thioctic acid has been researched along with Peripheral Nerve Diseases in 31 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This randomized double-blind placebo-controlled prospective study included 64 patients with breast cancer who were randomized into control group (n = 32) which received 4 cycles of doxorubicin plus cyclophosphamide (every 21 days) followed by weekly doses of paclitaxel for 12 weeks plus placebo tablets once daily and ALA group (n = 32) which received the same chemotherapeutic regimen plus ALA 600 once daily for 6 months." | 9.51 | Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients. ( Elshafiey, RA; Elzawawy, S; Ghoneim, A; Mostafa, TM; Werida, RH, 2022) |
| " After 15 days, rats were investigated for the presence of mechanical and cold allodynia, and those with allodynia received intraperitoneal injection with normal saline or 1, 5, or 10 mg/kg thioctic acid." | 7.81 | The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model. ( Chung, EY; Kahng, J; Kim, TK; Kim, YS; Moon, JY, 2015) |
| "To evaluate the efficacy of combination of alpha-lipoic acid and acetylcholinesterase inhibitor (ipidacrine hydrochloride) to prevent the development and improve the course of paclitaxel-induced peripheral neuropathy (PIPN) in patients with breast cancer according to the Total Neuropathy Score." | 5.51 | EVALUATION OF THE EFFICIENCY OF ALPHA-LIPOIC ACID AND IPIDACRINE HYDROCHLORIDE FOR THE PREVENTION OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY ACCORDING TO THE TOTAL NEUROPATHY SCORE. ( Holotiuk, IS; Holotiuk, SI; Holotiuk, VV; Kryzhanivska, AY; Maliborska, SV, 2022) |
| "This randomized double-blind placebo-controlled prospective study included 64 patients with breast cancer who were randomized into control group (n = 32) which received 4 cycles of doxorubicin plus cyclophosphamide (every 21 days) followed by weekly doses of paclitaxel for 12 weeks plus placebo tablets once daily and ALA group (n = 32) which received the same chemotherapeutic regimen plus ALA 600 once daily for 6 months." | 5.51 | Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients. ( Elshafiey, RA; Elzawawy, S; Ghoneim, A; Mostafa, TM; Werida, RH, 2022) |
| "To investigate the neurofunctional parameters in breast cancer (BC) patients with paclitaxel-induced peripheral neuropathy (PIPN) and to clarify the feasibility of using alpha-lipoic acid (ALA) in combination with the acetylcholinesterase inhibitor ipidacrine hydrochloride (IPD) for its prevention." | 5.51 | EFFECTIVENESS OF ALPHA-LIPOIC ACID AND IPIDACRINE HYDROCHLORIDE IN PREVENTION OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY ASSESSED BY ELECTRONEUROMYOGRAPHY OF SUPERFICIAL PERONEAL AND SURAL NERVES. ( Holotiuk, IS; Holotiuk, SI; Holotiuk, VV; Kryzhanivska, AY; Maliborska, SV, 2022) |
| "Thioctic acid is a naturally occurring antioxidant existing in two optical isomers (+)- and (-)-thioctic acid and in the racemic form." | 5.39 | Neuroprotective activity of thioctic acid in central nervous system lesions consequent to peripheral nerve injury. ( Amenta, F; Di Cesare Mannelli, L; Ghelardini, C; Nwankwo, IE; Pacini, A; Tayebati, SK; Tomassoni, D, 2013) |
