thioctic acid has been researched along with Pregnancy in 68 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study revealed a marked stereospecificity in the prevention of buthionine sulfoximine-induced cataract, and in the protection of lens antioxidants, in newborn rats by alpha-lipoate, R- and racemic alpha-lipoate decreased cataract formation from 100% (buthionine sulfoximine only) to 55% (buthionine sulfoximine + R-alpha-lipoic acid) and 40% (buthionine sulfoximine + rac-alpha-lipoic acid) (p<0." | 7.69 | Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats. ( Maitra, I; Packer, L; Serbinova, E; Tritschler, HJ, 1996) |
| "N(epsilon)-(Carboxymethyl)lysine (CML), a major product of oxidative modification of glycated proteins, has been suggested to represent a general marker of oxidative stress and long-term damage to proteins in aging, atherosclerosis, and diabetes." | 7.69 | Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. ( Nerlich, AG; Schleicher, ED; Wagner, E, 1997) |
| " The aim of the current clinical trial study was to explore the effects of ALA supplementation on maternal circulating values of adiponectin (A), leptin (L); and A/L, L/A, adiponectin/homeostatic model assessment for insulin resistance (A/H), and malondialdehyde/total antioxidant capacity (MDA/TAC) ratios in pregnant women with gestational diabetes mellitus (GDM)." | 5.30 | Elevation of the adiponectin/leptin ratio in women with gestational diabetes mellitus after supplementation with alpha-lipoic acid. ( Aslfalah, H; Jamilian, M; Khosrowbeygi, A, 2019) |
| "This study revealed a marked stereospecificity in the prevention of buthionine sulfoximine-induced cataract, and in the protection of lens antioxidants, in newborn rats by alpha-lipoate, R- and racemic alpha-lipoate decreased cataract formation from 100% (buthionine sulfoximine only) to 55% (buthionine sulfoximine + R-alpha-lipoic acid) and 40% (buthionine sulfoximine + rac-alpha-lipoic acid) (p<0." | 3.69 | Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats. ( Maitra, I; Packer, L; Serbinova, E; Tritschler, HJ, 1996) |
| "N(epsilon)-(Carboxymethyl)lysine (CML), a major product of oxidative modification of glycated proteins, has been suggested to represent a general marker of oxidative stress and long-term damage to proteins in aging, atherosclerosis, and diabetes." | 3.69 | Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. ( Nerlich, AG; Schleicher, ED; Wagner, E, 1997) |
| "Albino rats of Wistar strain (Tamura 1950) breeded in a closed colony were administered arsenic trioxide orally during pregnancy (from the 0 day to the 20th day)." | 3.65 | [Arsenic metabolism. (17) Studies of placental transfer of arsenic and the effects of antidotes and diet]. ( Tanaka, I, 1976) |
| "To observe the clinical efficacy of Jujing Decoction combined with lipoic acid in the treatment of asthenospermia and teratospermia." | 3.11 | [Efficacy of Jujing Decoction combined with lipoic acid in the treatment of asthenospermia and teratospermia]. ( Chang, FJ; Chen, Y; Fan, Q; Han, ZY; Sun, ZX; Xue, JG, 2022) |
| " Stimulation of spermatogenesis using the antioxidant complex SpermActin Forte is an effective and safe method of treating male infertility." | 2.90 | [Double-blind, randomized placebo-controlled study of efficiency and safety of complex acetyl-L-carnitine, L-carnitine fumarate and alpha-lipoic acid (Spermactin Forte) for treatment of male infertility]. ( Gamidov, SI; Ovchinnikov, RI; Popova, AY, 2019) |
| "Women with gestational diabetes mellitus (n = 60) during 24-28 weeks of gestation were selected and divided randomly into drug (n = 30) and placebo (n = 30) groups." | 2.90 | Reduction in maternal serum values of glucose and gamma-glutamyltransferase after supplementation with alpha-lipoic acid in women with gestational diabetes mellitus. ( Aslfalah, H; Jamilian, M; Khosrowbeygi, A; Rafiei, F, 2019) |
