thioctic acid has been researched along with Reperfusion Injury in 64 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of erdosteine and alpha lipoic acid (ALA) in a rat model of ovarian ischaemia-reperfusion injury." | 7.80 | Antioxidant effect of erdosteine and lipoic acid in ovarian ischemia-reperfusion injury. ( Dokuyucu, R; Duru, M; Gokce, H; Karateke, A; Karateke, F; Kurt, RK; Ozcan, O; Ozturk, S; Tas, ZA, 2014) |
| "To investigate the effects of erdosteine and alpha lipoic acid (ALA) in a rat model of ovarian ischaemia-reperfusion injury." | 3.80 | Antioxidant effect of erdosteine and lipoic acid in ovarian ischemia-reperfusion injury. ( Dokuyucu, R; Duru, M; Gokce, H; Karateke, A; Karateke, F; Kurt, RK; Ozcan, O; Ozturk, S; Tas, ZA, 2014) |
| "To evaluate the protective effects of two naturally occurring antioxidants, α-Lipoic acid and coenzyme Q10 on the response to in vitro ischemia of the rabbit urinary bladder." | 3.77 | The effect of antioxidants on the response of the rabbit urinary bladder to in vitro ischemia/reperfusion. ( Leggett, RE; Levin, RM; Radu, F; Schuler, C, 2011) |
| "Alpha-lipoic (LA) acid pretreatment has previously been described to reduce ischemia/reperfusion injury (IRI) after warm liver ischemia, whereas glycine pretreatment has been shown to be protective mostly in models of cold hepatic ischemia." | 3.73 | Different protection mechanisms after pretreatment with glycine or alpha-lipoic acid in a rat model of warm hepatic ischemia. ( Duenschede, F; Dutkowski, P; Erbes, K; Ewald, P; Junginger, T; Kiemer, AK; Kircher, A; Miesner, I; Riegler, N; Schad, A; Schaefer, H; Schneider, J; Westermann, S, 2006) |
| "alpha-Lipoic acid (thioctic acid) was tested for its neuroprotective activity in a Mongolian gerbil model of forebrain ischemia/reperfusion." | 3.69 | The free radical scavenger, alpha-lipoic acid, protects against cerebral ischemia-reperfusion injury in gerbils. ( Cao, X; Phillis, JW, 1995) |
| " No serious adverse events were reported in a placebo-controlled, sequential dose escalation Phase 1 clinical trial." | 2.79 | Pre-clinical and Clinical Safety Studies of CMX-2043: a cytoprotective lipoic acid analogue for ischaemia-reperfusion injury. ( Beeuwkes, R; Casale, R; Kates, SA; Lader, AS, 2014) |
| "Hydrogen sulfide (H(2)S) is a gasomediator synthesized from L- and D-cysteine in various tissues." | 2.53 | Medical Functions of Hydrogen Sulfide. ( Olas, B, 2016) |
| "Ischemia was performed in adult male rats by bilateral femoral artery occlusion, then ischemia-reperfusion was done for 1 day and 7 days." | 1.72 | Ameliorative role of alpha-lipoic acid in renal cortical structural damage, induced by limb ischemia-reperfusion injury in the rat. ( Mubarak, HA; Othman, MA; Sayed, MM, 2022) |
