Topics: Aldehydes; Alzheimer Disease; Amine Oxidase (Copper-Containing); Amyloid beta-Peptides; Benzothiazoles; Brain; Cell Adhesion Molecules; Fluorometry; Formaldehyde; Humans; Lipid Peroxidation; Malondialdehyde; Microscopy, Atomic Force; Neurofibrillary Tangles; Oxidative Stress; Polymers; Protein Folding; Proteomics; Pyruvaldehyde; Spectrum Analysis; Thiazoles | 2006 |
Proline and glycine control protein self-organization into elastomeric or amyloid fibrils.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Chickens; Elastin; Entropy; Glycine; Humans; Insecta; Models, Molecular; Molecular Sequence Data; Peptides; Proline; Protein Conformation; Thiazoles; Triticum | 2006 |
Analytical method for beta-amyloid fibrils using CE-laser induced fluorescence and its application to screening for inhibitors of beta-amyloid protein aggregation.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Daunorubicin; Fluorescence; Fluorescent Dyes; Humans; Indoles; Lasers; Mass Screening; Melatonin; Molecular Sequence Data; Propionates; Sensitivity and Specificity; Thiazoles; Time Factors | 2007 |
Formation of toxic fibrils of Alzheimer's amyloid beta-protein-(1-40) by monosialoganglioside GM1, a neuronal membrane component.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Membrane; Chromatography, Gel; Circular Dichroism; G(M1) Ganglioside; Microscopy, Electron, Transmission; Neurons; PC12 Cells; Peptide Fragments; Protein Structure, Secondary; Rats; Thiazoles | 2007 |
TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Benzothiazoles; Brain; Chromatography, High Pressure Liquid; Immunotherapy; Mice; Mice, Transgenic; Molecular Sequence Data; Plaque, Amyloid; Protein Processing, Post-Translational; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles | 2007 |
Differentiating Alzheimer disease-associated aggregates with small molecules.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Mass Spectrometry; Neurofibrillary Tangles; Peptide Library; Plaque, Amyloid; tau Proteins; Thiazines; Thiazoles | 2007 |
Thioflavin derivatives as markers for amyloid-beta fibrils: insights into structural features important for high-affinity binding.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Biomarkers; Heterocyclic Compounds; Peptides; Protein Structure, Tertiary; Structure-Activity Relationship; Thiazoles | 2008 |
Congo red and thioflavin-T analogs detect Abeta oligomers.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Coloring Agents; Congo Red; Fluorescent Dyes; Hippocampus; Humans; Microscopy, Electron, Transmission; Neuroblastoma; Surface Plasmon Resonance; Thiazoles | 2008 |
Anti-amyloidogenic activity of S-allyl-L-cysteine and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzothiazoles; Cysteine; Humans; Macromolecular Substances; Microscopy, Electron, Transmission; Neuroprotective Agents; Protein Binding; Protein Conformation; Protein Folding; Thiazoles | 2007 |
Apoptotic death induces Abeta production and fibril formation to a much larger extent than necrotic-like death in CGNs.
Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Apoptosis; Benzothiazoles; Cerebellum; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Humans; Huntington Disease; Membrane Proteins; Microfilament Proteins; Microscopy, Electron, Transmission; Necrosis; Parkinson Disease; Reticulin; Thiazoles | 2007 |
A multimeric quinacrine conjugate as a potential inhibitor of Alzheimer's beta-amyloid fibril formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Dose-Response Relationship, Drug; Drug Design; Microscopy, Atomic Force; Protein Binding; Quinacrine; Spectrometry, Fluorescence; Thiazoles | 2008 |
Posterior parahippocampal gyrus pathology in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Cerebral Cortex; Female; Humans; Immunohistochemistry; Male; Neurofibrillary Tangles; Neurofilament Proteins; Parahippocampal Gyrus; Parvalbumins; Thiazoles | 2008 |
Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer's disease. II. Ageing, Korsakoff's disease, Parkinson's disease, and Alzheimer's disease.
