thioctic acid has been researched along with Polyneuropathy, Acquired in 12 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Its efficacy in neuropathic pain in diabetes mellitus still lacks enough research." | 3.11 | The 8-Week Efficacy of Frequency Rhythmic Electrical Modulated System (FREMS) as an Add-on Therapy in the Treatment of Symptomatic Diabetic Peripheral Polyneuropathy. ( Dziemidok, P; Gorczyca-Siudak, D, 2022) |
| "Polyneuropathies were specified as toxic/metabolic with the prevalence of a demyelinating component within the main disease in 18 (67%) patients." | 1.38 | [Demyelinating polyneuropathies in patients with diabetes mellitus and chronic alcoholic intoxication]. ( Kovrazhkina, EA, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Esin, RG | 1 |
| Khairullin, IK | 1 |
| Esin, OR | 1 |
| Gorczyca-Siudak, D | 1 |
| Dziemidok, P | 1 |
| Piddubna, OO | 1 |
| Lytvynenko, NV | 1 |
| Krivchun, AM | 1 |
| Taryanyk, KA | 1 |
| Akhmedzhanova, LT | 1 |
| Barinov, AN | 1 |
| Garcia-Alcala, H | 1 |
| Santos Vichido, CI | 1 |
| Islas Macedo, S | 1 |
| Genestier-Tamborero, CN | 1 |
| Minutti-Palacios, M | 1 |
| Hirales Tamez, O | 1 |
| García, C | 1 |
| Ziegler, D | 2 |
| Kempler, P | 1 |
| Artamonova, VG | 1 |
| Lashina, EL | 1 |
| Kovrazhkina, EA | 1 |
| Gedlicka, C | 1 |
| Kornek, GV | 1 |
| Schmid, K | 1 |
| Scheithauer, W | 1 |
| Braune, S | 1 |
| Láhoda, F | 1 |
| Reljanovic, M | 1 |
| Mehnert, H | 1 |
| Gries, FA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment With Alpha-lipoic Acid Over 16 Weeks in Type 2 Diabetic Patients With Symptomatic Polyneuropathy Who Responded to Initial 4-week High-dose Loading[NCT02439879] | Phase 4 | 45 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total symptoms score is a summation of presence, severity, and duration of the four main positive neuropathic sensory symptoms: lancinating/stabbing pain, burning pain, paresthesia, and asleep numbness (NCT02439879)
Timeframe: 20 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Alpha Lipoic Acid Treatment | 2.5 |
| Alpha Lipoic Acid Withdrawal | 3.1 |
3 reviews available for thioctic acid and Polyneuropathy, Acquired
| Article | Year |
|---|---|
[Polyneuropathy in elderly patients].
Topics: Aged; Anticonvulsants; Humans; Middle Aged; Polyneuropathies; Thioctic Acid; Vitamin B Complex | 2015 |
[Evidence-based pharmacotherapy of neuropathic pain syndromes].
Topics: Amines; Analgesics; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Antioxidants; Cyclohexanec | 2004 |
Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials.
Topics: Clinical Trials as Topic; Diabetic Neuropathies; Germany; Humans; Polyneuropathies; Protein Isoforms | 1999 |
4 trials available for thioctic acid and Polyneuropathy, Acquired
| Article | Year |
|---|---|
The 8-Week Efficacy of Frequency Rhythmic Electrical Modulated System (FREMS) as an Add-on Therapy in the Treatment of Symptomatic Diabetic Peripheral Polyneuropathy.
Topics: Diabetes Mellitus; Diabetic Neuropathies; Humans; Neuralgia; Polyneuropathies; Quality of Life; Sing | 2022 |
Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading.
Topics: Administration, Oral; Adolescent; Adult; Analgesics; Antioxidants; Diabetes Mellitus, Type 2; Diabet | 2015 |
[Tiolepta (thioctic acid) in the treatment of vibration disease].
Topics: Adult; Combined Modality Therapy; Female; Hand-Arm Vibration Syndrome; Humans; Male; Middle Aged; Po | 2011 |
Amelioration of docetaxel/cisplatin induced polyneuropathy by alpha-lipoic acid.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Cisplatin; Docetaxel; Fem | 2003 |
5 other studies available for thioctic acid and Polyneuropathy, Acquired
| Article | Year |
|---|---|
[Diabetic encephalopathy: current insights and potential therapeutic strategies].
Topics: Antioxidants; Brain Diseases; Diabetes Mellitus; Diabetic Neuropathies; Humans; Polyneuropathies; Th | 2021 |
THE EFFECT OF α-LIPOIC ACID ON THE FUNCTIONAL STATE OF PERIPHERAL NERVE FIBERS IN POLYNEUROPATHY OF THE LOWER EXTREMITIES IN PATIENTS WITH CHRONIC HEMOBLASTOSIS.
Topics: Electromyography; Humans; Lower Extremity; Nerve Fibers; Polyneuropathies; Thioctic Acid | 2020 |
[Treatment of neuropathies].
Topics: Adjuvants, Immunologic; Adrenergic Uptake Inhibitors; Amines; Analgesics; Antioxidants; Capsaicin; C | 2010 |
[Demyelinating polyneuropathies in patients with diabetes mellitus and chronic alcoholic intoxication].
Topics: Acute Disease; Alcoholism; Antioxidants; Diabetic Nephropathies; Electromyography; Humans; Polyneuro | 2012 |
[Therapeutic possibilities in polyneuropathies].
Topics: Adult; Aged; Diabetic Neuropathies; Humans; Methionine; Middle Aged; Nervous System Diseases; Neurit | 1982 |