| "Postpartum pain is a frequent condition that negatively affects women's quality of life, interferring with everyday life." | 2.52 | [Use of alpha-lipoic acid and omega-3 in postpartum pain treatment]. ( Bounous, VE; Costantino, D; Costantino, M; Guaraldi, C, 2015) |
| "Antioxidant and anti-inflammatory treatments in endometriosis should be investigated as new treatment modalities for implantation problems." | 1.72 | Receptivity, autophagy, and implantation in endometriosis; does antioxidant work? An experimental study. ( Baser, E; Doganyigit, Z; Kirmizi, DA; Okan, A, 2022) |
| " Having determined the effective concentrations of LPS (1 mg/mL) that could reduce blastocyst formation rate by around 50% and the optimal concentration of ALA (10 μM) that could attenuate the toxic effects of LPS on blastocyst formation, the following indices were defined: inner cell mass and trophectoderm cell numbers, blastocyst mitochondrial distribution, ROS and GSH levels, as well as the relative expression of Tlr-4." | 1.56 | The attenuation of the toxic effects of LPS on mouse pre-implantation development by alpha-lipoic acid. ( Hajian, M; Kowsar, R; Mahdavi, AH; Mokhtari, S; Nasr-Esfahani, MH; Varnosfaderani, SR, 2020) |
| "Fulminant type 1 diabetes mellitus (FT1DM) has received clinical attention for its low incidence and poor prognosis." | 1.56 | Fulminant type 1 diabetes mellitus in pregnancy. ( Li, CY; Li, Y; Liu, YR; Mu, T; Wang, YJ; Yi, ZM; You, ZY; Zhang, YW; Zhao, CZ, 2020) |
| "Tobacco use during pregnancy is known to have several negative effects on the offspring's reproductive health in the long term." | 1.56 | Chronic Maternal Tobacco Smoke Exposure and/or Alpha-Lipoic Acid Treatment Causes Long-Term Deterioration of Testis and Sexual Behavior in Adult Male Rats. ( Akkoc, RF; Canpolat, S; Erdem Guzel, E; Kaya Tektemur, N; Ozan, IE; Tektemur, A; Ulker, N; Yardimci, A, 2020) |
| "Obesity is becoming pandemic and is associated with impaired reproductive potential." | 1.56 | Effects of α-lipoic acid and myo-inositol supplementation on the oocyte environment of infertile obese women: A preliminary study. ( Anelli, GM; Cetin, I; Lisso, F; Mandò, C; Marzorati, A; Novielli, C; Oneta, M; Parrilla, B; Savasi, VM, 2020) |
| " Results showed that vaginal ALA was well absorbed and distributed." | 1.51 | α-Lipoic Acid Vaginal Administration Contrasts Inflammation and Preterm Delivery in Rats. ( Ergur, BU; Fuso, A; Goker, A; Kuscu, K; Micili, SC, 2019) |
| " Used as dietary supplement alpha-lipoic acid was demonstrated to be safe for living organisms even when administered at high doses." | 1.46 | Safety of oral alpha-lipoic acid treatment in pregnant women: a retrospective observational study. ( Colannino, G; Monastra, G; Parente, E; Picconi, O, 2017) |
| "To investigate the effect of alpha-lipoic acid (α-LA) combined with tamoxifen citrate (TC) in the treatment of oligoasthenospermia." | 1.46 | [Efficacy of alpha-lipoic acid combined with tamoxifen citrate in the treatment of oligoasthenospermia]. ( Chang, XL; Li, JD; Li, W; Teng, ZH; Wang, YX; Yang, SW; Zhang, H; Zhang, YP, 2017) |
| "Smoking during pregnancy is associated with numerous fetal and developmental complications and reproductive dysfunctions in the offspring." | 1.43 | α-Lipoic acid attenuates transplacental nicotine-induced germ cell and oxidative DNA damage in adult mice. ( Anto, SK; Jena, G; Khan, S; Koyada, N, 2016) |
| "Hypochlorous acid (HOCl) is a powerful oxidant which is highly reactive towards a range of biological substrates." | 1.31 | Hypochlorous acid is a potent inhibitor of GST P1-1. ( Bast, A; den Hartog, GJ; Evelo, CT; Haenen, GR; van Haaften, RI, 2001) |