Topics: Adult; Aged; Aging; Alcohol Amnestic Disorder; Alzheimer Disease; Benzothiazoles; Cell Count; Dendrites; Female; Fluorescent Dyes; Histocytochemistry; Humans; Male; Middle Aged; Nerve Degeneration; Neuronal Plasticity; Parkinson Disease; Prosencephalon; Staining and Labeling; Thiazoles | 1995 |
Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments.
Topics: Alzheimer Disease; Benzothiazoles; Brain; Cysteine; Fluorescent Dyes; Humans; Neurofibrillary Tangles; Oxidation-Reduction; Phosphorylation; Protein Conformation; Sulfhydryl Reagents; tau Proteins; Thiazoles | 1995 |
Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Benzothiazoles; Female; Hippocampus; Humans; Immunoblotting; Immunohistochemistry; Male; Middle Aged; Neurofilament Proteins; Neurons; Reference Values; Thiazoles | 1994 |
Two types of dystrophic neurites in senile plaques of Alzheimer disease and elderly non-demented cases.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Antigens; Benzothiazoles; Cerebral Cortex; Chromogranin A; Chromogranins; Fluorescent Dyes; Humans; Immunohistochemistry; Neurites; tau Proteins; Thiazoles; Ubiquitins | 1994 |
Neuritic involvement within bFGF immunopositive plaques of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Antibodies, Monoclonal; Benzothiazoles; Biomarkers; Child; Child, Preschool; Down Syndrome; Fibroblast Growth Factor 2; Fluorescent Dyes; Heparitin Sulfate; Humans; Immunohistochemistry; Middle Aged; Nerve Fibers; Neurites; Neurofibrillary Tangles; Thiazoles | 1993 |
Alzheimer's disease-type neurofibrillary degeneration in verrucose dysplasias of the cerebral cortex.
Topics: Aged; Alzheimer Disease; Benzothiazoles; Cerebral Cortex; Cholinesterases; Female; Fluorescent Dyes; Humans; Immunohistochemistry; Male; Nerve Degeneration; Neurofibrillary Tangles; tau Proteins; Thiazoles; Tissue Fixation | 1995 |
Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding Sites; Brain; Butyrylcholinesterase; Cattle; Fluorescent Dyes; Humans; Mice; Microscopy, Electron; Mutation; Neurofibrils; Propidium; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 1996 |
First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Biological; Peptide Fragments; Temperature; Thiazoles | 1996 |
Relative efficacies of amyloid beta peptide (A beta) binding proteins in A beta aggregation.
Topics: alpha 1-Antichymotrypsin; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Benzothiazoles; Complement C1q; Humans; Prealbumin; Protein Binding; Serum Amyloid P-Component; Spectrometry, Fluorescence; Thiazoles | 1996 |
Self-assembly of the brain MAP-2 microtubule-binding region into polymeric structures resembling Alzheimer filaments.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Benzothiazoles; Brain; Cattle; Fluorescent Dyes; Microtubule-Associated Proteins; Molecular Sequence Data; Peptide Fragments; Polymers; Protein Binding; Recombinant Proteins; Thiazoles | 1996 |
The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Chromatography, High Pressure Liquid; Down Syndrome; Electrophoresis, Polyacrylamide Gel; Fluorometry; Humans; Mass Spectrometry; Thiazoles | 1996 |
Neurofibrillary tangles in the dentate granule cells of patients with Alzheimer's disease, Lewy body disease and progressive supranuclear palsy.