| " After 15 days, rats were investigated for the presence of mechanical and cold allodynia, and those with allodynia received intraperitoneal injection with normal saline or 1, 5, or 10 mg/kg thioctic acid." | 3.81 | The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model. ( Chung, EY; Kahng, J; Kim, TK; Kim, YS; Moon, JY, 2015) |
| " High attrition rates due to poor patient compliance and manner of dosage administration in this trial demonstrated a lack of feasibility for this intervention." | 2.79 | Oral alpha-lipoic acid to prevent chemotherapy-induced peripheral neuropathy: a randomized, double-blind, placebo-controlled trial. ( Dakhil, SR; Eng, C; Fisch, MJ; Forman, A; Gilman, P; Guo, Y; Jones, D; Mills, GM; Noga, SJ; Overman, MJ; Palmer, JL; Velasco, MR; Weiss, M, 2014) |
| " The incidence rates of adverse effects were 25." | 2.75 | [Efficacy and safety of high-dose α-lipoic acid in the treatment of diabetic polyneuropathy]. ( Chen, L; Gu, XM; Li, H; Liu, C; Lu, ZQ; Ning, G; Tang, ZY; Wu, JC; Zhang, SS, 2010) |
| "The objective of this study was to determine the impact of prolonged gastric emptying in patients with insulin dependent diabetes mellitus (IDDM) on the bioavailability of the R(+)- and S(-)-thioctic acid (TA) enantiomers." | 2.69 | Gastric emptying in patients with insulin dependent diabetes mellitus and bioavailability of thioctic acid-enantiomers. ( Gleiter, CH; Hermann, R; Niebch, G; Nowak, H; Ruus, P; Wildgrube, HJ, 1998) |
| "Thioctic acid is a naturally occurring antioxidant existing in two optical isomers (+)- and (-)-thioctic acid and in the racemic form." | 1.39 | Neuroprotective activity of thioctic acid in central nervous system lesions consequent to peripheral nerve injury. ( Amenta, F; Di Cesare Mannelli, L; Ghelardini, C; Nwankwo, IE; Pacini, A; Tayebati, SK; Tomassoni, D, 2013) |
| "The study investigates if alpha-lipoic acid is neuroprotective against chemotherapy induced neurotoxicity, if mitochondrial damage plays a critical role in toxic neurodegenerative cascade, and if neuroprotective effects of alpha-lipoic acid depend on mitochondria protection." | 1.35 | Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy. ( Camozzi, F; Lauria, G; Melli, G; Podini, P; Quattrini, A; Taiana, M; Taroni, F; Triolo, D, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.23) | 18.7374 |
| 1990's | 2 (6.45) | 18.2507 |
| 2000's | 4 (12.90) | 29.6817 |
| 2010's | 21 (67.74) | 24.3611 |
| 2020's | 3 (9.68) | 2.80 |
| Authors | Studies |
|---|---|
| Holotiuk, IS | 2 |
| Kryzhanivska, AY | 2 |
| Holotiuk, SI | 2 |
| Maliborska, SV | 2 |
| Holotiuk, VV | 2 |
| Werida, RH | 1 |
| Elshafiey, RA | 1 |
| Ghoneim, A | 1 |
| Elzawawy, S | 1 |
| Mostafa, TM | 1 |
| Lee, KA | 1 |
| Lee, NY | 1 |
| Park, TS | 1 |
| Jin, HY | 1 |
| Dinicola, S | 1 |
| Fuso, A | 1 |
| Cucina, A | 1 |
| Santiago-Reyes, M | 1 |
| Verna, R | 1 |
| Unfer, V | 2 |
| Monastra, G | 1 |
| Bizzarri, M | 1 |
| Maschio, M | 1 |
| Zarabla, A | 1 |
| Maialetti, A | 1 |
| Marchesi, F | 1 |
| Giannarelli, D | 1 |
| Gumenyuk, S | 1 |
| Pisani, F | 1 |
| Renzi, D | 1 |
