thioctic acid has been researched along with Polyneuropathies in 12 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Polyneuropathies: Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Its efficacy in neuropathic pain in diabetes mellitus still lacks enough research." | 3.11 | The 8-Week Efficacy of Frequency Rhythmic Electrical Modulated System (FREMS) as an Add-on Therapy in the Treatment of Symptomatic Diabetic Peripheral Polyneuropathy. ( Dziemidok, P; Gorczyca-Siudak, D, 2022) |
| "Polyneuropathies were specified as toxic/metabolic with the prevalence of a demyelinating component within the main disease in 18 (67%) patients." | 1.38 | [Demyelinating polyneuropathies in patients with diabetes mellitus and chronic alcoholic intoxication]. ( Kovrazhkina, EA, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Esin, RG | 1 |
| Khairullin, IK | 1 |
| Esin, OR | 1 |
| Gorczyca-Siudak, D | 1 |
| Dziemidok, P | 1 |
| Piddubna, OO | 1 |
| Lytvynenko, NV | 1 |
| Krivchun, AM | 1 |
| Taryanyk, KA | 1 |
| Akhmedzhanova, LT | 1 |
| Barinov, AN | 1 |
| Garcia-Alcala, H | 1 |
| Santos Vichido, CI | 1 |
| Islas Macedo, S | 1 |
| Genestier-Tamborero, CN | 1 |
| Minutti-Palacios, M | 1 |
| Hirales Tamez, O | 1 |
| García, C | 1 |
| Ziegler, D | 2 |
| Kempler, P | 1 |
| Artamonova, VG | 1 |
| Lashina, EL | 1 |
| Kovrazhkina, EA | 1 |
| Gedlicka, C | 1 |
| Kornek, GV | 1 |
| Schmid, K | 1 |
| Scheithauer, W | 1 |
| Braune, S | 1 |
| Láhoda, F | 1 |
| Reljanovic, M | 1 |
| Mehnert, H | 1 |
| Gries, FA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment With Alpha-lipoic Acid Over 16 Weeks in Type 2 Diabetic Patients With Symptomatic Polyneuropathy Who Responded to Initial 4-week High-dose Loading[NCT02439879] | Phase 4 | 45 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total symptoms score is a summation of presence, severity, and duration of the four main positive neuropathic sensory symptoms: lancinating/stabbing pain, burning pain, paresthesia, and asleep numbness (NCT02439879)
Timeframe: 20 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Alpha Lipoic Acid Treatment | 2.5 |
| Alpha Lipoic Acid Withdrawal | 3.1 |
3 reviews available for thioctic acid and Polyneuropathies
| Article | Year |
|---|---|
[Polyneuropathy in elderly patients].
Topics: Aged; Anticonvulsants; Humans; Middle Aged; Polyneuropathies; Thioctic Acid; Vitamin B Complex | 2015 |
[Evidence-based pharmacotherapy of neuropathic pain syndromes].
Topics: Amines; Analgesics; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Antioxidants; Cyclohexanec | 2004 |
Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials.
Topics: Clinical Trials as Topic; Diabetic Neuropathies; Germany; Humans; Polyneuropathies; Protein Isoforms | 1999 |
4 trials available for thioctic acid and Polyneuropathies
| Article | Year |
|---|---|
The 8-Week Efficacy of Frequency Rhythmic Electrical Modulated System (FREMS) as an Add-on Therapy in the Treatment of Symptomatic Diabetic Peripheral Polyneuropathy.
Topics: Diabetes Mellitus; Diabetic Neuropathies; Humans; Neuralgia; Polyneuropathies; Quality of Life; Sing | 2022 |
Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading.
Topics: Administration, Oral; Adolescent; Adult; Analgesics; Antioxidants; Diabetes Mellitus, Type 2; Diabet | 2015 |
[Tiolepta (thioctic acid) in the treatment of vibration disease].
Topics: Adult; Combined Modality Therapy; Female; Hand-Arm Vibration Syndrome; Humans; Male; Middle Aged; Po | 2011 |
Amelioration of docetaxel/cisplatin induced polyneuropathy by alpha-lipoic acid.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Cisplatin; Docetaxel; Fem | 2003 |
5 other studies available for thioctic acid and Polyneuropathies
| Article | Year |
|---|---|
[Diabetic encephalopathy: current insights and potential therapeutic strategies].
Topics: Antioxidants; Brain Diseases; Diabetes Mellitus; Diabetic Neuropathies; Humans; Polyneuropathies; Th | 2021 |
THE EFFECT OF α-LIPOIC ACID ON THE FUNCTIONAL STATE OF PERIPHERAL NERVE FIBERS IN POLYNEUROPATHY OF THE LOWER EXTREMITIES IN PATIENTS WITH CHRONIC HEMOBLASTOSIS.
Topics: Electromyography; Humans; Lower Extremity; Nerve Fibers; Polyneuropathies; Thioctic Acid | 2020 |
[Treatment of neuropathies].
Topics: Adjuvants, Immunologic; Adrenergic Uptake Inhibitors; Amines; Analgesics; Antioxidants; Capsaicin; C | 2010 |
[Demyelinating polyneuropathies in patients with diabetes mellitus and chronic alcoholic intoxication].
Topics: Acute Disease; Alcoholism; Antioxidants; Diabetic Nephropathies; Electromyography; Humans; Polyneuro | 2012 |
[Therapeutic possibilities in polyneuropathies].
Topics: Adult; Aged; Diabetic Neuropathies; Humans; Methionine; Middle Aged; Nervous System Diseases; Neurit | 1982 |