Topics: Alzheimer Disease; Antibodies, Monoclonal; Benzothiazoles; Dentate Gyrus; Fluorescent Dyes; Humans; Immunohistochemistry; Microscopy, Immunoelectron; Neurofibrillary Tangles; Parkinson Disease; Supranuclear Palsy, Progressive; Thiazoles | 1997 |
Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Carnosine; Cognition; Cross-Linking Reagents; Fructose; Glycation End Products, Advanced; Guanidines; Humans; Memory; Neuropeptide Y; Particle Size; Peptide Fragments; Piperazines; Protein Structure, Secondary; Solubility; Temperature; Thiazoles; Thiophenes | 1997 |
The cellular basis for the relative resistance of parvalbumin and calretinin immunoreactive neocortical neurons to the pathology of Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Calbindin 2; Cerebral Cortex; Cross Reactions; Fluorescent Antibody Technique; Fluorescent Dyes; Frontal Lobe; Humans; Middle Aged; Nerve Tissue Proteins; Neurites; Neurofilament Proteins; Parvalbumins; Phosphorylation; S100 Calcium Binding Protein G; Staining and Labeling; Thiazoles | 1997 |
Stopped-flow kinetics reveal multiple phases of thioflavin T binding to Alzheimer beta (1-40) amyloid fibrils.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Fluorescence; Fluorescent Dyes; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Molecular Sequence Data; Molecular Structure; Naphthalenesulfonates; Osmolar Concentration; Peptide Fragments; Protein Binding; Protein Conformation; Protein Structure, Secondary; Sodium Chloride; Temperature; Thiazoles | 1997 |
Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Animals; Astrocytes; Benzothiazoles; Brain; Cerebral Amyloid Angiopathy; Humans; Mice; Mice, Inbred BALB C; Mice, Transgenic; Thiazoles; Transforming Growth Factor beta | 1997 |
Butyrylcholinesterase in the life cycle of amyloid plaques.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Butyrylcholinesterase; Case-Control Studies; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Plaque, Amyloid; Temporal Lobe; Thiazoles | 1997 |
Rat microglia exhibit increased density on Alzheimer's plaques in vitro.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Benzothiazoles; Brain; Carbocyanines; Cell Count; Cells, Cultured; Fluorescent Dyes; Humans; Lipoproteins, LDL; Microglia; Middle Aged; Plaque, Amyloid; Rats; Rats, Sprague-Dawley; Reference Values; Thiazoles | 1998 |
Sympathetic neurite outgrowth is greater on plaque-poor vs. plaque-rich regions of Alzheimer's disease cryostat sections.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amygdala; Animals; Benzothiazoles; Case-Control Studies; Chick Embryo; Cryopreservation; Fluorescent Dyes; Humans; Neurites; Plaque, Amyloid; Sympathetic Nervous System; Thiazoles | 1998 |
The neurotoxicity of amyloid beta protein in aged primates.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Antigens; Benzothiazoles; Brain; Female; Haplorhini; Immunohistochemistry; Male; Microinjections; Microscopy, Fluorescence; Neurons; Peptide Fragments; Thiazoles; Ubiquitins | 1998 |
Relationship between plaques, tangles, and loss of cortical cholinergic fibers in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cerebral Cortex; Choline O-Acetyltransferase; Fluorescent Dyes; Humans; Nerve Fibers; Neurofibrillary Tangles; Organ Specificity; Plaque, Amyloid; Reference Values; Regression Analysis; Thiazoles | 1998 |
Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution.
Topics: Alzheimer Disease; Benzothiazoles; Buffers; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Neurofibrillary Tangles; Polyelectrolytes; Polymers; Protein Structure, Secondary; Salts; Solutions; Spectrometry, Fluorescence; tau Proteins; Temperature; Thiazoles | 1998 |
ApoE associated with lipid has a reduced capacity to inhibit beta-amyloid fibril formation.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Apolipoproteins E; Benzothiazoles; Cholesterol; Fluorescent Dyes; Humans; Neurofibrillary Tangles; Thiazoles | 1998 |
The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Antibodies, Monoclonal; Benzothiazoles; Brain; Brain Chemistry; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Peptide Fragments; Plaque, Amyloid; Reference Values; Solubility; Thiazoles | 1999 |
The molecular chaperone alphaB-crystallin enhances amyloid beta neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Apoptosis; Benzothiazoles; Cell Survival; Cells, Cultured; Cerebral Cortex; Crystallins; Dose-Response Relationship, Drug; Hippocampus; Molecular Chaperones; Neurons; Peptide Fragments; Plaque, Amyloid; Protein Binding; Protein Structure, Secondary; Rats; Thiazoles | 1999 |
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Apolipoproteins E; Benzothiazoles; Disease Models, Animal; Genetic Predisposition to Disease; Hippocampus; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Nerve Degeneration; Neurites; Plaque, Amyloid; Protein Isoforms; Thiazoles; Time Factors | 2000 |
Orbitofrontal cortex pathology in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Fluorescent Dyes; Frontal Lobe; Humans; Middle Aged; Neurofibrillary Tangles; Organ Size; Plaque, Amyloid; Thiazoles | 2000 |
High density lipoprotein inhibits assembly of amyloid beta-peptides into fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Fluorometry; Humans; Lipoproteins, HDL; Nerve Tissue Proteins; Particle Size; Peptide Fragments; Plaque, Amyloid; Protein Binding; Solubility; Thiazoles | 2000 |
Human apolipoprotein C-II forms twisted amyloid ribbons and closed loops.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Apolipoprotein C-II; Apolipoproteins C; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Congo Red; Humans; Microscopy, Electron; Protein Conformation; Spectrometry, Fluorescence; Thiazoles; Tryptophan; Ultracentrifugation | 2000 |
X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology.
