thioctic acid has been researched along with Sepsis in 15 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sepsis is a life-threatening immune disorder resulting from an dysregulated host response to infection." | 3.30 | Adjuvant Lipoic acid Injection in Sepsis treatment in China (ALIS study): protocol for a randomised, single-blind, placebo-controlled trial. ( Chen, C; Chen, X; He, Y; Hu, L; Huang, J; Huang, X; Li, S; Wang, G; Wu, K; Wu, Q; Zhou, X, 2023) |
| "Sepsis is a complication of an infection which imbalance the normal regulation of several organ systems, including the central nervous system (CNS)." | 1.46 | Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis. ( Barichello, T; Bellettini-Santos, T; Budni, J; da Rosa, N; Dal-Pizzol, F; Danielski, LG; Della Giustina, A; Fileti, ME; Florentino, D; Fortunato, JJ; Garbossa, L; Goldim, MP; Martins Laurentino, AO; Mathias, K; Mina, F; Oliveira Junior, AN; Petronilho, F; Zarbato, GF, 2017) |
| "Sepsis is often initiated by invasive infection, characterized by overwhelming induction of pro-inflammatory cytokines." | 1.42 | Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. ( Fu, J; Ji, K; Li, G; Luan, T; Zang, B; Zhao, Y, 2015) |
| "Acute kidney injury is a frequent and serious complication in patients with severe sepsis." | 1.40 | α-Lipoic acid prolongs survival and attenuates acute kidney injury in a rat model of sepsis. ( Chen, W; Gao, L; Gong, X; Jia, J; Li, G; Zang, B, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 9 (60.00) | 24.3611 |
| 2020's | 3 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, L | 1 |
| Zhou, X | 1 |
| Huang, J | 1 |
| He, Y | 1 |
| Wu, Q | 1 |
| Huang, X | 1 |
| Wu, K | 1 |
| Wang, G | 1 |
| Li, S | 1 |
| Chen, X | 1 |
| Chen, C | 1 |
| Giustina, AD | 1 |
| de Souza Goldim, MP | 1 |
| Danielski, LG | 3 |
| Garbossa, L | 2 |
| Junior, ANO | 1 |
| Cidreira, T | 1 |
| Denicol, T | 1 |
| Bonfante, S | 2 |
| da Rosa, N | 2 |
| Fortunato, JJ | 2 |
| Palandi, J | 1 |
| de Oliveira, BH | 1 |
| Martins, DF | 1 |
| Bobinski, F | 1 |
| Garcez, M | 1 |
| Bellettini-Santos, T | 2 |
| Budni, J | 2 |
| Colpo, G | 1 |
| Scaini, G | 1 |
| Giridharan, VV | 1 |
| Barichello, T | 2 |
| Petronilho, F | 3 |
| Pagano, G | 1 |
| Manfredi, C | 1 |
| Pallardó, FV | 1 |
| Lyakhovich, A | 1 |
| Tiano, L | 1 |
| Trifuoggi, M | 1 |
| Della Giustina, A | 1 |
| Goldim, MP | 2 |
| Florentino, D | 2 |
| Mathias, K | 1 |
| Oliveira Junior, AN | 1 |
| Fileti, ME | 1 |
| Zarbato, GF | 1 |
| Martins Laurentino, AO | 1 |
| Mina, F | 1 |
| Dal-Pizzol, F | 1 |
| Jia, J | 2 |
| Gong, X | 2 |
| Zhao, Y | 2 |
| Yang, Z | 1 |
| Ji, K | 2 |
| Luan, T | 2 |
| Zang, B | 3 |
| Li, G | 3 |
| Hiller, S | 1 |
| DeKroon, R | 1 |
| Xu, L | 2 |
| Robinette, J | 1 |
| Winnik, W | 1 |
| Alzate, O | 1 |
| Simington, S | 1 |
| Maeda, N | 2 |
| Yi, X | 2 |
| Gao, L | 1 |
| Chen, W | 1 |
| Fu, J | 1 |
| Shen, HH | 1 |
| Lam, KK | 1 |
| Cheng, PY | 1 |
| Kung, CW | 1 |
| Chen, SY | 1 |
| Lin, PC | 1 |
| Chung, MT | 1 |
| Lee, YM | 1 |
| Vieira, LC | 1 |
| Martins, MM | 1 |
| Vieira, A | 1 |
| Vuolo, F | 1 |
| Zorzoli, A | 1 |
| Grayczyk, JP | 1 |
| Alonzo, F | 1 |
| Kim, K | 1 |
| Yuan, W | 1 |
| Kim, HS | 1 |
| Homeister, JW | 1 |
| Key, NS | 1 |
| Vanasco, V | 1 |
| Cimolai, MC | 1 |
| Evelson, P | 1 |
| Alvarez, S | 1 |
| Cadirci, E | 1 |
| Altunkaynak, BZ | 1 |
| Halici, Z | 1 |
| Odabasoglu, F | 1 |
| Uyanik, MH | 1 |
| Gundogdu, C | 1 |
| Suleyman, H | 1 |
| Halici, M | 1 |