| "In rats treated only during pregnancy days 1 to 5 (before diabetes induction), lipoic acid failed to exert its protective effects against neural tube defects, which emphasizes the importance of the presence of lipoic acid during the organogenesis period." | 1.30 | Lipoic acid prevention of neural tube defects in offspring of rats with streptozocin-induced diabetes. ( Ayalon, N; Bashan, N; Hershkovitz, R; Khamaisi, M; Reece, EA; Trischler, H; Wiznitzer, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (10.29) | 18.7374 |
| 1990's | 6 (8.82) | 18.2507 |
| 2000's | 6 (8.82) | 29.6817 |
| 2010's | 32 (47.06) | 24.3611 |
| 2020's | 17 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Namvarpour, Z | 1 |
| Afsordeh, K | 1 |
| Amini, A | 1 |
| Fathabady, FF | 1 |
| Kirmizi, DA | 1 |
| Baser, E | 1 |
| Okan, A | 1 |
| Doganyigit, Z | 1 |
| Menichini, D | 2 |
| Imbrogno, MG | 2 |
| Basile, L | 2 |
| Monari, F | 2 |
| Ferrari, F | 3 |
| Neri, I | 3 |
| Yuan, M | 1 |
| Sano, H | 1 |
| Nishino, T | 1 |
| Chen, H | 1 |
| Li, RS | 1 |
| Matsuo, Y | 2 |
| Nishida, K | 2 |
| Koga, T | 2 |
| Takeda, T | 2 |
| Tanaka, Y | 1 |
| Ishii, Y | 2 |
| Fan, Q | 1 |
| Chang, FJ | 1 |
| Xue, JG | 1 |
| Han, ZY | 1 |
| Sun, ZX | 1 |
| Chen, Y | 1 |
| Gamidov, SI | 1 |
| Ovchinnikov, RI | 1 |
| Popova, AY | 1 |
| Sharma, A | 1 |
| Kumar, D | 6 |
| Moore, RM | 6 |
| Deshmukh, A | 1 |
| Mercer, BM | 5 |
| Mansour, JM | 6 |
| Moore, JJ | 6 |
| Mokhtari, S | 1 |
| Mahdavi, AH | 1 |
| Hajian, M | 1 |
| Kowsar, R | 1 |
| Varnosfaderani, SR | 1 |
| Nasr-Esfahani, MH | 1 |
| Artini, PG | 1 |
| Obino, MER | 1 |
| Micelli, E | 1 |
| Malacarne, E | 1 |
| Vacca, C | 1 |
| Papini, F | 1 |
| Cela, V | 1 |
| Gardner, DK | 1 |
| Kuramoto, T | 1 |
| Tanaka, M | 1 |
| Mitzumoto, S | 1 |
| Montag, M | 1 |
| Yoshida, A | 1 |
| Li, CY | 1 |
| Li, Y | 1 |
| You, ZY | 1 |
| Liu, YR | 1 |
| Wang, YJ | 1 |
| Mu, T | 1 |
| Zhao, CZ | 1 |
| Yi, ZM | 1 |
| Zhang, YW | 1 |
| Katri, R | 1 |
| Mercer, B | 1 |
| Yardimci, A | 1 |
| Akkoc, RF | 1 |
| Tektemur, A | 1 |
| Ulker, N | 1 |
| Kaya Tektemur, N | 1 |
| Erdem Guzel, E | 1 |
| Canpolat, S | 1 |
| Ozan, IE | 1 |
| Leonard, MM | 1 |
| Karathia, H | 1 |
| Pujolassos, M | 1 |
| Troisi, J | 1 |
| Valitutti, F | 1 |
| Subramanian, P | 1 |
| Camhi, S | 1 |
| Kenyon, V | 1 |
| Colucci, A | 1 |
| Serena, G | 1 |
| Cucchiara, S | 1 |
| Montuori, M | 1 |
| Malamisura, B | 1 |
| Francavilla, R | 1 |
| Elli, L | 1 |
| Fanelli, B | 1 |
| Colwell, R | 1 |
| Hasan, N | 1 |
| Zomorrodi, AR | 1 |
| Fasano, A | 1 |
| Rabaglino, MB | 1 |
| Moreira-Espinoza, MJ | 1 |
| Lagares, C | 1 |
| Garay, MI | 1 |
| Quiroga, P | 1 |
| Pasqualini, ME | 1 |
| Francini, F | 1 |
| Beltramo, D | 1 |
| Biernat-Sudolska, M | 1 |
| Rojek-Zakrzewska, D | 1 |
| Bilska-Wilkosz, A | 1 |
| Novielli, C | 1 |
| Anelli, GM | 1 |
| Lisso, F | 1 |
| Marzorati, A | 1 |
| Parrilla, B | 1 |
| Oneta, M | 1 |
| Savasi, VM | 1 |
| Cetin, I | 1 |
| Mandò, C | 1 |
| Parente, E | 1 |
| Colannino, G | 1 |
| Picconi, O | 1 |
| Monastra, G | 2 |
| Micili, SC | 1 |
| Goker, A | 2 |
| Kuscu, K | 1 |
| Ergur, BU | 1 |
| Fuso, A | 1 |
| Di Tucci, C | 1 |
| Di Feliciantonio, M | 1 |
| Vena, F | 1 |
| Capone, C | 1 |
| Schiavi, MC | 1 |
| Pietrangeli, D | 1 |
| Muzii, L | 1 |
| Benedetti Panici, P | 1 |
| Zhang, H | 1 |
| Wang, YX | 1 |
| Li, JD | 1 |
| Chang, XL | 1 |
| Teng, ZH | 1 |
| Zhang, YP | 1 |
| Yang, SW | 1 |
| Li, W | 1 |
| Lete, I | 1 |
| Mendoza, N | 1 |
| de la Viuda, E | 1 |
| Carmona, F | 1 |
| Ren, F | 1 |
| Feng, T | 1 |
| Dai, G | 1 |
| Wang, Y | 1 |
| Zhu, H | 1 |
| Hu, J | 1 |
| Aslfalah, H | 2 |
| Jamilian, M | 2 |
| Khosrowbeygi, A | 2 |