Topics: Aged; Aged, 80 and over; Alkenes; Alzheimer Disease; Amyloid; Amyloidosis; Benzoates; Benzothiazoles; Coloring Agents; Congo Red; Female; Fluorescent Dyes; Histocytochemistry; Humans; Male; Middle Aged; Neurofibrillary Tangles; Plaque, Amyloid; Protein Structure, Secondary; Silver; Thiazoles | 2000 |
Interaction between beta-amyloid and lens alphaB-crystallin.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Crystallins; Humans; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles; Tryptophan; Ultraviolet Rays | 2000 |
Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Disease Models, Animal; Disease Progression; Feedback; Fluorescent Dyes; Image Processing, Computer-Assisted; Male; Mice; Mice, Transgenic; Microscopy; Plaque, Amyloid; Thiazoles | 2001 |
Anti-amyloidogenic activity of tetracyclines: studies in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Doxycycline; Fluorescent Dyes; Humans; Hydrolysis; In Vitro Techniques; Macromolecular Substances; Microscopy, Electron; Peptide Fragments; Tetracycline; Tetracyclines; Thiazoles; Trypsin | 2001 |
Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Complement C1q; Down Syndrome; Encephalitis; Female; Humans; Immunohistochemistry; Male; Microglia; Middle Aged; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; Thiazoles | 2001 |
Promotion of formation of amyloid fibrils by aluminium adenosine triphosphate (AlATP).
Topics: Adenosine; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Islet Amyloid Polypeptide; Organometallic Compounds; Suramin; Thiazoles | 2001 |
The relationship between the aggregational state of the amyloid-beta peptides and free radical generation by the peptides.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Survival; Circular Dichroism; Electron Spin Resonance Spectroscopy; Fluorescent Dyes; Free Radicals; Humans; PC12 Cells; Rats; Thiazoles | 2001 |
Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease.
Topics: Aging; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Immunohistochemistry; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Nerve Degeneration; Neurofibrillary Tangles; Oxidative Stress; Thiazoles; Tyrosine | 2001 |
Inhibition of beta-amyloid(40) fibrillogenesis and disassembly of beta-amyloid(40) fibrils by short beta-amyloid congeners containing N-methyl amino acids at alternate residues.
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acids; Amyloid beta-Peptides; Benzothiazoles; Chymotrypsin; Drug Resistance; Humans; Methylation; Microscopy, Fluorescence; Molecular Sequence Data; Peptide Fragments; Protein Structure, Secondary; Protein Structure, Tertiary; Thiazoles; Ultracentrifugation | 2001 |
Statistical aspects of quantitative image analysis of beta-amyloid in the APP(V717F) transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cell Count; Data Interpretation, Statistical; Disease Models, Animal; Hippocampus; Image Processing, Computer-Assisted; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Plaque, Amyloid; Reproducibility of Results; Statistical Distributions; Thiazoles | 2001 |
The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cerebral Cortex; Fluorescent Dyes; Humans; Immunohistochemistry; Microscopy, Confocal; Nerve Degeneration; Neurites; Neurofilament Proteins; Phenotype; Plaque, Amyloid; tau Proteins; Thiazoles | 2001 |
Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption.
