thioctic acid has been researched along with Seizures in 17 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was proposed to investigate the potential protective effect of alpha-lipoic acid (α-LA) against potassium cyanide (KCN)-induced seizures and lethality in mice." | 7.77 | Alpha-lipoic acid protects against potassium cyanide-induced seizures and mortality. ( Abdel Moneim, WM; Abdel-Hady, RH; Abdel-Zaher, AO; Salim, SY, 2011) |
| "In this study, we investigated the effects of lipoic acid (LA) in the hippocampus oxidative stress caused by pilocarpine-induced seizures in adult rats." | 7.77 | Neuropharmacological effects of lipoic acid and ubiquinone on δ-aminolevulinic dehydratase, Na(+) , K(+) -ATPase, and Mg(2+) -ATPase activities in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; Feng, D; Jordán, J, 2011) |
| "The purpose of this study was to investigate the neuroprotective effects of lipoic acid and ubiquinone on interleukin-1β (IL-1β) mRNA levels and acetylcholinesterase (AChE) activities in rat hippocampus after pilocarpine-induced seizures." | 7.77 | Neuropharmacological effects of lipoic acid and ubiquinone on the mRNA level of interleukin-1β and acetylcholinesterase activity in rat hippocampus after seizures. ( de Freitas, RM; Gomes, KN; Saldanha, GB, 2011) |
| "This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA)." | 7.77 | Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; de Oliveira Silva, F; Jordán, J; Saldanha, GB, 2011) |
| "Pilocarpine-induced seizures can be mediated by increases in oxidative stress and by cerebral amino acid changes." | 7.77 | Lipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizures. ( Campêlo, LM; Feitosa, CM; Freitas, RL; Freitas, RM; Saldanha, GB; Santos, PS, 2011) |
| "In the present study, we investigated the effects of lipoic acid (LA) in the brain oxidative stress caused by pilocarpine-induced seizures in adult rats." | 7.76 | Lipoic acid alters delta-aminolevulinic dehydratase, glutathione peroxidase and Na+,K+-ATPase activities and glutathione-reduced levels in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM, 2010) |
| "In the present study we investigated the effects of lipoic acid (LA) on delta-aminolevulinic dehydratase (delta-ALA-D) and Na(+), K(+)-ATPase activities in rat brain after seizures induction by pilocarpine." | 7.76 | Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain. ( de Freitas, RM; de Souza, GF; Feitosa, CM; Feng, D; Jordán, J; Santos, IM; Tomé, Ada R, 2010) |
| "Systemic injection of pilocarpine has been shown to induce recurrent seizures and epileptic discharges demonstrated by EEG monitoring." | 7.76 | Lipoic acid effects on monoaminergic system after pilocarpine-induced seizures. ( Feng, D; Freitas, RM; Jordán, J, 2010) |
| "It has been suggested that pilocarpine-induced seizures is mediated by increases in oxidative stress." | 7.75 | The evaluation of effects of lipoic acid on the lipid peroxidation, nitrite formation and antioxidant enzymes in the hippocampus of rats after pilocarpine-induced seizures. ( Freitas, RM, 2009) |
| "The risk of seizures increases to the extent that the injury is associated with sub-arachnoid hemorrhage and hematoma." | 5.32 | Lipoic acid pretreatment attenuates ferric chloride-induced seizures in the rat. ( Lee, JK; Meyerhoff, JL; Rittase, BW; Tsang, AY; Yourick, DL, 2004) |
| "This study was proposed to investigate the potential protective effect of alpha-lipoic acid (α-LA) against potassium cyanide (KCN)-induced seizures and lethality in mice." | 3.77 | Alpha-lipoic acid protects against potassium cyanide-induced seizures and mortality. ( Abdel Moneim, WM; Abdel-Hady, RH; Abdel-Zaher, AO; Salim, SY, 2011) |
| "In this study, we investigated the effects of lipoic acid (LA) in the hippocampus oxidative stress caused by pilocarpine-induced seizures in adult rats." | 3.77 | Neuropharmacological effects of lipoic acid and ubiquinone on δ-aminolevulinic dehydratase, Na(+) , K(+) -ATPase, and Mg(2+) -ATPase activities in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; Feng, D; Jordán, J, 2011) |
| "The purpose of this study was to investigate the neuroprotective effects of lipoic acid and ubiquinone on interleukin-1β (IL-1β) mRNA levels and acetylcholinesterase (AChE) activities in rat hippocampus after pilocarpine-induced seizures." | 3.77 | Neuropharmacological effects of lipoic acid and ubiquinone on the mRNA level of interleukin-1β and acetylcholinesterase activity in rat hippocampus after seizures. ( de Freitas, RM; Gomes, KN; Saldanha, GB, 2011) |
