thioctic acid has been researched along with Renal Insufficiency in 6 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Compared with control rats, D developed increased urinary excretion of albumin and transforming growth factor beta, renal insufficiency, glomerular mesangial matrix expansion, and glomerulosclerosis in association with depletion of glutathione and accumulation of malondialdehyde in renal cortex." | 3.71 | Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. ( Craven, PA; DeRubertis, FR; Liachenko, J; Melhem, MF, 2002) |
| " However, nephrotoxicity is considered to be a critical adverse effect that limits CMS's clinical use." | 1.62 | Alpha-lipoic acid alleviates colistin nephrotoxicity in rats. ( Arslan, S; Bilici, G; Cavdar, C; Cavdar, Z; Heybeli, C; Kocak, A; Oktan, MA; Ozbal, S; Ural, C; Yilmaz, O, 2021) |
| "Malondialdehyde was increased as an indicator of free radical formation in AK-induced group and decreased with ALA treatment." | 1.42 | The impact of alpha-lipoic acid on amikacin-induced nephrotoxicity. ( Asci, H; Bayram, D; Candan, IA; Cankara, FN; Ilhan, I; Saygin, M; Yesilot, S, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Oktan, MA | 1 |
| Heybeli, C | 1 |
| Ural, C | 1 |
| Kocak, A | 1 |
| Bilici, G | 1 |
| Cavdar, Z | 1 |
| Ozbal, S | 1 |
| Arslan, S | 1 |
| Yilmaz, O | 1 |
| Cavdar, C | 1 |
| Jo, SH | 1 |
| Kim, SA | 1 |
| Kim, HS | 1 |
| Han, SJ | 1 |
| Park, WJ | 1 |
| Choi, YJ | 1 |
| Asci, H | 1 |
| Saygin, M | 1 |
| Cankara, FN | 1 |
| Bayram, D | 1 |
| Yesilot, S | 1 |
| Candan, IA | 1 |
| Ilhan, I | 1 |
| Poh, ZX | 1 |
| Goh, KP | 1 |
| Sehirli, O | 1 |
| Sener, E | 1 |
| Cetinel, S | 1 |
| Yüksel, M | 1 |
| Gedik, N | 1 |
| Sener, G | 1 |
| Melhem, MF | 1 |
| Craven, PA | 1 |
| Liachenko, J | 1 |
| DeRubertis, FR | 1 |
1 review available for thioctic acid and Renal Insufficiency
| Article | Year |
|---|---|
A current update on the use of alpha lipoic acid in the management of type 2 diabetes mellitus.
Topics: Antioxidants; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic Neuropath | 2009 |
1 trial available for thioctic acid and Renal Insufficiency
| Article | Year |
|---|---|
Alpha-lipoic acid for the prevention of contrast-induced nephropathy in patients undergoing coronary angiography: the ALIVE study - a prospective randomized trial.
Topics: Administration, Oral; Aged; Angina, Stable; Antioxidants; Contrast Media; Coronary Angiography; Crea | 2013 |
4 other studies available for thioctic acid and Renal Insufficiency
| Article | Year |
|---|---|
Alpha-lipoic acid alleviates colistin nephrotoxicity in rats.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Colistin; Humans; Male; Models, Animal; Protective Age | 2021 |
The impact of alpha-lipoic acid on amikacin-induced nephrotoxicity.
Topics: Amikacin; Animals; Anti-Bacterial Agents; Antioxidants; Blood Urea Nitrogen; Creatinine; Disease Mod | 2015 |
Alpha-lipoic acid protects against renal ischaemia-reperfusion injury in rats.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Creatinine; Kidney; Male; Rats; Rats, Wistar; Renal Insu | 2008 |
Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes.
Topics: Albuminuria; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephrop | 2002 |