Topics: Action Potentials; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Dendrites; In Vitro Techniques; Mice; Mice, Transgenic; Microscopy, Confocal; Models, Neurological; Neurites; Plaque, Amyloid; Reaction Time; Thiazoles | 2001 |
Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Chemical Phenomena; Chemistry, Physical; Female; Fluorescent Dyes; Histocytochemistry; Hydrogen-Ion Concentration; Mice; Protein Binding; Solubility; Spectrometry, Fluorescence; Thiazoles; Tomography, Emission-Computed | 2001 |
Plasmin cleaves Abeta42 in vitro and prevents its aggregation into beta-pleated sheet structures.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Chromatography, High Pressure Liquid; Drug Interactions; Fibrinolysin; Humans; Peptide Fragments; Protein Structure, Secondary; Thiazoles | 2001 |
Relationship of calbindin D28K-immunoreactive cells and neuropathological changes in the hippocampal formation of Alzheimer's disease.
Topics: Age of Onset; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Benzothiazoles; Calbindin 1; Calbindins; Female; Fluorescent Dyes; Hippocampus; Humans; Immunohistochemistry; Male; Middle Aged; Neurofibrillary Tangles; Plaque, Amyloid; Pyramidal Cells; S100 Calcium Binding Protein G; Thiazoles | 2001 |
Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; Congo Red; Disease Models, Animal; Gene Expression Regulation, Developmental; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Microscopy, Electron; Mutagenesis, Insertional; Mutation; Neurites; Neurons; Peptide Fragments; Plaque, Amyloid; Presynaptic Terminals; Promoter Regions, Genetic; Thiazoles | 2001 |
A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.
Topics: Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Binding, Competitive; Brain; Chemical Phenomena; Chemistry, Physical; Mice; Mice, Transgenic; Microscopy; Plaque, Amyloid; Radiopharmaceuticals; Structure-Activity Relationship; Thiazoles; Tomography, Emission-Computed | 2002 |
A liposome-based therapeutic vaccine against beta -amyloid plaques on the pancreas of transgenic NORBA mice.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Enzyme-Linked Immunosorbent Assay; Immune Sera; Immunity; Liposomes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Palmitic Acid; Pancreas; Peptides; Species Specificity; Thiazoles; Time Factors; Vaccines | 2002 |
Type IV collagen prevents amyloid beta-protein fibril formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Circular Dichroism; Collagen Type IV; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Microscopy, Electron; Peptide Fragments; Spectrometry, Fluorescence; Thiazoles | 2002 |
Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Cerebral Amyloid Angiopathy; Chromatography, High Pressure Liquid; Formazans; Humans; Molecular Sequence Data; PC12 Cells; Peptide Fragments; Protein Conformation; Protein Structure, Secondary; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Thiazoles | 2002 |
An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Fluorescent Dyes; Hippocampus; Humans; Neurofibrillary Tangles; Staining and Labeling; Thiazoles | 1992 |
A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Humans; Immunohistochemistry; Neurofibrillary Tangles; Staining and Labeling; Thiazoles | 1992 |
Racemized D-aspartate in Alzheimer neurofibrillary tangles.
Topics: Alzheimer Disease; Aspartic Acid; Benzothiazoles; Chromatography, Gas; Fluorescent Dyes; Humans; Nerve Tissue Proteins; Neurofibrillary Tangles; Stereoisomerism; Thiazoles | 1992 |
Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Cerebral Cortex; Female; Humans; Male; Middle Aged; Nerve Degeneration; Neurons; Staining and Labeling; Thiazoles | 1990 |
Senile dementia of the Alzheimer type: is there a correlation between entorhinal cortex and dentate gyrus lesions?
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Cerebral Cortex; Dementia, Vascular; Female; Hippocampus; Humans; Immunohistochemistry; Middle Aged; Neurofibrillary Tangles; tau Proteins; Thiazoles | 1991 |
Evidence for axonal loss in regions occupied by senile plaques in Alzheimer cortex.