| "This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA)." | 3.77 | Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; de Oliveira Silva, F; Jordán, J; Saldanha, GB, 2011) |
| "Pilocarpine-induced seizures can be mediated by increases in oxidative stress and by cerebral amino acid changes." | 3.77 | Lipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizures. ( Campêlo, LM; Feitosa, CM; Freitas, RL; Freitas, RM; Saldanha, GB; Santos, PS, 2011) |
| "In the present study, we investigated the effects of lipoic acid (LA) in the brain oxidative stress caused by pilocarpine-induced seizures in adult rats." | 3.76 | Lipoic acid alters delta-aminolevulinic dehydratase, glutathione peroxidase and Na+,K+-ATPase activities and glutathione-reduced levels in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM, 2010) |
| "In the present study we investigated the effects of lipoic acid (LA) on delta-aminolevulinic dehydratase (delta-ALA-D) and Na(+), K(+)-ATPase activities in rat brain after seizures induction by pilocarpine." | 3.76 | Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain. ( de Freitas, RM; de Souza, GF; Feitosa, CM; Feng, D; Jordán, J; Santos, IM; Tomé, Ada R, 2010) |
| "Systemic injection of pilocarpine has been shown to induce recurrent seizures and epileptic discharges demonstrated by EEG monitoring." | 3.76 | Lipoic acid effects on monoaminergic system after pilocarpine-induced seizures. ( Feng, D; Freitas, RM; Jordán, J, 2010) |
| "It has been suggested that pilocarpine-induced seizures is mediated by increases in oxidative stress." | 3.75 | The evaluation of effects of lipoic acid on the lipid peroxidation, nitrite formation and antioxidant enzymes in the hippocampus of rats after pilocarpine-induced seizures. ( Freitas, RM, 2009) |
| " Although it is a safe oral molecule, there have been eight cases of ALA toxicity reported." | 1.91 | Alpha Lipoic Acid Toxicity: The First Reported Mortality in an Adult Patient After Multiorgan Failure. ( Abu-Alfa, A; Al Balushi, H; El Helou, C; El Zahran, T; Gittinger, M; Halabi, Z; Kaakour, A; Steck, AR, 2023) |
| "The seizures were unresponsive to bolus midazolam, phenytoin infusion and levetiracetam infusion." | 1.42 | A rare cause of status epilepticus; alpha lipoic acid intoxication, case report and review of the literature. ( Çelik, T; Çelik, Ü; Gezgin, AE; Kaya, MS; Kömür, M; Tolunay, O, 2015) |
| "Kainic acid (30 mg/kg, i." | 1.40 | Synergic effect of exercise and lipoic acid on protection against kainic acid induced seizure activity and oxidative stress in mice. ( Jin, EH; Kim, HJ; Kim, JS; Kwon, MS; Park, S; Song, W, 2014) |
| "The risk of seizures increases to the extent that the injury is associated with sub-arachnoid hemorrhage and hematoma." | 1.32 | Lipoic acid pretreatment attenuates ferric chloride-induced seizures in the rat. ( Lee, JK; Meyerhoff, JL; Rittase, BW; Tsang, AY; Yourick, DL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 12 (70.59) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Halabi, Z | 1 |
| El Helou, C | 1 |
| Al Balushi, H | 1 |
| Gittinger, M | 1 |
| Steck, AR | 1 |
| Kaakour, A | 1 |
| Abu-Alfa, A | 1 |
| El Zahran, T | 1 |
| Kim, HJ | 1 |
| Song, W | 1 |
| Kim, JS | 1 |
| Jin, EH | 1 |
| Kwon, MS | 1 |
| Park, S | 1 |
| Tolunay, O | 1 |
| Çelik, T | 1 |
| Kömür, M | 1 |
| Gezgin, AE | 1 |
| Kaya, MS | 1 |
| Çelik, Ü | 1 |
| Freitas, RM | 4 |
| de Freitas, RM | 6 |
| Abdel-Zaher, AO | 1 |
| Abdel-Hady, RH | 1 |
| Abdel Moneim, WM | 1 |
| Salim, SY | 1 |
| Santos, IM | 1 |
| Tomé, Ada R | 2 |
| Feitosa, CM | 3 |
| de Souza, GF | 1 |
| Feng, D | 4 |
| Jordán, J | 4 |
| Gomes, KN | 1 |
| Saldanha, GB | 5 |
| de Oliveira Silva, F | 1 |
| Souza, GF | 1 |
| dos Santos, PS | 1 |
| Santos, PS | 1 |
| Campêlo, LM | 1 |
| Freitas, RL | 1 |
| Gordon, N | 1 |
| Newton, RW | 1 |
| UENO, Y | 1 |
| MIURA, S | 1 |
| TAKEMURA, N | 1 |
| HASEGAWA, Y | 1 |
| Meyerhoff, JL | 1 |
| Lee, JK | 1 |
| Rittase, BW | 1 |
| Tsang, AY | 1 |
| Yourick, DL | 1 |
1 review available for thioctic acid and Seizures
| Article | Year |
|---|---|
Glucose transporter type1 (GLUT-1) deficiency.