| Galiè, E | 1 |
| Mengarelli, A | 1 |
| Rowin, J | 1 |
| Trevisan, G | 1 |
| Materazzi, S | 1 |
| Fusi, C | 1 |
| Altomare, A | 1 |
| Aldini, G | 1 |
| Lodovici, M | 1 |
| Patacchini, R | 1 |
| Geppetti, P | 1 |
| Nassini, R | 1 |
| Schloss, JM | 1 |
| Colosimo, M | 1 |
| Airey, C | 1 |
| Masci, PP | 1 |
| Linnane, AW | 1 |
| Vitetta, L | 1 |
| Xu, Q | 1 |
| Pan, J | 1 |
| Yu, J | 1 |
| Liu, X | 1 |
| Liu, L | 1 |
| Zuo, X | 1 |
| Wu, P | 1 |
| Deng, H | 1 |
| Zhang, J | 1 |
| Ji, A | 1 |
| Guo, Y | 1 |
| Jones, D | 1 |
| Palmer, JL | 1 |
| Forman, A | 1 |
| Dakhil, SR | 1 |
| Velasco, MR | 1 |
| Weiss, M | 1 |
| Gilman, P | 1 |
| Mills, GM | 1 |
| Noga, SJ | 1 |
| Eng, C | 1 |
| Overman, MJ | 1 |
| Fisch, MJ | 1 |
| Bhadri, N | 1 |
| Sanji, T | 1 |
| Madakasira Guggilla, H | 1 |
| Razdan, R | 1 |
| Tomassoni, D | 1 |
| Amenta, F | 1 |
| Di Cesare Mannelli, L | 1 |
| Ghelardini, C | 1 |
| Nwankwo, IE | 1 |
| Pacini, A | 1 |
| Tayebati, SK | 1 |
| He, F | 1 |
| Zhang, Y | 2 |
| Sun, L | 1 |
| He, S | 1 |
| Pan, YN | 1 |
| Zhang, ZY | 1 |
| Costantino, M | 1 |
| Guaraldi, C | 1 |
| Costantino, D | 1 |
| De Grazia, S | 1 |
| Kahng, J | 1 |
| Kim, TK | 1 |
| Chung, EY | 1 |
| Kim, YS | 1 |
| Moon, JY | 1 |
| Okanović, A | 1 |
| Prnjavorac, B | 1 |
| Jusufović, E | 1 |
| Sejdinović, R | 1 |
| Onysko, M | 1 |
| Legerski, P | 1 |
| Potthoff, J | 1 |
| Erlandson, M | 1 |
| Han, Y | 1 |
| Wang, M | 1 |
| Shen, J | 1 |
| Zhang, Z | 1 |
| Zhao, M | 1 |
| Huang, J | 1 |
| Chen, Y | 1 |
| Chen, Z | 1 |
| Hu, Y | 1 |
| Wang, Y | 1 |
| Desideri, I | 1 |
| Francolini, G | 1 |
| Becherini, C | 1 |
| Terziani, F | 1 |
| Delli Paoli, C | 1 |
| Olmetto, E | 1 |
| Loi, M | 1 |
| Perna, M | 1 |
| Meattini, I | 1 |
| Scotti, V | 1 |
| Greto, D | 1 |
| Bonomo, P | 1 |
| Sulprizio, S | 1 |
| Livi, L | 1 |
| Melli, G | 1 |
| Taiana, M | 1 |
| Camozzi, F | 1 |
| Triolo, D | 1 |
| Podini, P | 1 |
| Quattrini, A | 1 |
| Taroni, F | 1 |
| Lauria, G | 1 |
| Tuncer, S | 1 |
| Dalkilic, N | 1 |
| Akif Dunbar, M | 1 |
| Keles, B | 1 |
| Gu, XM | 1 |
| Zhang, SS | 1 |
| Wu, JC | 1 |
| Tang, ZY | 1 |
| Lu, ZQ | 1 |
| Li, H | 1 |
| Liu, C | 1 |
| Chen, L | 1 |
| Ning, G | 1 |
| Gerlinger, I | 1 |
| Braune, S | 1 |
| Hermann, R | 1 |
| Wildgrube, HJ | 1 |
| Ruus, P | 1 |
| Niebch, G | 1 |
| Nowak, H | 1 |
| Gleiter, CH | 1 |
| Liu, F | 1 |
| Yang, M | 1 |
| Liu, B | 1 |
| Shen, YD | 1 |
| Jia, WP | 1 |
| Xiang, KS | 1 |
| Láhoda, F | 1 |
| Reljanovic, M | 1 |
| Reichel, G | 1 |
| Rett, K | 1 |
| Lobisch, M | 1 |
| Schuette, K | 1 |
| Möller, W | 1 |
| Tritschler, HJ | 1 |
| Mehnert, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Alpha-Lipoic Acid Against Chemotherapy Induced Toxicities in Breast Cancer Patients[NCT03908528] | 64 participants (Actual) | Interventional | 2019-03-01 | Completed | |||
| Dose Finding and Tolerability Study of Alpha-lipoic Acid in Patients at Risk for Paclitaxel Induced Peripheral Neuropathy[NCT01313117] | Phase 1/Phase 2 | 9 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| The Effect of Alpha Lipoic Acid on the Incidence and Severity of Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients[NCT05023863] | Phase 2/Phase 3 | 70 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) Randomised, Double-blind,Placebo-controlled Multicentre Trial With 4 Parallel Groups[NCT00328601] | Phase 3 | 170 participants | Interventional | 2005-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01313117)