| "Testicular torsion is one of the urologic emergencies occurring frequently in neonatal and adolescent period." | 1.38 | The effects of α-lipoic acid against testicular ischemia-reperfusion injury in Rats. ( Bagrıyanık, A; Cavdar, Z; Erbil, G; Ergur, BU; Ozbal, S; Tekmen, I, 2012) |
| " Eight full-thickness bladder strips were isolated from each of 4 treated and 4 control rabbit bladders, and a dose-response curve to H(2)O(2) (0." | 1.37 | Differential effects of coenzyme Q10 and α-lipoic acid on two models of in vitro oxidative damage to the rabbit urinary bladder. ( Leggett, RE; Levin, RM; Li, HT; Schuler, C, 2011) |
| " (c) Ethanol mediated a dose-response enhancement of the contractile dysfunctions caused by in vitro ischemia." | 1.33 | Effect of ethanol on the response of the rat urinary bladder to in vitro ischemia: protective effect of alpha-lipoic acid. ( Danek, M; Haugaard, N; Levin, RM; Whitbeck, C, 2005) |
| "To reduce reperfusion injury, conditions were ameliorated including the treatment with antioxidants, lipoate or dihydrolipoate." | 1.31 | Lipoate ameliorates ischemia-reperfusion in animal models. ( Freisleben, HJ, 2000) |
| "Ischemia was produced by the ligature of each of the supplying arteries to the sciatic-tibial nerve of the right hind-limb for predetermined periods of time (either 3 or 5 h), followed by the release of the ligatures, resulting in reperfusion." | 1.30 | Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve. ( Low, PA; Mitsui, M; Mitsui, Y; Schmelzer, JD; Tritschler, HJ; Zollman, PJ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.56) | 18.7374 |
| 1990's | 7 (10.94) | 18.2507 |
| 2000's | 20 (31.25) | 29.6817 |
| 2010's | 32 (50.00) | 24.3611 |
| 2020's | 4 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Ding, Y | 1 |
| Zhang, Y | 1 |
| Zhang, W | 1 |
| Shang, J | 1 |
| Xie, Z | 1 |
| Chen, C | 1 |
| Othman, MA | 1 |
| Mubarak, HA | 1 |
| Sayed, MM | 1 |
| Dogan Ozcil, M | 1 |
| Ozcan, O | 2 |
| Hakverdi, S | 1 |
| Bayraktar, HS | 1 |
| Dirican, E | 1 |
| Kacmaz, F | 1 |
| Dogan, U | 1 |
| Yilmaz, AH | 1 |
| Yildirim, S | 1 |
| Ellidag, HY | 1 |
| Aslaner, A | 1 |
| Cakir, RC | 1 |
| Koctekin, B | 1 |
| Karakas, BR | 1 |
| Cakir, T | 1 |
| Ren, Y | 1 |
| Wang, LH | 1 |
| Deng, FS | 1 |
| Li, JS | 1 |
| Jiang, L | 1 |
| Ambrosi, N | 3 |
| Guerrieri, D | 2 |
| Caro, F | 2 |
| Sanchez, F | 1 |
| Haeublein, G | 1 |
| Casadei, D | 1 |
| Incardona, C | 3 |
| Chuluyan, E | 2 |
| Gao, X | 1 |
| Chen, W | 1 |
| Li, J | 1 |
| Shen, C | 1 |
| Zhou, P | 1 |
| Che, X | 1 |
| Li, X | 1 |
| Xie, R | 1 |
| Casciato, P | 1 |
| Vazquez, M | 1 |
| Müllen, E | 1 |