| Rafiei, F | 1 |
| Canepa, P | 1 |
| Dal Lago, A | 1 |
| De Leo, C | 1 |
| Gallo, M | 1 |
| Rizzo, C | 1 |
| Licata, E | 1 |
| Anserini, P | 1 |
| Rago, R | 1 |
| Scaruffi, P | 1 |
| Sammour, H | 1 |
| Elkholy, A | 1 |
| Rasheedy, R | 1 |
| Fadel, E | 1 |
| Tanaka, T | 1 |
| Masubuchi, Y | 1 |
| Okada, R | 1 |
| Nakajima, K | 1 |
| Nakamura, K | 1 |
| Masuda, S | 1 |
| Nakahara, J | 1 |
| Maronpot, RR | 1 |
| Yoshida, T | 1 |
| Koyanagi, M | 1 |
| Hayashi, SM | 1 |
| Shibutani, M | 1 |
| Di Nicuolo, F | 1 |
| D'Ippolito, S | 1 |
| Castellani, R | 1 |
| Rossi, ED | 1 |
| Masciullo, V | 1 |
| Specchia, M | 1 |
| Mariani, M | 1 |
| Pontecorvi, A | 1 |
| Scambia, G | 1 |
| Di Simone, N | 1 |
| Deslauriers, J | 1 |
| Racine, W | 1 |
| Sarret, P | 1 |
| Grignon, S | 1 |
| Costantino, M | 3 |
| Guaraldi, C | 3 |
| Costantino, D | 3 |
| De Grazia, S | 2 |
| Unfer, V | 2 |
| Di Tomo, P | 1 |
| Di Silvestre, S | 1 |
| Cordone, VG | 1 |
| Giardinelli, A | 1 |
| Faricelli, B | 1 |
| Pipino, C | 1 |
| Lanuti, P | 1 |
| Peng, T | 1 |
| Formoso, G | 1 |
| Yang, D | 1 |
| Arduini, A | 1 |
| Chiarelli, F | 1 |
| Pandolfi, A | 1 |
| Di Pietro, N | 1 |
| Shen, T | 1 |
| Jiang, ZL | 1 |
| Li, CJ | 1 |
| Hu, XC | 1 |
| Li, QW | 1 |
| Porcaro, G | 1 |
| Brillo, E | 1 |
| Giardina, I | 1 |
| Di Iorio, R | 1 |
| Bounous, VE | 1 |
| Cilaker Micili, S | 1 |
| Anto, SK | 1 |
| Koyada, N | 1 |
| Khan, S | 1 |
| Jena, G | 1 |
| Grandi, G | 1 |
| Pignatti, L | 1 |
| Dante, G | 1 |
| Facchinetti, F | 1 |
| Fiore, E | 1 |
| Perillo, L | 1 |
| Piccione, G | 1 |
| Gianesella, M | 1 |
| Bedin, S | 1 |
| Armato, L | 1 |
| Giudice, E | 1 |
| Morgante, M | 1 |
| Al-Matubsi, HY | 1 |
| Oriquat, GA | 1 |
| Abu-Samak, M | 1 |
| Al Hanbali, OA | 1 |
| Salim, MD | 1 |
| Fujiki, A | 1 |
| Hattori, Y | 1 |
| Yamada, H | 1 |
| Novak, JB | 1 |
| Sugimura, Y | 1 |
| Murase, T | 1 |
| Kobayashi, K | 1 |
| Oyama, K | 1 |
| Hayasaka, S | 1 |
| Kanou, Y | 1 |
| Oiso, Y | 1 |
| Murata, Y | 1 |
| Bentov, Y | 1 |
| Esfandiari, N | 1 |
| Burstein, E | 1 |
| Casper, RF | 1 |
| Adamo, AM | 1 |
| Zago, MP | 1 |
| Mackenzie, GG | 1 |
| Aimo, L | 1 |
| Keen, CL | 1 |
| Keenan, A | 1 |
| Oteiza, PI | 1 |
| Schatz, F | 2 |
| Abdelrahim, A | 1 |
| Rangaswamy, N | 2 |
| Bartel, C | 1 |
| Lockwood, CJ | 2 |
| Bai, XM | 1 |
| Ma, QG | 1 |
| Zhao, LH | 1 |
| Xi, L | 1 |
| Ji, C | 1 |
| Houng, WL | 1 |
| Lin, CJ | 1 |
| Shen, JL | 1 |
| Yeh, HI | 1 |
| Wang, HH | 1 |
| Chang, WH | 1 |
| Chan, WH | 1 |
| SAVONA, B | 1 |
| BARRESI, M | 1 |
| MARTUCCI, E | 1 |
| ZIMBALATTI, F | 1 |
| Coughlan, MT | 1 |
| Permezel, M | 1 |
| Georgiou, HM | 1 |
| Rice, GE | 1 |
| De Assis, MC | 1 |
| Saliba, AM | 1 |
| Vidipó, LA | 1 |
| De Salles, JB | 1 |
| Plotkowski, MC | 1 |
| Al Ghafli, MH | 1 |
| Padmanabhan, R | 1 |
| Kataya, HH | 1 |
| Berg, B | 1 |
| Savvov, VI | 1 |
| Karpov, LM | 1 |
| Maitra, I | 1 |
| Serbinova, E | 1 |
| Tritschler, HJ | 1 |
| Packer, L | 1 |
| Arnér, ES | 1 |
| Nordberg, J | 1 |
| Holmgren, A | 1 |
| Schleicher, ED | 1 |
| Wagner, E | 1 |
| Nerlich, AG | 1 |
| Prasad, PD | 1 |
| Ramamoorthy, S | 1 |
| Leibach, FH | 1 |
| Ganapathy, V | 1 |
| Wiznitzer, A | 1 |
| Ayalon, N | 1 |
| Hershkovitz, R | 1 |
| Khamaisi, M | 1 |
| Reece, EA | 1 |
| Trischler, H | 1 |
| Bashan, N | 1 |
| van Haaften, RI | 1 |
| den Hartog, GJ | 1 |
| Evelo, CT | 1 |
| Haenen, GR | 1 |
| Bast, A | 1 |
| Carreau, JP | 2 |
| Tanaka, I | 1 |
| Lapous, D | 1 |
| Raulin, J | 1 |
| Burlev, VA | 1 |
| Mamedalieva, NM | 1 |
| Sidel'nikova, VM | 1 |
| Znamenácek, K | 1 |
| Pribylová, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Repeated Antioxidant Supplementation of Embryo Culture Media on Blastocyst Utilization and Expansion Rate Under Two Different O2 Concentrations[NCT05919186] | 293 participants (Actual) | Interventional | 2021-10-12 | Completed | |||
