Page last updated: 2024-10-19

thioctic acid and Weight Reduction

thioctic acid has been researched along with Weight Reduction in 15 studies

Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Research Excerpts

ExcerptRelevanceReference
"Eicosapentaenoic acid (EPA) and α-lipoic acid (α-LA) have been investigated for their beneficial effects on obesity and cardiovascular risk factors."9.27Untargeted metabolomic on urine samples after α-lipoic acid and/or eicosapentaenoic acid supplementation in healthy overweight/obese women. ( González-Navarro, CJ; Huerta, AE; Martínez, JA; Moreno-Aliaga, MJ; Ramos-López, O; Romo-Hualde, A, 2018)
"We compared body weight and food intake among vehicle-, olanzapine-, and olanzapine plus ALA-treated mice, and measured hypothalamic AMP-activated protein kinase (AMPK) activity by detecting levels of Thr(172) and Ser(485/491) phosphorylation, which indicate activation and inhibition of AMPK, respectively."7.80Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine. ( Cho, HS; Jeong, J; Kim, E; Kim, H; Lee, BI; Lee, SK; Namkoong, K; Park, JY; Park, M, 2014)
"Body weight loss was significantly higher (P<0."6.80Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. ( Huerta, AE; Martínez, JA; Moreno-Aliaga, MJ; Navas-Carretero, S; Prieto-Hontoria, PL, 2015)
"Eicosapentaenoic acid (EPA) and α-lipoic acid (α-LA) have been investigated for their beneficial effects on obesity and cardiovascular risk factors."5.27Untargeted metabolomic on urine samples after α-lipoic acid and/or eicosapentaenoic acid supplementation in healthy overweight/obese women. ( González-Navarro, CJ; Huerta, AE; Martínez, JA; Moreno-Aliaga, MJ; Ramos-López, O; Romo-Hualde, A, 2018)
" The objectives of the present study were to analyse the relationship between irisin and glucose metabolism at baseline and during an oral glucose tolerance test (OGTT) and to determine the effects of eicosapentaenoic acid (EPA) and/or α-lipoic acid treatment on irisin production in cultured human adipocytes and in vivo in healthy overweight/obese women following a weight loss program."5.20Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid. ( Cuervo, M; Fernández-Galilea, M; Huerta, AE; Martínez, JA; Moreno-Aliaga, MJ; Prieto-Hontoria, PL; Sáinz, N, 2015)
"We compared body weight and food intake among vehicle-, olanzapine-, and olanzapine plus ALA-treated mice, and measured hypothalamic AMP-activated protein kinase (AMPK) activity by detecting levels of Thr(172) and Ser(485/491) phosphorylation, which indicate activation and inhibition of AMPK, respectively."3.80Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine. ( Cho, HS; Jeong, J; Kim, E; Kim, H; Lee, BI; Lee, SK; Namkoong, K; Park, JY; Park, M, 2014)
"Obesity is defined as a chronic disease, and is known as a public health problem in developed and developing countries."3.01The effect of alpha-lipoic acid supplementation and electrical isotonic contraction on anthropometric parameters, body composition and angiogenesis factor, sirtunin-1 and peroxisome proliferator-activated receptor-γ coactivator-1α in obese people under a ( Ahmadi-Angali, K; Helli, B; Mohammadshahi, M; Ravanbakhsh, M; Zakizadeh, E, 2021)
"Body weight loss was significantly higher (P<0."2.80Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. ( Huerta, AE; Martínez, JA; Moreno-Aliaga, MJ; Navas-Carretero, S; Prieto-Hontoria, PL, 2015)
"There are numerous trials reported the effect of alpha-lipoic acid (ALA) on obesity measurements; while no summarised dose-response meta-analysis is available to address the effects of dose and duration of ALA supplementation on obesity measurements."2.66Alpha-lipoic acid supplementation significantly reduces the risk of obesity in an updated systematic review and dose response meta-analysis of randomised placebo-controlled clinical trials. ( Abbasalizad Farhangi, M; Vajdi, M, 2020)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (6.67)18.2507
2000's2 (13.33)29.6817
2010's9 (60.00)24.3611
2020's3 (20.00)2.80