| Gadano, A | 1 |
| de Santibañes, E | 1 |
| de Santibañes, M | 1 |
| Zandomeni, M | 1 |
| Chahdi, M | 1 |
| Lazarte, JC | 1 |
| Biagiola, DA | 1 |
| Iaquinandi, JC | 1 |
| Santofimia-Castaño, P | 1 |
| Iovanna, J | 1 |
| Zhang, J | 3 |
| Xiao, F | 1 |
| Zhang, L | 1 |
| Wang, X | 2 |
| Lai, X | 1 |
| Shen, Y | 1 |
| Zhang, M | 1 |
| Zhou, B | 1 |
| Lang, H | 1 |
| Yu, P | 1 |
| Hua, F | 1 |
| Modgil, S | 1 |
| Bammidi, S | 1 |
| Banik, A | 1 |
| Sharma, VL | 1 |
| Anand, A | 1 |
| Cavdar, Z | 2 |
| Ozbal, S | 2 |
| Celik, A | 1 |
| Ergur, BU | 2 |
| Guneli, E | 1 |
| Ural, C | 1 |
| Camsari, T | 1 |
| Guner, GA | 1 |
| Carter, SE | 1 |
| Faulkner, A | 1 |
| Rakobowchuk, M | 1 |
| Kates, SA | 2 |
| Casale, RA | 1 |
| Baguisi, A | 1 |
| Beeuwkes, R | 2 |
| Connell, BJ | 6 |
| Saleh, MC | 4 |
| Kucukkaya, I | 2 |
| Abd-El-Aziz, AS | 2 |
| Khan, BV | 4 |
| Saleh, TM | 6 |
| Rajagopal, D | 3 |
| Lader, AS | 1 |
| Casale, R | 1 |
| Dudek, M | 1 |
| Knutelska, J | 1 |
| Bednarski, M | 1 |
| Nowiński, L | 1 |
| Zygmunt, M | 1 |
| Bilska-Wilkosz, A | 1 |
| Iciek, M | 1 |
| Otto, M | 1 |
| Żytka, I | 1 |
| Sapa, J | 1 |
| Włodek, L | 1 |
| Filipek, B | 1 |
| Dokuyucu, R | 1 |
| Karateke, A | 1 |
| Gokce, H | 1 |
| Kurt, RK | 1 |
| Ozturk, S | 1 |
| Tas, ZA | 1 |
| Karateke, F | 1 |
| Duru, M | 1 |
| Deng, H | 2 |
| Zuo, X | 2 |
| Liu, X | 2 |
| Liu, L | 2 |
| Xu, Q | 2 |
| Wu, Z | 2 |
| Ji, A | 2 |
| Peng, X | 1 |
| Arrosagaray, V | 1 |
| Uva, PD | 1 |
| Petroni, J | 1 |
| Herrera, MB | 1 |
| Iovanna, JL | 1 |
| León, L | 1 |
| Chuluyan, HE | 1 |
| Casadei, DH | 1 |
| Olas, B | 1 |
| Aydın, A | 1 |
| Yıldırım, AM | 1 |
| Guven, A | 2 |
| Tunc, T | 2 |
| Topal, T | 2 |
| Kul, M | 2 |
| Korkmaz, A | 2 |
| Gundogdu, G | 1 |
| Onguru, O | 2 |
| Ozturk, H | 1 |
| Oter, S | 1 |
| Sarici, U | 1 |
| Osborne, NN | 2 |
| Ji, D | 1 |
| Abdul Majid, AS | 1 |
| Fawcett, RJ | 1 |
| Sparatore, A | 1 |
| Del Soldato, P | 1 |
| Li, HT | 1 |
| Schuler, C | 2 |
| Leggett, RE | 2 |
| Levin, RM | 3 |
| Emmez, H | 1 |
| Yildirim, Z | 1 |
| Kale, A | 1 |
| Tönge, M | 1 |
| Durdağ, E | 1 |
| Börcek, AO | 1 |
| Uçankuş, LN | 1 |
| Doğulu, F | 1 |
| Kiliç, N | 1 |
| Baykaner, MK | 1 |
| Saleh, M | 1 |
| Koga, H | 1 |
| Hagiwara, S | 2 |
| Kusaka, J | 1 |
| Goto, K | 1 |
| Uchino, T | 1 |
| Shingu, C | 1 |
| Kai, S | 1 |
| Noguchi, T | 2 |
| Radu, F | 1 |
| Yu, Y | 1 |
| Ji, L | 1 |
| Liang, X | 1 |
| Zhang, T | 1 |
| Hai, CX | 1 |
| Röhnert, P | 1 |
| Schröder, UH | 1 |
| Ziabreva, I | 1 |
| Täger, M | 1 |
| Reymann, KG | 1 |
| Striggow, F | 1 |
| Masuda, T | 1 |
| Iwashita, Y | 1 |
| Ohta, M | 1 |
| Inomata, M | 1 |
| Kitano, S | 1 |
| Erbil, G | 1 |
| Tekmen, I | 1 |
| Bagrıyanık, A | 1 |
