thioctic acid has been researched along with Weight Reduction in 15 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eicosapentaenoic acid (EPA) and α-lipoic acid (α-LA) have been investigated for their beneficial effects on obesity and cardiovascular risk factors." | 9.27 | Untargeted metabolomic on urine samples after α-lipoic acid and/or eicosapentaenoic acid supplementation in healthy overweight/obese women. ( González-Navarro, CJ; Huerta, AE; Martínez, JA; Moreno-Aliaga, MJ; Ramos-López, O; Romo-Hualde, A, 2018) |
| "We compared body weight and food intake among vehicle-, olanzapine-, and olanzapine plus ALA-treated mice, and measured hypothalamic AMP-activated protein kinase (AMPK) activity by detecting levels of Thr(172) and Ser(485/491) phosphorylation, which indicate activation and inhibition of AMPK, respectively." | 7.80 | Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine. ( Cho, HS; Jeong, J; Kim, E; Kim, H; Lee, BI; Lee, SK; Namkoong, K; Park, JY; Park, M, 2014) |
| "Body weight loss was significantly higher (P<0." | 6.80 | Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. ( Huerta, AE; Martínez, JA; Moreno-Aliaga, MJ; Navas-Carretero, S; Prieto-Hontoria, PL, 2015) |
| "Eicosapentaenoic acid (EPA) and α-lipoic acid (α-LA) have been investigated for their beneficial effects on obesity and cardiovascular risk factors." | 5.27 | Untargeted metabolomic on urine samples after α-lipoic acid and/or eicosapentaenoic acid supplementation in healthy overweight/obese women. ( González-Navarro, CJ; Huerta, AE; Martínez, JA; Moreno-Aliaga, MJ; Ramos-López, O; Romo-Hualde, A, 2018) |
| " The objectives of the present study were to analyse the relationship between irisin and glucose metabolism at baseline and during an oral glucose tolerance test (OGTT) and to determine the effects of eicosapentaenoic acid (EPA) and/or α-lipoic acid treatment on irisin production in cultured human adipocytes and in vivo in healthy overweight/obese women following a weight loss program." | 5.20 | Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid. ( Cuervo, M; Fernández-Galilea, M; Huerta, AE; Martínez, JA; Moreno-Aliaga, MJ; Prieto-Hontoria, PL; Sáinz, N, 2015) |
| "We compared body weight and food intake among vehicle-, olanzapine-, and olanzapine plus ALA-treated mice, and measured hypothalamic AMP-activated protein kinase (AMPK) activity by detecting levels of Thr(172) and Ser(485/491) phosphorylation, which indicate activation and inhibition of AMPK, respectively." | 3.80 | Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine. ( Cho, HS; Jeong, J; Kim, E; Kim, H; Lee, BI; Lee, SK; Namkoong, K; Park, JY; Park, M, 2014) |
| "Obesity is defined as a chronic disease, and is known as a public health problem in developed and developing countries." | 3.01 | The effect of alpha-lipoic acid supplementation and electrical isotonic contraction on anthropometric parameters, body composition and angiogenesis factor, sirtunin-1 and peroxisome proliferator-activated receptor-γ coactivator-1α in obese people under a ( Ahmadi-Angali, K; Helli, B; Mohammadshahi, M; Ravanbakhsh, M; Zakizadeh, E, 2021) |
| "Body weight loss was significantly higher (P<0." | 2.80 | Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. ( Huerta, AE; Martínez, JA; Moreno-Aliaga, MJ; Navas-Carretero, S; Prieto-Hontoria, PL, 2015) |