Topics: Anticonvulsants; Antioxidants; Ascorbic Acid; Blood-Brain Barrier; Caffeine; Central Nervous System | 2003 |
16 other studies available for thioctic acid and Seizures
| Article | Year |
|---|---|
Alpha Lipoic Acid Toxicity: The First Reported Mortality in an Adult Patient After Multiorgan Failure.
Topics: Acidosis; Adolescent; Adult; Anticonvulsants; Antioxidants; Child; Female; Humans; Seizures; Thiocti | 2023 |
Synergic effect of exercise and lipoic acid on protection against kainic acid induced seizure activity and oxidative stress in mice.
Topics: Animals; Combined Modality Therapy; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neuroprotective Agent | 2014 |
A rare cause of status epilepticus; alpha lipoic acid intoxication, case report and review of the literature.
Topics: Anticonvulsants; Epilepsies, Myoclonic; Female; Humans; Infant; Levetiracetam; Midazolam; Piracetam; | 2015 |
The evaluation of effects of lipoic acid on the lipid peroxidation, nitrite formation and antioxidant enzymes in the hippocampus of rats after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Catalase; Hippocampus; Lipid Peroxidation; Muscarinic Agonists; Neuroprotecti | 2009 |
Lipoic acid alters delta-aminolevulinic dehydratase, glutathione peroxidase and Na+,K+-ATPase activities and glutathione-reduced levels in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Convulsants; Disease Models, Animal; Down-Regulation; Enzymes; Glutathione; G | 2010 |
Alpha-lipoic acid protects against potassium cyanide-induced seizures and mortality.
Topics: Animals; Antioxidants; Brain; Dose-Response Relationship, Drug; Glutamic Acid; Glutathione; Glutathi | 2011 |
Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain.
Topics: Animals; Brain; Male; Pilocarpine; Porphobilinogen Synthase; Rats; Rats, Wistar; Seizures; Sodium-Po | 2010 |
Lipoic acid effects on monoaminergic system after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Biogenic Monoamines; Dopamine; Hippocampus; Hydroxyindoleacetic Acid; Male; N | 2010 |
Neuropharmacological effects of lipoic acid and ubiquinone on δ-aminolevulinic dehydratase, Na(+) , K(+) -ATPase, and Mg(2+) -ATPase activities in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Ca(2+) Mg(2+)-ATPase; Disease Models, Animal; Hippocampus; Male; Oxidative St | 2011 |
Neuropharmacological effects of lipoic acid and ubiquinone on the mRNA level of interleukin-1β and acetylcholinesterase activity in rat hippocampus after seizures.
Topics: Acetylcholinesterase; Animals; Hippocampus; Interleukin-1beta; Male; Pilocarpine; Rats; Rats, Wistar | 2011 |
Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dialysis; Excitatory Amino Acids; gamma-Aminobutyric Acid; | 2011 |
Lipoic acid increases glutathione peroxidase, Na+, K+-ATPase and acetylcholinesterase activities in rat hippocampus after pilocarpine-induced seizures?
Topics: Acetylcholinesterase; Animals; Antioxidants; Glutathione Peroxidase; Hippocampus; Male; Pilocarpine; | 2010 |
Lipoic acid inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after pilocarpine-induced seizures.
Topics: Animals; Blotting, Western; Caspases; Cell Death; Hippocampus; Male; Neuroprotective Agents; Pilocar | 2011 |
Lipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Chromatography, High Pressure Liquid; Glutamic Acid; Hippocampus; Male; Piloc | 2011 |
[CONVULSION CAUSED BY TELODRIN POISONING].
Topics: Drug Therapy; Electroencephalography; Insecticides; Phenobarbital; Poisoning; Seizures; Thioctic Aci | 1964 |
Lipoic acid pretreatment attenuates ferric chloride-induced seizures in the rat.
Topics: Animals; Antioxidants; Chlorides; Disease Models, Animal; Electroencephalography; Ferric Compounds; | 2004 |