| Chidlow, G | 1 |
| Schmidt, KG | 1 |
| Wood, JP | 1 |
| Melena, J | 1 |
| Müller, C | 1 |
| Dünschede, F | 2 |
| Koch, E | 1 |
| Vollmar, AM | 1 |
| Kiemer, AK | 6 |
| do Vale, OC | 1 |
| Fonteles, DS | 1 |
| Cabral, FR | 1 |
| Fonteles, MC | 1 |
| Danek, M | 1 |
| Whitbeck, C | 1 |
| Haugaard, N | 1 |
| Duenschede, F | 4 |
| Westermann, S | 5 |
| Riegler, N | 3 |
| Miesner, I | 2 |
| Erbes, K | 4 |
| Ewald, P | 3 |
| Kircher, A | 4 |
| Schaefer, H | 1 |
| Schneider, J | 1 |
| Schad, A | 5 |
| Dutkowski, P | 3 |
| Junginger, T | 4 |
| Seifert, J | 1 |
| Oliver, K | 1 |
| Theodor, J | 1 |
| Guimarães, SB | 1 |
| Santos, JM | 1 |
| Aragão, AA | 1 |
| de Sandes Kimura, O | 1 |
| Barbosa, PH | 1 |
| de Vasconcelos, PR | 1 |
| Dulundu, E | 1 |
| Ozel, Y | 1 |
| Topaloglu, U | 1 |
| Sehirli, O | 2 |
| Ercan, F | 1 |
| Gedik, N | 2 |
| Sener, G | 2 |
| Kempski, O | 1 |
| Albrecht-Schöck, S | 2 |
| Kneist, W | 1 |
| Korenkov, M | 1 |
| Miesmer, I | 1 |
| Gockel, I | 1 |
| Sener, E | 1 |
| Cetinel, S | 1 |
| Yüksel, M | 1 |
| Cosar, E | 1 |
| Sahin, FK | 1 |
| Köken, G | 1 |
| Toy, H | 1 |
| Basarali, K | 1 |
| Büyükbas, S | 1 |
| Bae, EH | 1 |
| Lee, KS | 1 |
| Lee, J | 1 |
| Ma, SK | 1 |
| Kim, NH | 1 |
| Choi, KC | 1 |
| Frøkiaer, J | 1 |
| Nielsen, S | 1 |
| Kim, SY | 1 |
| Kim, SZ | 1 |
| Kim, SH | 1 |
| Kim, SW | 1 |
| Cao, X | 1 |
| Phillis, JW | 1 |
| Haramaki, N | 1 |
| Packer, L | 4 |
| Assadnazari, H | 1 |
| Zimmer, G | 1 |
| Werker, PM | 1 |
| Kon, M | 1 |
| Green, CJ | 1 |
| Franken, RJ | 1 |
| Overgoor, ML | 1 |
| Panigrahi, M | 1 |
| Sadguna, Y | 1 |
| Shivakumar, BR | 1 |
| Kolluri, SV | 1 |
| Roy, S | 1 |
| Ravindranath, V | 1 |
| Tritschler, HJ | 2 |
| Wessel, K | 1 |
| Mitsui, Y | 1 |
| Schmelzer, JD | 1 |
| Zollman, PJ | 1 |
| Mitsui, M | 1 |
| Low, PA | 1 |
| Freisleben, HJ | 1 |
| Ko, KM | 1 |
| Yiu, HY | 1 |
| Lynch, MA | 1 |
| Takaoka, M | 1 |
| Ohkita, M | 1 |
| Kobayashi, Y | 1 |
| Yuba, M | 1 |
| Matsumura, Y | 1 |
| Roldán, EJ | 1 |
| Kerzberg, EM | 1 |
| Boveris, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of The Effect of Alpha Lipoic Acid Administration on Oxidative Stress Markers and Occurrence of No-Reflow Phenomenon in Post Myocardial Infarction Patients[NCT05360602] | 60 participants (Anticipated) | Interventional | 2022-07-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for thioctic acid and Reperfusion Injury
| Article | Year |
|---|---|
Effects of Lipoic Acid on Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cognition; Humans; Ischemia; Reperfusion Injury; Spinal Cord Injuries; Thioct | 2021 |
Alpha Lipoic Acid: A Therapeutic Strategy that Tend to Limit the Action of Free Radicals in Transplantation.