| "There are numerous trials reported the effect of alpha-lipoic acid (ALA) on obesity measurements; while no summarised dose-response meta-analysis is available to address the effects of dose and duration of ALA supplementation on obesity measurements." | 2.66 | Alpha-lipoic acid supplementation significantly reduces the risk of obesity in an updated systematic review and dose response meta-analysis of randomised placebo-controlled clinical trials. ( Abbasalizad Farhangi, M; Vajdi, M, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 9 (60.00) | 24.3611 |
| 2020's | 3 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vajdi, M | 1 |
| Abbasalizad Farhangi, M | 1 |
| Mohammadshahi, M | 1 |
| Zakizadeh, E | 1 |
| Ahmadi-Angali, K | 1 |
| Ravanbakhsh, M | 1 |
| Helli, B | 1 |
| Bobe, G | 1 |
| Michels, AJ | 1 |
| Zhang, WJ | 1 |
| Purnell, JQ | 1 |
| Woffendin, C | 1 |
| Pereira, C | 1 |
| Vita, JA | 1 |
| Thomas, NO | 1 |
| Traber, MG | 1 |
| Frei, B | 1 |
| Hagen, TM | 1 |
| Al-Ghamdi, MA | 1 |
| Choudhry, H | 1 |
| Al-Doghather, HA | 1 |
| Huwait, EH | 1 |
| Kumosani, TA | 1 |
| Moselhy, SS | 1 |
| Romo-Hualde, A | 1 |
| Huerta, AE | 3 |
| González-Navarro, CJ | 1 |
| Ramos-López, O | 1 |
| Moreno-Aliaga, MJ | 3 |
| Martínez, JA | 3 |
| Jia, J | 1 |
| Gong, X | 1 |
| Zhao, Y | 1 |
| Yang, Z | 1 |
| Ji, K | 1 |
| Luan, T | 1 |
| Zang, B | 1 |
| Li, G | 1 |
| Ratliff, JC | 1 |
| Palmese, LB | 1 |
| Reutenauer, EL | 1 |
| Tek, C | 2 |
| Redmer, J | 1 |
| Longmier, E | 1 |
| Wedel, P | 1 |
| Kim, H | 1 |
| Park, M | 1 |
| Lee, SK | 1 |
| Jeong, J | 1 |
| Namkoong, K | 1 |
| Cho, HS | 2 |
| Park, JY | 1 |
| Lee, BI | 1 |
| Kim, E | 2 |
| Navas-Carretero, S | 1 |
| Prieto-Hontoria, PL | 2 |
| Fernández-Galilea, M | 1 |
| Sáinz, N | 1 |
| Cuervo, M | 1 |
| Kucukgoncu, S | 1 |
| Zhou, E | 1 |
| Lucas, KB | 1 |
| Park, DW | 1 |
| Choi, SH | 1 |
| Kim, JJ | 1 |
| Nagamatsu, M | 1 |
| Nickander, KK | 1 |
| Schmelzer, JD | 1 |
| Raya, A | 1 |
| Wittrock, DA | 1 |
| Tritschler, H | 1 |
| Low, PA | 1 |
| Andreassen, OA | 1 |
| Dedeoglu, A | 1 |
| Friedlich, A | 1 |
| Ferrante, KL | 1 |
| Hughes, D | 1 |
| Szabo, C | 1 |
| Beal, MF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of R-alpha Lipoic Acid in Prevention of Atherosclerotic Vascular Disease[NCT00765310] | Phase 2/Phase 3 | 100 participants (Anticipated) | Interventional | 2009-04-30 | Active, not recruiting | ||
| Cellular and Molecular Effects of Lipoic Acid and Eicosapentaenoic Acid (EPA) on Adipose Tissue: Potential Application in Human Obesity[NCT01138774] | 103 participants (Actual) | Interventional | 2010-01-31 | Completed | |||
| The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
| An Open-Label Pilot Trial of Alpha Lipoic Acid (ALA) for Weight Loss in Schizophrenia[NCT01355952] | 17 participants (Actual) | Interventional | 2011-05-31 | Completed | |||
| Dysfunction of Adipose Tissue in Obesity, Inflammation and Aging: Mechanisms and Effects of Physical Exercise and Omega-3 Fatty Acids.[NCT03300388] | 85 participants (Actual) | Interventional | 2017-08-21 | Completed | |||
| Alpha-lipoic Acid Adjunctive Therapy in Schizophrenia: A Randomized, Double-blind, Placebo-controlled Trial[NCT03788759] | Phase 2/Phase 3 | 48 participants (Actual) | Interventional | 2019-09-01 | Completed | ||
| Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) Randomised, Double-blind,Placebo-controlled Multicentre Trial With 4 Parallel Groups[NCT00328601] | Phase 3 | 170 participants | Interventional | 2005-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thioctic acid and Weight Reduction
| Article | Year |
|---|---|
Alpha-lipoic acid supplementation significantly reduces the risk of obesity in an updated systematic review and dose response meta-analysis of randomised placebo-controlled clinical trials.