Topics: Alzheimer Disease; Amyloid; Axons; Benzothiazoles; Cytoskeleton; Fluorescent Antibody Technique; Fluorescent Dyes; Frontal Lobe; Humans; Image Processing, Computer-Assisted; Nerve Tissue Proteins; Neurofilament Proteins; Thiazoles | 1991 |
[Neuropathologic study of 50 cases of senile dementia].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloidosis; Benzothiazoles; Brain; Cerebrovascular Disorders; Dementia; Dementia, Vascular; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Prospective Studies; Thiazoles | 1990 |
Hypothalamic pathology in Alzheimer's disease.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Benzothiazoles; Cerebral Cortex; Female; Hippocampus; Humans; Hypothalamus; Male; Middle Aged; Neurofibrils; Staining and Labeling; Thiazoles | 1987 |
Observation of morphological relationships between angiopathic blood vessels and degenerative neurites in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Benzothiazoles; Brain; Cerebrovascular Disorders; Congo Red; Female; Humans; Neurofibrils; Staining and Labeling; Thiazoles | 1987 |
Transformation of degenerating neurofibrils into amyloid substance in Alzheimer's disease: histochemical and immunohistochemical studies.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Benzothiazoles; Brain; Histocytochemistry; Humans; Immunohistochemistry; Nerve Degeneration; Neurofibrils; Staining and Labeling; Thiazoles | 1987 |
Does amyloid precede paired helical filaments in the senile plaque? A study of 15 cases with graded intellectual status in aging and Alzheimer disease.
Topics: Aged; Aging; Alzheimer Disease; Amyloid; Benzothiazoles; Brain; Female; Humans; Immunohistochemistry; Intermediate Filaments; Staining and Labeling; Thiazoles | 1988 |
[Alzheimer's disease: immunohistochemical characterization of cerebral amyloid deposits].
Topics: Alzheimer Disease; Amyloid; Antibodies; Benzothiazoles; Cerebral Cortex; Fluorescent Dyes; Glycoside Hydrolases; Humans; Immunohistochemistry; Periodic Acid; Thiazoles | 1989 |
Monoclonal antibody to embryonic CNS antigen A2B5 provides evidence for the involvement of membrane components at sites of Alzheimer degeneration and detects sulfatides as well as gangliosides.
Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal; Antigens, Surface; Benzothiazoles; Brain Chemistry; Cell Membrane; Chick Embryo; Fluorescent Antibody Technique; Frontal Lobe; Gangliosides; Hippocampus; Histocytochemistry; Humans; Immunoenzyme Techniques; Mice; Neurofibrils; Retina; Sulfoglycosphingolipids; Thiazoles | 1989 |
[Quantitative analysis of the distribution of acetylcholinesterase-positive senile plaques in the hippocampal formation in patients with senile dementia of Alzheimer type].
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Hippocampus; Humans; Thiazoles | 1988 |
Cortical angiopathy in Alzheimer's disease: the formation of dystrophic perivascular neurites is related to the exudation of amyloid fibrils from the pathological vessels.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Arterioles; Benzothiazoles; Capillaries; Cerebral Cortex; Fluorescent Dyes; Humans; Immunohistochemistry; Nerve Fibers; Thiazoles | 1988 |
Flow cytometric purification of Alzheimer's disease amyloid plaque core protein using thioflavin T.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Brain Chemistry; Flow Cytometry; Fluorescent Dyes; Humans; Lipofuscin; Microscopy, Fluorescence; Spectrometry, Fluorescence; Thiazoles | 1987 |
Comparison of methods for analysis of CSF proteins in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Cerebrospinal Fluid Proteins; Electrophoresis; Humans; Microscopy, Electron; Middle Aged; Silver; Thiazoles | 1987 |
Neuronal pathology in the nucleus basalis and associated cell groups in senile dementia of the Alzheimer's type: possible role in cell loss.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Basal Ganglia; Benzothiazoles; Brain; Female; Humans; Male; Neurofibrils; Phenothiazines; Substantia Innominata; Thiazoles | 1985 |
Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autoradiography; Benzene Derivatives; Blood-Brain Barrier; Brain; Down Syndrome; Humans; Indicators and Reagents; Iodine Radioisotopes; Isotope Labeling; Kinetics; Ligands; Mice; Peptide Fragments; Structure-Activity Relationship; Styrenes; Thiazoles; Tissue Distribution | 2001 |