Topics: Animals; Clinical Trials as Topic; Disease Models, Animal; Free Radicals; Humans; Reperfusion Injury | 2018 |
Medical Functions of Hydrogen Sulfide.
Topics: Angiogenesis Inducing Agents; Cardiovascular Agents; Cysteine; Diclofenac; Disulfides; Heart; Humans | 2016 |
Neuroprotection by the metabolic antioxidant alpha-lipoic acid.
Topics: Animals; Antioxidants; Brain; Humans; Nerve Degeneration; Nervous System; Neuroprotective Agents; Ox | 1997 |
alpha-Lipoic acid: a metabolic antioxidant which regulates NF-kappa B signal transduction and protects against oxidative injury.
Topics: Animals; Antioxidants; Brain; Humans; NF-kappa B; Oxidative Stress; Reperfusion Injury; Signal Trans | 1998 |
Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue.
Topics: Aging; Animals; Antioxidants; Glutamic Acid; Humans; Long-Term Potentiation; Mitochondria; Nervous S | 2001 |
4 trials available for thioctic acid and Reperfusion Injury
| Article | Year |
|---|---|
α-lipoic acid reduces postreperfusion syndrome in human liver transplantation - a pilot study.
Topics: Aged; Alarmins; Apoptosis; Biopsy; Cold Ischemia; Cytokines; Double-Blind Method; Female; Follow-Up | 2018 |
Pre-clinical and Clinical Safety Studies of CMX-2043: a cytoprotective lipoic acid analogue for ischaemia-reperfusion injury.
Topics: Administration, Intravenous; Adolescent; Adult; Animals; CHO Cells; Cricetinae; Cricetulus; Dipeptid | 2014 |
α-Lipoic Acid Protects Against Ischemia-Reperfusion Injury in Simultaneous Kidney-Pancreas Transplantation.
Topics: Adult; Anti-Inflammatory Agents; Antioxidants; Argentina; Biomarkers; Female; Humans; Inflammation M | 2016 |
Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by alpha-lipoic acid in humans.
Topics: Adenosine Triphosphate; Adult; Aged; Alanine Transaminase; Antioxidants; Aspartate Aminotransferases | 2006 |
54 other studies available for thioctic acid and Reperfusion Injury
| Article | Year |
|---|---|
Ameliorative role of alpha-lipoic acid in renal cortical structural damage, induced by limb ischemia-reperfusion injury in the rat.
Topics: Animals; Antioxidants; Ischemia; Kidney; Male; Rats; Reperfusion Injury; Thioctic Acid | 2022 |
Impact of Enoxaparin +α Lipoic acid combination on oxidative stress, follicle development and apoptotic damage in ovarian ischemia reperfusion model.
Topics: Animals; Antioxidants; Biomarkers; Catalase; Enoxaparin; Female; Follicle Stimulating Hormone; Gluta | 2022 |
The effect of alpha-lipoic acid on oxidative parameters, SCUBE-1 and SCUBE-2 in hepatic ischemia-reperfusion injury in cholestatic rats.
Topics: Animals; Antioxidants; Bilirubin; Biomarkers; Cholestasis; Female; Oxidants; Oxidative Stress; Rats; | 2023 |
Protective effect and mechanism of alpha-lipoic acid on partial hepatic ischemia-reperfusion injury in adult male rats.
