thioctic acid has been researched along with Phenylketonurias in 3 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Phenylketonurias: A group of autosomal recessive disorders marked by a deficiency of the hepatic enzyme PHENYLALANINE HYDROXYLASE or less frequently by reduced activity of DIHYDROPTERIDINE REDUCTASE (i.e., atypical phenylketonuria). Classical phenylketonuria is caused by a severe deficiency of phenylalanine hydroxylase and presents in infancy with developmental delay; SEIZURES; skin HYPOPIGMENTATION; ECZEMA; and demyelination in the central nervous system. (From Adams et al., Principles of Neurology, 6th ed, p952).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Lipoic acid (LA) is considered a potent antioxidant which is well absorbed from diet and can easily cross the blood-brain barrier." | 1.36 | Lipoic acid prevents oxidative stress in vitro and in vivo by an acute hyperphenylalaninemia chemically-induced in rat brain. ( Coelho, J; da Rosa, A; de Oliveira, A; Dutra-Filho, CS; Moraes, TB; Petrillo, F; Wajner, M; Zanin, F, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moraes, TB | 3 |
| Dalazen, GR | 2 |
| Jacques, CE | 2 |
| de Freitas, RS | 1 |
| Rosa, AP | 2 |
| Dutra-Filho, CS | 3 |
| Zanin, F | 1 |
| da Rosa, A | 1 |
| de Oliveira, A | 1 |
| Coelho, J | 1 |
| Petrillo, F | 1 |
| Wajner, M | 1 |
| Terra, M | 1 |
| Coelho, JG | 1 |
3 other studies available for thioctic acid and Phenylketonurias
| Article | Year |
|---|---|
Glutathione metabolism enzymes in brain and liver of hyperphenylalaninemic rats and the effect of lipoic acid treatment.
Topics: Animals; Brain; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; | 2014 |
Lipoic acid prevents oxidative stress in vitro and in vivo by an acute hyperphenylalaninemia chemically-induced in rat brain.
Topics: Analysis of Variance; Animals; Antioxidants; Brain; Catalase; Glucosephosphate Dehydrogenase; Glutat | 2010 |
Role of catalase and superoxide dismutase activities on oxidative stress in the brain of a phenylketonuria animal model and the effect of lipoic acid.
Topics: Animals; Brain; Catalase; Disease Models, Animal; DNA Damage; Enzyme Inhibitors; Female; Lipid Perox | 2013 |