Authors

AuthorsStudies
Vajdi, M1
Abbasalizad Farhangi, M1
Mohammadshahi, M1
Zakizadeh, E1
Ahmadi-Angali, K1
Ravanbakhsh, M1
Helli, B1
Bobe, G1
Michels, AJ1
Zhang, WJ1
Purnell, JQ1
Woffendin, C1
Pereira, C1
Vita, JA1
Thomas, NO1
Traber, MG1
Frei, B1
Hagen, TM1
Al-Ghamdi, MA1
Choudhry, H1
Al-Doghather, HA1
Huwait, EH1
Kumosani, TA1
Moselhy, SS1
Romo-Hualde, A1
Huerta, AE3
González-Navarro, CJ1
Ramos-López, O1
Moreno-Aliaga, MJ3
Martínez, JA3
Jia, J1
Gong, X1
Zhao, Y1
Yang, Z1
Ji, K1
Luan, T1
Zang, B1
Li, G1
Ratliff, JC1
Palmese, LB1
Reutenauer, EL1
Tek, C2
Redmer, J1
Longmier, E1
Wedel, P1
Kim, H1
Park, M1
Lee, SK1
Jeong, J1
Namkoong, K1
Cho, HS2
Park, JY1
Lee, BI1
Kim, E2
Navas-Carretero, S1
Prieto-Hontoria, PL2
Fernández-Galilea, M1
Sáinz, N1
Cuervo, M1
Kucukgoncu, S1
Zhou, E1
Lucas, KB1
Park, DW1
Choi, SH1
Kim, JJ1
Nagamatsu, M1
Nickander, KK1
Schmelzer, JD1
Raya, A1
Wittrock, DA1
Tritschler, H1
Low, PA1
Andreassen, OA1
Dedeoglu, A1
Friedlich, A1
Ferrante, KL1
Hughes, D1
Szabo, C1
Beal, MF1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Role of R-alpha Lipoic Acid in Prevention of Atherosclerotic Vascular Disease[NCT00765310]Phase 2/Phase 3100 participants (Anticipated)Interventional2009-04-30Active, not recruiting
Cellular and Molecular Effects of Lipoic Acid and Eicosapentaenoic Acid (EPA) on Adipose Tissue: Potential Application in Human Obesity[NCT01138774]103 participants (Actual)Interventional2010-01-31Completed
The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946]Phase 2/Phase 360 participants (Anticipated)Interventional2023-03-10Recruiting
An Open-Label Pilot Trial of Alpha Lipoic Acid (ALA) for Weight Loss in Schizophrenia[NCT01355952]17 participants (Actual)Interventional2011-05-31Completed
Dysfunction of Adipose Tissue in Obesity, Inflammation and Aging: Mechanisms and Effects of Physical Exercise and Omega-3 Fatty Acids.[NCT03300388]85 participants (Actual)Interventional2017-08-21Completed
Alpha-lipoic Acid Adjunctive Therapy in Schizophrenia: A Randomized, Double-blind, Placebo-controlled Trial[NCT03788759]Phase 2/Phase 348 participants (Actual)Interventional2019-09-01Completed
Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) Randomised, Double-blind,Placebo-controlled Multicentre Trial With 4 Parallel Groups[NCT00328601]Phase 3170 participants Interventional2005-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for thioctic acid and Weight Reduction

ArticleYear
Alpha-lipoic acid supplementation significantly reduces the risk of obesity in an updated systematic review and dose response meta-analysis of randomised placebo-controlled clinical trials.
    International journal of clinical practice, 2020, Volume: 74, Issue:6

    Topics: Antioxidants; Body Mass Index; Body Weight; Dietary Supplements; Female; Humans; Male; Obesity; Thio

2020
Alpha-lipoic acid (ALA) as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials.
    Obesity reviews : an official journal of the International Association for the Study of Obesity, 2017, Volume: 18, Issue:5

    Topics: Antioxidants; Body Mass Index; Dietary Supplements; Humans; Randomized Controlled Trials as Topic; T