Topics: Animals; Chemokine CXCL2; Cytoprotection; Disease Models, Animal; Free Radical Scavengers; Glutathio | 2019 |
The protective effect of alpha-lipoic acid against brain ischemia and reperfusion injury via mTOR signaling pathway in rats.
Topics: Animals; Brain Ischemia; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injur | 2018 |
Alpha-Lipoic Acid Preconditioning and Ischaemic Postconditioning Synergistically Protect Rats from Cerebral Injury Induced by Ischemia and Reperfusion Partly via Inhibition TLR4/MyD88/ NF-κB Signaling Pathway.
Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Ischemia; Ischemic Postconditioning; Male; Myeloid D | 2018 |
Alpha lipoic acid attenuates the long-term effects of lead exposure in retinal ischemic injury mouse model.
Topics: Animals; Ciliary Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor; Glial Fibrillary | 2019 |
The effects of alpha-lipoic acid on MMP-2 and MMP-9 activities in a rat renal ischemia and re-perfusion model.
Topics: Animals; Antioxidants; Enzyme Activation; Kidney; Male; Matrix Metalloproteinase 2; Matrix Metallopr | 2014 |
The role of prostaglandin and antioxidant availability in recovery from forearm ischemia-reperfusion injury in humans.
Topics: Adult; Antioxidants; Ascorbic Acid; Blood Flow Velocity; Brachial Artery; Endothelium, Vascular; Fem | 2014 |
Lipoic acid analogs with enhanced pharmacological activity.
Topics: Animals; Dipeptides; Disease Models, Animal; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Spra | 2014 |
UPEI-300, a conjugate of lipoic acid and edaravone, mediates neuroprotection in ischemia/reperfusion.
Topics: Animals; Antipyrine; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Drug Combinations; Male; Neocort | 2014 |
Co-administration of resveratrol and lipoic acid, or their synthetic combination, enhances neuroprotection in a rat model of ischemia/reperfusion.
Topics: Animals; Antioxidants; Brain Ischemia; Disease Models, Animal; Humans; Male; Rats; Rats, Sprague-Daw | 2014 |
Alpha lipoic acid protects the heart against myocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Antioxidants; Arrhythmias, C | 2014 |
Antioxidant effect of erdosteine and lipoic acid in ovarian ischemia-reperfusion injury.
Topics: Animals; Antioxidants; Drug Therapy, Combination; Female; Models, Animal; Ovarian Follicle; Ovary; O | 2014 |
Α‑lipoic acid protects against cerebral ischemia/reperfusion-induced injury in rats.
Topics: Animals; Antioxidants; Apoptosis; Brain Edema; Brain Ischemia; Brain-Derived Neurotrophic Factor; Ca | 2015 |
α-Lipoic acid protects against hypoxia/reoxygenation-induced injury in human umbilical vein endothelial cells through suppression of apoptosis and autophagy.
Topics: Adenine; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase 3; Cel | 2015 |
UPEI-400, a conjugate of lipoic acid and scopoletin, mediates neuroprotection in a rat model of ischemia/reperfusion.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Male; Neuroprotective Agents; Rats; Rats, Sprague-D | 2017 |
Effects of alpha lipoic acid on ischemia-reperfusion injury in rat hindlimb ischemia model.
Topics: Animals; Antioxidants; Disease Models, Animal; Hindlimb; Infusions, Parenteral; Ischemia; Male; Musc | 2016 |
Alpha-lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine.
Topics: Animals; Antioxidants; Azoles; Disease Models, Animal; Intestinal Diseases; Intestine, Small; Isoind | 2008 |
Protective effect of sulfhydryl-containing antioxidants against ischemia/reperfusion injury of prepubertal rat intestine.
Topics: Acetylcysteine; Animals; Antioxidants; Constriction; Disease Models, Animal; Glutathione Peroxidase; | 2009 |
ACS67, a hydrogen sulfide-releasing derivative of latanoprost acid, attenuates retinal ischemia and oxidative stress to RGC-5 cells in culture.