| Celiac Disease Genomic Environmental Microbiome and Metabolomic (CDGEMM) Study[NCT02061306] | 500 participants (Anticipated) | Observational | 2014-03-31 | Recruiting | |||
| Vaginal Administration of Alpha Lipoic Acid vs Progesterone for the Subchorionic Hematoma Treatment[NCT02601898] | Phase 4 | 54 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| [NCT03023514] | Phase 4 | 172 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| The Effect of Concomitant Co Enzyme Q10 Use on Pregnancy Outcome of IVF[NCT01048385] | 34 participants (Actual) | Interventional | 2009-12-31 | Terminated (stopped due to A new study had shown that polar body biopsies might negatively effect the implantation potential of the embryo.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for thioctic acid and Pregnancy
| Article | Year |
|---|---|
Mechanism of Human Fetal Membrane Biomechanical Weakening, Rupture and Potential Targets for Therapeutic Intervention.
Topics: Extraembryonic Membranes; Female; Fetal Membranes, Premature Rupture; Granulocyte-Macrophage Colony- | 2020 |
Alpha lipoic acid in obstetrics and gynecology.
Topics: Abortion, Threatened; Antioxidants; Dietary Supplements; Female; Gynecology; Humans; Obstetrics; Oxi | 2018 |
Peripheral neuropathy in obstetrics: efficacy and safety of α-lipoic acid supplementation.
Topics: Animals; Antioxidants; Dietary Supplements; Female; Humans; Neuralgia; Obstetrics; Peripheral Nervou | 2014 |
[Use of alpha-lipoic acid and omega-3 in postpartum pain treatment].
Topics: Anti-Inflammatory Agents; Dietary Supplements; Fatty Acids, Omega-3; Female; Humans; Pain; Postpartu | 2015 |
Immunomodulatory activities of alpha lipoic acid with a special focus on its efficacy in preventing miscarriage.
Topics: Abortion, Spontaneous; Anti-Inflammatory Agents; Antioxidants; Female; Humans; Mitochondria; Oxidati | 2016 |
12 trials available for thioctic acid and Pregnancy
| Article | Year |
|---|---|
[Efficacy of Jujing Decoction combined with lipoic acid in the treatment of asthenospermia and teratospermia].
Topics: Asthenozoospermia; Drugs, Chinese Herbal; Female; Humans; Male; Pregnancy; Semen; Sperm Count; Sperm | 2022 |
[Double-blind, randomized placebo-controlled study of efficiency and safety of complex acetyl-L-carnitine, L-carnitine fumarate and alpha-lipoic acid (Spermactin Forte) for treatment of male infertility].
Topics: Acetylcarnitine; Adult; Carnitine; Double-Blind Method; Female; Fumarates; Humans; Infertility, Male | 2019 |
Prospective randomized multicentre comparison on sibling oocytes comparing G-Series media system with antioxidants versus standard G-Series media system.
Topics: Acetylcarnitine; Acetylcysteine; Adult; Antioxidants; Culture Media; Embryo Culture Techniques; Embr | 2020 |
Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study.
Topics: Acetylcysteine; Adult; Antioxidants; Bromelains; Drug Combinations; Endometriosis; Female; Humans; P | 2018 |
Elevation of the adiponectin/leptin ratio in women with gestational diabetes mellitus after supplementation with alpha-lipoic acid.
Topics: Adiponectin; Adult; Antioxidants; Blood Glucose; Diabetes, Gestational; Dietary Supplements; Double- | 2019 |
Reduction in maternal serum values of glucose and gamma-glutamyltransferase after supplementation with alpha-lipoic acid in women with gestational diabetes mellitus.
Topics: Adult; Antioxidants; Blood Glucose; Diabetes, Gestational; Double-Blind Method; Female; gamma-Glutam | 2019 |
The effect of alpha lipoic acid on uterine wound healing after primary cesarean section: a triple-blind placebo-controlled parallel-group randomized clinical trial.