| Albayrak, M | 1 |
| Unal, B | 1 |
| Zhang, WJ | 1 |
| Wei, H | 1 |
| Hagen, T | 1 |
| Frei, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for thioctic acid and Sepsis
| Article | Year |
|---|---|
Potential roles of mitochondrial cofactors in the adjuvant mitigation of proinflammatory acute infections, as in the case of sepsis and COVID-19 pneumonia.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carnitine; Chemotherapy, Adjuvant; COVID-19 Drug T | 2021 |
1 trial available for thioctic acid and Sepsis
| Article | Year |
|---|---|
Adjuvant Lipoic acid Injection in Sepsis treatment in China (ALIS study): protocol for a randomised, single-blind, placebo-controlled trial.
Topics: Humans; Intensive Care Units; Prognosis; Randomized Controlled Trials as Topic; Sepsis; Single-Blind | 2023 |
13 other studies available for thioctic acid and Sepsis
| Article | Year |
|---|---|
Lipoic Acid and Fish Oil Combination Potentiates Neuroinflammation and Oxidative Stress Regulation and Prevents Cognitive Decline of Rats After Sepsis.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Catalase; Cells, Cultured; Cognitive Dysfunction; | 2020 |
Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis.
Topics: Acute Disease; Animals; Antioxidants; Brain; Cognitive Dysfunction; Coinfection; Inflammation; Infla | 2017 |
Autophagy Enhancing Contributes to the Organ Protective Effect of Alpha-Lipoic Acid in Septic Rats.
Topics: Animals; Apoptosis; Autophagy; Cytokines; Disease Models, Animal; Inflammation; Male; NF-kappa B; Pr | 2019 |
α-Lipoic acid protects mitochondrial enzymes and attenuates lipopolysaccharide-induced hypothermia in mice.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Electron Transport Complex III; Energy Metabolism; Fe | 2014 |
α-Lipoic acid prolongs survival and attenuates acute kidney injury in a rat model of sepsis.
Topics: Acute Kidney Injury; Animals; Antioxidants; Cecum; Ligation; Male; NF-kappa B; Punctures; Rats; Rats | 2014 |
Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Cel | 2015 |
Alpha-lipoic acid prevents endotoxic shock and multiple organ dysfunction syndrome induced by endotoxemia in rats.
Topics: Animals; Antioxidants; Antithrombins; Aorta; Caspase 3; Disulfides; Endotoxemia; Enzyme Activation; | 2015 |
Alpha-Lipoic Acid Attenuates Oxidative Damage in Organs After Sepsis.
Topics: Animals; Antioxidants; Catalase; Cecum; Inflammation; Kidney; Lipid Peroxidation; Liver; Lung; Male; | 2016 |
Staphylococcus aureus Tissue Infection During Sepsis Is Supported by Differential Use of Bacterial or Host-Derived Lipoic Acid.
Topics: Adaptation, Physiological; Animals; Disease Models, Animal; Female; Mice; Mutagenesis, Site-Directed | 2016 |
Mice with heterozygous deficiency of lipoic acid synthase have an increased sensitivity to lipopolysaccharide-induced tissue injury.
Topics: Animals; Cytokines; E-Selectin; Energy Metabolism; Heterozygote; Lipopolysaccharides; Liver; Lung; M | 2009 |
The oxidative stress and the mitochondrial dysfunction caused by endotoxemia are prevented by alpha-lipoic acid.
Topics: Animals; Antioxidants; Endotoxemia; Female; Lipopolysaccharides; Mitochondria; Muscle, Skeletal; Nit | 2008 |
Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats.
Topics: Acute Lung Injury; Animals; Cecum; Disease Models, Animal; Interleukin-6; Ligation; Male; NF-kappa B | 2010 |
Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line, Tumor; Humans; Inflammation; Lipopolysac | 2007 |