Topics: Animals; Blotting, Western; Caspases; Cells, Cultured; Disease Models, Animal; Electrophoresis, Poly | 2010 |
Differential effects of coenzyme Q10 and α-lipoic acid on two models of in vitro oxidative damage to the rabbit urinary bladder.
Topics: Animals; Antioxidants; Disease Models, Animal; Drug Therapy, Combination; Follow-Up Studies; Hydroxy | 2011 |
Anti-apoptotic and neuroprotective effects of α-lipoic acid on spinal cord ischemia-reperfusion injury in rabbits.
Topics: Animals; Apoptosis; Disease Models, Animal; Male; Nerve Degeneration; Neuroprotective Agents; Rabbit | 2010 |
Lipoic acid protects against reperfusion injury in the early stages of cerebral ischemia.
Topics: Animals; Antioxidants; Baroreflex; Blotting, Western; Brain Ischemia; Cerebral Infarction; Cerebrova | 2011 |
New α-lipoic acid derivative, DHL-HisZn, ameliorates renal ischemia-reperfusion injury in rats.
Topics: Acute Kidney Injury; Animals; Cell Line; Histidine; Kidney; Kidney Function Tests; Male; Malondialde | 2012 |
The effect of antioxidants on the response of the rabbit urinary bladder to in vitro ischemia/reperfusion.
Topics: Animals; Antioxidants; Fatty Acids, Nonesterified; Ischemia; Lipid Peroxidation; Male; Malondialdehy | 2011 |
Alpha-lipoic acid protects against myocardial ischemia/reperfusion injury via multiple target effects.
Topics: Animals; Antioxidants; Apoptosis; Blotting, Western; Catalase; Creatine Kinase; Glutathione; Male; M | 2011 |
Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion.
Topics: Animals; Brain Ischemia; Cell Death; Disease Models, Animal; Ethidium; Fluoresceins; Gerbillinae; Gl | 2012 |
Dihydrolipoyl histidinate zinc complex, a new antioxidant, attenuates hepatic ischemia-reperfusion injury in rats.
Topics: Alanine Transaminase; Animals; Antimycin A; Antioxidants; Aspartate Aminotransferases; Biomarkers; B | 2011 |
Co-administration of apocynin with lipoic acid enhances neuroprotection in a rat model of ischemia/reperfusion.
Topics: Acetophenones; Animals; Brain; Brain Ischemia; Drug Combinations; Humans; Male; Neuroprotective Agen | 2012 |
UPEI-100, a conjugate of lipoic acid and apocynin, mediates neuroprotection in a rat model of ischemia/reperfusion.
Topics: Acetophenones; Animals; Biomarkers; Disease Models, Animal; Glutathione Disulfide; Infarction, Middl | 2012 |
The effects of α-lipoic acid against testicular ischemia-reperfusion injury in Rats.
Topics: Animals; Antioxidants; Caspase 3; In Situ Nick-End Labeling; Male; Malondialdehyde; Oxidative Stress | 2012 |
Alpha-lipoic acid protects the retina against ischemia-reperfusion.
Topics: Anesthetics, Local; Animals; Antioxidants; Binding, Competitive; Brain-Derived Neurotrophic Factor; | 2002 |
Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway.
Topics: Adenosine Triphosphate; Animals; Caspase 3; Caspases; Enzyme Activation; Ischemic Preconditioning; L | 2003 |
A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Dr | 2003 |
Effect of ethanol on the response of the rat urinary bladder to in vitro ischemia: protective effect of alpha-lipoic acid.
Topics: Animals; Carbachol; Ethanol; In Vitro Techniques; Ischemia; Male; Muscle Contraction; Protective Age | 2005 |
Different protection mechanisms after pretreatment with glycine or alpha-lipoic acid in a rat model of warm hepatic ischemia.