Topics: Adolescent; Adult; Cesarean Section; Female; Humans; Pregnancy; Thioctic Acid; Uterine Diseases; Wou | 2019 |
Alpha Lipoic Acid (ALA) effects on subchorionic hematoma: preliminary clinical results.
Topics: Abortion, Threatened; Adult; Chorion; Female; Hematoma; Humans; Pregnancy; Pregnancy Complications; | 2015 |
Resolution of subchorionic hematoma and symptoms of threatened miscarriage using vaginal alpha lipoic acid or progesterone: clinical evidences.
Topics: Abortion, Spontaneous; Abortion, Threatened; Female; Hematoma; Humans; Pregnancy; Progesterone; Thio | 2016 |
Vaginal alpha-lipoic acid shows an anti-inflammatory effect on the cervix, preventing its shortening after primary tocolysis. A pilot, randomized, placebo-controlled study.
Topics: Administration, Intravaginal; Anti-Inflammatory Agents; Cervical Length Measurement; Cervix Uteri; E | 2017 |
Effect of combined acetylmethionine, cyanocobalamin and α-lipoic acid on hepatic metabolism in high-yielding dairy cow.
Topics: 3-Hydroxybutyric Acid; Acetylation; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bili | 2016 |
Effects of alpha-lipoic acid supplementation on antioxidative ability and performance of sows and nursing piglets.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Animals, Suckling; Antioxidants; D | 2012 |
51 other studies available for thioctic acid and Pregnancy
| Article | Year |
|---|---|
Alpha lipoic acid ameliorates detrimental effects of maternal lipopolysaccharides exposure on prefrontal white matter in adult male offspring rats.
Topics: Animals; Cell Count; Female; Lipopolysaccharides; Male; Maternal Exposure; Neurons; Prefrontal Corte | 2021 |
Receptivity, autophagy, and implantation in endometriosis; does antioxidant work? An experimental study.
Topics: Animals; Antioxidants; Autophagy; Beclin-1; Endometriosis; Endometrium; Female; Humans; Infertility; | 2022 |
Oral supplementation of α-lipoic acid (ALA), magnesium, vitamin B6 and vitamin D stabilizes cervical changes in women presenting risk factors for preterm birth.
Topics: Cervical Length Measurement; Cervix Uteri; Dietary Supplements; Female; Humans; Infant, Newborn; Mag | 2022 |
Oral supplementation of α-lipoic acid (ALA), magnesium, vitamin B6 and vitamin D stabilizes cervical changes in women presenting risk factors for preterm birth.
Topics: Cervical Length Measurement; Cervix Uteri; Dietary Supplements; Female; Humans; Infant, Newborn; Mag | 2022 |
Oral supplementation of α-lipoic acid (ALA), magnesium, vitamin B6 and vitamin D stabilizes cervical changes in women presenting risk factors for preterm birth.
Topics: Cervical Length Measurement; Cervix Uteri; Dietary Supplements; Female; Humans; Infant, Newborn; Mag | 2022 |
Oral supplementation of α-lipoic acid (ALA), magnesium, vitamin B6 and vitamin D stabilizes cervical changes in women presenting risk factors for preterm birth.
Topics: Cervical Length Measurement; Cervix Uteri; Dietary Supplements; Female; Humans; Infant, Newborn; Mag | 2022 |
α-Lipoic acid eliminates dioxin-induced offspring sexual immaturity by improving abnormalities in folic acid metabolism.
Topics: Animals; Female; Fetus; Folic Acid; Hypothalamus; Male; Maternal Exposure; Polychlorinated Dibenzodi | 2023 |
Granulocyte macrophage colony stimulating factor (GM-CSF), the critical intermediate of inflammation-induced fetal membrane weakening, primarily exerts its weakening effect on the choriodecidua rather than the amnion.
Topics: Amnion; Chorion; Culture Media, Conditioned; Female; Fetal Membranes, Premature Rupture; Granulocyte | 2020 |
The attenuation of the toxic effects of LPS on mouse pre-implantation development by alpha-lipoic acid.
Topics: Animals; Blastocyst; Embryo Culture Techniques; Embryonic Development; Female; Lipopolysaccharides; | 2020 |
Effect of d-chiro-inositol and alpha-lipoic acid combination on COH outcomes in overweight/obese PCOS women.
Topics: Adult; Drug Therapy, Combination; Female; Fertility Agents, Female; Fertilization in Vitro; Gonadotr | 2020 |
Fulminant type 1 diabetes mellitus in pregnancy.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Glycated Hemoglobin; Humans; Incidence; Inf | 2020 |
α-Lipoic acid blocks the GMCSF induced protease/protease inhibitor spectrum associated with fetal membrane weakening in-vitro.
Topics: Cystatins; Extraembryonic Membranes; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Human | 2020 |
Chronic Maternal Tobacco Smoke Exposure and/or Alpha-Lipoic Acid Treatment Causes Long-Term Deterioration of Testis and Sexual Behavior in Adult Male Rats.