2017

Trials

6 trials available for thioctic acid and Weight Reduction

ArticleYear
The effect of alpha-lipoic acid supplementation and electrical isotonic contraction on anthropometric parameters, body composition and angiogenesis factor, sirtunin-1 and peroxisome proliferator-activated receptor-γ coactivator-1α in obese people under a
    Nutrition and health, 2021, Volume: 27, Issue:1

    Topics: Adolescent; Adult; Angiogenesis Inducing Agents; Body Composition; Dietary Supplements; Female; Huma

2021
A Randomized Controlled Trial of Long-Term (R)-α-Lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults without Altering Baseline Elevated Plasma Triglyceride Concentrations.
    The Journal of nutrition, 2020, 09-01, Volume: 150, Issue:9

    Topics: Adult; Dietary Supplements; Drug Administration Schedule; Exercise; Female; Humans; Male; Middle Age

2020
Untargeted metabolomic on urine samples after α-lipoic acid and/or eicosapentaenoic acid supplementation in healthy overweight/obese women.
    Lipids in health and disease, 2018, May-09, Volume: 17, Issue:1

    Topics: Adipose Tissue; Adult; Antioxidants; Cardiovascular Diseases; Dietary Supplements; Eicosapentaenoic

2018
Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss.
    Obesity (Silver Spring, Md.), 2015, Volume: 23, Issue:2

    Topics: Administration, Oral; Adult; Antioxidants; Body Composition; Cholesterol; Dietary Supplements; Doubl

2015
Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid.
    Journal of physiology and biochemistry, 2015, Volume: 71, Issue:3

    Topics: Adipocytes, White; Adult; Blood Glucose; Caloric Restriction; Cells, Cultured; Double-Blind Method;

2015
A preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophrenia.
    Journal of clinical psychopharmacology, 2008, Volume: 28, Issue:2

    Topics: Adult; Antioxidants; Antipsychotic Agents; Appetite; Blood Glucose; Body Mass Index; Brief Psychiatr

2008

Other Studies

7 other studies available for thioctic acid and Weight Reduction

ArticleYear
POTENTIAL ADMINISTRATION OF LIPOIC ACID AND COENZYME Q AGAINST ADIPOGENSIS: TARGET FOR WEIGHT REDUCTION.
    African journal of traditional, complementary, and alternative medicines : AJTCAM, 2017, Volume: 14, Issue:1

    Topics: Adipogenesis; Animals; Anti-Obesity Agents; Humans; Lipoprotein Lipase; Male; Obesity; Rats; Thiocti

2017
Autophagy Enhancing Contributes to the Organ Protective Effect of Alpha-Lipoic Acid in Septic Rats.
    Frontiers in immunology, 2019, Volume: 10

    Topics: Animals; Apoptosis; Autophagy; Cytokines; Disease Models, Animal; Inflammation; Male; NF-kappa B; Pr

2019
An open-label pilot trial of alpha-lipoic acid for weight loss in patients with schizophrenia without diabetes.
    Clinical schizophrenia & related psychoses, 2015, Volume: 8, Issue:4

    Topics: Adolescent; Adult; Aged; Antioxidants; Antipsychotic Agents; Female; Humans; Male; Middle Aged; Obes

2015
Targeting diabetes: the benefits of an integrative approach.
    The Journal of family practice, 2013, Volume: 62, Issue:7

    Topics: Acupuncture Therapy; Antioxidants; Cinnamomum zeylanicum; Complementary Therapies; Diabetes Mellitus

2013
Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine.
    Psychopharmacology, 2014, Volume: 231, Issue:20

    Topics: AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Antipsychotic Agents; Benzodiazepines;

2014
Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy.
    Diabetes care, 1995, Volume: 18, Issue:8

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Spinal; Glutathione; Human

1995
Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice.
    Experimental neurology, 2001, Volume: 168, Issue:2

    Topics: Amphetamines; Amyotrophic Lateral Sclerosis; Animals; Female; Male; Mice; Mice, Transgenic; Motor Sk

2001