Topics: Animals; Apoptosis; Cytoprotection; Glutathione Transferase; Glycine; In Situ Nick-End Labeling; L-L | 2006 |
Protective effect of alpha-lipoic acid in experimental spermatic cord torsion.
Topics: Animals; Antioxidants; Disease Models, Animal; Free Radical Scavengers; Glutathione; Injections, Int | 2007 |
Alpha-lipoic acid protects against hepatic ischemia-reperfusion injury in rats.
Topics: Acridines; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Glutathione; He | 2007 |
Protection from hepatic ischemia/reperfusion injury and improvement of liver regeneration by alpha-lipoic acid.
Topics: Animals; Apoptosis; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Hepatocytes; In Situ Nick- | 2007 |
Hepatocellular injury of nonischemic liver tissue after selective clamping in rats--protective action by pharmacological pretreatment with lipoic acid.
Topics: Animals; Antioxidants; Constriction; Disease Models, Animal; Ischemia; Lipid Peroxidation; Liver; Li | 2007 |
Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Caspase 3; Caspase 9; | 2007 |
Alpha-lipoic acid protects against renal ischaemia-reperfusion injury in rats.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Creatinine; Kidney; Male; Rats; Rats, Wistar; Renal Insu | 2008 |
The protective effect of alpha-lipoic acid in experimental ovarian ischaemia-reperfusion injury.
Topics: Animals; Disease Models, Animal; Female; Malondialdehyde; Nitric Oxide; Ovary; Rats; Rats, Wistar; R | 2007 |
Effects of alpha-lipoic acid on ischemia-reperfusion-induced renal dysfunction in rats.
Topics: Adenylyl Cyclases; Animals; Antioxidants; Aquaporins; Cyclic GMP; Endothelin-1; Guanylate Cyclase; K | 2008 |
The free radical scavenger, alpha-lipoic acid, protects against cerebral ischemia-reperfusion injury in gerbils.
Topics: Animals; Brain Ischemia; Free Radical Scavengers; Gerbillinae; Locomotion; Reperfusion Injury; Thioc | 1995 |
Cardiac recovery during post-ischemic reperfusion is improved by combination of vitamin E with dihydrolipoic acid.
Topics: Analysis of Variance; Animals; Biomarkers; Coronary Circulation; Food, Fortified; Hypoxia; In Vitro | 1993 |
Neither desferrioxamine nor lipoic acid enhances the cold ischaemic tolerance of epigastric free flaps in rats.
Topics: Adipose Tissue; Animals; Citrates; Cold Temperature; Deferoxamine; Free Radicals; Graft Survival; Hy | 1993 |
alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats.
Topics: Animals; Antioxidants; Brain Chemistry; Brain Ischemia; Glutathione; Injections, Intravenous; Male; | 1996 |
Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve.
Topics: Action Potentials; Animals; Gait; Hindlimb; Ischemia; Male; Muscle, Skeletal; Neuroprotective Agents | 1999 |
Lipoate ameliorates ischemia-reperfusion in animal models.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Aorta, Thoracic; Cell Hypoxia; Constriction; Creatine | 2000 |
Schisandrin B modulates the ischemia-reperfusion induced changes in non-enzymatic antioxidant levels in isolated-perfused rat hearts.
Topics: Animals; Antioxidants; Ascorbic Acid; Cyclooctanes; Female; Heart; L-Lactate Dehydrogenase; Lignans; | 2001 |
Protective effect of alpha-lipoic acid against ischaemic acute renal failure in rats.
Topics: Acute Kidney Injury; Animals; Antioxidants; Blood Urea Nitrogen; Creatinine; Endothelin-1; Male; Rat | 2002 |
[Kinetics of chemoluminiscence of rat intestine during ischemia and reperfusion].
Topics: Analysis of Variance; Animals; Free Radicals; Intestines; Ischemia; Ligation; Luminescent Measuremen | 1989 |