Topics: Animals; Female; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Sexual Maturation; Testis | 2020 |
Multi-omics analysis reveals the influence of genetic and environmental risk factors on developing gut microbiota in infants at risk of celiac disease.
Topics: Bacteroides; Celiac Disease; Cesarean Section; Cross-Sectional Studies; Environment; Female; Gastroi | 2020 |
Maternal intake of alpha-lipoic acid prevents development of symptoms associated with a fructose-rich diet in the male offspring in Wistar rats.
Topics: Animals; Diet; Disease Models, Animal; Female; Fructose; Maternal Exposure; Pregnancy; Prenatal Expo | 2021 |
In-vitro activity of lipoic acid against Ureaplasma urealyticum and Ureaplasma parvum isolated from women with infections of the urogenital tract. A pilot study.
Topics: Adult; Anti-Bacterial Agents; Female; Humans; Microbial Sensitivity Tests; Pregnancy; Thioctic Acid; | 2020 |
Effects of α-lipoic acid and myo-inositol supplementation on the oocyte environment of infertile obese women: A preliminary study.
Topics: Adult; Anti-Inflammatory Agents; Antioxidants; Dietary Supplements; DNA, Mitochondrial; Female; Fert | 2020 |
Safety of oral alpha-lipoic acid treatment in pregnant women: a retrospective observational study.
Topics: Abortion, Spontaneous; Administration, Oral; Adolescent; Adult; Antioxidants; Apgar Score; Birth Wei | 2017 |
α-Lipoic Acid Vaginal Administration Contrasts Inflammation and Preterm Delivery in Rats.
Topics: Administration, Intravaginal; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cervix Uteri; Embryo | 2019 |
[Efficacy of alpha-lipoic acid combined with tamoxifen citrate in the treatment of oligoasthenospermia].
Topics: Antioxidants; Asthenozoospermia; Biomarkers; Carnitine; Drug Therapy, Combination; Female; Humans; M | 2017 |
Lycopene and alpha-lipoic acid improve semen antioxidant enzymes activity and cashmere goat sperm function after cryopreservation.
Topics: Animals; Antioxidants; China; Cryopreservation; Female; Goats; Lycopene; Male; Pregnancy; Pregnancy | 2018 |
Combined treatment with myo-inositol, alpha-lipoic acid, folic acid and vitamins significantly improves sperm parameters of sub-fertile men: a multi-centric study.
Topics: Adult; Female; Folic Acid; Humans; Infertility, Male; Inositol; Male; Middle Aged; Pregnancy; Reacti | 2018 |
Ameliorating effect of postweaning exposure to antioxidant on disruption of hippocampal neurogenesis induced by developmental hypothyroidism in rats.
Topics: Animals; Antioxidants; Apoptosis; Doublecortin Protein; Female; Gene Expression Regulation, Developm | 2019 |
Effect of alpha-lipoic acid and myoinositol on endometrial inflammasome from recurrent pregnancy loss women.
Topics: Abortion, Habitual; Biopsy; Caspase 1; Cells, Cultured; Down-Regulation; Endometrium; Enzyme-Linked | 2019 |
Preventive effect of α-lipoic acid on prepulse inhibition deficits in a juvenile two-hit model of schizophrenia.
Topics: Aging; Animals; Disease Models, Animal; Female; Male; Mice, Inbred C57BL; Prefrontal Cortex; Pregnan | 2014 |
Centella asiatica and lipoic acid, or a combination thereof, inhibit monocyte adhesion to endothelial cells from umbilical cords of gestational diabetic women.
Topics: Adult; Antioxidants; Cell Adhesion; Cell Adhesion Molecules; Centella; Diabetes, Gestational; Endoth | 2015 |
Effect of alpha-lipoic acid on boar spermatozoa quality during freezing-thawing.
Topics: Animals; Aspartate Aminotransferases; Catalase; Cryopreservation; Cryoprotective Agents; Dose-Respon | 2016 |
α-Lipoic acid attenuates transplacental nicotine-induced germ cell and oxidative DNA damage in adult mice.
Topics: Age Factors; Animals; DNA Damage; Female; Germ Cells; Male; Maternal-Fetal Exchange; Mice; Nicotine; | 2016 |
Effects of Lipoic Acid Supplementation on Activities of Cyclooxygenases and Levels of Prostaglandins E
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dinoprost; Dinoprostone; Disea | 2016 |
α-Lipoic acid potentially targets AMP-activated protein kinase and energy production in the fetal brain to ameliorate dioxin-produced attenuation in fetal steroidogenesis.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Brain; Female; Fetus; Gonadotropin-R | 2017 |
Alpha-lipoic acid inhibits tumor necrosis factor-induced remodeling and weakening of human fetal membranes.
Topics: Amnion; Cells, Cultured; Dinoprostone; Drug Evaluation, Preclinical; Epithelial Cells; Extraembryoni | 2009 |
Alpha-lipoic acid reduces congenital malformations in the offspring of diabetic mice.
Topics: Animals; Blood Glucose; Cardiovascular Abnormalities; Congenital Abnormalities; Diabetes Mellitus, E | 2009 |
The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients.