Topics: Antioxidants; Body Mass Index; Body Weight; Dietary Supplements; Female; Humans; Male; Obesity; Thio | 2020 |
Alpha-lipoic acid (ALA) as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials.
Topics: Antioxidants; Body Mass Index; Dietary Supplements; Humans; Randomized Controlled Trials as Topic; T | 2017 |
6 trials available for thioctic acid and Weight Reduction
| Article | Year |
|---|---|
The effect of alpha-lipoic acid supplementation and electrical isotonic contraction on anthropometric parameters, body composition and angiogenesis factor, sirtunin-1 and peroxisome proliferator-activated receptor-γ coactivator-1α in obese people under a
Topics: Adolescent; Adult; Angiogenesis Inducing Agents; Body Composition; Dietary Supplements; Female; Huma | 2021 |
A Randomized Controlled Trial of Long-Term (R)-α-Lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults without Altering Baseline Elevated Plasma Triglyceride Concentrations.
Topics: Adult; Dietary Supplements; Drug Administration Schedule; Exercise; Female; Humans; Male; Middle Age | 2020 |
Untargeted metabolomic on urine samples after α-lipoic acid and/or eicosapentaenoic acid supplementation in healthy overweight/obese women.
Topics: Adipose Tissue; Adult; Antioxidants; Cardiovascular Diseases; Dietary Supplements; Eicosapentaenoic | 2018 |
Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss.
Topics: Administration, Oral; Adult; Antioxidants; Body Composition; Cholesterol; Dietary Supplements; Doubl | 2015 |
Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid.
Topics: Adipocytes, White; Adult; Blood Glucose; Caloric Restriction; Cells, Cultured; Double-Blind Method; | 2015 |
A preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophrenia.
Topics: Adult; Antioxidants; Antipsychotic Agents; Appetite; Blood Glucose; Body Mass Index; Brief Psychiatr | 2008 |
7 other studies available for thioctic acid and Weight Reduction
| Article | Year |
|---|---|
POTENTIAL ADMINISTRATION OF LIPOIC ACID AND COENZYME Q AGAINST ADIPOGENSIS: TARGET FOR WEIGHT REDUCTION.
Topics: Adipogenesis; Animals; Anti-Obesity Agents; Humans; Lipoprotein Lipase; Male; Obesity; Rats; Thiocti | 2017 |
Autophagy Enhancing Contributes to the Organ Protective Effect of Alpha-Lipoic Acid in Septic Rats.
Topics: Animals; Apoptosis; Autophagy; Cytokines; Disease Models, Animal; Inflammation; Male; NF-kappa B; Pr | 2019 |
An open-label pilot trial of alpha-lipoic acid for weight loss in patients with schizophrenia without diabetes.
Topics: Adolescent; Adult; Aged; Antioxidants; Antipsychotic Agents; Female; Humans; Male; Middle Aged; Obes | 2015 |
Targeting diabetes: the benefits of an integrative approach.
Topics: Acupuncture Therapy; Antioxidants; Cinnamomum zeylanicum; Complementary Therapies; Diabetes Mellitus | 2013 |
Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Antipsychotic Agents; Benzodiazepines; | 2014 |
Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Spinal; Glutathione; Human | 1995 |
Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice.
Topics: Amphetamines; Amyotrophic Lateral Sclerosis; Animals; Female; Male; Mice; Mice, Transgenic; Motor Sk | 2001 |