Timeframe: 4 months
| Intervention | participants (Number) |
|---|---|
| Alpha Lipoic Acid | 9 |
Based on acceptable adverse event (AE) profile and continual reassessment method dose escalation. (NCT01313117)
Timeframe: 4 months
| Intervention | mg (Number) |
|---|---|
| Alpha Lipoic Acid | 500 |
(NCT01313117)
Timeframe: 4 months
| Intervention | participants (Number) |
|---|---|
| Alpha Lipoic Acid | 7 |
8 reviews available for thioctic acid and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Natural products - alpha-lipoic acid and acetyl-L-carnitine - in the treatment of chemotherapy-induced peripheral neuropathy.
Topics: Acetylcarnitine; Animals; Antineoplastic Agents; Biological Products; Humans; Peripheral Nervous Sys | 2018 |
Integrative neuromuscular medicine: Neuropathy and neuropathic pain: Consider the alternatives.
Topics: Acetylcarnitine; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Diet; Diet Therapy; Dietary Supp | 2019 |
Nutraceuticals and chemotherapy induced peripheral neuropathy (CIPN): a systematic review.
Topics: Acetylcarnitine; Acetylcysteine; Antineoplastic Agents; Dietary Supplements; Fatty Acids, Omega-3; G | 2013 |
Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy.
Topics: Diabetic Neuropathies; Drug Therapy, Combination; Humans; Peripheral Nervous System Diseases; Thioct | 2013 |
Peripheral neuropathy in obstetrics: efficacy and safety of α-lipoic acid supplementation.
Topics: Animals; Antioxidants; Dietary Supplements; Female; Humans; Neuralgia; Obstetrics; Peripheral Nervou | 2014 |
Targeting neuropathic pain: consider these alternatives.
Topics: Acetylcarnitine; Capsaicin; Complementary Therapies; Family Practice; gamma-Linolenic Acid; Humans; | 2015 |
[Burning sensation in oral cavity--burning mouth syndrome in everyday medical practice].
Topics: Acetamides; Amines; Anti-Anxiety Agents; Antidepressive Agents; Antioxidants; Burning Mouth Syndrome | 2012 |
[Evidence-based pharmacotherapy of neuropathic pain syndromes].
Topics: Amines; Analgesics; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Antioxidants; Cyclohexanec | 2004 |
11 trials available for thioctic acid and Peripheral Nerve Diseases
| Article | Year |
|---|---|
EVALUATION OF THE EFFICIENCY OF ALPHA-LIPOIC ACID AND IPIDACRINE HYDROCHLORIDE FOR THE PREVENTION OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY ACCORDING TO THE TOTAL NEUROPATHY SCORE.
Topics: Acetylcholinesterase; Aminoquinolines; Breast Neoplasms; Cholinesterase Inhibitors; Female; Humans; | 2022 |
Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cardiotoxicity; Doxorubicin; Femal | 2022 |
EFFECTIVENESS OF ALPHA-LIPOIC ACID AND IPIDACRINE HYDROCHLORIDE IN PREVENTION OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY ASSESSED BY ELECTRONEUROMYOGRAPHY OF SUPERFICIAL PERONEAL AND SURAL NERVES.