Topics: Age Factors; Aging; Animals; Dietary Supplements; DNA, Mitochondrial; Energy Metabolism; Female; Hum | 2010 |
The role of zinc in the modulation of neuronal proliferation and apoptosis.
Topics: Analysis of Variance; Animals; Antioxidants; Apoptosis; Caspase 3; Cell Cycle; Cell Proliferation; C | 2010 |
Alpha-lipoic acid inhibits thrombin-induced fetal membrane weakening in vitro.
Topics: Blotting, Western; Dose-Response Relationship, Drug; Extraembryonic Membranes; Female; Fetal Membran | 2010 |
The effects of thrombin and cytokines upon the biomechanics and remodeling of isolated amnion membrane, in vitro.
Topics: Acid Phosphatase; Amnion; Apoptosis; Biomechanical Phenomena; Blotting, Western; Densitometry; Femal | 2011 |
Dihydrolipoic acid induces cytotoxicity in mouse blastocysts through apoptosis processes.
Topics: Animals; Apoptosis; Blastocyst; Cell Proliferation; Embryo Implantation; Embryo Transfer; Embryonic | 2012 |
[The effect of thioctic acid on hyperpyruvemia in pregnancy].
Topics: Pregnancy; Pyruvates; Thioctic Acid; Vitamin A; Vitamin K; Vitamins | 1957 |
[Contribution to the therapy of the pathological jaundice in the newborn].
Topics: Erythroblastosis, Fetal; Female; Fetal Therapies; Hematologic Diseases; Jaundice; Prednisolone; Preg | 1960 |
Repression of oxidant-induced nuclear factor-kappaB activity mediates placental cytokine responses in gestational diabetes.
Topics: Adult; Antioxidants; Case-Control Studies; Cytokines; Diabetes, Gestational; DNA; Female; Humans; Hy | 2004 |
Pseudomonas aeruginosa-induced production of free radicals by IFNgamma plus TNFalpha-activated human endothelial cells: mechanism of host defense or of bacterial pathogenesis?
Topics: Endothelial Cells; Endothelium, Vascular; Female; Humans; Interferon-gamma; Lipid Peroxidation; Memb | 2004 |
Effects of alpha-lipoic acid supplementation on maternal diabetes-induced growth retardation and congenital anomalies in rat fetuses.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Bone Development; Diabetes Mellitus, Experimental | 2004 |
[Characteristics of 35S-lipoic acid absorption by the blood cells in breast cancer].
Topics: Absorption; Acute Disease; Adenocarcinoma, Scirrhous; Adenofibroma; Breast Neoplasms; Erythrocytes; | 1982 |
Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats.
Topics: Animals; Animals, Newborn; Ascorbic Acid; Buthionine Sulfoximine; Cataract; Female; Glutathione; Glu | 1996 |
Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase.
Topics: Animals; Cattle; Chromatography, Ion Exchange; Female; Humans; Kinetics; Liver; Mammals; Oxidation-R | 1996 |
Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.
Topics: Adult; Aged; Aging; Antibodies; Arteries; Arteriosclerosis; Biomarkers; Blood Proteins; Catalase; Ch | 1997 |
Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells.
Topics: Anions; Biological Transport; Biotin; Carrier Proteins; Cations, Monovalent; Choriocarcinoma; Female | 1997 |
Lipoic acid prevention of neural tube defects in offspring of rats with streptozocin-induced diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Neural Tube Defects; Placenta; Pregnancy; Pregnanc | 1999 |
Hypochlorous acid is a potent inhibitor of GST P1-1.
Topics: Dose-Response Relationship, Drug; Drug Antagonism; Enzyme Inhibitors; Erythrocytes; Female; Glutathi | 2001 |
Biosynthesis of lipoic acid via unsaturated fatty acids.
Topics: Animals; Carbon Radioisotopes; Chromatography, Gas; Chromatography, Thin Layer; Female; Isotope Labe | 1979 |
[Arsenic metabolism. (17) Studies of placental transfer of arsenic and the effects of antidotes and diet].
Topics: Animals; Antidotes; Arsenic; Ascorbic Acid; Diet; Dimercaprol; Female; Fetus; Male; Maternal-Fetal E | 1976 |
[A possible essential metabolite of linoleic acid: lipoic acid, the universal coenzyme of alpha-keto acid oxidation].
Topics: Animals; Female; Linoleic Acids; Liver; Multienzyme Complexes; Pregnancy; Rats; Thioctic Acid | 1975 |
[Acid-base equilibrium and blood gases in pregnant women with habitual abortion after metabolic therapy].
Topics: Abortion, Habitual; Acid-Base Equilibrium; Acidosis; Adult; Carbon Dioxide; Drug Combinations; Drug | 1992 |
[Adenosine triphosphoric acid in the treatment of newborn infants of diabetic mothers].
Topics: Adenosine Triphosphate; Asphyxia Neonatorum; Female; Humans; Infant, Newborn; Infant, Newborn, Disea | 1966 |