Topics: Acetylcholinesterase; Breast Neoplasms; Female; Humans; Paclitaxel; Peripheral Nervous System Diseas | 2022 |
Oral alpha-lipoic acid to prevent chemotherapy-induced peripheral neuropathy: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cispl | 2014 |
Differential efficacy of methylcobalamin and alpha-lipoic acid treatment on symptoms of diabetic peripheral neuropathy.
Topics: Aged; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Humans; Male; Middle A | 2018 |
Use of an alpha lipoic, methylsulfonylmethane and bromelain dietary supplement (Opera
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bromelains; Diet | 2017 |
[Efficacy and safety of high-dose α-lipoic acid in the treatment of diabetic polyneuropathy].
Topics: Aged; Antioxidants; Diabetic Neuropathies; Double-Blind Method; Female; Humans; Male; Middle Aged; P | 2010 |
Gastric emptying in patients with insulin dependent diabetes mellitus and bioavailability of thioctic acid-enantiomers.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Diabetes | 1998 |
Complications & side effects. Supplements and CD4+ counts: study finds surprising results.
Topics: Acetylcarnitine; Acetylcysteine; Antioxidants; CD4 Lymphocyte Count; Dose-Response Relationship, Dru | 2004 |
[Curative effect of alpha-lipoic acid on peripheral neuropathy in type 2 diabetes: a clinical study].
Topics: Aged; Antioxidants; Blood Glucose; C-Reactive Protein; Diabetes Mellitus, Type 2; Diabetic Nephropat | 2007 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
12 other studies available for thioctic acid and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Comparison of peripheral nerve protection between insulin-based glucose control and alpha lipoic acid (ALA) in the streptozotocin (STZ)-induced diabetic rat.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hypoglycemic Agents; | 2018 |
Prevention of Bortezomib-Related Peripheral Neuropathy With Docosahexaenoic Acid and α-Lipoic Acid in Patients With Multiple Myeloma: Preliminary Data.
Topics: Aged; Antineoplastic Agents; Bortezomib; Docosahexaenoic Acids; Female; Humans; Male; Middle Aged; M | 2018 |
Novel therapeutic strategy to prevent chemotherapy-induced persistent sensory neuropathy by TRPA1 blockade.
Topics: Acetanilides; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Mice; Mice, Inbred C57BL; O | 2013 |
Amelioration of behavioural, biochemical, and neurophysiological deficits by combination of monosodium glutamate with resveratrol/alpha-lipoic acid/coenzyme Q10 in rat model of cisplatin-induced peripheral neuropathy.
Topics: Animals; Behavior, Animal; Catalase; Disease Models, Animal; Drug Therapy, Combination; Glutathione; | 2013 |
Neuroprotective activity of thioctic acid in central nervous system lesions consequent to peripheral nerve injury.
Topics: Animals; Antioxidants; Central Nervous System; Humans; Neuroprotective Agents; Oxidative Stress; Per | 2013 |
Comment on Xu et al.: Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy.
Topics: Diabetic Neuropathies; Humans; Peripheral Nervous System Diseases; Thioctic Acid; Vitamin B 12 | 2014 |
Comment on Xu et al.: Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy.
Topics: Diabetic Neuropathies; Humans; Peripheral Nervous System Diseases; Thioctic Acid; Vitamin B 12 | 2014 |
The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationship, | 2015 |
Alpha-lipoic acid reduces body weight and regulates triglycerides in obese patients with diabetes mellitus.
Topics: Body Weight; Cholesterol; Diabetes Mellitus, Type 2; Female; Humans; Male; Metformin; Middle Aged; O | 2015 |
Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Axons; C | 2008 |
Comparative effects of α lipoic acid and melatonin on cisplatin-induced neurotoxicity.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cisplatin; Male; Melatonin; Peripheral Nervous System | 2010 |
[Therapeutic possibilities in polyneuropathies].
Topics: Adult; Aged; Diabetic Neuropathies; Humans; Methionine; Middle Aged; Nervous System Diseases; Neurit | 1982 |